Association of HLA-A in autoimmune myasthenia gravis with thymoma

Journal of Neuroimmunology

Volumn 210, Issue 1-2, 2009, Pages 120-123

  Vandiedonck, Claire ^a   Raffoux, Colette ^b   Eymard, Bruno ^c   Tranchant, Christine ^d   Dulmet, Elisabeth ^e   Krumeich, Sophie ^a   Gajdos, Philippe ^f   Garchon, Henri Jean ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b SAINT LOUIS HOSPITAL   (France)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^d UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^e CENTRE CHIRURGICAL MARIE LANNELONGUE   (France)

^f RAYMOND POINCARÉ HOSPITAL   (France)

Author keywords

Genetic susceptibility; HLA; Major histocompatibility complex; Myasthenia gravis; Paraneoplastic syndrome; Thymoma

Indexed keywords

HLA A ANTIGEN;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; CAUCASIAN; CONTROLLED STUDY; DISEASE CLASSIFICATION; FEMALE; FRANCE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETICS; HISTOPATHOLOGY; HLA SYSTEM; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MYASTHENIA GRAVIS; NEUROPROTECTION; PRIORITY JOURNAL; THYMOMA;

ADULT; AUTOANTIBODIES; DNA MUTATIONAL ANALYSIS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FRANCE; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENETICS, POPULATION; GENOTYPE; HETEROZYGOTE; HISTOCOMPATIBILITY TESTING; HLA-A ANTIGENS; HUMANS; MALE; MYASTHENIA GRAVIS; THYMOMA; THYMUS GLAND;

EID: 67349175324     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2009.02.004     Document Type: Article

References (31)

1. Aarli J.A., Romi F., Skeie G.O., and Gilhus N.E. Myasthenia gravis in individuals over 40. Ann. N. Y. Acad. Sci. 998 (2003) 424-431
2. Carlsson B., Wallin J., Pirskanen R., Matell G., and Smith C.I. Different HLA DR-DQ associations in subgroups of idiopathic myasthenia gravis. Immunogenetics 31 (1990) 285-290
3. Chan S.H., Tan C.B., Lin Y.N., Wee G.B., Degli-Esposti M.A., and Dawkins R.L. HLA and Singaporean Chinese myasthenia gravis. Int. Arch. Allergy Immunol. 101 (1993) 119-125
4. Chen G., Marx A., Wen-Hu C., Yong J., Puppe B., Stroebel P., and Mueller-Hermelink H.K. New WHO histologic classification predicts prognosis of thymic epithelial tumors: a clinicopathologic study of 200 thymoma cases from China. Cancer 95 (2002) 420-429
5. Drachman D.B. Myasthenia gravis. N. Engl. J. Med. 330 (1994) 1797-1810
6. Excoffier L., and Slatkin M. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol. Biol. Evol. 12 (1995) 921-927
7. Feltkamp T.E., van den Berg-Loonen P.M., Nijenhuis L.E., Engelfriet C.P., van Rossum A.L., van Loghem J.J., and Oosterhuis H.J. Myasthenia gravis, autoantibodies, and HL-A antigens. Br. Med. J. 1 (1974) 131-133
8. Garcia-Ramos G., Tellez-Zenteno J.F., Zapata-Zuniga M., Yamamoto-Furusho J.K., Ruiz-Morales J.A., Villarreal-Garza C., Vargas-Alarcon G., Estanol B., Llorente L., and Granados J. HLA class II genotypes in Mexican Mestizo patients with myasthenia gravis. Eur. J. Neurol. 10 (2003) 707-710
9. Giraud M., Beaurain G., Yamamoto A.M., Eymard B., Tranchant C., Gajdos P., and Garchon H.J. Linkage of HLA to myasthenia gravis and genetic heterogeneity depending on anti-titin antibodies. Neurology 57 (2001) 1555-1560
10. Hjelmstrom P., Giscombe R., Lefvert A.K., Pirskanen R., Kockum I., Landin-Olsson M., and Sanjeevi C.B. Polymorphic amino acid domains of the HLA-DQ molecule are associated with disease heterogeneity in myasthenia gravis. J. Neuroimmunol. 65 (1996) 125-131
11. Horton R., Wilming L., Rand V., Lovering R.C., Bruford E.A., Khodiyar V.K., Lush M.J., Povey S., Talbot Jr. C.C., Wright M.W., Wain H.M., Trowsdale J., Ziegler A., and Beck S. Gene map of the extended human MHC. Nat. Rev. Genet. 5 (2004) 889-899
12. Inoue M., Marx A., Zettl A., Strobel P., Muller-Hermelink H.K., and Starostik P. Chromosome 6 suffers frequent and multiple aberrations in thymoma. Am. J. Pathol. 161 (2002) 1507-1513
13. Inoue M., Starostik P., Zettl A., Strobel P., Schwarz S., Scaravilli F., Henry K., Willcox N., Muller-Hermelink H.K., and Marx A. Correlating genetic aberrations with World Health Organization-defined histology and stage across the spectrum of thymomas. Cancer Res. 63 (2003) 3708-3715
14. Lanier L.L. Up on the tightrope: natural killer cell activation and inhibition. Nat. Immunol. 9 (2008) 495-502
15. Lu C.C., Chen J.C., Tsai S.T., Jin Y.T., Tsai J.C., Chan S.H., and Su I.J. Nasopharyngeal carcinoma-susceptibility locus is localized to a 132 kb segment containing HLA-A using high-resolution microsatellite mapping. Int. J. Cancer 115 (2005) 742-746
16. Machens A., Loliger C., Pichlmeier U., Emskotter T., Busch C., and Izbicki J.R. Correlation of thymic pathology with HLA in myasthenia gravis. Clin. Immunol. 91 (1999) 296-301
17. Machulla H.K., Steinborn F., Schaaf A., Heidecke V., and Rainov N.G. Brain glioma and human leukocyte antigens (HLA)-is there an association. J. Neurooncol. 52 (2001) 253-261
18. Marx A., Schultz A., Wilisch A., Helmreich M., Nenninger R., and Muller-Hermelink H.K. Paraneoplastic autoimmunity in thymus tumors. Dev. Immunol. 6 (1998) 129-140
19. McAulay K.A., Higgins C.D., Macsween K.F., Lake A., Jarrett R.F., Robertson F.L., Williams H., and Crawford D.H. HLA class I polymorphisms are associated with development of infectious mononucleosis upon primary EBV infection. J. Clin. Invest. 117 (2007) 3042-3048
20. Meager A., Wadhwa M., Dilger P., Bird C., Thorpe R., Newsom-Davis J., and Willcox N. Anti-cytokine autoantibodies in autoimmunity: preponderance of neutralizing autoantibodies against interferon-alpha, interferon-omega and interleukin-12 in patients with thymoma and/or myasthenia gravis. Clin. Exp. Immunol. 132 (2003) 128-136
21. Okumura M., Ohta M., Tateyama H., Nakagawa K., Matsumura A., Maeda H., Tada H., Eimoto T., Matsuda H., and Masaoka A. The World Health Organization histologic classification system reflects the oncologic behavior of thymoma: a clinical study of 273 patients. Cancer 94 (2002) 624-632
22. Rosai J. Histological Typing of Tumours of the Thymus (1999), Springer-Verlag, Berlin
23. Scarpino S., Di Napoli A., Stoppacciaro A., Antonelli M., Pilozzi E., Chiarle R., Palestro G., Marino M., Facciolo F., Rendina E.A., Webster K.E., Kinkel S.A., Scott H.S., and Ruco L. Expression of autoimmune regulator gene (AIRE) and T regulatory cells in human thymomas. Clin. Exp. Immunol. 149 (2007) 504-512
24. Spurkland A., Gilhus N.E., Ronningen K.S., Aarli J.A., and Vartdal F. Myasthenia gravis patients with thymus hyperplasia and myasthenia gravis patients with thymoma display different HLA associations. Tissue Antigens 37 (1991) 90-93
25. Storkus W.J., Salter R.D., Alexander J., Ward F.E., Ruiz R.E., Cresswell P., and Dawson J.R. Class I-induced resistance to natural killing: identification of nonpermissive residues in HLA-A2. Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 5989-5992
26. Strobel P., Rosenwald A., Beyersdorf N., Kerkau T., Elert O., Murumagi A., Sillanpaa N., Peterson P., Hummel V., Rieckmann P., Burek C., Schalke B., Nix W., Kiefer R., Muller-Hermelink H.K., and Marx A. Selective loss of regulatory T cells in thymomas. Ann. Neurol. 56 (2004) 901-904
27. Strobel P., Murumagi A., Klein R., Luster M., Lahti M., Krohn K., Schalke B., Nix W., Gold R., Rieckmann P., Toyka K., Burek C., Rosenwald A., Muller-Hermelink H.K., Pujoll-Borrell R., Meager A., Willcox N., Peterson P., and Marx A. Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS-1). J. Pathol. 211 (2007) 563-571
28. Vandiedonck C., Beaurain G., Giraud M., Hue-Beauvais C., Eymard B., Tranchant C., Gajdos P., Dausset J., and Garchon H.J. Pleiotropic effects of the 8.1 HLA haplotype in patients with autoimmune myasthenia gravis and thymus hyperplasia. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 15464-15469
29. Vandiedonck C., Giraud M., and Garchon H.J. Genetics of autoimmune myasthenia gravis: the multifaceted contribution of the HLA complex. J. Autoimmun. 25 Suppl (2005) 6-11
30. Vincent A., Palace J., and Hilton-Jones D. Myasthenia gravis. Lancet 357 (2001) 2122-2128
31. Yamamoto A.M., Gajdos P., Eymard B., Tranchant C., Warter J.M., Gomez L., Bourquin C., Bach J.F., and Garchon H.J. Anti-titin antibodies in myasthenia gravis: tight association with thymoma and heterogeneity of nonthymoma patients. Arch. Neurol. 58 (2001) 885-890