NF-k{cyrillic}B-regulated micro RNAs (miRNAs) in primary human brain cells

Experimental Neurology

Volumn 235, Issue 2, 2012, Pages 484-490

  Lukiw, Walter J ^a  

^a LSU Neuroscience Center   (United States)

Author keywords

15 lipoxygenase (15 LOX); Alzheimer's disease (AD); Amyloidogenesis; Complement factor H (CFH); Evolution; Micro RNA 125b (miRNA 125b); MiRNA 146a; Synapsin 2 (SYN 2); Tetraspanin 12 (TSPAN12)

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; ARACHIDONATE 15 LIPOXYGENASE; COMPLEMENT FACTOR H; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MICRORNA 125B; MICRORNA 146A; MICRORNA 9; PYRROLIDINE DITHIOCARBAMATE; RESVERATROL; SYNAPSIN II; TETRASPANIN; TETRASPANIN 12; TRANS 3,5,4' TRIHYDROXSTILBENE; UNCLASSIFIED DRUG; AMYLOID; MICRORNA; NERVE GROWTH FACTOR;

ARTICLE; ASTROCYTE; BRAIN CELL; CELLULAR DISTRIBUTION; COCULTURE; COMPLEX FORMATION; CONTROLLED STUDY; DNA BINDING; DOT HYBRIDIZATION; HUMAN; HUMAN CELL; INNATE IMMUNITY; NEUROTROPISM; NORTHERN BLOTTING; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN RNA BINDING; PROTEIN SYNTHESIS; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION; BRAIN; COMPARATIVE STUDY; CYTOLOGY; GENETICS; GLIA; IMMUNOLOGY; INFLAMMATION; NERVE CELL; PATHOLOGY; PHYSIOLOGY; SYNAPSE;

AMYLOID; BRAIN; COCULTURE TECHNIQUES; HUMANS; IMMUNITY, INNATE; INFLAMMATION; MICRORNAS; NERVE GROWTH FACTORS; NEUROGLIA; NEURONS; NF-KAPPA B; SIGNAL TRANSDUCTION; SYNAPSES;

EID: 84860364449     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.11.022     Document Type: Article

References (71)

1. Alexandrov P.N., Zhao Y., Pogue A.I., Tarr M.A., Kruck T.P., Percy M.E., Cui J.G., Lukiw W.J. Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells. J. Alzheimers Dis. 2005, 8(2):117-127.
2. Ambros V. The functions of animal microRNAs. Nature 2004, 431(7006):350-355.
3. Aronica E., Fluiter K., Iyer A., Zurolo E., Vreijling J., van Vliet E.A., Baayen J.C., Gorter J.A. Expression pattern of miRNA-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy. Eur. J. Neurosci. 2010, 31(16):1100-1107.
4. Arroyo J.D., Chevillet J.R., Kroh E.M., Ruf I.K., Pritchard C.C., Gibson D.F., Mitchell P.S., Bennett C.F., Pogosova-Agadjanyan E.L., Stirewalt D.L., Tait J.F., Tewari M. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc. Natl. Acad. Sci. U. S. A. 2011, 108(12):5003-5008.
5. Baltimore D. NF-κB is 25. Nat. Immunol. 2011, 12(8):683-685.
6. Bazzoni F., Rossato M., Fabbri M., Gaudiosi D., Mirolo M., Mori L., Tamassia N., Mantovani A., Cassatella M.A., Locati M. Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals. Proc. Natl. Acad. Sci. U. S. A. 2009, 106(13):5282-5287.
7. Bonev B., Pisco A., Papalopulu N. MicroRNA-9 reveals regional diversity of neural progenitors along the anterior-posterior axis. Dev. Cell 2011, 20(1):19-32.
8. Burmistrova O.A., Goltsov A.Y., Abramova L.I., Kaleda V.G., Orlova V.A., Rogaev E.I. MicroRNA in schizophrenia: genetic and expression analysis of miR-130b (22q11). Biochemistry (Mosc) 2007, 72(5):578-582.
9. Chao T.F., Zhang Y., Yan X.Q., Yin B., Gong Y.H., Yuan J.G., Qiang B.Q., Peng X.Z. MiR-9 regulates the expression of CBX7 in human glioma. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2008, 30(3):268-274.
10. Colangelo V., Schurr J., Ball M.J., Pelaez R.P., Bazan N.G., Lukiw W.J. Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling. J. Neurosci. Res. 2002, 70(3):462-473.
11. Coolen M., Bally-Cuif L. MicroRNAs in brain development and physiology. Curr. Opin. Neurobiol. 2009, 19(5):461-470.
12. Cui J.G., Kuroda H., Chandrasekharan N.V., Pelaez R.P., Simmons D.L., Bazan N.G., Lukiw W.J. Cyclooxygenase-3 gene expression in Alzheimer hippocampus and in stressed human neural cells. Neurochem. Res. 2004, 29(9):1731-1737.
13. Cui J.G., Zhao Y., Lukiw W.J. Isolation of high spectral quality RNA using run-on gene transcription; application to gene expression profiling of human brain. Cell. Mol. Neurobiol. 2005, 25(3-4):789-794.
14. Cui J.G., Li Y.Y., Zhao Y., Bhattacharjee S., Lukiw W.J. Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease. J. Biol. Chem. 2010, 285(50):38951-38960.
15. Eikelenboom P., Veerhuis R., van Exel E., Hoozemans J.J., Rozemuller A.J., van Gool W.A. The early involvement of the innate immunity in the pathogenesis of late-onset Alzheimer's disease: neuropathological, epidemiological and genetic evidence. Curr. Alzheimer Res. 2011, 8(2):142-150.
16. Ershov A.V., Lukiw W.J., Bazan N.G. Selective transcription factor induction in retinal pigment epithelial cells during photoreceptor phagocytosis. J. Biol. Chem. 1996, 271(45):28458-28462.
17. Fabian M.R., Sonenberg N., Filipowicz W. Regulation of mRNA translation and stability by microRNAs. Annu. Rev. Biochem. 2010, 79(1):351-379.
18. Feng J., Kim S.T., Liu W., Kim J.W., Zhang Z., Zhu Y., Berens M., Sun J., Xu J. An integrated analysis of germline and somatic, genetic and epigenetic alterations at 9p21.3 in glioblastoma. Cancer 2011, 10.1002/cncr.26250.
19. Guo H., Ingolia N.T., Weissman J.S., Bartel D.P. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 2010, 466(7308):835-840.
20. Hébert S.S., De Strooper B. Alterations of the microRNA network cause neurodegenerative disease. Trends Neurosci. 2009, 32(4):199-206.
21. Hennig R., Kehl T., Noor S., Ding X.Z., Rao S.M., Bergmann F., Fürstenberger G., Büchler M.W., Friess H., Krieg P., Adrian T.E. 15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth. Neoplasia 2007, 9(11):917-926.
22. Higaki S., Gebhardt B.M., Lukiw W.J., Thompson H.W., Hill J.M. Effect of immunosuppression on gene expression in the HSV-1 latently infected mouse trigeminal ganglion. Investig. Ophthalmol. Vis. Sci. 2002, 43(6):1862-1869.
23. Hill J.M., Lukiw W.J., Gebhardt B.M., Higaki S., Loutsch J.M., Myles M.E., Thompson H.W., Kwon B.S., Bazan N.G., Kaufman H.E. Gene expression analyzed by microarrays in HSV-1 latent mouse trigeminal ganglion following heat stress. Virus Genes 2001, 23(3):273-280.
24. Hill J.M., Zhao Y., Clement C., Neumann D.M., Lukiw W.J. HSV-1 infection of human brain cells induces miRNA-146a and Alzheimer-type inflammatory signaling. Neuroreport 2009, 20(16):1500-1505.
25. Junge H.J., Yang S., Burton J.B., Paes K., Shu X., French D.M., Costa M., Rice D.S., Ye W. TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling. Cell 2009, 139(2):299-311.
26. Kinders R., Jones T., Root R., Bruce C., Murchison H., Corey M., Williams L., Enfield D., Hass G.M. Complement factor H or a related protein is a marker for transitional cell cancer of the bladder. Clin. Cancer Res. 1998, 4(10):2511-2520.
27. Lee Y.J., Han S.B., Nam S.Y., Oh K.W., Hong J.T. Inflammation and Alzheimer's disease. Arch. Pharm. Res. 2010, 33(10):1539-1556.
28. Li Y.Y., Cui J.G., Dua P., Pogue A.I., Bhattacharjee S., Lukiw W.J. Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells. Neurosci. Lett. 2011, 499(2):109-113.
29. Li Y.Y., Cui J.G., Hill J.M., Bhattacharjee S., Zhao Y., Lukiw W.J. Increased expression of miRNA-146a in Alzheimer's disease transgenic models. Neurosci. Lett. 2011, 487(1):94-98.
30. Loring J.F., Wen X., Lee J.M., Seilhamer J., Somogyi R. A gene expression profile of Alzheimer's disease. DNA Cell Biol. 2001, 20(11):683-695.
31. Lukiw W.J. Gene expression profiling in fetal, aged, and Alzheimer hippocampus: a continuum of stress-related signaling. Neurochem. Res. 2004, 29(6):1287-1297.
32. Lukiw W.J. Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus. Neuroreport 2007, 18(3):297-300.
33. Lukiw W.J., Bazan N.G. Strong nuclear factor-kappaB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex. J. Neurosci. Res. 1998, 53(5):583-592.
34. Lukiw W.J., Bazan N.G. Survival signaling in Alzheimer's disease. Biochem. Soc. Trans. 2006, 34(6):1277-1282.
35. Lukiw W.J., Bazan N.G. Docosahexaenoic acid and the aging brain. J. Nutr. 2008, 138(12):2510-2514.
36. Lukiw W.J., Pogue A.I. Induction of specific micro RNA (miRNA) species by ROS-generating metal sulfates in primary human brain cells. J. Inorg. Biochem. 2007, 101(9):1265-1269.
37. Lukiw W.J., Handley P., Wong L., McLachlan D.R.C. BC200 and other small RNAs RNA in normal human neocortex, non-Alzheimer dementia (NAD), and senile dementia of the Alzheimer type (AD). Neurochem. Res. 1992, 17(6):591-597.
38. Lukiw W.J., LeBlanc H.J., Carver L., McLachlan D.R.C., Bazan N.G. Run-on gene transcription in human neocortical nuclei. Inhibition by nanomolar aluminum and implications for neurodegenerative disease. J. Mol. Neurosci. 1998, 11(1):67-78.
39. Lukiw W.J., Percy M.E., Kruck T.P.a. Nanomolar aluminum induces pro-inflammatory and pro-apoptotic gene expression in human brain cells in primary culture. J. Inorg. Biochem. 2005, 99(9):1895-1898.
40. Lukiw W.J., Cui J.G., Marcheselli V.L., Bodker M., Botkjaer A., Gotlinger K., Serhan C.N., Bazan N.G. A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J. Clin. Invest. 2005, 115(10):2774-2783.
41. Lukiw W.J., Zhao Y., Cui J.G. An NF-k{cyrillic}B-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J. Biol. Chem. 2008, 283(46):31315-31322.
42. Lukiw W.J., Cui J.G., Lukiw W.J., Cui J.G., Li Y.Y., Culicchia F. Up-regulation of miRNA-221 (chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM). J. Neurooncol. 2009, 91(1):27-32.
43. Lukiw W.J., Cui J.G., Yuan Y.Y., Bhattacharjee P.S., Corkern M., Clement C., Hill J.M. Acyclovir or Aβ42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells. Neuroreport 2010, 21(14):922-927.
44. Lukiw W.J., Dua P., Pogue A.I., Eicken C., Hill J.M. Upregulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob Disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) syndrome. J. Toxicol. Environ. Health A 2011, 74(22-24):1460-1468.
45. Ma X., Becker Buscaglia L.E., Barker J.R., Li Y.Y. MicroRNAs in NF-kB signaling. J. Mol. Cell Biol. 2011, 3(3):159-166.
46. Madathil S.K., Nelson P.T., Saatman K.E., Wilfred B.R. MicroRNAs in CNS injury: potential roles and therapeutic implications. Bioessays 2011, 33(1):21-26.
47. Perron M.P., Provost P. Protein components of the microRNA pathway and human diseases. Methods Mol. Biol. 2009, 487(1):369-385.
48. Pogue A.I., Lukiw W.J. Angiogenic signaling in Alzheimer's disease. Neuroreport 2004, 15(9):1507-1510.
49. Pogue A.I., Li Y.Y., Cui J.G., Zhao Y., Kruck T.P., Percy M.E., Tarr M.A., Lukiw W.J. Characterization of an NF-k{cyrillic}B-regulated, miRNA-146a-mediated down-regulation of complement factor H (CFH) in metal-sulfate-stressed human brain cells. J. Inorg. Biochem. 2009, 103(11):1591-1595.
50. Pogue A.I., Cui J.G., Li Y.Y., Zhao Y., Culicchia F., Lukiw W.J. miRNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation. Neurosci. Lett. 2010, 476(1):18-22.
51. Riazanskaia N., Lukiw W.J., Grigorenko A., Korovaitseva G., Dvoryanchikov G., Moliaka Y., Nicolaou M., Farrer L., Bazan N.G., Rogaev E. Regulatory region variability in the human presenilin-2 (PSEN2) gene: potential contribution to the gene activity and risk for AD. Mol. Psychiatry 2002, 7(8):891-898.
52. Saba R., Goodman C.D., Huzarewich R.L., Robertson C., Booth S.A. A miRNA signature of prion induced neurodegeneration. PLoS One 2008, 3:e3652.
53. Sana J., Hajduch M., Michalek J., Vyzula R., Slaby O. MicroRNAs and glioblastoma: roles in core signaling pathways and potential clinical implications. J. Cell. Mol. Med. 2011, 15(8):1636-1644.
54. Sempere L.F., Freemantle S., Pitha-Rowe I., Moss E., Dmitrovsky E., Ambros V. Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol. 2004, 5(3):R13.
55. Sen R. The origins of NF-κB. Nat. Immunol. 2011, 12(8):686-688.
56. Sethi P., Lukiw W.J. Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex. Neurosci. Lett. 2009, 459(2):100-104.
57. Shibata M., Nakao H., Kiyonari H., Abe T., Aizawa S. MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors. J. Neurosci. 2011, 31(9):3407-3422.
58. Shukitt-Hale B., Lau F.C., Carey A.N., Galli R.L., Spangler E.L., Ingram D.K., Joseph J.A. Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus. Nutr. Neurosci. 2008, 11(4):172-182.
59. Smale S.T. Hierarchies of NF-κB target-gene regulation. Nat. Immunol. 2011, 12(8):689-694.
60. Taft R.J., Pang K.C., Mercer T.R., Dinger M., Mattick J.S. Non-coding RNAs: regulators of disease. J. Pathol. 2010, 220(2):126-139.
61. Taganov K.D., Boldin M.P., Chang K.J., Baltimore D. NF-k{cyrillic}B-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl. Acad. Sci. U. S. A. 2006, 103(33):12481-12486.
62. Tsitsiou E., Lindsay M.A. microRNAs and the immune response. Curr. Opin. Pharmacol. 2009, 9(4):514-520.
63. Wang K., Zhang S., Weber J., Baxter D., Galas D.J. Export of microRNAs and microRNA-protective protein by mammalian cells. Nucleic Acids Res. 2010, 38(20):7248-7259.
64. Witkos T.M., Koscianska E., Krzyzosiak W.J. Practical Aspects of microRNA target prediction. Curr. Mol. Med. 2011, 11(2):93-109.
65. Xu D., Sharma C., Hemler M.E. Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein. FASEB J. 2009, 23(11):3674-3681.
66. Yao P.J., Zhu M., Pyun E.I., Brooks A.I., Therianos S., Meyers V.E., Coleman P.D. Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease. Neurobiol. Dis. 2003, 12(2):97-109.
67. Yuva-Aydemir Y., Simkin A., Gascon E., Gao F.B. MicroRNA-9: functional evolution of a conserved small regulatory RNA. RNA Biol. 2011, 8(4). [Epub ahead of print].
68. Zhang Z., Chang H., Li Y., Zhang T., Zou J., Zheng X., Wu J. MicroRNAs: potential regulators involved in human anencephaly. Int. J. Biochem. Cell Biol. 2010, 42(2):367-374.
69. Zhao Y., Calon F., Julien C., Winkler J.W., Petasis N.A., Lukiw W.J., Bazan N.G. Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models. PLoS One 2011, 6(1):e15816.
70. Zhou R., Hu G., Liu J., Gong A.Y., Drescher K.M., Chen X.M. NF-kB p65-dependent transactivation of miRNA genes following cryptosporidium parvum infection stimulates epithelial cell immune responses. PLoS Pathog. 2009, 5(12):e1000681.
71. Zhou R., Hu G., Gong A.Y., Chen X.M. Binding of NF-kB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes. Nucleic Acids Res. 2010, 38(10):3222-3232.