메뉴 건너뛰기




Volumn 7, Issue 3, 2011, Pages 309-317

Metabolomic changes in autopsy-confirmed Alzheimer's disease

Author keywords

Alzheimer's; Biomarkers; Diagnosis; Metabolomics; Purine; Staging; Tryptophan; Tyrosine

Indexed keywords

3 HYDROXYANTHRANILIC ACID; 5 HYDROXYINDOLEACETIC ACID; 5 HYDROXYTRYPTOPHAN; ALPHA TOCOPHEROL; ASCORBIC ACID; CYSTINE; DOPAMINE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GUANOSINE; HOMOVANILLIC ACID; HYPOXANTHINE; INDOLEACETIC ACID; KYNURENINE; LEVODOPA; METHIONINE; N ACETYLSEROTONIN; NORADRENALIN; PHENYLALANINE; PURINE; SEROTONIN; SULFUR AMINO ACID; TOCOPHEROL; TRYPTOPHAN; TYRAMINE; TYROSINE; URIC ACID; VANILMANDELIC ACID; XANTHINE; XANTHOSINE;

EID: 79956130559     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2010.06.001     Document Type: Article
Times cited : (131)

References (41)
  • 1
    • 79956144220 scopus 로고    scopus 로고
    • Alzheimer's disease facts and figures
    • Alzheimer's Association
    • Alzheimer's Association. Alzheimer's disease facts and figures. Alzheimers Dement 2009;5:3.
    • (2009) Alzheimers Dement , vol.5 , pp. 3
  • 2
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-44.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 3
    • 0004235298 scopus 로고    scopus 로고
    • American Psychiatric Association. 4th ed. Washington, DC: American Psychiatric Association
    • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 2000.
    • (2000) Diagnostic and Statistical Manual of Mental Disorders
  • 4
    • 0344034779 scopus 로고    scopus 로고
    • Diagnosing cognitive impairment and dementia in primary health care - A more active approach is needed
    • DOI 10.1093/ageing/afg097
    • Lopponen M, Raiha I, Isoaho R, Vahlberg T, Kivela SL. Diagnosing cognitive impairment and dementia in primary health care - a more active approach is needed. Age Ageing 2003;32:606-12. (Pubitemid 37461568)
    • (2003) Age and Ageing , vol.32 , Issue.6 , pp. 606-612
    • Lopponen, M.1    Raiha, I.2    Isoaho, R.3    Vahlberg, T.4    Kivela, S.-L.5
  • 5
    • 0031255112 scopus 로고    scopus 로고
    • Consensus recommendations for the post-mortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease
    • Hyman BT, Trojanowski JQ. Consensus recommendations for the post-mortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease. J Neuropathol Exp Neurol 1997;56:1095-7.
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 1095-1097
    • Hyman, B.T.1    Trojanowski, J.Q.2
  • 6
    • 0034087231 scopus 로고    scopus 로고
    • Mild cognitive impairment: Transition between aging and Alzheimer's disease
    • Petersen RC. Mild cognitive impairment: transition between aging and Alzheimer's disease. Neurologia 2000;15:93-101. (Pubitemid 30340226)
    • (2000) Neurologia , vol.15 , Issue.3 , pp. 93-101
    • Petersen, R.C.1
  • 7
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • DOI 10.1126/science.1072994
    • Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002;297:353-6. (Pubitemid 34790756)
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 8
    • 0033624419 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease
    • Albers DS, Beal MF. Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. J Neural Transm Suppl 2000;59:133-54. (Pubitemid 30479414)
    • (2000) Journal of Neural Transmission, Supplement , Issue.59 , pp. 133-154
    • Albers, D.S.1    Flint, B.M.2
  • 10
    • 34548410134 scopus 로고    scopus 로고
    • High-performance liquid chromatography separations coupled with coulometric electrode array detectors: A unique approach to metabolomics
    • Kristal BS, Shurubor YI, Kaddurah-Daouk R, Matson WR. High-performance liquid chromatography separations coupled with coulometric electrode array detectors: a unique approach to metabolomics. Methods Mol Biol 2006;358:159-74.
    • (2006) Methods Mol Biol , vol.358 , pp. 159-174
    • Kristal, B.S.1    Shurubor, Y.I.2    Kaddurah-Daouk, R.3    Matson, W.R.4
  • 11
    • 34548789029 scopus 로고    scopus 로고
    • Metabolomics in the study of aging and caloric restriction
    • DOI 10.1385/1-59745-361-7:393, Biological Aging: Methods and Protocols
    • Kristal BS, Shurubor YI, Kaddurah-Daouk R, Matson WR. Metabolomics in the study of aging and caloric restriction. Methods Mol Biol 2007;371:393-409. (Pubitemid 350183437)
    • (2007) Methods in Molecular Biology , vol.371 , pp. 393-409
    • Kristal, B.S.1    Shurubor, Y.I.2    Kaddurah-Daouk, R.3    Matson, W.R.4
  • 13
    • 57649121825 scopus 로고    scopus 로고
    • Metabolomics: A global biochemical approach to the study of central nervous system disease
    • Kaddurah-Daouk R, Krishnan KR. Metabolomics: a global biochemical approach to the study of central nervous system disease. Neuropsychopharmacology 2009;34:173-86.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 173-186
    • Kaddurah-Daouk, R.1    Krishnan, K.R.2
  • 14
    • 2942676743 scopus 로고    scopus 로고
    • Metabolomics and systems biology: Making sense of the soup
    • DOI 10.1016/j.mib.2004.04.012, PII S1369527404000505
    • Kell DB. Metabolomics and systems biology: making sense of the soup. Curr Opin Microbiol 2004;7:296-307. (Pubitemid 38765114)
    • (2004) Current Opinion in Microbiology , vol.7 , Issue.3 , pp. 296-307
    • Kell, D.B.1
  • 16
    • 0035023152 scopus 로고    scopus 로고
    • Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: Molecular characterization using electrospray ionization mass spectrometry
    • DOI 10.1046/j.1471-4159.2001.00332.x
    • Han X, Holtzman DM, McKeel DW Jr. Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry. J Neurochem 2001;77:1168-80. (Pubitemid 32467071)
    • (2001) Journal of Neurochemistry , vol.77 , Issue.4 , pp. 1168-1180
    • Han, X.1    Holtzman, D.M.2    McKeel Jr., D.W.3
  • 18
    • 21644479604 scopus 로고    scopus 로고
    • Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis
    • DOI 10.1021/ac0481001
    • Wang C, Kong H, Guan Y, Yang J, Gu J, Yang S, et al. Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis. Anal Chem 2005;77:4108-16. (Pubitemid 40934277)
    • (2005) Analytical Chemistry , vol.77 , Issue.13 , pp. 4108-4116
    • Wang, C.1    Kong, H.2    Guan, Y.3    Yang, J.4    Gu, J.5    Yang, S.6    Xu, G.7
  • 22
    • 77956434935 scopus 로고    scopus 로고
    • Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia
    • Yao JK, Dougherty GG Jr, Reddy RD, Keshavan MS, Montrose DM, Matson WR, et al. Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia. Mol Psychiatry 2009;28:1-16.
    • (2009) Mol Psychiatry , vol.28 , pp. 1-16
    • Yao, J.K.1    Dougherty Jr., G.G.2    Reddy, R.D.3    Keshavan, M.S.4    Montrose, D.M.5    Matson, W.R.6
  • 26
    • 0025863618 scopus 로고
    • Neuropathological staging of Alzheimer-related changes
    • Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 1991;82:239-59.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 27
    • 0025908356 scopus 로고
    • The consortium to establish a registry for Alzheimer's Disease (CERAD) Part II. Standardization of the neuropathological assessment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, et al. The consortium to establish a registry for Alzheimer's Disease (CERAD) Part II. Standardization of the neuropathological assessment of Alzheimer's disease. Neurology 1991;41:479-86.
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6
  • 28
    • 0042424602 scopus 로고    scopus 로고
    • Statistical significance for genome-wide studies
    • Storey JD, Tibshirani R. Statistical significance for genome-wide studies. Proc Natl Acad Sci U S A 2003;100:9440-5.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 9440-9445
    • Storey, J.D.1    Tibshirani, R.2
  • 33
    • 0018305844 scopus 로고
    • Changes in the brain catecholamines in patients with dementia of Alzheimer type
    • Adolfsson R, Gottfries CG, Roos BE, Winblad B. Changes in the brain catecholamines in patients with dementia of Alzheimer type. Br J Psychiatry 1979;135:216-23. (Pubitemid 9244805)
    • (1979) British Journal of Psychiatry , vol.135 , Issue.3 , pp. 216-223
    • Adolfsson, R.1    Gottfries, C.G.2    Roos, B.E.3    Winblad, B.4
  • 34
    • 0022379837 scopus 로고
    • 2-Adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates
    • Arnsten AF, Goldman-Rakic PS. Alpha 2-adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates. Science 1985;230:1273-6. (Pubitemid 16194533)
    • (1985) Science , vol.230 , Issue.4731 , pp. 1273-1276
    • Arnsten, A.F.T.1    Goldman-Rakic, P.S.2
  • 35
    • 0019872434 scopus 로고
    • Selective loss of neurons of origin of adrenergic projection to cerebral cortex (nucleus locus coeruleus) in senile dementia
    • Bondareff W, Mountjoy CQ, Roth M. Selective loss of neurons of origin of adrenergic projection to cerebral cortex (nucleus locus coeruleus) in senile dementia. Lancet 1981;1:783-4.
    • (1981) Lancet , vol.1 , pp. 783-784
    • Bondareff, W.1    Mountjoy, C.Q.2    Roth, M.3
  • 36
    • 0019496060 scopus 로고
    • Reduced dopamine-beta-hydroxylase activity in Alzheimer's disease
    • Cross AJ, Crow TJ, Perry EK, Perry RH, Blessed G, Tomlinson BE. Reduced dopamine-beta-hydroxylase activity in Alzheimer's disease. Br Med J (Clin Res Ed) 1981;282:93-4. (Pubitemid 11138339)
    • (1981) British Medical Journal , vol.282 , Issue.6258 , pp. 93-94
    • Cross, A.J.1    Crow, T.J.2    Perry, E.K.3
  • 38
    • 0033232474 scopus 로고    scopus 로고
    • The role of norepinephrine in the pathophysiology of cognitive disorders: Potential applications to the treatment of cognitive dysfunction in schizophrenia and Alzheimer's disease
    • DOI 10.1016/S0006-3223(99)00232-2, PII S0006322399002322
    • Friedman JI, Adler DN, David KL. The role of norepinephrine in the pathophysiology of cognitive disorders: potential applications to the treatment of cognitive dysfunction in schizophrenia and Alzheimer's disease. Biol Psychiatry 1999;46:1243-52. (Pubitemid 30114441)
    • (1999) Biological Psychiatry , vol.46 , Issue.9 , pp. 1243-1252
    • Friedman, J.I.1    Adler, D.N.2    Davis, K.L.3
  • 40
    • 0037465449 scopus 로고    scopus 로고
    • CSF Abeta 42 levels correlate with amyloid-neuropathology in a population-based autopsy study
    • Strozyk D, Blennow K, White LR, Launer LJ. CSF Abeta 42 levels correlate with amyloid-neuropathology in a population-based autopsy study. Neurology 2003;60:652-6. (Pubitemid 36246085)
    • (2003) Neurology , vol.60 , Issue.4 , pp. 652-656
    • Strozyk, D.1    Blennow, K.2    White, L.R.3    Launer, L.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.