Cooperative Electrostatic Interactions Drive Functional Evolution in the Alkaline Phosphatase Superfamily

Journal of the American Chemical Society

Volumn 137, Issue 28, 2015, Pages 9061-9076

  Barrozo, Alexandre ^a   Duarte, Fernanda ^a   Bauer, Paul ^a   Carvalho, Alexandra T P ^a   Kamerlin, Shina C L ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINITY; ELECTROSTATICS; PHOSPHATASES; SOL-GELS; SOLUTIONS;

ACTIVATION BARRIERS; ALKALINE PHOSPHATASE; BURKHOLDERIA CARYOPHYLLI; COMPUTATIONAL MODEL; DIFFERENT SUBSTRATES; EXTENSIVE SIMULATIONS; RHIZOBIUM LEGUMINOSARUM; TRANSITION STATE GEOMETRY;

ENZYMES;

ALKALINE PHOSPHATASE; BACTERIAL ENZYME; HYDROLASE;

AQUEOUS SOLUTION; ARTICLE; BACTERIUM MUTANT; BURKHOLDERIA; COMPUTER MODEL; CONTROLLED STUDY; ENZYME BINDING; ENZYME CONFORMATION; EVOLUTION; GEOMETRY; MOLECULAR DYNAMICS; NONHUMAN; PH; QUALITATIVE ANALYSIS; RHIZOBIUM LEGUMINOSARUM; SIMULATION; STATIC ELECTRICITY; WILD TYPE; BIOLOGICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR MODEL; MUTATION; PROTEIN CONFORMATION; QUANTUM THEORY;

ALKALINE PHOSPHATASE; BURKHOLDERIA; CATALYTIC DOMAIN; COMPUTER SIMULATION; EVOLUTION, MOLECULAR; HYDROGEN-ION CONCENTRATION; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; QUANTUM THEORY; RHIZOBIUM LEGUMINOSARUM; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY;

EID: 84937681734     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b03945     Document Type: Article

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