The natural antioxidant alpha-lipoic acid induces p27Kip1-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells

European Journal of Pharmacology

Volumn 641, Issue 1, 2010, Pages 29-34

  Dozio, Elena ^a   Ruscica, Massimiliano ^a   Passafaro, Luca ^a   Dogliotti, Giada ^a   Steffani, Liliana ^a   Pagani, Alessandra ^a   Demartini, Germana ^a   Esposti, Daniele ^a   Fraschini, Franco ^a   Magni, Paolo ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Akt; Alpha lipoic acid; MCF 7 cells; P27Kip1; Reactive oxygen species

Indexed keywords

ANTINEOPLASTIC AGENT; PROTEIN KINASE B; PROTEIN P27; REACTIVE OXYGEN METABOLITE; SCAVENGER; THIOCTIC ACID; ANTIOXIDANT; BIOLOGICAL PRODUCT; CYCLIN DEPENDENT KINASE INHIBITOR 1B; PHOSPHATIDYLINOSITOL 3 KINASE;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL GROWTH; CELL STRAIN MCF 7; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; BREAST TUMOR; CELL CYCLE; CELL PROLIFERATION; DOWN REGULATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIOXIDANTS; APOPTOSIS; BIOLOGICAL PRODUCTS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THIOCTIC ACID; PHOSPHATIDYLINOSITOL 3-KINASES;

EID: 77953812337     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.05.009     Document Type: Article

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