Preferential expression of AChR ε-subunit in thymomas from patients with myasthenia gravis

Journal of Neuroimmunology

Volumn 201-202, Issue C, 2008, Pages 28-32

  MacLennan, Calman A ^a,b   Vincent, Angela ^a   Marx, Alexander ^c   Willcox, Nicholas ^a   Gilhus, Nils Eric ^d   Newsom Davis, John ^a   Beeson, David ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF BERGEN   (Norway)

Author keywords

AChR subunit; Myasthenia gravis; RNase protection; Thymoma

Indexed keywords

AUTOANTIBODY; CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR EPSILON SUBUNIT; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; MYASTHENIA GRAVIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBONUCLEASE PROTECTION ASSAY; SOUTHERN BLOTTING; THYMOMA;

ADOLESCENT; ADULT; AGED; AUTOANTIBODIES; FEMALE; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; MYASTHENIA GRAVIS; RECEPTORS, NICOTINIC; RNA, MESSENGER; THYMECTOMY; THYMOMA; THYMUS NEOPLASMS;

EID: 51649128231     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2008.06.016     Document Type: Article

References (24)

1. Beeson D., Morris A., Vincent A., and Newsom-Davis J. The human nicotinic acetylcholine receptor α subunit exists as two isoforms: a novel exon. EMBO J. 9 (1990) 2101-2106
2. Beeson D., Amar M., Bermudez I., Vincent A., and Newsom-Davis J. Stable functional expression of the adult subtype of human muscle acetylcholine receptor following transfection of the human rhabdomyosarcoma cell line TE671 with cDNA encoding the ε subunit. Neurosci. Lett. 207 (1996) 57-60
3. Beeson D., Brydson M., Betty M., Jeremiah S., Povey S., Vincent A., and Newsom-Davis J. Primary structure of the human muscle acetylcholine receptor. cDNA cloning of the γ and ε subunits. Eur. J. Biochem. 215 (1993) 229-238
4. Bruno R., Sabater L., Tolosa E., Sospedra M., Ferrer-Francesch X., Coll J., Foz M., Melms A., and Pujol-Borrell R. Different patterns of nicotinic acetylcholine receptor subunit transcription in human thymus. J. Neuroimmunol. 149 (2004) 147-159
5. Buckley C., Newsom-Davis J., Willcox N., and Vincent A. Mature, long-lived CD4+ and CD8+ T cells are generated by the thymoma in myasthenia gravis. Ann Neurol. 50 (2001) 64-72
6. Gilhus N.E., Willcox N., Harcourt G., Nagvekar N., Beeson D., Vincent A., and Newsom-Davis J. Antigen presentation by thymoma epithelial cells from myasthenia gravis patients to potentially pathogenic T cells. J. Neuroimmunol. 56 (1995) 65-76
7. Giraud M., Taubert R., Vandiedonck C., Ke X., Lévi-Strauss M., Pagani F., Baralle F.E., Eymard B., Tranchant C., Gajdos P., Vincent A., Willcox N., Beeson D., Kyewski B., and Garchon H.J. An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. Nat. 448 (2007) 934-937
8. Hill M., Beeson D., Moss P., Jacobson L., Bond A., Corlett L., Newsom-Davis J., Vincent A., and Willcox N. Early-onset myasthenia gravis: a recurring T-cell epitope in the adult-specific acetylcholine receptor ε subunit presented by the susceptibility allele HLA-DR52a. Ann Neurol. 45 (1999) 224-231
9. Johnnidis J.B., Venanzi E.S., Taxman D.J., Ting J.P., Benoist C.O., and Mathis D.J. Chromosomal clustering of genes controlled by the aire transcription factor. Proc. Natl. Acad. Sci. U S A. 102 (2005) 7233-7238
10. Leite M.I., Jones M., Ströbel P., Marx A., Gold R., Niks E., Verschuuren J.J., Berrih-Aknin S., Scaravilli F., Canelhas A., Morgan B.P., Vincent A., and Willcox N. Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status. Am. J. Pathol. 171 (2007) 893-905
11. MacLennan C., Beeson D., Buijs A.M., Vincent A., and Newsom-Davis J. Acetylcholine receptor expression in human extraocular muscles and their susceptibility to myasthenia gravis. Ann Neurol. 41 (1997) 423-431
12. Marx A., Wilisch A., Schultz A., Gattenlöhner S., Nenninger R., and Müller-Hermelink H.K. Pathogenesis of myasthenia gravis. Virchows Arch. 430 (1997) 355-364
13. Marx A., and Müller-Hermelink H.K. From basic immunobiology to the upcoming WHO-classification of tumors of the thymus. The Second Conference on Biological and Clinical Aspects of Thymic Epithelial Tumors and related recent developments. Path Res. Pract. 195 (1999) 515-533
14. Muller-Hermelink H.K., and Marx A. Thymoma. Curr. Opin. Oncol. 12 (2000) 426
15. Nagvekar N., Moody A.M., Moss P., Roxanis I., Curnow J., Beeson D., Pantic N., Newsom-Davis J., Vincent A., and Willcox N. A pathogenic role for the thymoma in myasthenia gravis; autosensitization of IL-4-producing T cell clones recognizing extracellular AChR epitopes presented by minority class II isotypes. J. Clin. Invest. 101 (1998) 2268-2277
16. Newsom-Davis J., Vincent A., and Willcox H.N. Autoimmune disorders of the neuromuscular junction. In: Lachmann P.J., Peters D.K., Rosen F.S., and Walport N.J. (Eds). Clinical aspects of immunology. 5th ed. vol. 3 (1993), Blackwell Scientific Publications, Oxford 2091-2111
17. Ragheb S., Mohamed M., and Lisak R.P. Myasthenia gravis patients, but not healthy subjects, recognize epitopes that are unique to the epsilon-subunit of the acetylcholine receptor. J. Neuroimmunol. 159 (2005) 137-145
18. Rosai J., and Levine G.D. Tumors of the thymus. Atlas of Tumor Pathology, 2nd series (1976), US Armed Forces Institute of Pathology Fascicle 13
19. Sanes J.R., and Lichtman J.W. Induction, assembly, maturation and maintenance of a postsynaptic apparatus. Nat. Rev. Neurosci. 2 (2001) 791-805
20. Schluep M., Willcox N., Vincent A., Dhoot G.K., and Newsom-Davis J. Acetylcholine receptors in human thymic myoid cells in situ: an immunohistological study. Ann Neurol. 22 (1987) 212-222
21. Ströbel P., Bauer A., Puppe B., Kraushaar T., Krein A., Toyka K., Gold R., Semik M., Kiefer R., Nix W., Schalke B., Muller-Hermelink H.K., and Marx A. Tumor recurrence and survival in patients treated for thymomas and thymic squamous cell carcinomas: a retrospective analysis. J. Clin. Oncol. 22 (2004) 1501-1509
22. Ströbel P., Murumägi A., Klein R., Luster M., Lahti M., Krohn K., Schalke B., Nix W., Gold R., Rieckmann P., Toyka K., Burek C., Rosenwald A., Müller-Hermelink H.K., Pujoll-Borrell R., Meager A., Willcox N., Peterson P., and Marx A. Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS-1). J. Pathol. 211 (2007) 563-571
23. Vincent A., Willcox N., Hill M., Curnow J., MacLennan C., and Beeson D. Determinant spreading and immune responses to acetylcholine receptors in myasthenia gravis. Immunol. Rev. 164 (1998) 157-168
24. Wilisch A., Gutsche S., Hoffacker V., Schultz A., Tzartos S., Nix W., Schalke B., Schneider C., Müller-Hermelink H.K., and Marx A. Association of acetylcholine receptor α-subunit gene expression in mixed thymoma with myasthenia gravis. Neurol. 52 (1999) 1460-1466