The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type i interferon immune response

Nature Immunology

Volumn 13, Issue 12, 2012, Pages 1155-1161

  Parvatiyar, Kislay ^a   Zhang, Zhiqiang ^b   Teles, Rosane M ^c   Ouyang, Songying ^d   Jiang, Yan ^d   Iyer, Shankar S ^a   Zaver, Shivam A ^a   Schenk, Mirjam ^c   Zeng, Shang ^e   Zhong, Wenwan ^e   Liu, Zhi Jie ^d   Modlin, Robert L ^a,c   Liu, Yong Jun ^b   Cheng, Genhong ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BAYLOR INSTITUTE FOR IMMUNOLOGY RESEARCH   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d INSTITUTE OF BIOPHYSICS   (China)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CYCLIC AMP; CYCLIC GMP; HELIASE DDX41; HELICASE; INTERFERON; INTERFERON REGULATORY FACTOR 3; PATTERN RECOGNITION RECEPTOR; PROTEIN STING; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE INDUCTION; GENE SILENCING; HUMAN; HUMAN CELL; INNATE IMMUNITY; LISTERIA MONOCYTOGENES; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL LINE; CYCLIC GMP; DEAD-BOX RNA HELICASES; DINUCLEOSIDE PHOSPHATES; HUMANS; IMMUNITY, INNATE; INTERFERON REGULATORY FACTOR-3; INTERFERON TYPE I; LISTERIA MONOCYTOGENES; MACROPHAGES; MEMBRANE PROTEINS; MICE; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, PATTERN RECOGNITION; RNA INTERFERENCE; RNA, SMALL INTERFERING; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION;

EID: 84869403247     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2460     Document Type: Article

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