메뉴 건너뛰기




Volumn 56, Issue 8, 2010, Pages 937-947

A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease

Author keywords

1H NMR; Amyloid precursor protein; Animal models; Biomarkers; Metabonomics; Neurodegeneration

Indexed keywords

4 AMINOBUTYRIC ACID; ALANINE; AMYLOID PRECURSOR PROTEIN; BRAIN EXTRACT; CHOLINE; CREATINE; CREATINE PHOSPHATE; FATTY ACID; GLUTAMIC ACID; GLUTAMINE; GLYCINE; ISOLEUCINE; LACTIC ACID; LEUCINE; MUTANT PROTEIN; N ACETYLASPARTIC ACID; PHOSPHORYLCHOLINE; SUCCINIC ACID; TAURINE; VALINE;

EID: 77953124257     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2010.04.001     Document Type: Article
Times cited : (128)

References (75)
  • 1
    • 0036946621 scopus 로고    scopus 로고
    • Morphologically distinct plaque types differentially affect dendritic structure and organisation in the early and late stages of Alzheimer's disease
    • Adlard P.A., Vickers J.C. Morphologically distinct plaque types differentially affect dendritic structure and organisation in the early and late stages of Alzheimer's disease. Acta Neuropathol. 2002, 103:377-383.
    • (2002) Acta Neuropathol. , vol.103 , pp. 377-383
    • Adlard, P.A.1    Vickers, J.C.2
  • 3
    • 0028291438 scopus 로고
    • Glia and neurons in dialogue
    • Attwell D. Glia and neurons in dialogue. Nature 1994, 369:707-708.
    • (1994) Nature , vol.369 , pp. 707-708
    • Attwell, D.1
  • 4
    • 0037409849 scopus 로고    scopus 로고
    • N-acetylaspartate in the vertebrate brain: metabolism and function
    • Baslow M.H. N-acetylaspartate in the vertebrate brain: metabolism and function. Neurochem. Res. 2003, 28:941-953.
    • (2003) Neurochem. Res. , vol.28 , pp. 941-953
    • Baslow, M.H.1
  • 6
    • 0027426832 scopus 로고
    • Metabolic alterations common to neural and non-neural cells in Alzheimer's disease
    • Spec No
    • Blass J.P. Metabolic alterations common to neural and non-neural cells in Alzheimer's disease. Hippocampus 1993, 3(Spec No):45-53.
    • (1993) Hippocampus , vol.3 , pp. 45-53
    • Blass, J.P.1
  • 7
    • 0031683604 scopus 로고    scopus 로고
    • Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis
    • Borchelt D.R., Wong P.C., Sisodia S.S., Price D.L. Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis. Brain Pathol. 1998, 8:735-757.
    • (1998) Brain Pathol. , vol.8 , pp. 735-757
    • Borchelt, D.R.1    Wong, P.C.2    Sisodia, S.S.3    Price, D.L.4
  • 8
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. (Berl.) 1991, 82:239-259.
    • (1991) Acta Neuropathol. (Berl.) , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 9
    • 0030953922 scopus 로고    scopus 로고
    • Regulation of gene expression by hypertonicity
    • Burg M.B., Kwon E.D., Kultz D. Regulation of gene expression by hypertonicity. Annu. Rev. Physiol. 1997, 59:437-455.
    • (1997) Annu. Rev. Physiol. , vol.59 , pp. 437-455
    • Burg, M.B.1    Kwon, E.D.2    Kultz, D.3
  • 16
    • 2442582930 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile
    • Dedeoglu A., Choi J.K., Cormier K., Kowall N.W., Jenkins B.G. Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile. Brain Res. 2004, 1012:60-65.
    • (2004) Brain Res. , vol.1012 , pp. 60-65
    • Dedeoglu, A.1    Choi, J.K.2    Cormier, K.3    Kowall, N.W.4    Jenkins, B.G.5
  • 20
    • 33646922865 scopus 로고    scopus 로고
    • Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice
    • Esposito L., Raber J., Kekonius L., Yan F., Yu G.Q., Bien-Ly N., Puolivali J., Scearce-Levie K., Masliah E., Mucke L. Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice. J. Neurosci. 2006, 26:5167-5179.
    • (2006) J. Neurosci. , vol.26 , pp. 5167-5179
    • Esposito, L.1    Raber, J.2    Kekonius, L.3    Yan, F.4    Yu, G.Q.5    Bien-Ly, N.6    Puolivali, J.7    Scearce-Levie, K.8    Masliah, E.9    Mucke, L.10
  • 22
    • 0021330769 scopus 로고
    • Glutamate: a neurotransmitter in mammalian brain
    • Fonnum F. Glutamate: a neurotransmitter in mammalian brain. J. Neurochem. 1984, 42:1-11.
    • (1984) J. Neurochem. , vol.42 , pp. 1-11
    • Fonnum, F.1
  • 25
    • 0031737226 scopus 로고    scopus 로고
    • Abnormalities of mitochondrial enzymes in Alzheimer disease
    • Gibson G.E., Sheu K.F.R., Blass J.P. Abnormalities of mitochondrial enzymes in Alzheimer disease. J. Neural Transm. 1998, 105:855-870.
    • (1998) J. Neural Transm. , vol.105 , pp. 855-870
    • Gibson, G.E.1    Sheu, K.F.R.2    Blass, J.P.3
  • 27
    • 0034099574 scopus 로고    scopus 로고
    • Proton NMR chemical shifts and coupling constants for brain metabolites
    • Govindaraju V., Young K., Maudsley A.A. Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed. 2000, 13:129-153.
    • (2000) NMR Biomed. , vol.13 , pp. 129-153
    • Govindaraju, V.1    Young, K.2    Maudsley, A.A.3
  • 28
    • 0028866435 scopus 로고
    • The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway
    • Haass C., Lemere C.A., Capell A., Citron M., Seubert P., Schenk D., Lannfelt L., Selkoe D.J. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat. Med. 1995, 1:1291-1296.
    • (1995) Nat. Med. , vol.1 , pp. 1291-1296
    • Haass, C.1    Lemere, C.A.2    Capell, A.3    Citron, M.4    Seubert, P.5    Schenk, D.6    Lannfelt, L.7    Selkoe, D.J.8
  • 29
    • 16444378671 scopus 로고    scopus 로고
    • 1H MR spectroscopy using TE averaged PRESS: a more sensitive technique to detect neurodegeneration associated with Alzheimer's disease
    • Hancu I., Zimmerman E.A., Sailasuta N., Hurd R.E. 1H MR spectroscopy using TE averaged PRESS: a more sensitive technique to detect neurodegeneration associated with Alzheimer's disease. Magn. Reson. Med. 2005, 53:777-782.
    • (2005) Magn. Reson. Med. , vol.53 , pp. 777-782
    • Hancu, I.1    Zimmerman, E.A.2    Sailasuta, N.3    Hurd, R.E.4
  • 30
    • 84880187014 scopus 로고    scopus 로고
    • Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal
    • Hardy J. Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal. J. Alzheimers Dis. 2006, 9:151-153.
    • (2006) J. Alzheimers Dis. , vol.9 , pp. 151-153
    • Hardy, J.1
  • 31
    • 0032150877 scopus 로고    scopus 로고
    • Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau
    • Hardy J., Duff K., Hardy K.G., Perez-Tur J., Hutton M. Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. Nat. Neurosci. 1998, 1:355-358.
    • (1998) Nat. Neurosci. , vol.1 , pp. 355-358
    • Hardy, J.1    Duff, K.2    Hardy, K.G.3    Perez-Tur, J.4    Hutton, M.5
  • 32
    • 0026597063 scopus 로고
    • Alzheimer's disease: the amyloid cascade hypothesis
    • Hardy J.A., Higgins G.A. Alzheimer's disease: the amyloid cascade hypothesis. Science 1992, 256:184-185.
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 33
    • 0042023711 scopus 로고    scopus 로고
    • Alzheimer disease in the US population: prevalence estimates using the 2000 census
    • Hebert L.E., Scherr P.A., Bienias J.L., Bennett D.A., Evans D.A. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch. Neurol. 2003, 60:1119-1122.
    • (2003) Arch. Neurol. , vol.60 , pp. 1119-1122
    • Hebert, L.E.1    Scherr, P.A.2    Bienias, J.L.3    Bennett, D.A.4    Evans, D.A.5
  • 35
    • 0029689159 scopus 로고    scopus 로고
    • Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease
    • Hoyer S. Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease. Acta Neurol. Scand. Suppl. 1996, 165:18-24.
    • (1996) Acta Neurol. Scand. Suppl. , vol.165 , pp. 18-24
    • Hoyer, S.1
  • 36
    • 0030612192 scopus 로고    scopus 로고
    • Models of Alzheimer's disease: cellular and molecular aspects
    • Hoyer S. Models of Alzheimer's disease: cellular and molecular aspects. J. Neural Transm. Suppl. 1997, 49:11-21.
    • (1997) J. Neural Transm. Suppl. , vol.49 , pp. 11-21
    • Hoyer, S.1
  • 39
    • 0029996740 scopus 로고    scopus 로고
    • Role of glutamate and excitotoxicity in neurologic diseases
    • Hugon J., Vallat J.M., Dumas M. Role of glutamate and excitotoxicity in neurologic diseases. Rev. Neurol. (Paris) 1996, 152:239-248.
    • (1996) Rev. Neurol. (Paris) , vol.152 , pp. 239-248
    • Hugon, J.1    Vallat, J.M.2    Dumas, M.3
  • 40
    • 0024486498 scopus 로고
    • Taurine in the central nervous system and the mammalian actions of taurine
    • Huxtable R.J. Taurine in the central nervous system and the mammalian actions of taurine. Prog. Neurobiol. 1989, 32:471-533.
    • (1989) Prog. Neurobiol. , vol.32 , pp. 471-533
    • Huxtable, R.J.1
  • 41
    • 0030612033 scopus 로고    scopus 로고
    • APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1
    • Irizarry M.C., McNamara M., Fedorchak K., Hsiao K., Hyman B.T. APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1. J. Neuropathol. Exp. Neurol. 1997, 56:965-973.
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 965-973
    • Irizarry, M.C.1    McNamara, M.2    Fedorchak, K.3    Hsiao, K.4    Hyman, B.T.5
  • 45
    • 0034006477 scopus 로고    scopus 로고
    • Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice
    • Jenkins B.G., Klivenyi P., Kustermann E., Andreassen O.A., Ferrante R.J., Rosen B.R., Beal M.F. Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice. J. Neurochem. 2000, 74:2108-2119.
    • (2000) J. Neurochem. , vol.74 , pp. 2108-2119
    • Jenkins, B.G.1    Klivenyi, P.2    Kustermann, E.3    Andreassen, O.A.4    Ferrante, R.J.5    Rosen, B.R.6    Beal, M.F.7
  • 46
    • 23944432134 scopus 로고    scopus 로고
    • A comparative study of the different N-acetylaspartate measures of the medial temporal lobe in Alzheimer's disease
    • Jessen F., Traeber F., Freymann N., Maier W., Schild H.H., Heun R., Block W. A comparative study of the different N-acetylaspartate measures of the medial temporal lobe in Alzheimer's disease. Dement. Geriatr. Cogn. Disord. 2005, 20:178-183.
    • (2005) Dement. Geriatr. Cogn. Disord. , vol.20 , pp. 178-183
    • Jessen, F.1    Traeber, F.2    Freymann, N.3    Maier, W.4    Schild, H.H.5    Heun, R.6    Block, W.7
  • 47
    • 3042770430 scopus 로고    scopus 로고
    • 1H MRS evaluation of metabolism in Alzheimer's disease and vascular dementia
    • 1H MRS evaluation of metabolism in Alzheimer's disease and vascular dementia. Neurol Res. 2004, 26:488-495.
    • (2004) Neurol Res. , vol.26 , pp. 488-495
    • Jones, R.S.1    Waldman, A.D.2
  • 50
    • 0028294003 scopus 로고
    • Analysis of magnetic resonance spectra by mole percent: comparison to absolute units
    • Klunk W.E., Xu C.J., Panchalingam K., McClure R.J., Pettegrew J.W. Analysis of magnetic resonance spectra by mole percent: comparison to absolute units. Neurobiol. Aging 1994, 15:133-140.
    • (1994) Neurobiol. Aging , vol.15 , pp. 133-140
    • Klunk, W.E.1    Xu, C.J.2    Panchalingam, K.3    McClure, R.J.4    Pettegrew, J.W.5
  • 51
  • 53
  • 54
    • 49049150378 scopus 로고
    • Two-dimensional chemical exchange and cross-relaxation spectroscopy of coupled nuclear spins
    • Macura S., Huang Y. Two-dimensional chemical exchange and cross-relaxation spectroscopy of coupled nuclear spins. J. Magn. Reson. 1981, 43:259-281.
    • (1981) J. Magn. Reson. , vol.43 , pp. 259-281
    • Macura, S.1    Huang, Y.2
  • 56
    • 33646126924 scopus 로고    scopus 로고
    • A decade of modeling Alzheimer's disease in transgenic mice
    • McGowan E., Eriksen J., Hutton M. A decade of modeling Alzheimer's disease in transgenic mice. Trends Genet. 2006, 22:281-289.
    • (2006) Trends Genet. , vol.22 , pp. 281-289
    • McGowan, E.1    Eriksen, J.2    Hutton, M.3
  • 62
    • 0029609260 scopus 로고
    • Symbiosis between in vivo and in vitro NMR spectroscopy: the creatine, N-acetylaspartate, glutamate, and GABA content of the epileptic human brain
    • Petroff O.A., Pleban L.A., Spencer D.D. Symbiosis between in vivo and in vitro NMR spectroscopy: the creatine, N-acetylaspartate, glutamate, and GABA content of the epileptic human brain. Magn. Reson. Imaging 1995, 13:1197-1211.
    • (1995) Magn. Reson. Imaging , vol.13 , pp. 1197-1211
    • Petroff, O.A.1    Pleban, L.A.2    Spencer, D.D.3
  • 63
    • 0023714247 scopus 로고
    • Correlation of phosphorus-31 magnetic resonance spectroscopy and morphologic findings in Alzheimer's disease
    • Pettegrew J.W., Panchalingam K., Moossy J., Martinez J., Rao G., Boller F. Correlation of phosphorus-31 magnetic resonance spectroscopy and morphologic findings in Alzheimer's disease. Arch. Neurol. 1988, 45:1093-1096.
    • (1988) Arch. Neurol. , vol.45 , pp. 1093-1096
    • Pettegrew, J.W.1    Panchalingam, K.2    Moossy, J.3    Martinez, J.4    Rao, G.5    Boller, F.6
  • 65
    • 35449007976 scopus 로고    scopus 로고
    • GABA(A) receptors in aging and Alzheimer's disease
    • Rissman R.A., De Blas A.L., Armstrong D.M. GABA(A) receptors in aging and Alzheimer's disease. J. Neurochem. 2007, 103:1285-1292.
    • (2007) J. Neurochem. , vol.103 , pp. 1285-1292
    • Rissman, R.A.1    De Blas, A.L.2    Armstrong, D.M.3
  • 66
    • 0038650885 scopus 로고    scopus 로고
    • In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function
    • Rothman D.L., Behar K.L., Hyder F., Shulman R.G. In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function. Annu. Rev. Physiol. 2003, 65:401-427.
    • (2003) Annu. Rev. Physiol. , vol.65 , pp. 401-427
    • Rothman, D.L.1    Behar, K.L.2    Hyder, F.3    Shulman, R.G.4
  • 67
    • 0030774535 scopus 로고    scopus 로고
    • The genetics of Alzheimer's disease
    • Rubinsztein D.C. The genetics of Alzheimer's disease. Prog. Neurobiol. 1997, 52:447-454.
    • (1997) Prog. Neurobiol. , vol.52 , pp. 447-454
    • Rubinsztein, D.C.1
  • 69
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 2001, 81:741-766.
    • (2001) Physiol. Rev. , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 70
    • 0034705204 scopus 로고    scopus 로고
    • In search of gamma-secretase: presenilin at the cutting edge
    • Selkoe D.J., Wolfe M.S. In search of gamma-secretase: presenilin at the cutting edge. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:5690-5692.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 5690-5692
    • Selkoe, D.J.1    Wolfe, M.S.2
  • 72
    • 0036736218 scopus 로고    scopus 로고
    • Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease
    • Suh Y.H., Checler F. Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease. Pharmacol. Rev. 2002, 54:469-525.
    • (2002) Pharmacol. Rev. , vol.54 , pp. 469-525
    • Suh, Y.H.1    Checler, F.2
  • 73
    • 0028157335 scopus 로고
    • Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II)
    • Svennerholm L., Gottfries C.G. Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II). J. Neurochem. 1994, 62:1039-1047.
    • (1994) J. Neurochem. , vol.62 , pp. 1039-1047
    • Svennerholm, L.1    Gottfries, C.G.2
  • 75
    • 65249085666 scopus 로고    scopus 로고
    • Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging
    • Woodhouse A., Vickers J.C., Adlard P.A., Dickson T.C. Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging. Neurobiol. Aging 2009, 30:864-874.
    • (2009) Neurobiol. Aging , vol.30 , pp. 864-874
    • Woodhouse, A.1    Vickers, J.C.2    Adlard, P.A.3    Dickson, T.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.