Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction

Cell Research

Volumn 25, Issue 8, 2015, Pages 946-962

  Jia, Xiao E ^a,d   Ma, Ke ^a   Xu, Tao ^a   Gao, Lei ^a   Wu, Shuang ^a   Fu, Cong ^a   Zhang, Wenjuan ^a   Wang, Zhizhang ^a   Liu, Kaiyu ^f   Dong, Mei ^a   Jing, Changbin ^a   Ren, Chunguang ^a   Dong, Zhiwei ^a   Chen, Yi ^b   Jin, Yi ^b   Huang, Qiuhua ^b   Chang, Xing ^a   Deng, Min ^a   Li, Li ^h   Luo, Lingfei ^h   Zhu, Jun ^a,g   Dang, Yongjun ^f   Chang, Hung Chun ^e   Zon, Leonard I ^c   Zhou, Yi ^c   Chen, Saijuan ^a,b   Pan, Weijun ^a   more..

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BAOTOU MEDICAL COLLEGE   (China)

^e Chinese Academy of Sciences   (China)

^f FUDAN UNIVERSITY   (China)

^g SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^h SOUTHWEST UNIVERSITY   (China)

Author keywords

autophagy; Hematopoietic stem cells; kri1l; misfolded unfolded protein; PERK; ribosome biogenesis; zebrafish

Indexed keywords

DANIO RERIO;

ADENINE; GSK2656157; INDOLE DERIVATIVE; KRI1L PROTEIN, ZEBRAFISH; PERK KINASE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE R; ZEBRAFISH PROTEIN;

ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; AUTOPHAGY; GENETICS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; METABOLISM; MUTATION; ORGANELLE BIOGENESIS; PATHOLOGY; RIBOSOME; ZEBRA FISH;

ADENINE; ANIMALS; AUTOPHAGY; EIF-2 KINASE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; INDOLES; MUTATION; ORGANELLE BIOGENESIS; PROTEIN KINASE INHIBITORS; RIBOSOMES; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84938750079     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2015.81     Document Type: Article

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