Lack of evidence for epstein-barr virus infection in myasthenia gravis thymus

Annals of Neurology

Volumn 70, Issue 3, 2011, Pages 515-518

  Meyer, Mandy ^a   Höls, Ann Kathrin ^b   Liersch, Britta ^c   Leistner, Rasmus ^a   Gellert, Klaus ^c   Schalke, Berthold ^d   Marx, Alexander ^e   Niedobitek, Gerald ^a,b  

^a Institute for Pathology   (Germany)

^b Institute of Pathology   (Germany)

^c SANA KLINIKUM OFFENBACH   (Germany)

^d UNIVERSITY OF REGENSBURG   (Germany)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPSTEIN BARR VIRUS ANTIGEN 1; IMMEDIATE EARLY PROTEIN BZLF1; VIRUS RNA;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EPSTEIN BARR VIRUS INFECTION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LYMPHOFOLLICULAR THYMITIS; MALE; MYASTHENIA GRAVIS; PRIORITY JOURNAL; THYMUS; THYMUS DISEASE;

ADOLESCENT; ADULT; ANTIBODIES, MONOCLONAL; CARRIER PROTEINS; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; HASHIMOTO DISEASE; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; MYASTHENIA GRAVIS; RNA, VIRAL; THYMUS GLAND; THYROID GLAND; TISSUE FIXATION; TRANS-ACTIVATORS; YOUNG ADULT;

EID: 80052558224     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.22522     Document Type: Article

References (22)

1. Niedobitek G, Meru N, Delecluse HJ,. Epstein-Barr virus infection and human malignancies. Int J Exp Pathol 2001; 82: 149-170. (Pubitemid 32718497)
2. Fox RI, Pearson G, Vaughan JH,. Detection of Epstein-Barr virus-associated antigens and DNA in salivary gland biopsies from patients with Sjogren's syndrome. J Immunol 1986; 137: 3162-3168. (Pubitemid 17181684)
3. Takei M, Mitamura K, Fujiwara S, et al. Detection of Epstein-Barr virus-encoded small RNA 1 and latent membrane protein 1 in synovial lining cells from rheumatoid arthritis patients. Int Immunol 1997; 9: 739-743. (Pubitemid 27226397)
4. Gross AJ, Hochberg D, Rand WM, Thorley-Lawson DA,. EBV and systemic lupus erythematosus: a new perspective. J Immunol 2005; 174: 6599-6607. (Pubitemid 40705620)
5. Poole BD, Templeton AK, Guthridge JM, et al. Aberrant Epstein-Barr viral infection in systemic lupus erythematosus. Autoimmun Rev 2009; 8: 337-342.
6. Niedobitek G, Lisner R, Swoboda B, et al. Lack of evidence for an involvement of Epstein-Barr virus infection of synovial membranes in the pathogenesis of rheumatoid arthritis. Arthritis Rheum 2000; 43: 151-154. (Pubitemid 30368224)
7. Frangou P, Buettner M, Niedobitek G,. Epstein-Barr virus (EBV) infection in epithelial cells in vivo: rare detection of EBV replication in tongue mucosa but not in salivary glands. J Infect Dis 2005; 191: 238-242. (Pubitemid 40096382)
8. Serafini B, Rosicarelli B, Franciotta D, et al. Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain. J Exp Med 2007; 204: 2899-2912. (Pubitemid 350179559)
9. Serafini B, Severa M, Columba-Cabezas S, et al. Epstein-Barr virus latent infection and BAFF expression in B cells in the multiple sclerosis brain: implications for viral persistence and intrathecal B-cell activation. J Neuropathol Exp Neurol 2010; 69: 677-693.
10. Peferoen LA, Lamers F, Lodder LN, et al. Epstein Barr virus is not a characteristic feature in the central nervous system in established multiple sclerosis. Brain 2010; 133(-pt 5):e137.
11. Willis SN, Stadelmann C, Rodig SJ, et al. Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain 2009; 132 (pt 12): 3318-3328.
12. Cavalcante P, Serafini B, Rosicarelli B, et al. Epstein-Barr virus persistence and reactivation in myasthenia gravis thymus. Ann Neurol 2010; 67: 726-738.
13. Le Panse R, Bismuth J, Cizeron-Clairac G, et al. Thymic remodeling associated with hyperplasia in myasthenia gravis. Autoimmunity 2010; 43: 401-412.
14. Klavinskis LS, Willcox N, Oxford JS, Newsom-Davis J,. Antivirus antibodies in myasthenia gravis. Neurology 1985; 35: 1381-1384. (Pubitemid 15021612)
15. Klavinskis LS, Willcox HN, Richmond JE, Newsom-Davis J,. Attempted isolation of viruses from myasthenia gravis thymus. J Neuroimmunol 1986; 11: 287-299. (Pubitemid 16061169)
16. Niedobitek G, Herbst H,. In situ detection of Epstein-Barr virus and phenotype determination of EBV-infected cells. Methods Mol Biol 2006; 326: 115-137.
17. Mori K, Yoshida K,. Viral infection in induction of Hashimoto's thyroiditis: a key player or just a bystander? Curr Opin Endocrinol Diabetes Obes 2010; 17: 418-424.
18. Niedobitek G, Agathanggelou A, Steven N, Young LS,. Epstein-Barr virus (EBV) in infectious mononucleosis: detection of the virus in tonsillar B lymphocytes but not in desquamated oropharyngeal epithelial cells. Mol Pathol 2000; 53: 37-42. (Pubitemid 30075073)
19. Grasser FA, Murray PG, Kremmer E, et al. Monoclonal antibodies directed against the Epstein-Barr virus-encoded nuclear antigen 1 (EBNA1): immunohistologic detection of EBNA1 in the malignant cells of Hodgkin's disease. Blood 1994; 84: 3792-3798. (Pubitemid 24362478)
20. Niedobitek G, Agathanggelou A, Herbst H, et al. Epstein-Barr virus (EBV) infection in infectious mononucleosis: virus latency, replication and phenotype of EBV-infected cells. J Pathol 1997; 182: 151-159. (Pubitemid 27287835)
21. Munz C, Lunemann JD, Getts MT, Miller SD,. Antiviral immune responses: triggers of or triggered by autoimmunity? Nat Rev Immunol 2009; 9: 246-258.
22. Niedobitek G, Herbst H, Young LS, et al. Patterns of Epstein-Barr virus infection in non-neoplastic lymphoid tissue. Blood 1992; 79: 2520-2526.