메뉴 건너뛰기




Volumn 270, Issue , 2015, Pages 55-65

Thymoma related myasthenia gravis in humans and potential animal models

Author keywords

AIRE; Animal model; APS I; BUF Mna; Cat; Dog; Horse; Myasthenia gravis; Rat; Thymoma; Tiger

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; AZATHIOPRINE; CALCIUM CHANNEL; CHOLINERGIC RECEPTOR ANTIBODY; CORTICOSTEROID; DOUBLE STRANDED RNA; HLA ANTIGEN CLASS 2; MYCOPHENOLATE MOFETIL; POTASSIUM CHANNEL; PROTEIN KINASE R; PYRIDOSTIGMINE; RNA HELICASE; TOLL LIKE RECEPTOR 3; TRANSCRIPTION FACTOR FOXP3;

EID: 84939427681     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2015.02.010     Document Type: Review
Times cited : (75)

References (140)
  • 1
    • 0025146907 scopus 로고
    • Patients with myasthenia gravis and thymoma have in their sera IgG autoantibodies against titin
    • Aarli J.A., Stefansson K., Marton L.S., Wollmann R.L. Patients with myasthenia gravis and thymoma have in their sera IgG autoantibodies against titin. Clin. Exp. Immunol. 1990, 82:284-288.
    • (1990) Clin. Exp. Immunol. , vol.82 , pp. 284-288
    • Aarli, J.A.1    Stefansson, K.2    Marton, L.S.3    Wollmann, R.L.4
  • 2
    • 68949091938 scopus 로고    scopus 로고
    • Use of mycophenolate mofetil as a rescue agent in the treatment of severe generalized myasthenia gravis in three dogs
    • Abelson A.L., Shelton G.D., Whelan M.F., Cornejo L., Shaw S., O'Toole T.E. Use of mycophenolate mofetil as a rescue agent in the treatment of severe generalized myasthenia gravis in three dogs. J. Vet. Emerg. Crit. Care 2009, 19:369-374.
    • (2009) J. Vet. Emerg. Crit. Care , vol.19 , pp. 369-374
    • Abelson, A.L.1    Shelton, G.D.2    Whelan, M.F.3    Cornejo, L.4    Shaw, S.5    O'Toole, T.E.6
  • 3
    • 84895881440 scopus 로고    scopus 로고
    • T-lymphocyte-rich thymoma and myasthenia gravis in a Siberian tiger (Panthera tigris altaica)
    • Allan K., Masters N., Rivers S., Berry K., Routh A., Lamm C. T-lymphocyte-rich thymoma and myasthenia gravis in a Siberian tiger (Panthera tigris altaica). J. Comp. Pathol. 2014, 150:345-349.
    • (2014) J. Comp. Pathol. , vol.150 , pp. 345-349
    • Allan, K.1    Masters, N.2    Rivers, S.3    Berry, K.4    Routh, A.5    Lamm, C.6
  • 5
    • 34248598295 scopus 로고    scopus 로고
    • Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
    • Aschenbrenner K., D'Cruz L.M., Vollmann E.H., Hinterberger M., Emmerich J., Swee L.K., Rolink A., Klein L. Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat. Immunol. 2007, 8:351-358.
    • (2007) Nat. Immunol. , vol.8 , pp. 351-358
    • Aschenbrenner, K.1    D'Cruz, L.M.2    Vollmann, E.H.3    Hinterberger, M.4    Emmerich, J.5    Swee, L.K.6    Rolink, A.7    Klein, L.8
  • 8
    • 11244291391 scopus 로고    scopus 로고
    • Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis
    • Balandina A., Lecart S., Dartevelle P., Saoudi A., Berrih-Aknin S. Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis. Blood 2005, 105:735-741.
    • (2005) Blood , vol.105 , pp. 735-741
    • Balandina, A.1    Lecart, S.2    Dartevelle, P.3    Saoudi, A.4    Berrih-Aknin, S.5
  • 11
    • 84904308431 scopus 로고    scopus 로고
    • Myasthenia gravis: a comprehensive review of immune dysregulation and etiological mechanisms
    • Berrih-Aknin S., Le Panse R. Myasthenia gravis: a comprehensive review of immune dysregulation and etiological mechanisms. J. Autoimmun. 2014, 52:90-100.
    • (2014) J. Autoimmun. , vol.52 , pp. 90-100
    • Berrih-Aknin, S.1    Le Panse, R.2
  • 12
    • 0034957184 scopus 로고    scopus 로고
    • Mature, long-lived CD4+ and CD8+ T cells are generated by the thymoma in myasthenia gravis
    • Buckley C., Douek D., Newsom-Davis J., Vincent A., Willcox N. Mature, long-lived CD4+ and CD8+ T cells are generated by the thymoma in myasthenia gravis. Ann. Neurol. 2001, 50:64-72.
    • (2001) Ann. Neurol. , vol.50 , pp. 64-72
    • Buckley, C.1    Douek, D.2    Newsom-Davis, J.3    Vincent, A.4    Willcox, N.5
  • 13
    • 0035856446 scopus 로고    scopus 로고
    • Do titin and cytokine antibodies in MG patients predict thymoma or thymoma recurrence?
    • Buckley C., Newsom-Davis J., Willcox N., Vincent A. Do titin and cytokine antibodies in MG patients predict thymoma or thymoma recurrence?. Neurology 2001, 57:1579-1582.
    • (2001) Neurology , vol.57 , pp. 1579-1582
    • Buckley, C.1    Newsom-Davis, J.2    Willcox, N.3    Vincent, A.4
  • 21
    • 0023117445 scopus 로고
    • Thymomatous epithelial cells and skeletal muscle share a common epitope defined by a monoclonal antibody
    • Dardenne M., Savino W., Bach J.F. Thymomatous epithelial cells and skeletal muscle share a common epitope defined by a monoclonal antibody. Am. J. Pathol. 1987, 126:194-198.
    • (1987) Am. J. Pathol. , vol.126 , pp. 194-198
    • Dardenne, M.1    Savino, W.2    Bach, J.F.3
  • 22
    • 0016854018 scopus 로고
    • Myasthenia gravis, thymoma and myositis in a dog
    • Darke P.G., McCullagh K.G., Geldart P.H. Myasthenia gravis, thymoma and myositis in a dog. Vet. Rec. 1975, 97:392-393.
    • (1975) Vet. Rec. , vol.97 , pp. 392-393
    • Darke, P.G.1    McCullagh, K.G.2    Geldart, P.H.3
  • 23
    • 0031225599 scopus 로고    scopus 로고
    • Review of thymic pathology in 30 cats and 36 dogs
    • Day M.J. Review of thymic pathology in 30 cats and 36 dogs. J. Small Anim. Pract. 1997, 38:393-403.
    • (1997) J. Small Anim. Pract. , vol.38 , pp. 393-403
    • Day, M.J.1
  • 24
    • 84924352610 scopus 로고    scopus 로고
    • Histologic classification of thymoma: a practical guide for routine cases
    • den Bakker M.A., Roden A.C., Marx A., Marino M. Histologic classification of thymoma: a practical guide for routine cases. J. Thorac. Oncol. 2014, 9(9):S125-S130.
    • (2014) J. Thorac. Oncol. , vol.9 , Issue.9 , pp. S125-S130
    • den Bakker, M.A.1    Roden, A.C.2    Marx, A.3    Marino, M.4
  • 25
    • 0033793843 scopus 로고    scopus 로고
    • Age changes of neuromuscular junctions in the extensor digitorum longus muscle of spontaneous thymoma BUF/Mna rats. A scanning and transmission electron microscopic study
    • Ezaki T., Oki S., Matsuda Y., Desaki J. Age changes of neuromuscular junctions in the extensor digitorum longus muscle of spontaneous thymoma BUF/Mna rats. A scanning and transmission electron microscopic study. Virchows Arch. 2000, 437:388-395.
    • (2000) Virchows Arch. , vol.437 , pp. 388-395
    • Ezaki, T.1    Oki, S.2    Matsuda, Y.3    Desaki, J.4
  • 26
    • 77956394808 scopus 로고    scopus 로고
    • Autoimmune mediated neuromuscular junction defects
    • Farrugia M.E., Vincent A. Autoimmune mediated neuromuscular junction defects. Curr. Opin. Neurol. 2010, 23:489-495.
    • (2010) Curr. Opin. Neurol. , vol.23 , pp. 489-495
    • Farrugia, M.E.1    Vincent, A.2
  • 27
    • 78751616196 scopus 로고    scopus 로고
    • Recent insights into the role and molecular mechanisms of the autoimmune regulator (AIRE) gene in autoimmunity
    • Fierabracci A. Recent insights into the role and molecular mechanisms of the autoimmune regulator (AIRE) gene in autoimmunity. Autoimmun. Rev. 2011, 10:137-143.
    • (2011) Autoimmun. Rev. , vol.10 , pp. 137-143
    • Fierabracci, A.1
  • 28
    • 24644476622 scopus 로고    scopus 로고
    • Thymoma-associated exfoliative dermatitis in a rabbit
    • Florizoone K. Thymoma-associated exfoliative dermatitis in a rabbit. Vet. Dermatol. 2005, 16:281-284.
    • (2005) Vet. Dermatol. , vol.16 , pp. 281-284
    • Florizoone, K.1
  • 29
    • 0031255487 scopus 로고    scopus 로고
    • Resolution of exfoliative dermatitis and Malassezia pachydermatis overgrowth in a cat after surgical thymoma resection
    • Forster-Van Hijfte M.A., Curtis C.F., White R.N. Resolution of exfoliative dermatitis and Malassezia pachydermatis overgrowth in a cat after surgical thymoma resection. J. Small Anim. Pract. 1997, 38:451-454.
    • (1997) J. Small Anim. Pract. , vol.38 , pp. 451-454
    • Forster-Van Hijfte, M.A.1    Curtis, C.F.2    White, R.N.3
  • 30
    • 0015036190 scopus 로고
    • The thymoma-prone (NZB×CFW) F1 mouse
    • Francis D., Barnes R.D., Kramer J.J. The thymoma-prone (NZB×CFW) F1 mouse. J. Pathol. 1971, 103:188-193.
    • (1971) J. Pathol. , vol.103 , pp. 188-193
    • Francis, D.1    Barnes, R.D.2    Kramer, J.J.3
  • 31
    • 0030996826 scopus 로고    scopus 로고
    • Positive and negative CD4+ thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus
    • Fukui Y., Ishimoto T., Utsuyama M., Gyotoku T., Koga T., Nakao K., Hirokawa K., Katsuki M., Sasazuki T. Positive and negative CD4+ thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus. Immunity 1997, 6:401-410.
    • (1997) Immunity , vol.6 , pp. 401-410
    • Fukui, Y.1    Ishimoto, T.2    Utsuyama, M.3    Gyotoku, T.4    Koga, T.5    Nakao, K.6    Hirokawa, K.7    Katsuki, M.8    Sasazuki, T.9
  • 35
    • 84877815750 scopus 로고    scopus 로고
    • The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity
    • Gianchecchi E., Palombi M., Fierabracci A. The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity. Autoimmun. Rev. 2013, 12:717-725.
    • (2013) Autoimmun. Rev. , vol.12 , pp. 717-725
    • Gianchecchi, E.1    Palombi, M.2    Fierabracci, A.3
  • 38
    • 84870056636 scopus 로고    scopus 로고
    • Paraneoplastic neurological syndromes
    • Graus F., Dalmau J. Paraneoplastic neurological syndromes. Curr. Opin. Neurol. 2012, 25(6):795-801.
    • (2012) Curr. Opin. Neurol. , vol.25 , Issue.6 , pp. 795-801
    • Graus, F.1    Dalmau, J.2
  • 40
    • 0017941393 scopus 로고
    • High prevalence of thymoma in the dairy goat. Report of seventeen cases
    • Hadlow W.J. High prevalence of thymoma in the dairy goat. Report of seventeen cases. Vet. Pathol. 1978, 15:153-169.
    • (1978) Vet. Pathol. , vol.15 , pp. 153-169
    • Hadlow, W.J.1
  • 41
    • 0015408404 scopus 로고
    • Thymoma with myasthenia gravis in a dog
    • Hall G.A., Howell J.M., Lewis D.G. Thymoma with myasthenia gravis in a dog. J. Pathol. 1972, 108:177-180.
    • (1972) J. Pathol. , vol.108 , pp. 177-180
    • Hall, G.A.1    Howell, J.M.2    Lewis, D.G.3
  • 42
    • 79952513213 scopus 로고    scopus 로고
    • Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis
    • Higuchi O., Hamuro J., Motomura M., Yamanashi Y. Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis. Ann. Neurol. 2011, 69:418-422.
    • (2011) Ann. Neurol. , vol.69 , pp. 418-422
    • Higuchi, O.1    Hamuro, J.2    Motomura, M.3    Yamanashi, Y.4
  • 43
    • 84888052566 scopus 로고    scopus 로고
    • Putative paraneoplastic pemphigus and myasthenia gravis in a cat with a lymphocytic thymoma
    • Hill P.B., Brain P., Collins D., Fearnside S., Olivry T. Putative paraneoplastic pemphigus and myasthenia gravis in a cat with a lymphocytic thymoma. Vet. Dermatol. 2013, 24:646-649.
    • (2013) Vet. Dermatol. , vol.24 , pp. 646-649
    • Hill, P.B.1    Brain, P.2    Collins, D.3    Fearnside, S.4    Olivry, T.5
  • 44
    • 0035105784 scopus 로고    scopus 로고
    • Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies
    • Hoch W., McConville J., Helms S., Newsom-Davis J., Melms A., Vincent A. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat. Med. 2001, 7:365-368.
    • (2001) Nat. Med. , vol.7 , pp. 365-368
    • Hoch, W.1    McConville, J.2    Helms, S.3    Newsom-Davis, J.4    Melms, A.5    Vincent, A.6
  • 45
    • 0034551737 scopus 로고    scopus 로고
    • Thymomas alter the T-cell subset composition in the blood: a potential mechanism for thymoma-associated autoimmune disease
    • Hoffacker V., Schultz A., Tiesinga J.J., Gold R., Schalke B., Nix W., Kiefer R., Muller-Hermelink H.K., Marx A. Thymomas alter the T-cell subset composition in the blood: a potential mechanism for thymoma-associated autoimmune disease. Blood 2000, 96:3872-3879.
    • (2000) Blood , vol.96 , pp. 3872-3879
    • Hoffacker, V.1    Schultz, A.2    Tiesinga, J.J.3    Gold, R.4    Schalke, B.5    Nix, W.6    Kiefer, R.7    Muller-Hermelink, H.K.8    Marx, A.9
  • 46
    • 51649102734 scopus 로고    scopus 로고
    • Reflections on the "intrathymic pathogenesis" of myasthenia gravis
    • Hohlfeld R., Wekerle H. Reflections on the "intrathymic pathogenesis" of myasthenia gravis. J. Neuroimmunol. 2008, 201-202:21-27.
    • (2008) J. Neuroimmunol. , pp. 21-27
    • Hohlfeld, R.1    Wekerle, H.2
  • 47
  • 49
    • 77954374894 scopus 로고    scopus 로고
    • Characterization of T cell maturity in thymic epithelial cell tumors from BUF/Mna spontaneous thymoma rats and BUF/Mna-Rnu/+ rats showing delayed thymomagenesis
    • Inoue M., Matsuyama M., Shiono H., Honda O., Sumikawa H., Tomiyama N., Okumura M. Characterization of T cell maturity in thymic epithelial cell tumors from BUF/Mna spontaneous thymoma rats and BUF/Mna-Rnu/+ rats showing delayed thymomagenesis. Int. J. Clin. Exp. Pathol. 2010, 3:587-592.
    • (2010) Int. J. Clin. Exp. Pathol. , vol.3 , pp. 587-592
    • Inoue, M.1    Matsuyama, M.2    Shiono, H.3    Honda, O.4    Sumikawa, H.5    Tomiyama, N.6    Okumura, M.7
  • 50
    • 0017609810 scopus 로고
    • Plasmapheresis: great economy in the use of horses
    • Jones J.V. Plasmapheresis: great economy in the use of horses. N. Engl. J. Med. 1977, 297:1173-1175.
    • (1977) N. Engl. J. Med. , vol.297 , pp. 1173-1175
    • Jones, J.V.1
  • 51
    • 84879049198 scopus 로고    scopus 로고
    • Cervical type AB thymoma (Mixed) tumour diagnosis in a mynah as a model to study human: clinicohistological, immunohistochemical and cytohistopathological study
    • Khaki F., Javanbakht J., Sasani F., Gharagozlou M.J., Bahrami A., Moslemzadeh H., Sheikhzadeh R. Cervical type AB thymoma (Mixed) tumour diagnosis in a mynah as a model to study human: clinicohistological, immunohistochemical and cytohistopathological study. Diagn. Pathol. 2013, 8:98.
    • (2013) Diagn. Pathol. , vol.8 , pp. 98
    • Khaki, F.1    Javanbakht, J.2    Sasani, F.3    Gharagozlou, M.J.4    Bahrami, A.5    Moslemzadeh, H.6    Sheikhzadeh, R.7
  • 53
    • 0023119226 scopus 로고
    • Acetylcholine receptor epitopes on epithelial cells of thymoma in myasthenia gravis
    • Kirchner T., Hoppe F., Muller-Hermelink H.K., Schalke B., Tzartos S. Acetylcholine receptor epitopes on epithelial cells of thymoma in myasthenia gravis. Lancet 1987, 1:218.
    • (1987) Lancet , vol.1 , pp. 218
    • Kirchner, T.1    Hoppe, F.2    Muller-Hermelink, H.K.3    Schalke, B.4    Tzartos, S.5
  • 55
    • 79957573654 scopus 로고    scopus 로고
    • Mucocutaneous candidiasis and autoimmunity against cytokines in APECED and thymoma patients: clinical and pathogenetic implications
    • Kisand K., Lilic D., Casanova J.L., Peterson P., Meager A., Willcox N. Mucocutaneous candidiasis and autoimmunity against cytokines in APECED and thymoma patients: clinical and pathogenetic implications. Eur. J. Immunol. 2011, 41:1517-1527.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 1517-1527
    • Kisand, K.1    Lilic, D.2    Casanova, J.L.3    Peterson, P.4    Meager, A.5    Willcox, N.6
  • 56
    • 84880928569 scopus 로고    scopus 로고
    • Autoimmune associations and autoantibody screening show focused recognition in patient subgroups with generalized myasthenia gravis
    • Klein R., Marx A., Strobel P., Schalke B., Nix W., Willcox N. Autoimmune associations and autoantibody screening show focused recognition in patient subgroups with generalized myasthenia gravis. Hum. Immunol. 2013, 74:1184-1193.
    • (2013) Hum. Immunol. , vol.74 , pp. 1184-1193
    • Klein, R.1    Marx, A.2    Strobel, P.3    Schalke, B.4    Nix, W.5    Willcox, N.6
  • 57
    • 79953071798 scopus 로고    scopus 로고
    • Mixed thymoma in a young cynomolgus monkey (Macaca fascicularis)
    • Kotani Y., Sato J., Wako Y., Tsuchitani M. Mixed thymoma in a young cynomolgus monkey (Macaca fascicularis). J. Toxicol. Pathol. 2010, 23:141-145.
    • (2010) J. Toxicol. Pathol. , vol.23 , pp. 141-145
    • Kotani, Y.1    Sato, J.2    Wako, Y.3    Tsuchitani, M.4
  • 58
    • 0031795886 scopus 로고    scopus 로고
    • Thymic carcinoma arising in thymoma is associated with alterations in immunohistochemical profile
    • Kuo T.T., Chan J.K. Thymic carcinoma arising in thymoma is associated with alterations in immunohistochemical profile. Am. J. Surg. Pathol. 1998, 22:1474-1481.
    • (1998) Am. J. Surg. Pathol. , vol.22 , pp. 1474-1481
    • Kuo, T.T.1    Chan, J.K.2
  • 59
    • 84904701212 scopus 로고    scopus 로고
    • Survivin as a potential mediator to support autoreactive cell survival in myasthenia gravis: a human and animal model study
    • Kusner L.L., Ciesielski M.J., Marx A., Kaminski H.J., Fenstermaker R.A. Survivin as a potential mediator to support autoreactive cell survival in myasthenia gravis: a human and animal model study. PLoS One 2014, 9:e102231.
    • (2014) PLoS One , vol.9 , pp. e102231
    • Kusner, L.L.1    Ciesielski, M.J.2    Marx, A.3    Kaminski, H.J.4    Fenstermaker, R.A.5
  • 60
    • 73149112590 scopus 로고    scopus 로고
    • Aire, master of many trades
    • Kyewski B., Peterson P. Aire, master of many trades. Cell 2010, 140:24-26.
    • (2010) Cell , vol.140 , pp. 24-26
    • Kyewski, B.1    Peterson, P.2
  • 61
    • 0030098415 scopus 로고    scopus 로고
    • Focal myasthenia gravis as a paraneoplastic syndrome of canine thymoma: improvement following thymectomy
    • Lainesse M.F., Taylor S.M., Myers S.L., Haines D., Fowler J.D. Focal myasthenia gravis as a paraneoplastic syndrome of canine thymoma: improvement following thymectomy. J. Am. Anim. Hosp. Assoc. 1996, 32:111-117.
    • (1996) J. Am. Anim. Hosp. Assoc. , vol.32 , pp. 111-117
    • Lainesse, M.F.1    Taylor, S.M.2    Myers, S.L.3    Haines, D.4    Fowler, J.D.5
  • 63
    • 34548863119 scopus 로고    scopus 로고
    • Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status
    • Leite M.I., Jones M., Strobel P., Marx A., Gold R., Niks E., Verschuuren J.J., Berrih-Aknin S., Scaravilli F., Canelhas A., et al. Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status. Am. J. Pathol. 2007, 171:893-905.
    • (2007) Am. J. Pathol. , vol.171 , pp. 893-905
    • Leite, M.I.1    Jones, M.2    Strobel, P.3    Marx, A.4    Gold, R.5    Niks, E.6    Verschuuren, J.J.7    Berrih-Aknin, S.8    Scaravilli, F.9    Canelhas, A.10
  • 65
    • 84900829275 scopus 로고    scopus 로고
    • Autoimmune regulator expression in thymomas with or without autoimmune disease
    • Liu Y., Zhang H., Zhang P., Meng F., Chen Y., Wang Y., Yao Y., Qi B. Autoimmune regulator expression in thymomas with or without autoimmune disease. Immunol. Lett. 2014, 161:50-56.
    • (2014) Immunol. Lett. , vol.161 , pp. 50-56
    • Liu, Y.1    Zhang, H.2    Zhang, P.3    Meng, F.4    Chen, Y.5    Wang, Y.6    Yao, Y.7    Qi, B.8
  • 72
    • 84895786399 scopus 로고    scopus 로고
    • ITMIG consensus statement on the use of the WHO histological classification of thymoma and thymic carcinoma: refined definitions, histological criteria, and reporting
    • Marx A., Strobel P., Badve S.S., Chalabreysse L., Chan J.K., Chen G., de Leval L., Detterbeck F., Girard N., Huang J., et al. ITMIG consensus statement on the use of the WHO histological classification of thymoma and thymic carcinoma: refined definitions, histological criteria, and reporting. J. Thorac. Oncol. 2014, 9:596-611.
    • (2014) J. Thorac. Oncol. , vol.9 , pp. 596-611
    • Marx, A.1    Strobel, P.2    Badve, S.S.3    Chalabreysse, L.4    Chan, J.K.5    Chen, G.6    de Leval, L.7    Detterbeck, F.8    Girard, N.9    Huang, J.10
  • 74
    • 0023101442 scopus 로고
    • Possible single dosage effects of the nude gene: suppression of spontaneous development of thymoma and nephropathy in BUF/Mna-rnu/+ rats
    • Matsuyama M., Yamada C., Kojima A. Possible single dosage effects of the nude gene: suppression of spontaneous development of thymoma and nephropathy in BUF/Mna-rnu/+ rats. Jpn. J. Cancer Res. 1987, 78:40-44.
    • (1987) Jpn. J. Cancer Res. , vol.78 , pp. 40-44
    • Matsuyama, M.1    Yamada, C.2    Kojima, A.3
  • 75
    • 0037387254 scopus 로고    scopus 로고
    • Anti-cytokine autoantibodies in autoimmunity: preponderance of neutralizing autoantibodies against interferon-alpha, interferon-omega and interleukin-12 in patients with thymoma and/or myasthenia gravis
    • Meager A., Wadhwa M., Dilger P., Bird C., Thorpe R., Newsom-Davis J., Willcox N. Anti-cytokine autoantibodies in autoimmunity: preponderance of neutralizing autoantibodies against interferon-alpha, interferon-omega and interleukin-12 in patients with thymoma and/or myasthenia gravis. Clin. Exp. Immunol. 2003, 132:128-136.
    • (2003) Clin. Exp. Immunol. , vol.132 , pp. 128-136
    • Meager, A.1    Wadhwa, M.2    Dilger, P.3    Bird, C.4    Thorpe, R.5    Newsom-Davis, J.6    Willcox, N.7
  • 76
    • 0025992693 scopus 로고
    • The thymus in myasthenia gravis. Changes typical for the human disease are absent in experimental autoimmune myasthenia gravis of the Lewis rat
    • Meinl E., Klinkert W.E., Wekerle H. The thymus in myasthenia gravis. Changes typical for the human disease are absent in experimental autoimmune myasthenia gravis of the Lewis rat. Am. J. Pathol. 1991, 139:995-1008.
    • (1991) Am. J. Pathol. , vol.139 , pp. 995-1008
    • Meinl, E.1    Klinkert, W.E.2    Wekerle, H.3
  • 78
    • 0026575557 scopus 로고
    • T cells from normal and myasthenic individuals recognize the human acetylcholine receptor: heterogeneity of antigenic sites on the alpha-subunit
    • Melms A., Malcherek G., Gern U., Wietholter H., Muller C.A., Schoepfer R., Lindstrom J. T cells from normal and myasthenic individuals recognize the human acetylcholine receptor: heterogeneity of antigenic sites on the alpha-subunit. Ann. Neurol. 1992, 31:311-318.
    • (1992) Ann. Neurol. , vol.31 , pp. 311-318
    • Melms, A.1    Malcherek, G.2    Gern, U.3    Wietholter, H.4    Muller, C.A.5    Schoepfer, R.6    Lindstrom, J.7
  • 80
    • 33846952108 scopus 로고    scopus 로고
    • Metastatic thymoma and acquired generalized myasthenia gravis in a beagle
    • Moffet A.C. Metastatic thymoma and acquired generalized myasthenia gravis in a beagle. Can. Vet. J. 2007, 48:91-93.
    • (2007) Can. Vet. J. , vol.48 , pp. 91-93
    • Moffet, A.C.1
  • 82
    • 0032523840 scopus 로고    scopus 로고
    • A pathogenetic role for the thymoma in myasthenia gravis. Autosensitization of IL-4- producing T cell clones recognizing extracellular acetylcholine receptor epitopes presented by minority class II isotypes
    • Nagvekar N., Moody A.M., Moss P., Roxanis I., Curnow J., Beeson D., Pantic N., Newsom-Davis J., Vincent A., Willcox N. A pathogenetic role for the thymoma in myasthenia gravis. Autosensitization of IL-4- producing T cell clones recognizing extracellular acetylcholine receptor epitopes presented by minority class II isotypes. J. Clin. Invest. 1998, 101:2268-2277.
    • (1998) J. Clin. Invest. , vol.101 , pp. 2268-2277
    • Nagvekar, N.1    Moody, A.M.2    Moss, P.3    Roxanis, I.4    Curnow, J.5    Beeson, D.6    Pantic, N.7    Newsom-Davis, J.8    Vincent, A.9    Willcox, N.10
  • 83
    • 0141625783 scopus 로고    scopus 로고
    • Acquired canine myasthenia gravis associated with thymoma: histological features and immunohistochemical localization of HLA type II and IgG
    • Paciello O., Maiolino P., Navas L., Papparell S. Acquired canine myasthenia gravis associated with thymoma: histological features and immunohistochemical localization of HLA type II and IgG. Vet. Res. Commun. 2003, 27(Suppl. 1):715-718.
    • (2003) Vet. Res. Commun. , vol.27 , pp. 715-718
    • Paciello, O.1    Maiolino, P.2    Navas, L.3    Papparell, S.4
  • 84
    • 0017103485 scopus 로고
    • Thymomas in domestic animals
    • Parker G.A., Casey H.W. Thymomas in domestic animals. Vet. Pathol. 1976, 13:353-364.
    • (1976) Vet. Pathol. , vol.13 , pp. 353-364
    • Parker, G.A.1    Casey, H.W.2
  • 85
    • 0015935638 scopus 로고
    • Autoimmune response to acetylcholine receptor
    • Patrick J., Lindstrom J. Autoimmune response to acetylcholine receptor. Science 1973, 180:871-872.
    • (1973) Science , vol.180 , pp. 871-872
    • Patrick, J.1    Lindstrom, J.2
  • 89
    • 79951517228 scopus 로고    scopus 로고
    • Thymoma-associated myasthenia gravis without acetylcholine receptor antibodies
    • Rigamonti A., Lauria G., Piamarta F., Fiumani A., Agostoni E. Thymoma-associated myasthenia gravis without acetylcholine receptor antibodies. J. Neurol. Sci. 2011, 302:112-113.
    • (2011) J. Neurol. Sci. , vol.302 , pp. 112-113
    • Rigamonti, A.1    Lauria, G.2    Piamarta, F.3    Fiumani, A.4    Agostoni, E.5
  • 90
    • 84875208121 scopus 로고    scopus 로고
    • Thymoma in myasthenia gravis: from diagnosis to treatment
    • Romi F. Thymoma in myasthenia gravis: from diagnosis to treatment. Autoimmune Dis. 2011, 2011:474512.
    • (2011) Autoimmune Dis. , vol.2011 , pp. 474512
    • Romi, F.1
  • 91
    • 0036295743 scopus 로고    scopus 로고
    • Titin and ryanodine receptor epitopes are expressed in cortical thymoma along with costimulatory molecules
    • Romi F., Bo L., Skeie G.O., Myking A., Aarli J.A., Gilhus N.E. Titin and ryanodine receptor epitopes are expressed in cortical thymoma along with costimulatory molecules. J. Neuroimmunol. 2002, 128:82-89.
    • (2002) J. Neuroimmunol. , vol.128 , pp. 82-89
    • Romi, F.1    Bo, L.2    Skeie, G.O.3    Myking, A.4    Aarli, J.A.5    Gilhus, N.E.6
  • 92
    • 14844334966 scopus 로고    scopus 로고
    • Striational antibodies in myasthenia gravis: reactivity and possible clinical significance
    • Romi F., Skeie G.O., Gilhus N.E., Aarli J.A. Striational antibodies in myasthenia gravis: reactivity and possible clinical significance. Arch. Neurol. 2005, 62:442-446.
    • (2005) Arch. Neurol. , vol.62 , pp. 442-446
    • Romi, F.1    Skeie, G.O.2    Gilhus, N.E.3    Aarli, J.A.4
  • 93
    • 0035205671 scopus 로고    scopus 로고
    • True epithelial hyperplasia in the thymus of early-onset myasthenia gravis patients: implications for immunopathogenesis
    • Roxanis I., Micklem K., Willcox N. True epithelial hyperplasia in the thymus of early-onset myasthenia gravis patients: implications for immunopathogenesis. J. Neuroimmunol. 2001, 112:163-173.
    • (2001) J. Neuroimmunol. , vol.112 , pp. 163-173
    • Roxanis, I.1    Micklem, K.2    Willcox, N.3
  • 94
    • 0036231364 scopus 로고    scopus 로고
    • Thymic myoid cells and germinal center formation in myasthenia gravis; possible roles in pathogenesis
    • Roxanis I., Micklem K., McConville J., Newsom-Davis J., Willcox N. Thymic myoid cells and germinal center formation in myasthenia gravis; possible roles in pathogenesis. J. Neuroimmunol. 2002, 125:185-197.
    • (2002) J. Neuroimmunol. , vol.125 , pp. 185-197
    • Roxanis, I.1    Micklem, K.2    McConville, J.3    Newsom-Davis, J.4    Willcox, N.5
  • 95
    • 84863617599 scopus 로고    scopus 로고
    • The role of Dlc1 isoform 2 in K-Ras2(G12D) induced thymic cancer
    • Sabbir M.G., Prieditis H., Ravinsky E., Mowat M.R. The role of Dlc1 isoform 2 in K-Ras2(G12D) induced thymic cancer. PLoS One 2012, 7:e40302.
    • (2012) PLoS One , vol.7 , pp. e40302
    • Sabbir, M.G.1    Prieditis, H.2    Ravinsky, E.3    Mowat, M.R.4
  • 96
    • 24644431899 scopus 로고    scopus 로고
    • Thymus changes in anti-MuSK-positive and -negative myasthenia gravis
    • (author reply 782-783)
    • Saka E., Topcuoglu M.A., Akkaya B., Galati A., Onal M.Z., Vincent A. Thymus changes in anti-MuSK-positive and -negative myasthenia gravis. Neurology 2005, 65:782-783. (author reply 782-783).
    • (2005) Neurology , vol.65 , pp. 782-783
    • Saka, E.1    Topcuoglu, M.A.2    Akkaya, B.3    Galati, A.4    Onal, M.Z.5    Vincent, A.6
  • 97
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi S., Yamaguchi T., Nomura T., Ono M. Regulatory T cells and immune tolerance. Cell 2008, 133:775-787.
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 101
    • 0023189057 scopus 로고
    • Acetylcholine receptors in human thymic myoid cells in situ: an immunohistological study
    • Schluep M., Willcox N., Vincent A., Dhoot G.K., Newsom-Davis J. Acetylcholine receptors in human thymic myoid cells in situ: an immunohistological study. Ann. Neurol. 1987, 22:212-222.
    • (1987) Ann. Neurol. , vol.22 , pp. 212-222
    • Schluep, M.1    Willcox, N.2    Vincent, A.3    Dhoot, G.K.4    Newsom-Davis, J.5
  • 104
    • 0035834918 scopus 로고    scopus 로고
    • Titin and ryanodine receptor autoantibodies in dogs with thymoma and late-onset myasthenia gravis
    • Shelton G.D., Skeie G.O., Kass P.H., Aarli J.A. Titin and ryanodine receptor autoantibodies in dogs with thymoma and late-onset myasthenia gravis. Vet. Immunol. Immunopathol. 2001, 78:97-105.
    • (2001) Vet. Immunol. Immunopathol. , vol.78 , pp. 97-105
    • Shelton, G.D.1    Skeie, G.O.2    Kass, P.H.3    Aarli, J.A.4
  • 105
    • 12444300180 scopus 로고    scopus 로고
    • Spontaneous production of anti-IFN-alpha and anti-IL-12 autoantibodies by thymoma cells from myasthenia gravis patients suggests autoimmunization in the tumor
    • Shiono H., Wong Y.L., Matthews I., Liu J.L., Zhang W., Sims G., Meager A., Beeson D., Vincent A., Willcox N. Spontaneous production of anti-IFN-alpha and anti-IL-12 autoantibodies by thymoma cells from myasthenia gravis patients suggests autoimmunization in the tumor. Int. Immunol. 2003, 15:903-913.
    • (2003) Int. Immunol. , vol.15 , pp. 903-913
    • Shiono, H.1    Wong, Y.L.2    Matthews, I.3    Liu, J.L.4    Zhang, W.5    Sims, G.6    Meager, A.7    Beeson, D.8    Vincent, A.9    Willcox, N.10
  • 106
    • 0025976469 scopus 로고
    • Absence of acetylcholine-induced current in epithelial cells from thymus glands and thymomas of myasthenia gravis patients
    • Siara J., Rudel R., Marx A. Absence of acetylcholine-induced current in epithelial cells from thymus glands and thymomas of myasthenia gravis patients. Neurology 1991, 41:128-131.
    • (1991) Neurology , vol.41 , pp. 128-131
    • Siara, J.1    Rudel, R.2    Marx, A.3
  • 107
    • 77956561790 scopus 로고    scopus 로고
    • Thymoma-associated exfoliative dermatitis with post-thymectomy myasthenia gravis in a cat
    • Singh A., Boston S.E., Poma R. Thymoma-associated exfoliative dermatitis with post-thymectomy myasthenia gravis in a cat. Can. Vet. J. 2010, 51:757-760.
    • (2010) Can. Vet. J. , vol.51 , pp. 757-760
    • Singh, A.1    Boston, S.E.2    Poma, R.3
  • 108
    • 0025864107 scopus 로고
    • Acetylcholine receptor-reactive T lymphocytes from healthy subjects and myasthenia gravis patients
    • Sommer N., Harcourt G.C., Willcox N., Beeson D., Newsom-Davis J. Acetylcholine receptor-reactive T lymphocytes from healthy subjects and myasthenia gravis patients. Neurology 1991, 41:1270-1276.
    • (1991) Neurology , vol.41 , pp. 1270-1276
    • Sommer, N.1    Harcourt, G.C.2    Willcox, N.3    Beeson, D.4    Newsom-Davis, J.5
  • 109
    • 0029865274 scopus 로고    scopus 로고
    • Thymoma-associated myasthenia gravis. Transplantation of thymoma and extrathymomal thymic tissue into SCID mice
    • Spuler S., Sarropoulos A., Marx A., Hohlfeld R., Wekerle H. Thymoma-associated myasthenia gravis. Transplantation of thymoma and extrathymomal thymic tissue into SCID mice. Am. J. Pathol. 1996, 148:1359-1365.
    • (1996) Am. J. Pathol. , vol.148 , pp. 1359-1365
    • Spuler, S.1    Sarropoulos, A.2    Marx, A.3    Hohlfeld, R.4    Wekerle, H.5
  • 110
    • 3843145290 scopus 로고    scopus 로고
    • Acquired myasthenia gravis associated with a non-invasive thymic carcinoma in a dog
    • Stenner V.J., Parry B.W., Holloway S.A. Acquired myasthenia gravis associated with a non-invasive thymic carcinoma in a dog. Aust. Vet. J. 2003, 81:543-546.
    • (2003) Aust. Vet. J. , vol.81 , pp. 543-546
    • Stenner, V.J.1    Parry, B.W.2    Holloway, S.A.3
  • 111
    • 0014429596 scopus 로고
    • Spontaneous thymoma, polymyositis, and serum-autoantibodies to striated muscle in the rodent, subgenus Praomys (Mastomys) natalensis. Similarities to thymoma with myasthenia gravis in man
    • Strauss A.J., Snell K.C., Duntley B.J., Soban E.J., Stewart H.L. Spontaneous thymoma, polymyositis, and serum-autoantibodies to striated muscle in the rodent, subgenus Praomys (Mastomys) natalensis. Similarities to thymoma with myasthenia gravis in man. Lancet 1968, 1:1126-1129.
    • (1968) Lancet , vol.1 , pp. 1126-1129
    • Strauss, A.J.1    Snell, K.C.2    Duntley, B.J.3    Soban, E.J.4    Stewart, H.L.5
  • 113
    • 2342510977 scopus 로고    scopus 로고
    • Tumor recurrence and survival in patients treated for thymomas and thymic squamous cell carcinomas: a retrospective analysis
    • Strobel P., Bauer A., Puppe B., Kraushaar T., Krein A., Toyka K., Gold R., Semik M., Kiefer R., Nix W., et al. Tumor recurrence and survival in patients treated for thymomas and thymic squamous cell carcinomas: a retrospective analysis. J. Clin. Oncol. 2004, 22:1501-1509.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 1501-1509
    • Strobel, P.1    Bauer, A.2    Puppe, B.3    Kraushaar, T.4    Krein, A.5    Toyka, K.6    Gold, R.7    Semik, M.8    Kiefer, R.9    Nix, W.10
  • 115
    • 33947694597 scopus 로고    scopus 로고
    • Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS-1)
    • Strobel P., Murumagi A., Klein R., Luster M., Lahti M., Krohn K., Schalke B., Nix W., Gold R., Rieckmann P., et al. Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS-1). J. Pathol. 2007, 211:563-571.
    • (2007) J. Pathol. , vol.211 , pp. 563-571
    • Strobel, P.1    Murumagi, A.2    Klein, R.3    Luster, M.4    Lahti, M.5    Krohn, K.6    Schalke, B.7    Nix, W.8    Gold, R.9    Rieckmann, P.10
  • 120
    • 0027076303 scopus 로고
    • An intrinsic thymic epithelial abnormality is responsible for the spontaneous development of predominantly lymphocytic thymomas in BUF/Mna rats
    • Taguchi O., Kontani K., Ikeda H., Matsuyama M. An intrinsic thymic epithelial abnormality is responsible for the spontaneous development of predominantly lymphocytic thymomas in BUF/Mna rats. Jpn. J. Cancer Res. 1992, 83:1166-1171.
    • (1992) Jpn. J. Cancer Res. , vol.83 , pp. 1166-1171
    • Taguchi, O.1    Kontani, K.2    Ikeda, H.3    Matsuyama, M.4
  • 123
    • 0028827184 scopus 로고
    • Thymic epithelial neoplasms in transgenic mice expressing SV40 T antigen under the control of an erythroid-specific enhancer
    • Teitz T., Chang J.C., Kan Y.W., Yen T.S. Thymic epithelial neoplasms in transgenic mice expressing SV40 T antigen under the control of an erythroid-specific enhancer. J. Pathol. 1995, 177:309-315.
    • (1995) J. Pathol. , vol.177 , pp. 309-315
    • Teitz, T.1    Chang, J.C.2    Kan, Y.W.3    Yen, T.S.4
  • 126
  • 127
    • 84908548812 scopus 로고    scopus 로고
    • Critical assessment of human antibody generation in humanized mouse models
    • Villaudy J., Schotte R., Legrand N., Spits H. Critical assessment of human antibody generation in humanized mouse models. J. Immunol. Methods 2014, 410:18-27.
    • (2014) J. Immunol. Methods , vol.410 , pp. 18-27
    • Villaudy, J.1    Schotte, R.2    Legrand, N.3    Spits, H.4
  • 128
    • 77956191392 scopus 로고    scopus 로고
    • Autoimmune channelopathies: well-established and emerging immunotherapy-responsive diseases of the peripheral and central nervous systems
    • Vincent A. Autoimmune channelopathies: well-established and emerging immunotherapy-responsive diseases of the peripheral and central nervous systems. J. Clin. Immunol. 2010, 30(Suppl. 1):S97-S102.
    • (2010) J. Clin. Immunol. , vol.30 , pp. S97-S102
    • Vincent, A.1
  • 129
    • 0019366843 scopus 로고
    • Absence of anti-acetylcholine receptor antibodies in Praomys (Mastomys) natalensis
    • Vincent A., Solleveld H.A. Absence of anti-acetylcholine receptor antibodies in Praomys (Mastomys) natalensis. Clin. Exp. Immunol. 1981, 43:94-98.
    • (1981) Clin. Exp. Immunol. , vol.43 , pp. 94-98
    • Vincent, A.1    Solleveld, H.A.2
  • 133
    • 0026534616 scopus 로고
    • Paraneoplastic IgG striational autoantibodies produced by clonal thymic B cells and in serum of patients with myasthenia gravis and thymoma react with titin
    • Williams C.L., Hay J.E., Huiatt T.W., Lennon V.A. Paraneoplastic IgG striational autoantibodies produced by clonal thymic B cells and in serum of patients with myasthenia gravis and thymoma react with titin. Lab. Invest. 1992, 66:331-336.
    • (1992) Lab. Invest. , vol.66 , pp. 331-336
    • Williams, C.L.1    Hay, J.E.2    Huiatt, T.W.3    Lennon, V.A.4
  • 135
    • 79952788632 scopus 로고    scopus 로고
    • Cervical thymuses exist, but no cervical thymomas develop in thoracic thymoma-prone BUF rats
    • Yamada T., Matsuyama M., Yanagida T., Kato K., Sugiura S., Kuroda M. Cervical thymuses exist, but no cervical thymomas develop in thoracic thymoma-prone BUF rats. Int. J. Exp. Pathol. 2011, 92:117-120.
    • (2011) Int. J. Exp. Pathol. , vol.92 , pp. 117-120
    • Yamada, T.1    Matsuyama, M.2    Yanagida, T.3    Kato, K.4    Sugiura, S.5    Kuroda, M.6
  • 138
    • 84879129714 scopus 로고    scopus 로고
    • Serological diagnostics in myasthenia gravis based on novel assays and recently identified antigens
    • Zisimopoulou P., Brenner T., Trakas N., Tzartos S.J. Serological diagnostics in myasthenia gravis based on novel assays and recently identified antigens. Autoimmun. Rev. 2013, 12:924-930.
    • (2013) Autoimmun. Rev. , vol.12 , pp. 924-930
    • Zisimopoulou, P.1    Brenner, T.2    Trakas, N.3    Tzartos, S.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.