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Volumn 171, Issue 3, 2007, Pages 893-905

Myasthenia Gravis Thymus: Complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD59 ANTIGEN; CHOLINERGIC RECEPTOR; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C5A; DECAY ACCELERATING FACTOR; MEMBRANE COFACTOR PROTEIN; PROTEIN SUBUNIT;

EID: 34548863119     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2007.070240     Document Type: Article
Times cited : (106)

References (60)
  • 1
    • 0036779688 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of myasthenia gravis
    • Vincent A: Unravelling the pathogenesis of myasthenia gravis. Nat Rev Immunol 2002, 2:797-804
    • (2002) Nat Rev Immunol , vol.2 , pp. 797-804
    • Vincent, A.1
  • 3
    • 0019944059 scopus 로고
    • Functional activities of autoantibodies to acetylcholine receptors and the clinical severity of myasthenia gravis
    • Drachman DB, Adams RN, Josifek LF, Self SG: Functional activities of autoantibodies to acetylcholine receptors and the clinical severity of myasthenia gravis. N Engl J Med 1982, 307:769-775
    • (1982) N Engl J Med , vol.307 , pp. 769-775
    • Drachman, D.B.1    Adams, R.N.2    Josifek, L.F.3    Self, S.G.4
  • 4
    • 0017755136 scopus 로고
    • Immune complexes (IgG and C3) at the motor end-plate in myasthenia gravis: Ultrastructural and light microscopic localization and electrophysiologic correlations
    • Engel AG, Lambert EH, Howard FM: Immune complexes (IgG and C3) at the motor end-plate in myasthenia gravis: ultrastructural and light microscopic localization and electrophysiologic correlations. Mayo Clin Proc 1977, 52:267-280
    • (1977) Mayo Clin Proc , vol.52 , pp. 267-280
    • Engel, A.G.1    Lambert, E.H.2    Howard, F.M.3
  • 5
    • 0035105784 scopus 로고    scopus 로고
    • Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies
    • Hoch W, McConville J, Helms S, Newsom-Davis J, Melms A, Vincent A: Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med 2001, 7:365-368
    • (2001) Nat Med , vol.7 , pp. 365-368
    • Hoch, W.1    McConville, J.2    Helms, S.3    Newsom-Davis, J.4    Melms, A.5    Vincent, A.6
  • 12
    • 17044374662 scopus 로고    scopus 로고
    • Inhibition of acetylcholine receptor function by seronegative myasthenia gravis non-IgG factor correlates with desensitization
    • Spreadbury I, Kishore U, Beeson D, Vincent A: Inhibition of acetylcholine receptor function by seronegative myasthenia gravis non-IgG factor correlates with desensitization. J Neuroimmunol 2005, 162:149-156
    • (2005) J Neuroimmunol , vol.162 , pp. 149-156
    • Spreadbury, I.1    Kishore, U.2    Beeson, D.3    Vincent, A.4
  • 13
    • 0021329452 scopus 로고
    • Anti-AChR antibodies, thymic histology, and T cell subsets in myasthenia gravis
    • Berrih S, Morel E, Gaud C, Raimond F, Le Brigand H, Bach JF: Anti-AChR antibodies, thymic histology, and T cell subsets in myasthenia gravis. Neurology 1984, 34:66-71
    • (1984) Neurology , vol.34 , pp. 66-71
    • Berrih, S.1    Morel, E.2    Gaud, C.3    Raimond, F.4    Le Brigand, H.5    Bach, J.F.6
  • 15
    • 0036231364 scopus 로고    scopus 로고
    • Thymic myoid cells and germinal center formation in myasthenia gravis; possible roles in pathogenesis
    • Roxanis I, Micklem K, McConville J, Newsom-Davis J, Willcox N: Thymic myoid cells and germinal center formation in myasthenia gravis; possible roles in pathogenesis. J Neuroimmunol 2002, 125:185-197
    • (2002) J Neuroimmunol , vol.125 , pp. 185-197
    • Roxanis, I.1    Micklem, K.2    McConville, J.3    Newsom-Davis, J.4    Willcox, N.5
  • 16
    • 0035205671 scopus 로고    scopus 로고
    • True epithelial hyperplasia in the thymus of early-onset myasthenia gravis patients: Implications for immunopathogenesis
    • Roxanis I, Micklem K, Willcox N: True epithelial hyperplasia in the thymus of early-onset myasthenia gravis patients: implications for immunopathogenesis. J Neuroimmunol 2001, 112:163-173
    • (2001) J Neuroimmunol , vol.112 , pp. 163-173
    • Roxanis, I.1    Micklem, K.2    Willcox, N.3
  • 19
    • 0042090698 scopus 로고
    • The pathology of the thymus in myasthenia gravis: A study of 35 cases
    • Castleman B, Norris EH: The pathology of the thymus in myasthenia gravis: a study of 35 cases. Medicine 1949, 28:27-58
    • (1949) Medicine , vol.28 , pp. 27-58
    • Castleman, B.1    Norris, E.H.2
  • 20
    • 0030587964 scopus 로고    scopus 로고
    • Expression of acetylcholine receptor genes in human thymic epithelial cells: Implications for myasthenia gravis
    • Wakkach A, Guyon T, Bruand C, Tzartos S, Cohen-Kaminsky S, Berrih-Aknin S: Expression of acetylcholine receptor genes in human thymic epithelial cells: implications for myasthenia gravis. J Immunol 1996, 157:3752-3760
    • (1996) J Immunol , vol.157 , pp. 3752-3760
    • Wakkach, A.1    Guyon, T.2    Bruand, C.3    Tzartos, S.4    Cohen-Kaminsky, S.5    Berrih-Aknin, S.6
  • 21
    • 0031901865 scopus 로고    scopus 로고
    • Muscle nicotinic acetylcholine receptor mRNA expression in hyperplastic and neoplastic myasthenia gravis thymus
    • MacLennan CA, Beeson D, Willcox N, Vincent A, Newsom-Davis J: Muscle nicotinic acetylcholine receptor mRNA expression in hyperplastic and neoplastic myasthenia gravis thymus. Ann NY Acad Sci 1998, 841:407-410
    • (1998) Ann NY Acad Sci , vol.841 , pp. 407-410
    • MacLennan, C.A.1    Beeson, D.2    Willcox, N.3    Vincent, A.4    Newsom-Davis, J.5
  • 22
    • 0023189057 scopus 로고
    • Acetylcholine receptors in human thymic myoid cells in situ: An immunohistological study
    • Schluep M, Willcox N, Vincent A, Dhoot GK, Newsom-Davis J: Acetylcholine receptors in human thymic myoid cells in situ: an immunohistological study. Ann Neurol 1987, 22:212-222
    • (1987) Ann Neurol , vol.22 , pp. 212-222
    • Schluep, M.1    Willcox, N.2    Vincent, A.3    Dhoot, G.K.4    Newsom-Davis, J.5
  • 23
    • 0017408627 scopus 로고
    • Intrathymic pathogenesis and dual genetic control of myasthenia gravis
    • Wekerle H, Ketelsen UP: Intrathymic pathogenesis and dual genetic control of myasthenia gravis. Lancet 1977, 1:678-680
    • (1977) Lancet , vol.1 , pp. 678-680
    • Wekerle, H.1    Ketelsen, U.P.2
  • 24
    • 0027195312 scopus 로고
    • Myasthenia gravis: Quantitative immunocytochemical analysis of inflammatory cells and detection of complement membrane attack complex at the end-plate in 30 patients
    • Nakano S, Engel AG: Myasthenia gravis: quantitative immunocytochemical analysis of inflammatory cells and detection of complement membrane attack complex at the end-plate in 30 patients. Neurology 1993, 43:1167-1172
    • (1993) Neurology , vol.43 , pp. 1167-1172
    • Nakano, S.1    Engel, A.G.2
  • 27
    • 0029730735 scopus 로고    scopus 로고
    • A transfected human muscle cell line expressing the adult subtype of the human muscle acetylcholine receptor for diagnostic assays in myasthenia gravis
    • Beeson D, Jacobson L, Newsom-Davis J, Vincent A: A transfected human muscle cell line expressing the adult subtype of the human muscle acetylcholine receptor for diagnostic assays in myasthenia gravis. Neurology 1996, 47:1552-1555
    • (1996) Neurology , vol.47 , pp. 1552-1555
    • Beeson, D.1    Jacobson, L.2    Newsom-Davis, J.3    Vincent, A.4
  • 28
    • 0036284207 scopus 로고    scopus 로고
    • Local synthesis of complement component C3 regulates acute renal transplant rejection
    • Pratt JR, Basheer SA, Sacks SH: Local synthesis of complement component C3 regulates acute renal transplant rejection. Nat Med 2002, 8:582-587
    • (2002) Nat Med , vol.8 , pp. 582-587
    • Pratt, J.R.1    Basheer, S.A.2    Sacks, S.H.3
  • 29
    • 0037871469 scopus 로고    scopus 로고
    • Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells
    • Monsinjon T, Gasque P, Chan P, Ischenko A, Brady JJ, Fontaine MC: Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells. FASEB J 2003, 17:1003-1014
    • (2003) FASEB J , vol.17 , pp. 1003-1014
    • Monsinjon, T.1    Gasque, P.2    Chan, P.3    Ischenko, A.4    Brady, J.J.5    Fontaine, M.C.6
  • 31
    • 0026077255 scopus 로고
    • Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity
    • Adams EM, Brown MC, Nunge M, Krych M, Atkinson JP: Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity. J Immunol 1991, 147:3005-3011
    • (1991) J Immunol , vol.147 , pp. 3005-3011
    • Adams, E.M.1    Brown, M.C.2    Nunge, M.3    Krych, M.4    Atkinson, J.P.5
  • 32
    • 13444271717 scopus 로고    scopus 로고
    • Glycation of CD59 impairs complement regulation on erythrocytes from diabetic subjects
    • Davies CS, Harris CL, Morgan BP: Glycation of CD59 impairs complement regulation on erythrocytes from diabetic subjects. Immunology 2005, 114:280-286
    • (2005) Immunology , vol.114 , pp. 280-286
    • Davies, C.S.1    Harris, C.L.2    Morgan, B.P.3
  • 33
    • 0024425302 scopus 로고
    • Complement membrane attack on nucleated cells: Resistance, recovery and non-lethal effects
    • Morgan BP: Complement membrane attack on nucleated cells: resistance, recovery and non-lethal effects. Biochem J 1989, 264:1-14
    • (1989) Biochem J , vol.264 , pp. 1-14
    • Morgan, B.P.1
  • 34
    • 0027953417 scopus 로고
    • Membrane proteins that protect against complement lysis
    • Morgan BP, Meri S: Membrane proteins that protect against complement lysis. Springer Semin Immunopathol 1994, 15:369-396
    • (1994) Springer Semin Immunopathol , vol.15 , pp. 369-396
    • Morgan, B.P.1    Meri, S.2
  • 35
    • 0027265038 scopus 로고
    • Protection of germinal centres from complement attack: Decay-accelerating factor (DAF) is a constitutive protein on follicular dendritic cells. A study in reactive and neoplastic follicles
    • Lampert IA, Schofield JB, Amlot P, Van Noorden S: Protection of germinal centres from complement attack: decay-accelerating factor (DAF) is a constitutive protein on follicular dendritic cells. A study in reactive and neoplastic follicles. J Pathol 1993, 170:115-120
    • (1993) J Pathol , vol.170 , pp. 115-120
    • Lampert, I.A.1    Schofield, J.B.2    Amlot, P.3    Van Noorden, S.4
  • 36
    • 0026469891 scopus 로고
    • Distinct sites of production and deposition of the putative cell death marker clusterin in the human thymus
    • French LE, Sappino AP, Tschopp J, Schifferli JA: Distinct sites of production and deposition of the putative cell death marker clusterin in the human thymus. J Clin Invest 1992, 90:1919-1925
    • (1992) J Clin Invest , vol.90 , pp. 1919-1925
    • French, L.E.1    Sappino, A.P.2    Tschopp, J.3    Schifferli, J.A.4
  • 38
    • 0343384264 scopus 로고    scopus 로고
    • Detection of activated complement complex C5b-9 and complement receptor C5a in skin biopsies of patients with systemic sclerosis (scleroderma)
    • Sprott H, Muller-Ladner U, Distler O, Gay RE, Barnum SR, Landthaler M, Scholmerich J, Lang B, Gay S: Detection of activated complement complex C5b-9 and complement receptor C5a in skin biopsies of patients with systemic sclerosis (scleroderma). J Rheumatol 2000, 27:402-404
    • (2000) J Rheumatol , vol.27 , pp. 402-404
    • Sprott, H.1    Muller-Ladner, U.2    Distler, O.3    Gay, R.E.4    Barnum, S.R.5    Landthaler, M.6    Scholmerich, J.7    Lang, B.8    Gay, S.9
  • 39
    • 13544273533 scopus 로고    scopus 로고
    • van Beek J, van Meurs M, t Hart BA, Brok HP, Neal JW, Chatagner A, Harris CL, Omidvar N, Morgan BP, Laman JD, Gasque P: Decay-accelerating factor (CD55) is expressed by neurons in response to chronic but not acute autoimmune central nervous system inflammation associated with complement activation. J Immunol 2005, 174:2353-2365
    • van Beek J, van Meurs M, t Hart BA, Brok HP, Neal JW, Chatagner A, Harris CL, Omidvar N, Morgan BP, Laman JD, Gasque P: Decay-accelerating factor (CD55) is expressed by neurons in response to chronic but not acute autoimmune central nervous system inflammation associated with complement activation. J Immunol 2005, 174:2353-2365
  • 40
    • 0033198618 scopus 로고    scopus 로고
    • Induction of decay-accelerating factor by cytokines or the membrane-attack complex protects vascular endothelial cells against complement deposition
    • Mason JC, Yarwood H, Sugars K, Morgan BP, Davies KA, Haskard DO: Induction of decay-accelerating factor by cytokines or the membrane-attack complex protects vascular endothelial cells against complement deposition. Blood 1999, 94:1673-1682
    • (1999) Blood , vol.94 , pp. 1673-1682
    • Mason, J.C.1    Yarwood, H.2    Sugars, K.3    Morgan, B.P.4    Davies, K.A.5    Haskard, D.O.6
  • 42
    • 33646165128 scopus 로고    scopus 로고
    • A central role for central tolerance
    • Kyewski B, Klein L: A central role for central tolerance. Annu Rev Immunol 2006, 24:571-606
    • (2006) Annu Rev Immunol , vol.24 , pp. 571-606
    • Kyewski, B.1    Klein, L.2
  • 43
    • 4344686677 scopus 로고    scopus 로고
    • Expression of a functional C5a receptor in regenerating hepatocytes and its involvement in a proliferative signaling pathway in rat
    • Daveau M, Benard M, Scotte M, Schouft MT, Hiron M, Francois A, Salier JP, Fontaine M: Expression of a functional C5a receptor in regenerating hepatocytes and its involvement in a proliferative signaling pathway in rat. J Immunol 2004, 173:3418-3424
    • (2004) J Immunol , vol.173 , pp. 3418-3424
    • Daveau, M.1    Benard, M.2    Scotte, M.3    Schouft, M.T.4    Hiron, M.5    Francois, A.6    Salier, J.P.7    Fontaine, M.8
  • 44
    • 33745817407 scopus 로고    scopus 로고
    • C5b-9-induced endothelial cell proliferation and migration are dependent on Akt inactivation of forkhead transcription factor FOXO1
    • Fosbrink M, Niculescu F, Rus V, Shin ML, Rus H: C5b-9-induced endothelial cell proliferation and migration are dependent on Akt inactivation of forkhead transcription factor FOXO1. J Biol Chem 2006, 281:19009-19018
    • (2006) J Biol Chem , vol.281 , pp. 19009-19018
    • Fosbrink, M.1    Niculescu, F.2    Rus, V.3    Shin, M.L.4    Rus, H.5
  • 45
    • 0035017116 scopus 로고    scopus 로고
    • Role of the C5b-9 complement complex in cell cycle and apoptosis
    • Rus HG, Niculescu FI, Shin ML: Role of the C5b-9 complement complex in cell cycle and apoptosis. Immunol Rev 2001, 180:49-55
    • (2001) Immunol Rev , vol.180 , pp. 49-55
    • Rus, H.G.1    Niculescu, F.I.2    Shin, M.L.3
  • 46
    • 0038693797 scopus 로고    scopus 로고
    • Beyond lysis: How complement influences cell fate
    • Cole DS, Morgan BP: Beyond lysis: how complement influences cell fate. Clin Sci (Lond) 2003, 104:455-466
    • (2003) Clin Sci (Lond) , vol.104 , pp. 455-466
    • Cole, D.S.1    Morgan, B.P.2
  • 47
    • 0034032736 scopus 로고    scopus 로고
    • Terminal complement complexes concomitantly stimulate proliferation and rescue of Schwann cells from apoptosis
    • Dashiell SM, Rus H, Koski CL: Terminal complement complexes concomitantly stimulate proliferation and rescue of Schwann cells from apoptosis. Glia 2000, 30:187-198
    • (2000) Glia , vol.30 , pp. 187-198
    • Dashiell, S.M.1    Rus, H.2    Koski, C.L.3
  • 48
    • 0036841116 scopus 로고    scopus 로고
    • Markedly enhanced susceptibility to experimental autoimmune myasthenia gravis in the absence of decay-accelerating factor protection
    • Lin F, Kaminski HJ, Conti-Fine BM, Wang W, Richmonds C, Medof ME: Markedly enhanced susceptibility to experimental autoimmune myasthenia gravis in the absence of decay-accelerating factor protection. J Clin Invest 2002, 110:1269-1274
    • (2002) J Clin Invest , vol.110 , pp. 1269-1274
    • Lin, F.1    Kaminski, H.J.2    Conti-Fine, B.M.3    Wang, W.4    Richmonds, C.5    Medof, M.E.6
  • 49
    • 33750617634 scopus 로고    scopus 로고
    • Deficiency of decay accelerating factor and CD59 leads to crisis in experimental myasthenia
    • Kaminski HJ, Kusner LL, Richmonds C, Medof ME, Lin F: Deficiency of decay accelerating factor and CD59 leads to crisis in experimental myasthenia. Exp Neurol 2006, 202:287-293
    • (2006) Exp Neurol , vol.202 , pp. 287-293
    • Kaminski, H.J.1    Kusner, L.L.2    Richmonds, C.3    Medof, M.E.4    Lin, F.5
  • 50
    • 33750072293 scopus 로고    scopus 로고
    • The membrane attack pathway of complement drives pathology in passively induced experimental autoimmune myasthenia gravis in mice
    • Morgan BP, Chamberlain-Banoub J, Neal JW, Song W, Mizuno M, Harris CL: The membrane attack pathway of complement drives pathology in passively induced experimental autoimmune myasthenia gravis in mice. Clin Exp Immunol 2006, 146:294-302
    • (2006) Clin Exp Immunol , vol.146 , pp. 294-302
    • Morgan, B.P.1    Chamberlain-Banoub, J.2    Neal, J.W.3    Song, W.4    Mizuno, M.5    Harris, C.L.6
  • 51
    • 4544278812 scopus 로고    scopus 로고
    • Complement regulators in extraocular muscle and experimental autoimmune myasthenia gravis
    • Kaminski HJ, Li Z, Richmonds C, Lin F, Medof ME: Complement regulators in extraocular muscle and experimental autoimmune myasthenia gravis. Exp Neurol 2004, 189:333-342
    • (2004) Exp Neurol , vol.189 , pp. 333-342
    • Kaminski, H.J.1    Li, Z.2    Richmonds, C.3    Lin, F.4    Medof, M.E.5
  • 53
    • 0036182751 scopus 로고    scopus 로고
    • Roles of the complement system in human neurodegenerative disorders: Pro-inflammatory and tissue remodeling activities
    • Gasque P, Neal JW, Singhrao SK, McGreal EP, Dean YD, Van BJ, Morgan BP: Roles of the complement system in human neurodegenerative disorders: pro-inflammatory and tissue remodeling activities. Mol Neurobiol 2002, 25:1-17
    • (2002) Mol Neurobiol , vol.25 , pp. 1-17
    • Gasque, P.1    Neal, J.W.2    Singhrao, S.K.3    McGreal, E.P.4    Dean, Y.D.5    Van, B.J.6    Morgan, B.P.7
  • 56
    • 0035881829 scopus 로고    scopus 로고
    • Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in myasthenia gravis
    • Sims GP, Shiono H, Willcox N, Stott DI: Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in myasthenia gravis. J Immunol 2001, 167:1935-1944
    • (2001) J Immunol , vol.167 , pp. 1935-1944
    • Sims, G.P.1    Shiono, H.2    Willcox, N.3    Stott, D.I.4
  • 57
    • 0036796933 scopus 로고    scopus 로고
    • Antibodies to acetylcholine receptor in parous women with myasthenia: Evidence for immunization by fetal antigen
    • Matthews I, Sims G, Ledwidge S, Stott D, Beeson D, Willcox N, Vincent A: Antibodies to acetylcholine receptor in parous women with myasthenia: evidence for immunization by fetal antigen. Lab Invest 2002, 82:1407-1417
    • (2002) Lab Invest , vol.82 , pp. 1407-1417
    • Matthews, I.1    Sims, G.2    Ledwidge, S.3    Stott, D.4    Beeson, D.5    Willcox, N.6    Vincent, A.7
  • 58
    • 0031568670 scopus 로고    scopus 로고
    • Human anti-nicotinic acetylcholine receptor recombinant Fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies
    • Graus YF, de Baets MH, Parren PW, Berrih-Aknin S, Wokke J, van Breda Vriesman PJ, Burton DR: Human anti-nicotinic acetylcholine receptor recombinant Fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies. J Immunol 1997, 158:1919-1929
    • (1997) J Immunol , vol.158 , pp. 1919-1929
    • Graus, Y.F.1    de Baets, M.H.2    Parren, P.W.3    Berrih-Aknin, S.4    Wokke, J.5    van Breda Vriesman, P.J.6    Burton, D.R.7
  • 60
    • 34548816487 scopus 로고    scopus 로고
    • International Seronegative Myasthenia Gravis Survey: The prevalence of MuSK antibody positive myasthenia gravis worldwide
    • Vincent A, Lang B; International Seronegative Myasthenia Gravis Survey: The prevalence of MuSK antibody positive myasthenia gravis worldwide. J Neuroimmunol 2006, 178:233
    • (2006) J Neuroimmunol , vol.178 , pp. 233
    • Vincent, A.1    Lang, B.2


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