The role of Dlc1 isoform 2 in K-Ras2G12D induced thymic cancer

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Sabbir, Mohammad Golam ^a,b   Prieditis, Heather ^a   Ravinsky, Esther ^c   Mowat, Michael R A ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c HEALTH SCIENCES CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

RHO KINASE;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARCINOGENESIS; CELL MIGRATION; CELL MOTILITY; CELL STRUCTURE; CONTROLLED STUDY; DCL1 ISOFORM 2 GENE; DNA METHYLATION; ENZYME ACTIVITY; HETEROZYGOTE; IN VIVO STUDY; K RAS 2 GENE; LIFESPAN; LUNG METASTASIS; MOUSE; NONHUMAN; ONCOGENE; OVERALL SURVIVAL; PROMOTER REGION; PROTEIN EXPRESSION; T CELL LYMPHOMA; THYMUS LYMPHOMA; TUMOR SUPPRESSOR GENE;

ANIMALS; BASE SEQUENCE; CELL SHAPE; CELL SURFACE EXTENSIONS; CHROMOSOME MAPPING; CPG ISLANDS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GTPASE-ACTIVATING PROTEINS; LUNG NEOPLASMS; LYMPHOMA, T-CELL; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; NEOPLASMS, EXPERIMENTAL; PROMOTER REGIONS, GENETIC; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS P21(RAS); RHO GTP-BINDING PROTEINS; STRESS FIBERS; THYMOMA; THYMUS NEOPLASMS; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

MUS;

EID: 84863617599     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040302     Document Type: Article

References (56)

1. Wong CM, Lee JM, Ching YP, Jin DY, Ng IO, (2003) Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma. Cancer Res 63: 7646-7651.
2. Yuan BZ, Zhou X, Durkin ME, Zimonjic DB, Gumundsdottir K, et al. (2003) DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity. Oncogene 22: 445-450.
3. Yuan BZ, Durkin ME, Popescu NC, (2003) Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers. Cancer Genet Cytogenet 140: 113-117.
4. Yuan BZ, Jefferson AM, Baldwin KT, Thorgeirsson SS, Popescu NC, et al. (2004) DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas. Oncogene 23: 1405-1411.
5. Ng IO, Liang ZD, Cao L, Lee TK, (2000) DLC-1 is deleted in primary hepatocellular carcinoma and exerts inhibitory effects on the proliferation of hepatoma cell lines with deleted DLC-1. Cancer Res 60: 6581-6584.
6. Durkin ME, Avner MR, Huh CG, Yuan BZ, Thorgeirsson SS, et al. (2005) DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development. FEBS Lett 579: 1191-1196.
7. Xue W, Krasnitz A, Lucito R, Sordella R, Vanaelst L, et al. (2008) DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes Dev 22: 1439-1444.
8. Sabbir MG, Wigle N, Loewen S, Gu Y, Buse C, et al. (2010) Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform. BMC Biol 8: 17.
9. Kohl NE, Ruley HE, (1987) Role of c-myc in the transformation of REF52 cells by viral and cellular oncogenes. Oncogene 2: 41-48.
10. Ridley AJ, Paterson HF, Noble M, Land H, (1988) Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation. EMBO J 7: 1635-1645.
11. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW, (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88: 593-602.
12. Hicks GG, Egan SE, Greenberg AH, Mowat M, (1991) Mutant p53 tumor suppressor alleles release ras-induced cell cycle growth arrest. Mol Cell Biol 11: 1344-1352.
13. Pumiglia KM, Decker SJ, (1997) Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway. Proc Natl Acad Sci U S A 94: 448-452.
14. Lloyd AC, Obermuller F, Staddon S, Barth CF, McMahon M, et al. (1997) Cooperating oncogenes converge to regulate cyclin/cdk complexes. Genes Dev 11: 663-677.
15. Olson MF, Paterson HF, Marshall CJ, (1998) Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1. Nature 394: 295-299.
16. Sahai E, Olson MF, Marshall CJ, (2001) Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO J 20: 755-766.
17. Jackson EL, Willis N, Mercer K, Bronson RT, Crowley D, et al. (2001) Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev 15: 3243-3248.
18. Dooley J, Erickson M, Larochelle WJ, Gillard GO, Farr AG, (2007) FGFR2IIIb signaling regulates thymic epithelial differentiation. Dev Dyn 236: 3459-3471.
19. Bernatz PE, Harrison EG, Clagett OT, (1961) Thymoma: a clinicopathologic study. J Thorac Cardiovasc Surg 42: 424-444.
20. Small JV, Rottner K, Kaverina I, Anderson KI, (1998) Assembling an actin cytoskeleton for cell attachment and movement. Biochim Biophys Acta 1404: 271-281.
21. Heath JP, (1983) Behaviour and structure of the leading lamella in moving fibroblasts. I. Occurrence and centripetal movement of arc-shaped microfilament bundles beneath the dorsal cell surface. J Cell Sci 60: 331-354.
22. Horii A, Nakatsuru S, Ichii S, Nagase H, Nakamura Y, (1993) Multiple forms of the APC gene transcripts and their tissue-specific expression. Hum Mol Genet 2: 283-287.
23. Murray-Zmijewski F, Lane DP, Bourdon JC, (2006) p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress. Cell Death Differ 13: 962-972.
24. Xu CF, Brown MA, Chambers JA, Griffiths B, Nicolai H, et al. (1995) Distinct transcription start sites generate two forms of BRCA1 mRNA. Hum Mol Genet 4: 2259-2264.
25. Bourdon JC, Fernandes K, Murray-Zmijewski F, Liu G, Diot A, et al. (2005) p53 isoforms can regulate p53 transcriptional activity. Genes Dev 19: 2122-2137.
26. Davuluri RV, Suzuki Y, Sugano S, Plass C, Huang TH, (2008) The functional consequences of alternative promoter use in mammalian genomes. Trends Genet 24: 167-177.
27. Leung TH, Ching YP, Yam JW, Wong CM, Yau TO, et al. (2005) Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity. Proc Natl Acad Sci U S A 102: 15207-15212.
28. Durkin ME, Yuan BZ, Zhou X, Zimonjic DB, Lowy DR, et al. (2007) DLC-1:a Rho GTPase-activating protein and tumour suppressor. J Cell Mol Med 11: 1185-1207.
29. Low JS, Tao Q, Ng KM, Goh HK, Shu XS, et al. (2011) A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors. Oncogene 30: 1923-35.
30. Bryan J, Jabbes M, Berent L, Arthur G, Taylor K, et al. (2009) Hypermethylation of the DLC1 CpG island does not alter gene expression in canine lymphoma. BMC Genetics 10: 73.
31. Johnson L, Mercer K, Greenbaum D, Bronson RT, Crowley D, et al. (2001) Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410: 1111-1116.
32. Akagi K, Sandig V, Vooijs M, Van der Valk M, et al. (1997) Cre-mediated somatic site-specific recombination in mice. Nucl Acids Res 25: 1766-1773.
33. Wang Y, Krushel LA, Edelman GM, (1996) Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene. PNAS 93: 3932-3936.
34. Kim TY, Healy KD, Der CJ, Sciaky N, Bang YJ, et al. (2008) Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration. J Biol Chem 283: 32762-32770.
35. Zheng SL, Mychaleckyj JC, Hawkins GA, Isaacs SD, Wiley KE, et al. (2003) Evaluation of DLC1 as a prostate cancer susceptibility gene: mutation screen and association study. Mutat Res 528: 45-53.
36. Opavsky R, Wang SH, Trikha P, Raval A, Huang Y, et al. (2007) CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells. PLoS Genet 3: 1757-1769.
37. Song LJ, Ye SL, Wang KF, Weng YQ, Liang CM, et al. (2005) [Relationship between DLC-1 expressions and metastasis in hepatocellular carcinoma]. Zhonghua Gan Zang Bing Za Zhi 13: 428-431.
38. Gómez J, Martínez A, Giry M, García A, Rebollo A, (1997) Rho prevents apoptosis through Bcl-2 expression: Implications for interleukin-2 receptor signal transduction. Eur J Immunol 27: 2793-2799.
39. Costello PS, Cleverley SC, Galandrini R, Henning SW, Cantrell DA, (2000) The GTPase Rho Controls a p53-dependent Survival Checkpoint during Thymopoiesis. J Exp Med 192: 77-86.
40. Vielkind S, Gallagher-Gambarelli M, Gomez M, Hinton HJ, Cantrell DA, (2005) Integrin Regulation by RhoA in Thymocytes. J Immunol 175: 350-357.
41. Hogg N, Laschinger M, Giles K, McDowall A, (2003) T-cell integrins: more than just sticking points. J Cell Sci 116: 4695-4705.
42. Woodside D, Wooten D, Teague TK, Miyamoto Y, Caudell E, et al. (2003) Control of T lymphocyte morphology by the GTPase Rho. BMC Cell Biology 4: 2.
43. Smith A, Bracke M, Leitinger B, Porter JC, Hogg N, (2003) LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment. J Cell Sci 116: 3123-3133.
44. Martin-Caballero J, Flores JM, Garcia-Palencia P, Serrano M, (2001) Tumor susceptibility of p21(Waf1/Cip1)-deficient mice. Cancer Res 61: 6234-6238.
45. Philipp J, Vo K, Gurley KE, Seidel K, Kemp CJ, (1999) Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis. Oncogene 18: 4689-4698.
46. Topley GI, Okuyama R, Gonzales JG, Conti C, Dotto GP, (1999) p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential. Proc Natl Acad Sci U S A 96: 9089-9094.
47. Jackson RJ, Adnane J, Coppola D, Cantor A, Sebti SM, et al. (2002) Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models. Oncogene 21: 8486-8497.
48. Jackson RJ, Engelman RW, Coppola D, Cantor AB, Wharton W, et al. (2003) p21Cip1 nullizygosity increases tumor metastasis in irradiated mice. Cancer Res 63: 3021-3025.
49. Poole AJ, Heap D, Carroll RE, Tyner AL, (2004) Tumor suppressor functions for the Cdk inhibitor p21 in the mouse colon. Oncogene 23: 8128-8134.
50. Weinberg WC, Fernandez-Salas E, Morgan DL, Shalizi A, Mirosh E, et al. (1999) Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis. Cancer Res 59: 2050-2054.
51. Brugarolas J, Chandrasekaran C, Gordon JI, Beach D, Jacks T, et al. (1995) Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377: 552-557.
52. Deng C, Zhang P, Harper JW, Elledge SJ, Leder P, (1995) Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82: 675-684.
53. Dellagi K, Lipinski M, Paulin D, Portier MM, Lenoir GM, et al. (1987) Characterization of intermediate filaments expressed by Ewing tumor cell lines. Cancer Res 47: 1170-1173.
54. Sabbir MG, Roy A, Mandal S, Dam A, Roychoudhury S, et al. (2006) Deletion mapping of chromosome 13q in head and neck squamous cell carcinoma in Indian patients: correlation with prognosis of the tumour approximately 580 Kb surrounding the MYC gene is amplified in head and neck squamous cell carcinoma of Indian patients. International Journal of Experimental Pathology 87: 151-161.
55. Durkin ME, Yuan BZ, Thorgeirsson SS, Popescu NC, (2002) Gene structure, tissue expression, and linkage mapping of the mouse DLC-1 gene (Arhgap7). Gene 288: 119-127.
56. Rohnelt RK, Hoch G, Reiss Y, Engelhardt B, (1997) Immunosurveillance modelled in vitro: naive and memory T cells spontaneously migrate across unstimulated microvascular endothelium. Int Immunol 9: 435-450.