Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1

FASEB Journal

Volumn 26, Issue 5, 2012, Pages 2117-2124

  Siggens, Lee ^a   Figg, Nichola ^a   Bennett, Martin ^a   Foo, Roger ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

8 oxoG; Cardiomyopathy; Heart failure; Oxidative genomic damage

Indexed keywords

8 HYDROXYGUANINE; 8 OXOGUANINE DNA GLYCOSYLASE; BAFILOMYCIN; DNA GLYCOSYLTRANSFERASE; GAMMA HISTONE H2AX; HISTONE H2AX; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CARDIOMYOPATHY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; EXCISION REPAIR; FIBROBLAST; HEART FAILURE; HEART MUSCLE CELL; HISTOLOGY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MOUSE; NONHUMAN; NUTRIENT; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; BASE SEQUENCE; DNA DAMAGE; DNA GLYCOSYLASES; DNA PRIMERS; DNA REPAIR; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MYOCARDIUM;

MURINAE;

EID: 84860914325     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-197525     Document Type: Article

References (38)

1. Bozkurt, B., Mann, D. L., and Deswal, A. (2010) Biomarkers of inflammation in heart failure. Heart Fail. Rev. 15, 331-341
2. Whelan, R. S., Kaplinskiy, V., and Kitsis, R. N. (2010) Cell death in the pathogenesis of heart disease: mechanisms and significance. Annu. Rev. Physiol. 72, 19-44
3. Neubauer, S. (2007) The failing heart - an engine out of fuel. N. Engl. J. Med. 356, 1140-1151
4. Giordano, F. J. (2005) Oxygen, oxidative stress, hypoxia, and heart failure. J. Clin. Invest. 115, 500-508
5. Hare, J. M. (2001) Oxidative stress and apoptosis in heart failure progression. Circ. Res. 89, 198-200
6. Webster, K. A. (2007) Hypoxia: life on the edge. Antioxid. Redox Signal. 9, 1303-1307
7. Cooke, M. S., Evans, M. D., Dizdaroglu, M., and Lunec, J. (2003) Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J. 17, 1195-1214 (Pubitemid 36775767)
8. Jackson, S. P., and Bartek, J. (2009) The DNA-damage response in human biology and disease. Nature 461, 1071-1078
9. Lammens, K., Bemeleit, D. J., Mockel, C., Clausing, E., Schele, A., Hartung, S., Schiller, C. B., Lucas, M., Angermuller, C., Soding, J., Strasser, K., and Hopfner, K. P. (2011) The Mre11: Rad50 structure shows an ATP-dependent molecular clamp in DNA double-strand break repair. Cell 145, 54-66
10. Osley, M. A., Tsukuda, T., and Nickoloff, J. A. (2007) ATPdependent chromatin remodeling factors and DNA damage repair. Mutat. Res. 618, 65-80 (Pubitemid 46574743)
11. Tang, J. B., Goellner, E. M., Wang, X. H., Trivedi, R. N., St Croix, C. M., Jelezcova, E., Svilar, D., Brown, A. R., and Sobol, R. W. (2010) Bioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage. Mol. Cancer Res. 8, 67-79
12. Movassagh, M., Choy, M. K., Goddard, M., Bennett, M. R., Down, T. A., and Foo, R. S. (2010) Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure. PLoS One 5, e8564
13. Tachibana, H., Naga Prasad, S. V., Lefkowitz, R. J., Koch, W. J., and Rockman, H. A. (2005) Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure. Circulation 111, 591-597 (Pubitemid 40216486)
14. Foo, R. S., Chan, L. K., Kitsis, R. N., and Bennett, M. R. (2007) Ubiquitination and degradation of the anti-apoptotic protein ARC by MDM2. J. Biol. Chem. 282, 5529-5535 (Pubitemid 47093728)
15. Wencker, D., Chandra, M., Nguyen, K., Miao, W., Garantziotis, S., Factor, S. M., Shirani, J., Armstrong, R. C., and Kitsis, R. N. (2003) A mechanistic role for cardiac myocyte apoptosis in heart failure. J. Clin. Invest. 111, 1497-1504 (Pubitemid 38063282)
16. Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., and Ohsumi, Y. (2004) In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol. Biol. Cell 15, 1101-1111 (Pubitemid 38316219)
17. Claycomb, W. C., Lanson, N. A., Jr., Stallworth, B. S., Egeland, D. B., Delcarpio, J. B., Bahinski, A., and Izzo, N. J., Jr. (1998) HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proc. Natl. Acad. Sci. U. S. A. 95, 2979-2984 (Pubitemid 28135840)
18. Foo, R. S., Siow, R. C., Brown, M. J., and Bennett, M. R. (2006) Heme oxygenase-1 gene transfer inhibits angiotensin II-mediated rat cardiac myocyte apoptosis but not hypertrophy. J. Cell. Physiol. 209, 1-7 (Pubitemid 44318662)
19. Choy, M. K., Movassagh, M., Siggens, L., Vujic, A., Goddard, M., Sanchez, A., Perkins, N., Figg, N., Bennett, M., Carroll, J., and Foo, R. (2010) High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-κB- complex-dependent gene expression in human heart failure. Genome Med. 2, 37
20. Mirbahai, L., Kershaw, R. M., Green, R. M., Hayden, R. E., Meldrum, R. A., and Hodges, N. J. (2010) Use of a molecular beacon to track the activity of base excision repair protein OGG1 in live cells. DNA Repair (Amst.) 9, 144-152
21. Matsui, Y., Takagi, H., Qu, X., Abdellatif, M., Sakoda, H., Asano, T., Levine, B., and Sadoshima, J. (2007) Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ. Res. 100, 914-922 (Pubitemid 46555697)
22. Bialik, S., Cryns, V. L., Drincic, A., Miyata, S., Wollowick, A. L., Srinivasan, A., and Kitsis, R. N. (1999) The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes. Circ. Res. 85, 403-414 (Pubitemid 29409617)
23. Molkentin, J. D., and Dorn, G. W., 2nd (2001) Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annu Rev Physiol. 63, 391-426 (Pubitemid 32304323)
24. Sano, M., Minamino, T., Toko, H., Miyauchi, H., Orimo, M., Qin, Y., Akazawa, H., Tateno, K., Kayama, Y., Harada, M., Shimizu, I., Asahara, T., Hamada, H., Tomita, S., Molkentin, J. D., Zou, Y., and Komuro, I. (2007) p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature 446, 444-448 (Pubitemid 46474597)
25. Zhu, H., Tannous, P., Johnstone, J. L., Kong, Y., Shelton, J. M., Richardson, J. A., Le, V., Levine, B., Rothermel, B. A., and Hill, J. A. (2007) Cardiac autophagy is a maladaptive response to hemodynamic stress. J. Clin. Invest. 117, 1782-1793 (Pubitemid 47036312)
26. Takemura, G., Kanamori, H., Goto, K., Maruyama, R., Tsujimoto, A., Fujiwara, H., Seishima, M., and Minatoguchi, S. (2009) Autophagy maintains cardiac function in the starved adult. Autophagy 5, 1034-1036
27. Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X. H., Mizushima, N., Packer, M., Schneider, M. D., and Levine, B. (2005) Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122, 927-939 (Pubitemid 41345209)
28. Hill, J. W., Hu, J. J., and Evans, M. K. (2008) OGG1 is degraded by calpain following oxidative stress and cisplatin exposure. DNA Repair (Amst.) 7, 648-654
29. Mizushima, N., and Klionsky, D. J. (2007) Protein turnover via autophagy: implications for metabolism. Annu. Rev. Nutr. 27, 19-40 (Pubitemid 351373346)
30. Suliman, H. B., Welty-Wolf, K. E., Carraway, M., Tatro, L., and Piantadosi, C. A. (2004) Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis. Cardiovasc. Res. 64, 279-288 (Pubitemid 39361689)
31. Gottlieb, R. A., and Mentzer, R. M. (2010) Autophagy during cardiac stress: joys and frustrations of autophagy. Annu. Rev. Physiol. 72, 45-59
32. Knaapen, M. W., Davies, M. J., De Bie, M., Haven, A. J., Martinet, W., and Kockx, M. M. (2001) Apoptotic versus autophagic cell death in heart failure. Cardiovasc. Res. 51, 304-312 (Pubitemid 32695541)
33. Kubota, C., Torii, S., Hou, N., Saito, N., Yoshimoto, Y., Imai, H., and Takeuchi, T. (2010) Constitutive reactive oxygen species generation from autophagosome/lysosome in neuronal oxidative toxicity. J. Biol. Chem. 285, 667-674
34. Nakai, A., Yamaguchi, O., Takeda, T., Higuchi, Y., Hikoso, S., Taniike, M., Omiya, S., Mizote, I., Matsumura, Y., Asahi, M., Nishida, K., Hori, M., Mizushima, N., and Otsu, K. (2007) The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat. Med. 13, 619-624 (Pubitemid 46828485)
35. Epe, B. (2002) Role of endogenous oxidative DNA damage in carcinogenesis: what can we learn from repair-deficient mice? Biol. Chem. 383, 467-475
36. Saxowsky, T. T., Meadows, K. L., Klungland, A., and Doetsch, P. W. (2008) 8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 105, 18877-18882
37. David, S. S., O'Shea, V. L., and Kundu, S. (2007) Base-excision repair of oxidative DNA damage. Nature 447, 941-950 (Pubitemid 46975761)
38. Oka, S., Ohno, M., Tsuchimoto, D., Sakumi, K., Furuichi, M., and Nakabeppu, Y. (2008) Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs. EMBO J. 27, 421-432 (Pubitemid 351161663)