Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil

Archives of Toxicology

Volumn 89, Issue 10, 2015, Pages 1829-1846

  Dörsam, Bastian ^a   Göder, Anja ^a   Seiwert, Nina ^a   Kaina, Bernd ^a   Fahrer, Jörg ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

5 Fluorouracil; Cell death; Colorectal cancer; Genotoxicity; Lipoic acid; p53

Indexed keywords

CASPASE 3; CASPASE 7; CASPASE 9; DOXORUBICIN; FLUOROURACIL; PROTEIN P53; REACTIVE OXYGEN METABOLITE; THIOCTIC ACID; ANTINEOPLASTIC ANTIMETABOLITE; CASPASE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL VIABILITY; COLORECTAL CANCER; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA FRAGMENTATION; DNA STRAND BREAKAGE; DOSE RESPONSE; DRUG POTENTIATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MITOCHONDRIAL MEMBRANE POTENTIAL; PHOSPHORYLATION; PRIORITY JOURNAL; CACO 2 CELL LINE; CELL SURVIVAL; COLORECTAL NEOPLASMS; DRUG EFFECTS; HCT116 CELL LINE; METABOLISM; PATHOLOGY;

ANTIMETABOLITES, ANTINEOPLASTIC; CACO-2 CELLS; CASPASES; CELL DEATH; CELL SURVIVAL; COLORECTAL NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FLUOROURACIL; HCT116 CELLS; HUMANS; THIOCTIC ACID; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84942200293     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1434-0     Document Type: Article

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