Lipoic acid inhibits the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction

Carcinogenesis

Volumn 36, Issue 8, 2015, Pages 817-831

  Göder, Anja ^a   Nagel, Georg ^a   Kraus, Alexander ^a   Dörsam, Bastian ^a   Seiwert, Nina ^a   Kaina, Bernd ^a   Fahrer, Jörg ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

6 O METHYLGUANINE; ACETYLCYSTEINE; BECLIN 1; GLUTATHIONE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN P53; TEMOZOLOMIDE; THIOCTIC ACID; ALKYLATING AGENT; CYSTEINE; DACARBAZINE; DIHYDROLIPOATE; DNA METHYLTRANSFERASE; GUANINE; MGMT PROTEIN, HUMAN; O-(6)-METHYLGUANINE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; AUTOPHAGY; CANCER CELL; COLORECTAL CANCER; CYTOTOXICITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; COLORECTAL NEOPLASMS; DNA REPAIR; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; FEMALE; GENETICS; HCT116 CELL LINE; MALE; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; AUTOPHAGY; COLORECTAL NEOPLASMS; CYSTEINE; DACARBAZINE; DNA MODIFICATION METHYLASES; DNA REPAIR; DNA REPAIR ENZYMES; DRUG RESISTANCE, NEOPLASM; FEMALE; GLUTATHIONE; GUANINE; HCT116 CELLS; HUMANS; MALE; MICE, INBRED BALB C; MOLECULAR TARGETED THERAPY; THIOCTIC ACID; TUMOR SUPPRESSOR PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84938680412     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgv070     Document Type: Article

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