Expression of neurofilaments and of a titin epitope in thymic epithelial tumors. Implications for the pathogenesis of Myasthenia gravis

American Journal of Pathology

Volumn 148, Issue 6, 1996, Pages 1839-1850

  Marx, Alexander ^a   Wilisch, Annette ^a   Schultz, Anja ^a   Greiner, Axel ^a   Magi, Barbara ^b   Pallini, Vitaliano ^b   Schalke, Berthold ^a   Toyka, Klaus ^a   Nix, Wilfried ^c   Kirchner, Thomas ^d   Müller Hermelink, Hans Konrad ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF SIENA   (Italy)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CONNECTIN; EPITOPE; NEUROFILAMENT PROTEIN; RNA;

ADOLESCENT; ADULT; ANTIGEN PRESENTING CELL; ARTICLE; CELL DIFFERENTIATION; CHILD; CLINICAL ARTICLE; EPITHELIUM TUMOR; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; MYASTHENIA GRAVIS; NEUROFILAMENT; NEWBORN; PRIORITY JOURNAL; THYMOMA;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES; BASE SEQUENCE; EPITOPES; FEMALE; HUMANS; INTERMEDIATE FILAMENTS; MALE; MICROSCOPY, IMMUNOELECTRON; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUSCLE PROTEINS; MYASTHENIA GRAVIS; NEUROFILAMENT PROTEINS; POLYMERASE CHAIN REACTION; PROTEIN KINASES; RNA, NEOPLASM; THYMOMA; THYMUS GLAND; THYMUS NEOPLASMS;

EID: 0030001471     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Oosterhuis HJGH, Kuks JBM: Myasthenia gravis and myasthenic syndromes. Curr Opin Neurol Neurosurg 1992, 5:638-644
2. Vincent A, Whiting P, Schluep M, Heidenreich F, Lang B, Roberts A, Willcox N, Newsom-Davis J: Antibody heterogeneity and specificity in myasthenia gravis. Ann NY Acad Sci 1987, 505:106-120
3. Fujii Y, Monden Y, Nakahara K, Hashimoto J, Kawashima Y: Antibody to acetylcholine receptor in myasthenia gravis: production by lymphocytes from thymus and thymoma. Neurology 1984, 34:1182-1186
4. Müller-Hermelink HK, Marino M, Palestra G: Pathology of thymic epithelial tumors. Curr Top Pathol 1986, 75: 207-268
5. Kirchner T, Müller-Hermelink HK: New approaches to the diagnosis of thymic epithelial tumors. Progress in Surgical Pathology, vol 10. Edited by CM Fenoglio-Preiser, M Wolff, F Rilke. Philadelphia, Field and Wood, 1989, pp 167-186
6. Kirchner T, Schalke B, Buchwald J, Ritter M, Marx A, Müller-Hermelink HK: Well-differentiated thymic carcinoma. Am J Surg Pathol 1992, 16:1153-1169
7. Strauss AJL, Seegal BC, Hsu KC, Burkholder PM, Nastuk WL, Osserman KE: Immunofluorescence demonstration of a muscle binding, complement-fixing serum globulin fraction in myasthenia gravis. Proc Soc Exp Biol Med 1960, 105:184-191
8. Van der Geld HWR, Strauss AJL: Myasthenia gravis: immunological relationship between striated muscle and thymus. Lancet 1966, 1:57-60
9. Gilhus NE, Aarli JA, Christensson B, Matre R: Rabbit antiserum to citric acid extract of human skeletal muscle staining thymomas from myasthenia gravis patients. J Neuroimmunol 1984, 7:55-64
10. Dardenne M, Savino W, Bach JF: Thymomatous epithelial cells and skeletal muscle share a common epitope by a monoclonal antibody. Am J Pathol 1987, 126:194-198
11. Cikes N, Momoi MY, Williams CL, Howard FM, Hoagland HC, Whittingham S, Lennon VA: Striational autoantibodies: quantitative detection by enzyme immunoassay in myasthenia gravis, thymoma, and recipients of D-penicillamine or allogeneic bone marrow. Mayo Clin Proc 1988, 63:474-481
12. Aarli JA, Stefansson K, Marton LSG, Wollmann RL: Patients with myasthenia gravis have in their sera IgG autoantibodies against titin. Clin Exp Immunol 1990, 82:284-288
13. Gautel M, Lakey A, Barlow DP, Holmes Z, Scales S, Leonard K, Labeit S, Mygland A, Gilhus NE, Aarli JA: Titin antibodies in myasthenia gravis: identification of a major immunogenic region of titin. Neurology 1993, 43:1581-1585
14. Marx A, Osborn M, Tzartos S, Geuder KI, Schalke B, Nix W, Kirchner T, Müller-Hermelink HK: A striational muscle antigen and myasthenia gravis-associated thymomas share an acetylcholine-receptor epitope. Dev Immunol 1992, 2:77-84
15. Osborn M, Marx A, Kirchner T, Tzartos SJ, Plessman U, Weber K: A shared epitope in the acetylcholine receptor-α subunit and fast troponin I of skeletal muscle. Am J Pathol 1992, 140:1215-1223
16. Kirchner T, Tzartos S, Hoppe F, Schalke B, Wekerle H, Müller-Hermelink HK: Pathogenesis of myasthenia gravis: acetylcholine receptor-related antigenic determinants in tumor-free thymuses and thymic epithelial tumors. Am J Pathol 1988, 130:268-280
17. Siara J, Rüdel R, Marx A: Absence of acetylcholine-induced current in epithelial cells from thymus glands and thymomas of myasthenia gravis patients. Neurology 1991, 41:128-131
18. Geuder KI, Marx A, Witzemann V, Schalke B, Kirchner T, Müller-Hermelink HK: Genomic organization and lack of transcription of the nicotinic acetylcholine receptor subunit genes in myasthenia gravis-associated thymoma. Lab Invest 1992, 66:452-458
19. Marx A, O'Connor R, Geuder KI, Hoppe F, Schalke B, Tzartos S, Kalies I, Kirchner T, Müller-Hermelink HK: Characterization of a protein with an acetylcholine receptor epitope from myasthenia gravis-associated thymomas. Lab Invest 1990, 62:279-286
20. Shimizu T, Matsumara K, Itoh Y, Mannen T, Maruyama K: An immunological homology between neurofilament and muscle elastic filament: a monoclonal antibody cross-reacts with neurofilament subunits and connectin. Biomed Res 1988, 9:227-233
21. Mencarelli C, Magi B, Marzocchi B, Armellini D, Pallini V: Evolution of the "titin epitope" in neurofilament proteins. Comp Biochem Physiol B 1991, 100:741-744
22. Müller-Hermelink HK, Marx A, Kirchner T: Advances in the diagnosis and classification of thymic epithelial tumors. Rec Adv Histopathol 1994, 16:49
23. Masaoka A, Yasumasa M, Nakahara K, Tanioka T: Follow-up study of thymomas with special reference to their clinical stages. Cancer 1981, 48:2485-2492
24. Marx A, Kirchner T, Hoppe F, O'Connor R, Schalke B, Tzartos S, Müller-Hermelink HK: Proteins with epitopes of the acetylcholine receptor in epithelial cell cultures of thymomas in myasthenia gravis. Am J Pathol 1989, 134:865-877
25. Debus E, Weber K, Osborn M: Monoclonal antibodies specific for glial fibrillary acidic (GFA) protein and for each of the neurofilament triplet polypeptides. Differentiation 1983, 25:193-203
26. Franke FE, Schachenmayr W, Osborn M, Altmannsberger M: Unexpected immunoreactivities of intermediate filament antibodies in human brain and brain tumors. Am J Pathol 1991, 139:67-77
27. Shaw G, Osborn M, Weber K: Reactivity of a panel of neurofilament antibodies on phosphorylated neurofilaments. Eur J Cell Biol 1986, 42:1-9
28. Anderton BH, Breinberg D, Downes MJ, Green PJ, Tomlinson BE, Ulrich J, Wood JN, Kahn J: Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants. Nature 1982, 298:84-86
29. Fürst DO, Osborn M, Nave R, Weber K: The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at the Z line extends close to the M line. J Cell Biol 1988, 106:1563-1572
30. Julien JP, Grosveld F, Yaztanbaksh K, Flavell D, Meijer D, Mushynski W: The structure of a human neurofilament gene (NF-L): a unique exon-intron organization in the intermediate filament gene family. Biochim Biophys Acta 1987, 909:10-20
31. Myers MW, Lazzarini RA, Lee VM, Schlaepfer WW, Nelson DL: The human mid-size neurofilament subunit: a repeated protein sequence and relationship of its gene to the intermediate filament gene family. EMBO J 1987, 6:1617-1626
32. Lees JF, Schneidman PS, Skuntz SF, Garden MJ, Lazzarini RA: The structure and organization of the human heavy neurofilament (NF-H) and the gene encoding it. EMBO J 1988, 7:1947-1955
33. Arcari P, Martinell R, Salvatore F: The complete sequence of a full length cDNA for human liver glyceraldehyde-3-phosphate dehydrogenase: evidence for multiple mRNA species. Nucleic Acids Res 1984, 12: 1979-1989
34. Bennett GS, Hollander BA, Laskowska D: Expression and phosphorylation of the mid-sized neurofilament protein NF-M during chick spinal cord neurogenesis. J Neurosci Res 1988, 21:376-390
35. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 277:680-684
36. Williams CL, Hay JE, Huiatt TW, Lennon VA: Paraneoplastic IgG striational autoantibodies produced by clonal thymic B cells and in serum of patients with myasthenia gravis and thymoma react with titin. Lab Invest 1992, 66:331-336
37. Müller-Hermelink HK, Marx A, Geuder K, Kirchner T: The pathological basis of thymoma-associated myasthenia gravis. Ann NY Acad Sci 1993, 681:56-65
38. Garden MJ, Schlaepfer WW, Lee VM-Y: The structure, biochemical properties, and immunogenicity of neurofilament peripheral regions are determined by phosphorylation state. J Biol Chem 1985, 260:9805-9817
39. Yamasaki H, Bennett GS, Itakura C, Mizutani M: Defective expression of neurofilament protein subunits in hereditary hypothrophic axonopathy of quail. Lab Invest 1992, 66:734-743
40. Julien JP, Mushynski W: Multiple phosphorylation sites in mammalian neurofilament polypeptides. J Biol Chem 1982, 10467-10471
41. Marx A, Geuder KI, Altmannsberger M, Schömig E, Kirchner T, Müller-Hermelink HK: Neuronal acetylcholine receptors as differentiation markers in neuroblastoma and paraganglioma. Verh Dtsch Ges Pathol 1990, 74:354-358
42. Miettinen M, Clark R, Lehto VP, Virtanen I, Damjanov I: Intermediate-filament proteins in parathyroid glands and parathyroid adenoma. Arch Pathol Lab Med 1985, 109:986-989
43. Chin SS, Liem RK: Transfected rat high-molecular-weight neurofilament (NF-H) coassembles with vimentin in a predominantly nonphosphorylated form. J Neurosci 1990, 10:3714-3726
44. Jones SM, Williams RC: Phosphate content of mammalian neurofilaments. J Biol Chem 1982, 257:9902-9905
45. Chin SSM, Liem RKH: Expression of rat neurofilament proteins NF-L and NF-M in transfected non-neuronal cells. Eur J Cell Biol 1989, 50:475-490
46. Pleasure SJ, Lee VM, Nelson DL: Site-specific phosphorylation of the middle molecular weight human neurofilament protein in transfected non-neuronal cells. J Neurosci 1990, 10:2428-2437
47. Soifer D, Nicoletti V, Cabane K, Mack K, Poulos B: Expression of the neurofilament protein NF-H in L cells. J Neurosci 1991, 30:63-71
48. Hohlfeld R: Myasthenia gravis and thymoma: paraneoplastic failure of neuromuscular transmission. Lab Invest 1990, 62:241-243
49. Marx A, Kirchner T, Greiner A, Müller-Hermelink HK, Schalke B, Osborn M: Neurofilament epitopes in thymorna and antiaxonal autoantibodies in myasthenia gravis. Lancet 1992, 339:707-708
50. Sommer N, Willcox N, Harcourt GC, Newsom-Davis J: Myasthenic thymus and thymoma are selectively enriched in acetylcholine receptor-reactive T cells. Ann Neurol 1990, 28:312-319
51. Willcox N: Myasthenia gravis. Curr Opin Immunol 1993, 5:910-917
52. Gilhus NE, Willcox N, Harcourt G, Nagvekar N, Beeson D, Vincent A, Newsom-Davis J: Antigen presentation by thymoma epithelial cells from myasthenia gravis patients to potentially pathogenic T cells. J Neuroimmunol 1995, 56:65-76