Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway

PLoS Genetics

Volumn 10, Issue 5, 2014, Pages

  Heijnen, Harry F ^a   van Wijk, Richard ^a   Pereboom, Tamara C ^a   Goos, Yvonne J ^a   Seinen, Cor W ^a   van Oirschot, Brigitte A ^a   van Dooren, Rowie ^a   Gastou, Marc ^b   Giles, Rachel H ^a   van Solinge, Wouter ^a   Kuijpers, Taco W ^c   Gazda, Hanna T ^d,e,f   Bierings, Marc B ^a   Da Costa, Lydie ^g,h,i   MacInnes, Alyson W ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c EMMA CHILDREN S HOSPITAL   (Netherlands)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^g HÔPITAL ROBERT DEBRÉ   (France)

^h UNIVERSITÉ PARIS DESCARTES   (France)

ⁱ Broad Institute ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; INSULIN; PROTEIN P53; REACTIVE OXYGEN METABOLITE; RIBOSOME PROTEIN; S6 KINASE; TRANSCRIPTION FACTOR; RIBOSOMAL PROTEIN S19;

ANIMAL EXPERIMENT; ARTICLE; AUTOPHAGY; BLACKFAN DIAMOND ANEMIA; CANCER INHIBITION; CATABOLISM; CONTROLLED STUDY; DEREGULATION; EMBRYO; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ERYTHROCYTE; GENE MUTATION; HEMATOPOIESIS; INSULIN RESISTANCE; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN STABILITY; PURE RED CELL ANEMIA; TUMOR SUPPRESSOR GENE; ZEBRA FISH; ANIMAL; ANTAGONISTS AND INHIBITORS; BONE MARROW DISEASE; DRUG EFFECTS; ERYTHROPOIESIS; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; LIPOMATOSIS; METABOLISM; MUTATION; PANCREAS EXOCRINE INSUFFICIENCY; PATHOLOGY; SIGNAL TRANSDUCTION;

ANEMIA, DIAMOND-BLACKFAN; ANIMALS; AUTOPHAGY; BONE MARROW DISEASES; ERYTHROPOIESIS; EXOCRINE PANCREATIC INSUFFICIENCY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INSULIN; LIPOMATOSIS; MUTATION; RIBOSOMAL PROTEIN S6 KINASES; RIBOSOMAL PROTEINS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; ZEBRAFISH;

EID: 84901630158     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004371     Document Type: Article

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