Intriguing possibilities and beneficial aspects of transporter-conscious drug design

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 15, 2015, Pages 4119-4131

  Tashima, Toshihiko ^a  

^a Nippon Pharmaceutical Chemicals Company Ltd   (Japan)

Author keywords

ADMET; BBB; Drug delivery; Drug design; Transporter; Transporter conscious drug design

Indexed keywords

AMANTADINE; AMITRIPTYLINE; BIPERIDEN; BROMOCRIPTINE; BUSPIRONE; CHLORPROMAZINE; CHLORPROTHIXENE; CLOMIPRAMINE; DESIPRAMINE; DOXEPIN; ELETRIPTAN; FLUOXETINE; FLURAZEPAM; FLUVOXAMINE; IMIPRAMINE; LEVOMEPROMAZINE; MAPROTILINE; METERGOLINE; METHYSERGIDE; NALBUPHINE; NALOXONE; NALTREXONE; NOSCAPINE; PERPHENAZINE; PROCYCLIDINE; PROMAZINE; PROTRIPTYLINE; RISPERIDONE; TACRINE; UNINDEXED DRUG; ABC TRANSPORTER; CARRIER PROTEIN; DRUG; PRODRUG;

BLOOD BRAIN BARRIER; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; DRUG DELIVERY SYSTEM; DRUG DESIGN; HUMAN; MOLECULAR DOCKING; NONHUMAN; PHARMACOPHORE; REVIEW; TRANSPORTER-CONSCIOUS DRUG DESIGN; ANIMAL; BIOAVAILABILITY; CHEMISTRY; DRUG EFFECTS; METABOLISM; PHARMACOKINETICS; PROCEDURES;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL AVAILABILITY; BLOOD-BRAIN BARRIER; CARRIER PROTEINS; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HUMANS; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PRODRUGS;

EID: 84937523293     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.06.022     Document Type: Review

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