Antagonism of NF-κB-up-regulated micro RNAs (miRNAs) in sporadic Alzheimer's disease (AD)-anti-NF-κB vs. anti-miRNA strategies

Frontiers in Genetics

Volumn 4, Issue MAY, 2013, Pages

  Lukiw, Walter J ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84883540611     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2013.00077     Document Type: Article

References (45)

1. Aggarwal, B. B., and Shishodia, S. (2004). Suppression of the nuclear factor-kB activation pathway by spice-derived phytochemicals. Ann. N.Y. Acad. Sci. 1030, 434-441.
2. Alexandrov, P. N., Pogue, A., Bhattacharjee, S., and Lukiw, W. J. (2011). Retinal amyloid peptides and complement factor H in transgenic models of Alzheimer's disease. Neuroreport 22, 623-627.
3. Ambros, V. (2004). The functions of animal microRNAs. Nature 431, 350-355.
4. Baltimore, D., Boldin, M. P., O'Connell, R. M., Rao, D. S., and Taganov, K. D. (2008). MicroRNAs: new regulators of immune cell development and function. Nat. Immunol. 9, 839-845.
5. Bazzoni, F., Rossato, M., Fabbri, M., Gaudiosi, D., Mirolo, M., Mori, L., et al. (2009). Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals. Proc. Natl. Acad. Sci. U.S.A. 106, 5282-5287.
6. Boldin, M. P., and Baltimore, D. (2012). MicroRNAs, new effectors and regulators of NF-κ B. Immunol. Rev. 246, 205-220.
7. Bredy, T. W., Lin, Q., Wei, W., Baker-Andresen, D., and Mattick, J. S. (2011). MicroRNA regulation of neural plasticity and memory. Neurobiol. Learn Mem. 96, 89-94.
8. Cui, J. G., Li, Y. Y., Zhao, Y., Bhattacharjee, S., and Lukiw, W. J. (2010). Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by miRNA-146a and NF-κB in stressed human astroglial cells and in Alzheimer disease. J. Biol. Chem. 285, 38951-38960.
9. Cremer, T. J., Fatehchand, K., Shah, P., Gillette, D., Patel, H., Marsh, R. L., et al. (2012). miR-155 induction by microbes/microbial ligands requires NF-κ B-dependent de novo protein synthesis. Front. Cell Infect. Microbiol. 2, 73. doi: 10.3389/fcimb.2012.00073
10. Flannery, S., and Bowie, A. G. (2010). The interleukin-1 receptor-associated kinases: critical regulators of innate immune signaling. Biochem. Pharmacol. 80, 1981-1991.
11. Gilmore, T. D., and Garbati, M. R. (2011). Inhibition of NF-κ B signaling as a strategy in disease therapy. Curr. Top. Microbiol. Immunol. 349, 245-263.
12. Gilmore, T. D., and Herscovitch, M. (2006). Inhibitors of NF-κB signaling: 785 and counting. Oncogene 25, 6887-6899.
13. Guo, H., Ingolia, N. T., Weissman, J. S., and Bartel, D. P. (2010). Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466, 835-840.
14. Heneka, M. T., O'Banion, M. K., Terwel, D., and Kummer, M. P. (2010). Neuroinflammatory processes in Alzheimer's disease. J. Neural. Transm. 117, 919-947.
15. Lai, A., Filka, E., McGibbon, B., Nghiemphu, P. L., Graham, C., Yong, W. H., et al. (2008). Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability. Int. J. Radiat. Oncol. Biol. Phys. 71, 1372-1380.
16. Li, J., Wang, K., Chen, X., Meng, H., Song, M., Wang, Y., et al. (2012). Transcriptional activation of microRNA-34a by NF-κB in human esophageal cancer cells. BMC. Mol. Biol. 13, 4. doi: 10.1186/1471-2199-13-4
17. Li, Y. Y., Cui, J. G., Dua, P., Pogue, A. I., Bhattacharjee, S., and Lukiw, W. J. (2011). Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells. Neurosci. Lett. 499, 109-113.
18. Lukiw, W. J. (2007). Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus. Neuroreport 18, 297-300.
19. Lukiw, W. J. (2008). Emerging amyloid beta (Aβ) peptide modulators for the treatment of Alzheimer's disease (AD). Expert Opin. Emerg. Drugs 13, 255-271.
20. Lukiw, W. J. (2012a). NF-κB-regulated micro RNAs (miRNAs) in primary human brain cells. Exp. Neurol. 235, 484-490.
21. Lukiw, W. J. (2012b). NF-κ B-regulated, proinflammatory miRNAs in Alzheimer's disease. Alzheimers Res. Ther. 4, 47-55.
22. Lukiw, W. J. (2012c). Evolution and complexity of micro RNA in the human brain. Front Genet. 3, 166. doi: 10.3389/fgene.2012.00166
23. Lukiw, W. J. (2013). Amyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer's disease (AD). Expert Opin. Emerg. Drugs. doi: 10.1517/14728214.2012.672559. [Epub ahead of print].
24. Lukiw, W. J., and Alexandrov, P. N. (2012). Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimer's disease (AD) brain. Mol. Neurobiol. 46, 11-19.
25. Lukiw, W. J., Alexandrov, P. N., Zhao, Y., Hill, J. M., and Bhattacharjee, S. (2012). Spreading of Alzheimer's disease inflammatory signaling through soluble micro-RNA. Neuroreport 23, 621-626.
26. Lukiw, W. J., and Bazan, N. G. (1998). Strong NF-κB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex. J. Neurosci. Res. 53, 583-592.
27. Lukiw, W. J., and Bazan, N. G. (2010). Inflammatory, apoptotic, and survival gene signaling in Alzheimer's disease. A review on the bioactivity of neuroprotectin D1 and apoptosis. Mol. Neurobiol. 42, 10-16.
28. Lukiw, W. J., Zhao, Y., and Cui, J. G. (2008). An NF-κB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human neural cells. J. Biol. Chem. 283, 31315-31322.
29. Ma, X., Becker Buscaglia, L. E., Barker, J. R., and Li, Y. (2011). MicroRNAs in NF-κB signaling. J. Mol. Cell Biol. 3, 159-166.
30. Mattson, M. P., and Camandola, S. (2001). NF-κB in neuronal plasticity and neurodegenerative disorders. J. Clin. Invest. 107, 247-254.
31. Meffert, M. K., and Baltimore, D. (2005). Physiological functions for brain NF-κB. Trends Neurosci. 28, 37-43.
32. Magasawa, D. T., Chow, F., Yew, A., Kim, W., Cremer, N., and Yang, I. (2012). Temozolomide and other potential agents for the treatment of glioblastoma multiforme. Neurosurg. Clin. N. Am. 23, 307-322.
33. Nam, N. H. (2006). Naturally occurring NF-kappaB inhibitors. Mini Rev. Med. Chem. 6, 945-951.
34. Niemitz, E. (2012). TREM2 and Alzheimer's disease. Nat. Genet. 45, 11-12.
35. Pogue, A. I., Li, Y. Y., Cui, J. G., Zhao, Y., Kruck, T. P., Percy, M. E., et al. (2009). Characterization of an NF-κB-regulated, miRNA-146a-mediated down-regulation of complement factor H (CFH) in metal-sulfate-stressed human brain cells. J. Inorg. Biochem. 103, 1591-1595.
36. Pogue, A. I., Percy, M. E., Cui, J. G., Li, Y. Y., Bhattacharjee, S., Hill, J. M., et al. (2011). Up-regulation of NF-κB-sensitive miRNA-125b and miRNA-146a in metal sulfate-stressed human astroglial (HAG) primary cell cultures. J. Inorg. Biochem. 105, 1434-1437.
37. Shifera, A. S. (2010). Protein-protein interactions involving NEMO that promote the activation of NF-κB. J. Cell Physiol. 223, 558-561.
38. Sen, R., and Baltimore, D. (1986). Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell 47, 921-928.
39. Taganov, K. D., Boldin, M. P., Chang, K. J., and Baltimore, D. (2006). NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl. Acad. Sci. U.S.A. 103, 12481-12486.
40. Thomas, R. P., Recht, L., and Nagpal, S. (2013). Advances in the management of glioblastoma: the role of temozolomide and MGMT testing. Clin. Pharmacol. 5, 1-9.
41. Wong, D., Teixeira, A., Oikonomopoulos, S., Humburg, P., Lone, I. N., Saliba, D., et al. (2011). Extensive characterization of NF-κ B binding uncovers non-canonical motifs and advances the interpretation of genetic functional traits. Genome Biol. 12, R70.
42. Xu, D., Sharma, C., and Hemler, M. E. (2009). Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein. FASEB J. 23, 3674-3681.
43. Yamamoto, Y., and Gaynor, R. B. (2001). Role of the NF-kappaB pathway in the pathogenesis of human disease states. Curr. Mol. Med. 1, 287-296.
44. Yang, L., Tao, L. Y., and Chen, X. P. (2007). Roles of NF-κB in CNS damage and repair. Neurosci. Bull. 23, 307-313.
45. Zhao, Y., Bhattacharjee, S., Jones, B. M., Dua, P., Alexandrov, P. N., Hill, J. M., et al. (2013). Regulation of TREM2 expression by an NF-κB-sensitive miRNA-34a. Neuroreport 24, 318-323.