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Volumn 479-480, Issue , 2015, Pages 146-152

Innate immune recognition of DNA: A recent history

Author keywords

DNA sensing; Gene induction; Herpes viruses; Innate immunity; Pattern recognition receptors

Indexed keywords

DNA; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN;

EID: 84937763934     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2015.03.013     Document Type: Review
Times cited : (192)

References (79)
  • 1
    • 84899077215 scopus 로고    scopus 로고
    • Cytosolic DNA-mediated, STING-dependent pro-inflammatory gene induction necessitates canonical NF-kappaB activation through TBK1
    • Abe T., Barber G.N. Cytosolic DNA-mediated, STING-dependent pro-inflammatory gene induction necessitates canonical NF-kappaB activation through TBK1. J. Virol. 2014, 88(10):5328-5341.
    • (2014) J. Virol. , vol.88 , Issue.10 , pp. 5328-5341
    • Abe, T.1    Barber, G.N.2
  • 2
    • 84876085954 scopus 로고    scopus 로고
    • STING recognition of cytoplasmic DNA instigates cellular defense
    • Abe T., et al. STING recognition of cytoplasmic DNA instigates cellular defense. Mol. Cell 2013, 50(1):5-15.
    • (2013) Mol. Cell , vol.50 , Issue.1 , pp. 5-15
    • Abe, T.1
  • 3
    • 70349459734 scopus 로고    scopus 로고
    • RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
    • Ablasser A., et al. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat. Immunol. 2009, 10(10):1065-1072.
    • (2009) Nat. Immunol. , vol.10 , Issue.10 , pp. 1065-1072
    • Ablasser, A.1
  • 4
    • 84888637695 scopus 로고    scopus 로고
    • Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
    • Ablasser A., et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature 2013, 503(7477):530-534.
    • (2013) Nature , vol.503 , Issue.7477 , pp. 530-534
    • Ablasser, A.1
  • 5
    • 84908120748 scopus 로고    scopus 로고
    • Intrinsic self-DNA triggers inflammatory disease dependent on STING
    • Ahn J., Ruiz P., Barber G.N. Intrinsic self-DNA triggers inflammatory disease dependent on STING. J. Immunol. 2014, 193(9):4634-4642.
    • (2014) J. Immunol. , vol.193 , Issue.9 , pp. 4634-4642
    • Ahn, J.1    Ruiz, P.2    Barber, G.N.3
  • 6
    • 10344259136 scopus 로고    scopus 로고
    • The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-{beta} promoter
    • Andrejeva J., et al. The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-{beta} promoter. PNAS 2004, 101(49):17264-17269.
    • (2004) PNAS , vol.101 , Issue.49 , pp. 17264-17269
    • Andrejeva, J.1
  • 7
    • 84880617721 scopus 로고    scopus 로고
    • Constitutive interferon-inducible protein 16-inflammasome activation during Epstein-Barr virus latency I, II, and III in B and epithelial cells
    • Ansari M.A., et al. Constitutive interferon-inducible protein 16-inflammasome activation during Epstein-Barr virus latency I, II, and III in B and epithelial cells. J. Virol. 2013, 87(15):8606-8623.
    • (2013) J. Virol. , vol.87 , Issue.15 , pp. 8606-8623
    • Ansari, M.A.1
  • 8
    • 60749136484 scopus 로고    scopus 로고
    • An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
    • Burckstummer T., et al. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 2009, 10(3):266-272.
    • (2009) Nat. Immunol. , vol.10 , Issue.3 , pp. 266-272
    • Burckstummer, T.1
  • 9
    • 84871218439 scopus 로고    scopus 로고
    • STING and the innate immune response to nucleic acids in the cytosol
    • Burdette D.L., Vance R.E. STING and the innate immune response to nucleic acids in the cytosol. Nat. Immunol. 2013, 14(1):19-26.
    • (2013) Nat. Immunol. , vol.14 , Issue.1 , pp. 19-26
    • Burdette, D.L.1    Vance, R.E.2
  • 10
    • 80054966913 scopus 로고    scopus 로고
    • STING is a direct innate immune sensor of cyclic di-GMP
    • Burdette D.L., et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature 2011, 478(7370):515-518.
    • (2011) Nature , vol.478 , Issue.7370 , pp. 515-518
    • Burdette, D.L.1
  • 11
    • 84899131835 scopus 로고    scopus 로고
    • The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling
    • Cai X., Chiu Y.H., Chen Z.J. The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. Mol. Cell 2014, 54(2):289-296.
    • (2014) Mol. Cell , vol.54 , Issue.2 , pp. 289-296
    • Cai, X.1    Chiu, Y.H.2    Chen, Z.J.3
  • 12
    • 84896381627 scopus 로고    scopus 로고
    • Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation
    • Cai X., et al. Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation. Cell 2014, 156(6):1207-1222.
    • (2014) Cell , vol.156 , Issue.6 , pp. 1207-1222
    • Cai, X.1
  • 13
    • 68049092912 scopus 로고    scopus 로고
    • RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway
    • Chiu Y.H., Macmillan J.B., Chen Z.J. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 2009, 138(3):576-591.
    • (2009) Cell , vol.138 , Issue.3 , pp. 576-591
    • Chiu, Y.H.1    Macmillan, J.B.2    Chen, Z.J.3
  • 14
    • 84879408976 scopus 로고    scopus 로고
    • Structural mechanism of cytosolic DNA sensing by cGAS
    • Civril F., et al. Structural mechanism of cytosolic DNA sensing by cGAS. Nature 2013, 498(7454):332-337.
    • (2013) Nature , vol.498 , Issue.7454 , pp. 332-337
    • Civril, F.1
  • 15
    • 72849146138 scopus 로고    scopus 로고
    • Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1
    • DeFilippis V.R., et al. Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1. J. Virol. 2010, 84(1):585-598.
    • (2010) J. Virol. , vol.84 , Issue.1 , pp. 585-598
    • DeFilippis, V.R.1
  • 16
    • 84912128872 scopus 로고    scopus 로고
    • STING-Dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors
    • Deng L., et al. STING-Dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity 2014, 41(5):843-852.
    • (2014) Immunity , vol.41 , Issue.5 , pp. 843-852
    • Deng, L.1
  • 17
    • 84875224757 scopus 로고    scopus 로고
    • DNA-PK is a DNA sensor for IRF-3-dependent innate immunity
    • Ferguson B.J., et al. DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. eLife 2012, 1:e00047.
    • (2012) eLife , vol.1 , pp. e00047
    • Ferguson, B.J.1
  • 18
    • 63649145255 scopus 로고    scopus 로고
    • AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    • Fernandes-Alnemri T., et al. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 2009, 458(7237):509-513.
    • (2009) Nature , vol.458 , Issue.7237 , pp. 509-513
    • Fernandes-Alnemri, T.1
  • 19
    • 77951263260 scopus 로고    scopus 로고
    • The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
    • Fernandes-Alnemri T., et al. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat. Immunol. 2010, 11(5):385-393.
    • (2010) Nat. Immunol. , vol.11 , Issue.5 , pp. 385-393
    • Fernandes-Alnemri, T.1
  • 20
    • 84882896267 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses
    • Gao D., et al. Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science 2013, 341(6148):903-906.
    • (2013) Science , vol.341 , Issue.6148 , pp. 903-906
    • Gao, D.1
  • 21
    • 84878309796 scopus 로고    scopus 로고
    • Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase
    • Gao P., et al. Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 2013, 153(5):1094-1107.
    • (2013) Cell , vol.153 , Issue.5 , pp. 1094-1107
    • Gao, P.1
  • 22
    • 84908192059 scopus 로고    scopus 로고
    • Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates
    • Goubau D., et al. Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates. Nature 2014, 514(7522):372-375.
    • (2014) Nature , vol.514 , Issue.7522 , pp. 372-375
    • Goubau, D.1
  • 23
    • 84881027832 scopus 로고    scopus 로고
    • Innate immune detection of microbial nucleic acids
    • Gurtler C., Bowie A.G. Innate immune detection of microbial nucleic acids. Trends Microbiol. 2013, 21(8):413-420.
    • (2013) Trends Microbiol. , vol.21 , Issue.8 , pp. 413-420
    • Gurtler, C.1    Bowie, A.G.2
  • 24
    • 0034619794 scopus 로고    scopus 로고
    • A toll-like receptor recognizes bacterial DNA
    • Hemmi H., et al. A toll-like receptor recognizes bacterial DNA. Nature 2000, 408(6813):740-745.
    • (2000) Nature , vol.408 , Issue.6813 , pp. 740-745
    • Hemmi, H.1
  • 25
    • 84874246480 scopus 로고    scopus 로고
    • Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors
    • Horan K.A., et al. Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors. J. Immunol. 2013, 190(5):2311-2319.
    • (2013) J. Immunol. , vol.190 , Issue.5 , pp. 2311-2319
    • Horan, K.A.1
  • 26
    • 63649133278 scopus 로고    scopus 로고
    • AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
    • Hornung V., et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009, 458(7237):514-518.
    • (2009) Nature , vol.458 , Issue.7237 , pp. 514-518
    • Hornung, V.1
  • 27
    • 0343185886 scopus 로고
    • Foreign nucleic acids as the stimulus to make interferon
    • Isaacs A., Cox R.A., Rotem Z. Foreign nucleic acids as the stimulus to make interferon. Lancet 1963, 2(7299):113-116.
    • (1963) Lancet , vol.2 , Issue.7299 , pp. 113-116
    • Isaacs, A.1    Cox, R.A.2    Rotem, Z.3
  • 28
    • 29244471275 scopus 로고    scopus 로고
    • A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    • Ishii K.J., et al. A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat. Immunol. 2006, 7(1):40-48.
    • (2006) Nat. Immunol. , vol.7 , Issue.1 , pp. 40-48
    • Ishii, K.J.1
  • 29
    • 38949093002 scopus 로고    scopus 로고
    • TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
    • Ishii K.J., et al. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 2008, 451(7179):725-729.
    • (2008) Nature , vol.451 , Issue.7179 , pp. 725-729
    • Ishii, K.J.1
  • 30
    • 53349178089 scopus 로고    scopus 로고
    • STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
    • Ishikawa H., Barber G.N. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 2008, 455(7213):674-678.
    • (2008) Nature , vol.455 , Issue.7213 , pp. 674-678
    • Ishikawa, H.1    Barber, G.N.2
  • 31
    • 70349943834 scopus 로고    scopus 로고
    • STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
    • Ishikawa H., Ma Z., Barber G.N. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 2009, 461(7265):788-792.
    • (2009) Nature , vol.461 , Issue.7265 , pp. 788-792
    • Ishikawa, H.1    Ma, Z.2    Barber, G.N.3
  • 32
    • 84888002403 scopus 로고    scopus 로고
    • IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
    • Jakobsen M.R., et al. IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. Proc. Natl. Acad. Sci. USA 2013, 110(48):E4571-E4580.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , Issue.48 , pp. E4571-E4580
    • Jakobsen, M.R.1
  • 33
    • 0024955886 scopus 로고
    • Approaching the asymptote? Evolution and revolution in immunology
    • Janeway C.A. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 1989, 54(Pt 1):1-13.
    • (1989) Cold Spring Harb. Symp. Quant. Biol. , vol.54 , pp. 1-13
    • Janeway, C.A.1
  • 34
    • 49449115516 scopus 로고    scopus 로고
    • MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals
    • Jin L., et al. MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Mol. Cell. Biol. 2008, 28(16):5014-5026.
    • (2008) Mol. Cell. Biol. , vol.28 , Issue.16 , pp. 5014-5026
    • Jin, L.1
  • 35
    • 84859986329 scopus 로고    scopus 로고
    • Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor
    • Jin T., et al. Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity 2012, 36(4):561-571.
    • (2012) Immunity , vol.36 , Issue.4 , pp. 561-571
    • Jin, T.1
  • 36
    • 84876334378 scopus 로고    scopus 로고
    • Herpes simplex virus 1 infection induces activation and subsequent inhibition of the IFI16 and NLRP3 inflammasomes
    • Johnson K.E., Chikoti L., Chandran B. Herpes simplex virus 1 infection induces activation and subsequent inhibition of the IFI16 and NLRP3 inflammasomes. J. Virol. 2013, 87(9):5005-5018.
    • (2013) J. Virol. , vol.87 , Issue.9 , pp. 5005-5018
    • Johnson, K.E.1    Chikoti, L.2    Chandran, B.3
  • 37
    • 81355146737 scopus 로고    scopus 로고
    • Cytosolic DNA sensors regulating type I interferon induction
    • Keating S.E., Baran M., Bowie A.G. Cytosolic DNA sensors regulating type I interferon induction. Trends Immunol. 2011, 32(12):574-581.
    • (2011) Trends Immunol. , vol.32 , Issue.12 , pp. 574-581
    • Keating, S.E.1    Baran, M.2    Bowie, A.G.3
  • 38
    • 79956061094 scopus 로고    scopus 로고
    • IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi sarcoma-associated herpesvirus infection
    • Kerur N., et al. IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi sarcoma-associated herpesvirus infection. Cell Host Microbe 2011, 9(5):363-375.
    • (2011) Cell Host Microbe , vol.9 , Issue.5 , pp. 363-375
    • Kerur, N.1
  • 39
    • 77957009390 scopus 로고    scopus 로고
    • Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
    • Kim T., et al. Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc. Natl. Acad. Sci. USA 2010, 107(34):15181-15186.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , Issue.34 , pp. 15181-15186
    • Kim, T.1
  • 40
    • 84916894965 scopus 로고    scopus 로고
    • STING-mediated DNA sensing promotes antitumor and autoimmune responses to dying cells
    • Klarquist J., et al. STING-mediated DNA sensing promotes antitumor and autoimmune responses to dying cells. J. Immunol. 2014, 193(12):6124-6134.
    • (2014) J. Immunol. , vol.193 , Issue.12 , pp. 6124-6134
    • Klarquist, J.1
  • 41
    • 84874278336 scopus 로고    scopus 로고
    • DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking
    • Kondo T., et al. DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking. Proc. Natl. Acad. Sci. USA 2013, 110(8):2969-2974.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , Issue.8 , pp. 2969-2974
    • Kondo, T.1
  • 42
    • 84878592773 scopus 로고    scopus 로고
    • Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity
    • Kranzusch P.J., et al. Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. Cell Rep. 2013, 3(5):1362-1368.
    • (2013) Cell Rep. , vol.3 , Issue.5 , pp. 1362-1368
    • Kranzusch, P.J.1
  • 43
    • 84862976171 scopus 로고    scopus 로고
    • Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16
    • Li T., et al. Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16. Proc. Natl. Acad. Sci. USA 2012, 109(26):10558-10563.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , Issue.26 , pp. 10558-10563
    • Li, T.1
  • 44
    • 84887929864 scopus 로고    scopus 로고
    • Human cytomegalovirus tegument protein pUL83 Inhibits IFI16-mediated DNA Sensing for immune evasion
    • Li T., Chen J., Cristea I.M. Human cytomegalovirus tegument protein pUL83 Inhibits IFI16-mediated DNA Sensing for immune evasion. Cell Host Microbe 2013, 14(5):591-599.
    • (2013) Cell Host Microbe , vol.14 , Issue.5 , pp. 591-599
    • Li, T.1    Chen, J.2    Cristea, I.M.3
  • 45
    • 84884675857 scopus 로고    scopus 로고
    • Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects
    • Li X.D., et al. Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science 2013, 341(6152):1390-1394.
    • (2013) Science , vol.341 , Issue.6152 , pp. 1390-1394
    • Li, X.D.1
  • 46
    • 84905825645 scopus 로고    scopus 로고
    • Activated STING in a vascular and pulmonary syndrome
    • Liu Y., et al. Activated STING in a vascular and pulmonary syndrome. N. Engl. J. Med. 2014, 371(6):507-518.
    • (2014) N. Engl. J. Med. , vol.371 , Issue.6 , pp. 507-518
    • Liu, Y.1
  • 47
    • 84896332642 scopus 로고    scopus 로고
    • Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes
    • Lu A., et al. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell 2014, 156(6):1193-1206.
    • (2014) Cell , vol.156 , Issue.6 , pp. 1193-1206
    • Lu, A.1
  • 48
    • 84892946076 scopus 로고    scopus 로고
    • IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV
    • Monroe K.M., et al. IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science 2014, 343(6169):428-432.
    • (2014) Science , vol.343 , Issue.6169 , pp. 428-432
    • Monroe, K.M.1
  • 49
    • 84891933102 scopus 로고    scopus 로고
    • Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy
    • Morrone S.R., et al. Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy. Proc. Natl. Acad. Sci. USA 2014, 111(1):E62-E71.
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , Issue.1 , pp. E62-E71
    • Morrone, S.R.1
  • 50
    • 84907515304 scopus 로고    scopus 로고
    • Cellular sensing of viral DNA and viral evasion mechanisms
    • Orzalli M.H., Knipe D.M. Cellular sensing of viral DNA and viral evasion mechanisms. Annu. Rev. Microbiol. 2014, 68:477-492.
    • (2014) Annu. Rev. Microbiol. , vol.68 , pp. 477-492
    • Orzalli, M.H.1    Knipe, D.M.2
  • 51
    • 84868095535 scopus 로고    scopus 로고
    • Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein
    • Orzalli M.H., DeLuca N.A., Knipe D.M. Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein. Proc. Natl. Acad. Sci. USA 2012, 109(44):E3008-E3017.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , Issue.44 , pp. E3008-E3017
    • Orzalli, M.H.1    DeLuca, N.A.2    Knipe, D.M.3
  • 52
    • 84878232476 scopus 로고    scopus 로고
    • The history of toll-like receptors - redefining innate immunity
    • O'Neill L.A., Golenbock D., Bowie A.G. The history of toll-like receptors - redefining innate immunity. Nat. Rev. Immunol. 2013, 13(6):453-460.
    • (2013) Nat. Rev. Immunol. , vol.13 , Issue.6 , pp. 453-460
    • O'Neill, L.A.1    Golenbock, D.2    Bowie, A.G.3
  • 53
    • 84878190840 scopus 로고    scopus 로고
    • Immune sensing of DNA
    • Paludan S.R., Bowie A.G. Immune sensing of DNA. Immunity 2013, 38(5):870-880.
    • (2013) Immunity , vol.38 , Issue.5 , pp. 870-880
    • Paludan, S.R.1    Bowie, A.G.2
  • 54
    • 84869403247 scopus 로고    scopus 로고
    • The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response
    • Parvatiyar K., et al. The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat. Immunol. 2012, 13(12):1155-1161.
    • (2012) Nat. Immunol. , vol.13 , Issue.12 , pp. 1155-1161
    • Parvatiyar, K.1
  • 55
    • 77951269392 scopus 로고    scopus 로고
    • The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
    • Rathinam V.A., et al. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat. Immunol. 2010, 11(5):395-402.
    • (2010) Nat. Immunol. , vol.11 , Issue.5 , pp. 395-402
    • Rathinam, V.A.1
  • 56
    • 60749104535 scopus 로고    scopus 로고
    • HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
    • Roberts T.L., et al. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science 2009, 323(5917):1057-1060.
    • (2009) Science , vol.323 , Issue.5917 , pp. 1057-1060
    • Roberts, T.L.1
  • 57
    • 0001311171 scopus 로고
    • Inhibition of virus multiplication by foreign nucleic acid
    • Rotem Z., Cox R.A., Isaacs A. Inhibition of virus multiplication by foreign nucleic acid. Nature. 197 1963, 564-566.
    • (1963) Nature. 197 , pp. 564-566
    • Rotem, Z.1    Cox, R.A.2    Isaacs, A.3
  • 58
    • 84901038448 scopus 로고    scopus 로고
    • Rad50/Card9 interactions link cytosolic DNA sensing to IL-1beta production
    • Roth S.e.a. Rad50/Card9 interactions link cytosolic DNA sensing to IL-1beta production. Nat. Immunol. 2014.
    • (2014) Nat. Immunol.
    • Roth, S.1
  • 59
    • 84895904323 scopus 로고    scopus 로고
    • Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
    • Schoggins J.W., et al. Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature 2014, 505(7485):691-695.
    • (2014) Nature , vol.505 , Issue.7485 , pp. 691-695
    • Schoggins, J.W.1
  • 60
    • 30444450839 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    • Stetson D.B., Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 2006, 24(1):93-103.
    • (2006) Immunity , vol.24 , Issue.1 , pp. 93-103
    • Stetson, D.B.1    Medzhitov, R.2
  • 61
    • 84925841637 scopus 로고    scopus 로고
    • CGAS and Ifi204 cooperate to produce type I IFNs in response to francisella infection
    • (published ahead of print)
    • Storek K.M., et al. cGAS and Ifi204 cooperate to produce type I IFNs in response to francisella infection. J. Immunol. 2015, (published ahead of print). 10.4049/jimmunol.1402764.
    • (2015) J. Immunol.
    • Storek, K.M.1
  • 62
    • 84873711885 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
    • Sun L., et al. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 2013, 339(6121):786-791.
    • (2013) Science , vol.339 , Issue.6121 , pp. 786-791
    • Sun, L.1
  • 63
    • 66649109939 scopus 로고    scopus 로고
    • ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
    • Sun W., et al. ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc. Natl. Acad. Sci. USA 2009, 106(21):8653-8658.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , Issue.21 , pp. 8653-8658
    • Sun, W.1
  • 64
    • 34547143110 scopus 로고    scopus 로고
    • DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
    • Takaoka A., et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 2007, 448(7152):501-505.
    • (2007) Nature , vol.448 , Issue.7152 , pp. 501-505
    • Takaoka, A.1
  • 65
    • 84857937262 scopus 로고    scopus 로고
    • STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
    • Tanaka Y., Chen Z.J. STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci. Signal 2012, 5(214):ra20.
    • (2012) Sci. Signal , vol.5 , Issue.214 , pp. ra20
    • Tanaka, Y.1    Chen, Z.J.2
  • 66
    • 77958140656 scopus 로고    scopus 로고
    • IFI16 is an innate immune sensor for intracellular DNA
    • Unterholzner L., et al. IFI16 is an innate immune sensor for intracellular DNA. Nat. Immunol. 2010, 11(11):997-1004.
    • (2010) Nat. Immunol. , vol.11 , Issue.11 , pp. 997-1004
    • Unterholzner, L.1
  • 67
    • 77954593965 scopus 로고    scopus 로고
    • Virus inhibition of RIP3-dependent necrosis
    • Upton J.W., Kaiser W.J., Mocarski E.S. Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe 2010, 7(4):302-313.
    • (2010) Cell Host Microbe , vol.7 , Issue.4 , pp. 302-313
    • Upton, J.W.1    Kaiser, W.J.2    Mocarski, E.S.3
  • 68
    • 84858420051 scopus 로고    scopus 로고
    • DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA
    • Upton J.W., Kaiser W.J., Mocarski E.S. DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. Cell Host Microbe 2012, 11(3):290-297.
    • (2012) Cell Host Microbe , vol.11 , Issue.3 , pp. 290-297
    • Upton, J.W.1    Kaiser, W.J.2    Mocarski, E.S.3
  • 69
    • 0035833552 scopus 로고    scopus 로고
    • Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
    • Walker J.R., Corpina R.A., Goldberg J. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 2001, 412(6847):607-614.
    • (2001) Nature , vol.412 , Issue.6847 , pp. 607-614
    • Walker, J.R.1    Corpina, R.A.2    Goldberg, J.3
  • 70
    • 0032015647 scopus 로고    scopus 로고
    • Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo
    • Wathelet M.G., et al. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol. Cell 1998, 1(4):507-518.
    • (1998) Mol. Cell , vol.1 , Issue.4 , pp. 507-518
    • Wathelet, M.G.1
  • 71
    • 77249132637 scopus 로고    scopus 로고
    • Recognition of viruses by cytoplasmic sensors
    • Wilkins C., Gale M. Recognition of viruses by cytoplasmic sensors. Curr. Opin. Immunol. 2010, 22(1):41-47.
    • (2010) Curr. Opin. Immunol. , vol.22 , Issue.1 , pp. 41-47
    • Wilkins, C.1    Gale, M.2
  • 72
    • 84912120595 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
    • Woo S.R., et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity 2014, 41(5):830-842.
    • (2014) Immunity , vol.41 , Issue.5 , pp. 830-842
    • Woo, S.R.1
  • 73
    • 84873724533 scopus 로고    scopus 로고
    • Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
    • Wu J., et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 2013, 339(6121):826-830.
    • (2013) Science , vol.339 , Issue.6121 , pp. 826-830
    • Wu, J.1
  • 74
    • 77952566304 scopus 로고    scopus 로고
    • The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway
    • Yang P., et al. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat. Immunol. 2010, 11(6):487-494.
    • (2010) Nat. Immunol. , vol.11 , Issue.6 , pp. 487-494
    • Yang, P.1
  • 75
    • 3242813113 scopus 로고    scopus 로고
    • The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
    • Yoneyama M., et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 2004, 5(7):730-773.
    • (2004) Nat. Immunol. , vol.5 , Issue.7 , pp. 730-773
    • Yoneyama, M.1
  • 76
    • 79955004696 scopus 로고    scopus 로고
    • Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN
    • Zhang X., et al. Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN. J. Immunol. 2011, 186(8):4541-4545.
    • (2011) J. Immunol. , vol.186 , Issue.8 , pp. 4541-4545
    • Zhang, X.1
  • 77
    • 80555133355 scopus 로고    scopus 로고
    • DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cells
    • Zhang Z., et al. DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cells. J. Immunol. 2011, 187(9):4501-4508.
    • (2011) J. Immunol. , vol.187 , Issue.9 , pp. 4501-4508
    • Zhang, Z.1
  • 78
    • 80052969639 scopus 로고    scopus 로고
    • The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
    • Zhang Z., et al. The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat. Immunol. 2011, 12(10):959-965.
    • (2011) Nat. Immunol. , vol.12 , Issue.10 , pp. 959-965
    • Zhang, Z.1
  • 79
    • 53349168904 scopus 로고    scopus 로고
    • The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
    • Zhong B., et al. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 2008, 29(4):538-550.
    • (2008) Immunity , vol.29 , Issue.4 , pp. 538-550
    • Zhong, B.1


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