Amino acid metabolic dysfunction revealed in the prefrontal cortex of a rat model of depression

Behavioural Brain Research

Volumn 278, Issue , 2015, Pages 286-292

  Chen, Guanghui ^a,b   Yang, Deyu ^a   Yang, Yongtao ^a,b,c   Li, Juan ^a,b,c   Cheng, Ke ^a,b,c   Tang, Ge ^a,b   Zhang, Rufang ^a,b   Zhou, Jingjing ^a,b   Li, Wenwen ^a,b   Liu, Zhao ^a,b   Fan, Songhua ^a,b,c   Xie, Peng ^a,b  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b CHONGQING KEY LABORATORY OF NEUROBIOLOGY   (China)

^c THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Chronic unpredictable mild stress, CUMS; Depression, Major depressive disorder, MDD; Metabonomic, metabolomic; Prefrontal cortex, PFC

Indexed keywords

BETA ALANINE; GLYCEROL; ISOLEUCINE; N ACETYLASPARTIC ACID; AMINO ACID; ASPARTIC ACID; N-ACETYLASPARTATE;

ADULT; AMINO ACID METABOLISM; ANHEDONIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC STRESS; CONTROLLED STUDY; DEPRESSION; MALE; MASS FRAGMENTOGRAPHY; METABOLOMICS; MOLECULAR PATHOLOGY; NONHUMAN; OPEN FIELD TEST; PREFRONTAL CORTEX; RAT; SUCROSE PREFERENCE TEST; ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL BEHAVIOR; COMPLICATION; DISEASE MODEL; MAJOR DEPRESSION; MENTAL STRESS; METABOLISM; PSYCHOLOGY; SPRAGUE DAWLEY RAT;

AMINO ACIDS; ANIMALS; ASPARTIC ACID; BEHAVIOR, ANIMAL; BETA-ALANINE; DEPRESSIVE DISORDER, MAJOR; DISEASE MODELS, ANIMAL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLYCEROL; ISOLEUCINE; MALE; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; STRESS, PSYCHOLOGICAL;

EID: 84908429261     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2014.05.027     Document Type: Article

References (54)

1. Kessler R.C., Berglund P., Demler O., Jin R., Koretz D., Merikangas K.R., Rush A.J., Walters E.E., Wang P.S., National Comorbidity Survey Replication The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 2003, 289:3095-3105.
2. Simon G.E. Social and economic burden of mood disorders. Biol Psychiatry 2003, 54:208-215.
3. Cardinal R.N., Parkinson J.A., Hall J., Everitt B.J. Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci Biobehav Rev 2002, 26:321-352.
4. Murray E.A., Wise S.P. Interactions between orbital prefrontal cortex and amygdala: advanced cognition, learned responses and instinctive behaviors. Curr Opin Neurobiol 2010, 20:212-220.
5. Koenigs M., Grafman J. The functional neuroanatomy of depression: distinct roles for ventromedial and dorsolateral prefrontal cortex. Behav Brain Res 2009, 201:239-243.
6. Drevets W.C., Price J.L., Simpson J.R., Todd R.D., Reich T., Vannier M., Raichle M.E. Subgenual prefrontal cortex abnormalities in mood disorders. Nature 1997, 386:824-827.
7. Feyissa A.M., Chandran A., Stockmeier C.A., Karolewicz B. Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33:70-75.
8. Karolewicz B., Maciag D., O'Dwyer G., Stockmeier C.A., Feyissa A.M., Rajkowska G. Reduced level of glutamic acid decarboxylase-67kDa in the prefrontal cortex in major depression. Int J Neuropsychopharmacol 2010, 13:411-420.
9. Fales C.L., Barch D.M., Rundle M.M., Mintun M.A., Mathews J., Snyder A.Z., Sheline Y.I. Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression. J Affect Disord 2009, 112:206-211.
10. Schutter D.J. Antidepressant efficacy of high-frequency transcranial magnetic stimulation over the left dorsolateral prefrontal cortex in double-blind sham-controlled designs: a meta-analysis. Psychol Med 2009, 39:65-75.
11. Yang Y., Yang D., Tang G., Zhou C., Cheng K., Zhou J., Wu B., Peng Y., Liu C., Zhan Y., Chen J., Chen G., Xie P. Proteomics reveals energy and glutathione metabolic dysregulation in the prefrontal cortex of a rat model of depression. Neuroscience 2013, 247:191-200.
12. Nicholson J.K., Wilson I.D. Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat Rev Drug Discov 2003, 2:668-676.
13. Fiehn O. Metabolomics-the link between genotypes and phenotypes. Plant Mol Biol 2002, 48:155-171.
14. Nicholson J.K., Lindon J.C., Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999, 29:1181-1189.
15. Theodoridis G.A., Gika H.G., Want E.J., Wilson I.D. Liquid chromatography-mass spectrometry based global metabolite profiling: a review. Anal Chim Acta 2012, 711:7-16.
16. Lindon J.C., Nicholson J.K., Holmes E., Antti H., Bollard M.E., Keun H., Beckonert O., Ebbels T.M., Reily M.D., Robertson D. Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project. Toxicol Appl Pharmacol 2003, 187:137-146.
17. Liu X.-J., Hu J., Li Z.-Y., Qin X.-M., Zhang L.-Z., Guo X.-Q. Species classification and quality assessment of Chaihu (Radix Bupleuri) based on high-performance liquid chromatographic fingerprint and combined chemometrics methods. Arch Pharm Res 2011, 34:961-969.
18. Gao X., Zheng X., Li Z., Zhou Y., Sun H., Zhang L., Guo X., Du G., Qin X. Metabonomic study on chronic unpredictable mild stress and intervention effects of Xiaoyaosan in rats using gas chromatography coupled with mass spectrometry. J Ethnopharmacol 2011, 137:690-699.
19. Liu X.J., Zhou Y.Z., Li Z.F., Cui J., Li Z.Y., Gao X.X., Sun H.F., Zhang L.Z., Du G.H., Qin X.M. Anti-depressant effects of Xiaoyaosan on rat model of chronic unpredictable mild stress: a plasma metabonomics study based on NMR spectroscopy. J Pharm Pharmacol 2012, 64:578-588.
20. Ni Y., Su M., Lin J., Wang X., Qiu Y., Zhao A., Chen T., Jia W. Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress. FEBS Lett 2008, 582:2627-2636.
21. Shao W.-H., Fan S.-H., Lei Y., Yao G.-E., Chen J.-J., Zhou J., Xu H.-B., Liu H.-P., Wu B., Zheng P. Metabolomic identification of molecular changes associated with stress resilience in the chronic mild stress rat model of depression. Metabolomics 2013, 9:1-11.
22. (1)H-NMR plasma metabonomic study of acute and chronic stress models of depression in rats. Behav Brain Res 2013, 241:86-91.
23. Wang X., Zeng C., Lin J., Chen T., Zhao T., Jia Z., Xie X., Qiu Y., Su M., Jiang T., Zhou M., Zhao A., Jia W. Metabonomics approach to assessing the modulatory effects of St John's wort, ginsenosides, and clomipramine in experimental depression. J Proteome Res 2012, 11:6223-6230.
24. Zheng P., Chen J.-j., Huang T., Wang M.-j., Wang Y., Dong M.-x., Huang Y.-j., Zhou L.-k., Xie P. A novel urinary metabolite signature for diagnosing major depressive disorder. J Proteome Res 2013, 12:5904-5911.
25. Zheng P., Gao H.C., Li Q., Shao W.H., Zhang M.L., Cheng K., Yang de Y., Fan S.H., Chen L., Fang L., Xie P. Plasma metabonomics as a novel diagnostic approach for major depressive disorder. J Proteome Res 2012, 11:1741-1748.
26. Willner P. Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 2005, 52:90-110.
27. Clark J.D., Gebhart G.F., Gonder J.C., Keeling M.E., Kohn D.F. The 1996 guide for the care and use of laboratory animals. ILAR J 1997, 38:41-48.
28. Yang D., Liu X., Zhang R., Cheng K., Mu J., Fang L., Xie P. Increased apoptosis and different regulation of pro-apoptosis protein bax and anti-apoptosis protein bcl-2 in the olfactory bulb of a rat model of depression. Neurosci Lett 2011, 504:18-22.
29. Mu J., Xie P., Yang Z.S., Yang D.L., Lv F.J., Luo T.Y., Li Y. Neurogenesis and major depression: implications from proteomic analyses of hippocampal proteins in a rat depression model. Neurosci Lett 2007, 416:252-256.
30. Xie H., Zhu Y., Jiang W., Zhou Q., Yang H., Gu N., Zhang Y., Xu H., Xu H., Yang X. Lactoferrin-conjugated superparamagnetic iron oxide nanoparticles as a specific MRI contrast agent for detection of brain glioma in vivo. Biomaterials 2011, 32:495-502.
31. Luedemann A., Strassburg K., Erban A., Kopka J. TagFinder for the quantitative analysis of gas chromatography-mass spectrometry (GC-MS)-based metabolite profiling experiments. Bioinformatics 2008, 24:732-737.
32. Aarts K., Vanderhasselt M.A., Otte G., Baeken C., Pourtois G. Electrical brain imaging reveals the expression and timing of altered error monitoring functions in major depression. J Abnorm Psychol 2013, 122:939-950.
33. Wang D., An S.C., Zhang X. Prevention of chronic stress-induced depression-like behavior by inducible nitric oxide inhibitor. Neurosci Lett 2008, 433:59-64.
34. Bernard R., Kerman I.A., Thompson R.C., Jones E.G., Bunney W.E., Barchas J.D., Schatzberg A.F., Myers R.M., Akil H., Watson S.J. Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. Mol Psychiatry 2011, 16:634-646.
35. Choudary P.V., Molnar M., Evans S.J., Tomita H., Li J.Z., Vawter M.P., Myers R.M., Bunney W.E., Akil H., Watson S.J., Jones E.G. Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Nat Acad Sci USA 2005, 102:15653-15658.
36. Berberian V., Sanchez M.S., Celis M.E. Participation of the cholinergic system in the excessive grooming behavior induced by neuropeptide (N) glutamic acid (E) isoleucine (I) amide (NEI). Neurochem Res 2002, 27:1713-1717.
37. Fields H.L., Hjelmstad G.O., Margolis E.B., Nicola S.M. Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement. Annu Rev Neurosci 2007, 30:289-316.
38. Sanchez M.S., Barontini M., Armando I., Celis M.E. Correlation of increased grooming behavior and motor activity with alterations in nigrostriatal and mesolimbic catecholamines after alpha-melanotropin and neuropeptide glutamine-isoleucine injection in the rat ventral tegmental area. Cell Mol Neurobiol 2001, 21:523-533.
39. Patel T.B., Clark J.B. Synthesis of N-acetyl-l-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport. Biochem J 1979, 184:539-546.
40. Reynolds L.M., Reynolds G.P. Differential regional N-acetylaspartate deficits in postmortem brain in schizophrenia, bipolar disorder and major depressive disorder. J Psychiatr Res 2011, 45:54-59.
41. Miller S.L., Daikhin Y., Yudkoff M. Metabolism of N-acetyl-l-aspartate in rat brain. Neurochem Res 1996, 21:615-618.
42. Simmons M.L., Frondoza C.G., Coyle J.T. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience 1991, 45:37-45.
43. (1)H magnetic resonance spectroscopy. Psychiatry Res 2010, 182:48-52.
44. 1H-MRS. PLoS One 2011, 6:e28686.
45. Curtis D.R., Phillis J.W., Watkins J.C. The depression of spinal neurones by gamma-amino-n-butyric acid and beta-alanine. J Physiol 1959, 146:185-203.
46. Fowler J.C. Adenosine antagonists delay hypoxia-induced depression of neuronal activity in hippocampal brain slice. Brain Res 1989, 490:378-384.
47. Jones M.G., Cooper E., Amjad S., Goodwin C.S., Barron J.L., Chalmers R.A. Urinary and plasma organic acids and amino acids in chronic fatigue syndrome. Clin Chim Acta 2005, 361:150-158.
48. Kawamura N. Biomarker for depression, method for measuring a biomarker for depression, computer program, and recording medium. EP Patent 2466,312 2012.
49. Murakami T., Yamane H., Tomonaga S., Furuse M. Forced swimming and imipramine modify plasma and brain amino acid concentrations in mice. Eur J Pharmacol 2009, 602:73-77.
50. Nagasawa M., Ogino Y., Kurata K., Otsuka T., Yoshida J., Tomonaga S., Furuse M. Hypothesis with abnormal amino acid metabolism in depression and stress vulnerability in Wistar Kyoto rats. Amino Acids 2012, 43:2101-2111.
51. Mena Gomez M.A., Carlsson A., Garcia de Yebenes J. The effect of beta-alanine on motor behaviour, body temperature and cerebral monoamine metabolism in rat. J Neural Transm 1978, 43:1-9.
52. Tomonaga S., Tachibana T., Takagi T., Saito E.S., Zhang R., Denbow D.M., Furuse M. Effect of central administration of carnosine and its constituents on behaviors in chicks. Brain Res Bull 2004, 63:75-82.
53. Mehta D., Raison C.L., Woolwine B.J., Haroon E., Binder E.B., Miller A.H., Felger J.C. Transcriptional signatures related to glucose and lipid metabolism predict treatment response to the tumor necrosis factor antagonist infliximab in patients with treatment-resistant depression. Brain Behav Immun 2013, 31:205-215.
54. Prairie B.A., Wisniewski S.R., Luther J.F., Sit D., Wisner K.L. Postpartum lipid levels in women with major depression. J Womens Health (Larchmt) 2012, 21:534-538.