Evolution of Conformational Dynamics Determines the Conversion of a Promiscuous Generalist into a Specialist Enzyme

Molecular Biology and Evolution

Volumn 32, Issue 1, 2015, Pages 132-143

  Zou, Taisong ^a   Risso, Valeria A ^b   Gavira, Jose A ^c   Sanchez Ruiz, Jose M ^b   Ozkan, S Banu ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF GRANADA   (Spain)

^c CSIC   (Spain)

Author keywords

Ancestral enzyme; Molecular dynamics; Protein dynamics and structure

Indexed keywords

BETA LACTAMASE TEM 1; PENICILLIN DERIVATIVE; ANTIINFECTIVE AGENT; BETA LACTAMASE;

ARTICLE; DRUG BINDING; DRUG DEGRADATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME DEGRADATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; MOLECULAR DYNAMICS; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; BACTERIUM; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR EVOLUTION; MUTATION; PROTEIN TERTIARY STRUCTURE;

ANTI-BACTERIAL AGENTS; BACTERIA; BETA-LACTAMASES; CATALYTIC DOMAIN; EVOLUTION, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTATION; PRINCIPAL COMPONENT ANALYSIS; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

EID: 84922379085     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msu281     Document Type: Article

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