Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer's disease

Analytical Chemistry

Volumn 85, Issue 3, 2013, Pages 1803-1811

  Graham, Stewart F ^a   Chevallier, Olivier P ^a   Roberts, Dominic ^b   Hölscher, Christian ^c   Elliott, Christopher T ^a   Green, Brian D ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b WATERS CORPORATION   (United States)

^c UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGE-MATCHED CONTROLS; ALZHEIMER'S DISEASE; BLIND TEST; BRAIN DISORDERS; BRAIN TISSUE; CHEMOMETRICS; DIAGNOSTIC ACCURACY; EARLY DIAGNOSIS; HIGH RESOLUTION; HIGH RESOLUTION MASS SPECTROMETRY; HUMAN BRAIN; METABOLOMES; METABOLOMICS; MULTIVARIATE MODELS; NOVEL METHODS; PARTIAL LEAST SQUARES; PATHOPHYSIOLOGY; PREDICTIVE ACCURACY; PREDICTIVE POWER; ROOT MEAN SQUARED ERRORS; THERAPEUTIC TARGETS;

BRAIN; DISCRIMINANT ANALYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

DIAGNOSIS;

BIOLOGICAL MARKER;

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN; COHORT ANALYSIS; DRUG DELIVERY SYSTEM; EARLY DIAGNOSIS; FEMALE; HUMAN; MALE; METABOLISM; METABOLOME; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BIOLOGICAL MARKERS; BRAIN; COHORT STUDIES; DRUG DELIVERY SYSTEMS; EARLY DIAGNOSIS; FEMALE; HUMANS; MALE; METABOLOME; MIDDLE AGED;

EID: 84873388502     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac303163f     Document Type: Article

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