Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil

Bioconjugate Chemistry

Volumn 25, Issue 11, 2014, Pages 2046-2054

  Wang, Xinyi ^a   Li, Jianbo ^a   Xu, Chaoqun ^b   Li, Yanping ^a   Gong, Tao ^a   Sun, Xun ^a   Fu, Yao ^a   He, Qin ^a   Zhang, Zhirong ^a  

^a SICHUAN UNIVERSITY   (China)

^b Sichuan Academy of Chinese Medicine Sciences   (China)

Author keywords

[No Author keywords available]

Indexed keywords

TISSUE;

ALKYLATING AGENTS; BLOOD-BRAIN BARRIER; BRAIN TARGETING; BRAIN UPTAKE; C6 CELLS; PRODRUGS; SYNTHESISED; TARGETING EFFICACIES; THERAPEUTIC AGENTS; THERAPEUTIC DRUGS;

TOXICITY;

CHLORAMBUCIL; PRODRUG; SCOPINE; SCOPOLAMINE; UNCLASSIFIED DRUG; AMINE; CHLORAMBUCIL-SCOPINE; SCOPOLAMINE DERIVATIVE;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY ENDOTHELIAL CELL; BRAIN HOMOGENATE; BRAIN PERFUSION; BRAIN UPTAKE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG SAFETY; DRUG STABILITY; DRUG SYNTHESIS; DRUG TARGETING; DRUG UPTAKE; ELECTROSPRAY MASS SPECTROMETRY; ERYTHROCYTE; GLIOMA CELL; HEMOLYSIS; HISTOPATHOLOGY; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MITOSIS RATE; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; CELL CYCLE; CHEMISTRY; DRUG EFFECTS; GLIOMA; HUMAN; METABOLISM; PATHOLOGY; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

AMINES; ANIMALS; APOPTOSIS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CELL CYCLE; CELL LINE, TUMOR; CHLORAMBUCIL; DRUG STABILITY; GLIOMA; HEMOLYSIS; HUMANS; MICE; PRODRUGS; RATS; SCOPOLAMINE DERIVATIVES; TISSUE DISTRIBUTION;

EID: 84913600750     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc5004108     Document Type: Article

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