Do electrostatic interactions with positively charged active site groups tighten the transition state for enzymatic phosphoryl transfer?

Journal of the American Chemical Society

Volumn 126, Issue 38, 2004, Pages 11814-11819

  Nikolic Hughes, Ivana ^a,c   Rees, Douglas C ^c,d   Herschlag, Daniel ^a,b  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

^c California Institute of Technology   (United States)

^d CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHARGE TRANSFER; ELECTRON TRANSITIONS; ELECTROSTATICS; FREE ENERGY; HYDROLYSIS; NEGATIVE IONS;

CHARGE DISTRIBUTION; ELECTROSTATIC INTERACTIONS; LINEAR FREE ENERGY RELATIONSHIPS (LEFR); TRANSITION STATES;

ENZYMES;

ALKALINE PHOSPHATASE; ANION; ESTER; PHOSPHATE; PHOSPHOROTHIOIC ACID; SULFATE;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; ENERGY; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; HYDROLYSIS; LINEAR FREE ENERGY RELATIONSHIP; MOLECULAR INTERACTION;

ALKALINE PHOSPHATASE; BINDING SITES; ELECTROSTATICS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; LINEAR ENERGY TRANSFER; MODELS, MOLECULAR; PHOSPHORIC ACID ESTERS; SULFURIC ACID ESTERS;

EID: 4644314829     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0480421     Document Type: Article

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