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Volumn , Issue 3, 2006, Pages 323-325

Affinity prediction for substrates of the peptide transporter PepT1

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE TRANSPORTER 1;

EID: 33645458452     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b511996k     Document Type: Article
Times cited : (24)

References (29)
  • 12
    • 33645457676 scopus 로고    scopus 로고
    • 25
    • We found that commercial pharmacophore based modelling was reasonably successful for 'standard' substrates, but the prediction of activity was unreliable for structures outwith the initial training set, with high affinity often attributed to poor substrates
  • 29
    • 0036510392 scopus 로고    scopus 로고
    • As expected, our quantitative model is a good predictor of the binding of new substrates, as evidenced by the derivatives shown below, which were chosen to probe details of stereochemistry at residue 1 (ref. 7a), and at the 1st peptide bond (ref. 7b).
    • S. Theis I. Knütter B. Hartrodt M. Brandsch G. Kottra K. Neubert H. Daniel J. Biol. Chem. 2002 277 7287
    • (2002) J. Biol. Chem. , vol.277 , pp. 7287
    • Theis, S.1    Knütter, I.2    Hartrodt, B.3    Brandsch, M.4    Kottra, G.5    Neubert, K.6    Daniel, H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.