메뉴 건너뛰기




Volumn 55, Issue 15, 2012, Pages 6975-6979

Discovery of a series of 2-phenyl- N -(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K v7.2 (KCNQ2) channel pharmacology: Identification of (S)-2-phenyl- N -(2-(pyrrolidin-1-yl) phenyl)butanamide (ML252) as a potent, brain penetrant K v7.2 channel inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

(S) 2 PHENYL N (2 (PYRROLIDIN 1 YL)PHENYL)BUTANAMIDE; 2 PHENYL N (2 (PYRROLIDIN 1 YL)PHENYL)ACETAMIDE DERIVATIVE; ACETAMIDE DERIVATIVE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KCNQ2; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 84864927786     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300700v     Document Type: Article
Times cited : (28)

References (13)
  • 1
    • 84858225391 scopus 로고    scopus 로고
    • 2012 Alzheimer's disease facts and figures
    • 2012 Alzheimer's disease facts and figures. Alzheimer's Dementia 2012, 8, 131-168; http://www.alz.org/alzheimers-disease-facts-and-figures.asp.
    • (2012) Alzheimer's Dementia , vol.8 , pp. 131-168
  • 2
    • 0036482371 scopus 로고    scopus 로고
    • Cholinergic drugs in pharmacotherapy of Alzheimers disease
    • Camps, P.; Muñoz-Torrero, D. Cholinergic drugs in pharmacotherapy of Alzheimers disease Mini-Rev. Med. Chem. 2002, 2, 11-25
    • (2002) Mini-Rev. Med. Chem. , vol.2 , pp. 11-25
    • Camps, P.1    Muñoz-Torrero, D.2
  • 4
    • 0031809240 scopus 로고    scopus 로고
    • Two new potent neurotransmitter release enhancers, 10,10-bis(4- pyridinylmethyl)-9(10 H)-anthrancenone and 10,10-bis(2-fluoro-4-pyridinylmethyl) -9(10 H)-anthracenone: Comparison to linopirdine
    • Zaczek, R.; Chorvat, R. J.; Saye, J. A.; Pierdomenico, M. E.; Maciag, C. M.; Logue, A. R.; Rominger, D. H.; Earl, R. A. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10 H)-anthrancenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10 H)-anthracenone: comparison to linopirdine J. Pharmacol. Exp. Ther. 1998, 285 (2) 724-730
    • (1998) J. Pharmacol. Exp. Ther. , vol.285 , Issue.2 , pp. 724-730
    • Zaczek, R.1    Chorvat, R.J.2    Saye, J.A.3    Pierdomenico, M.E.4    MacIag, C.M.5    Logue, A.R.6    Rominger, D.H.7    Earl, R.A.8
  • 6
    • 0028889856 scopus 로고
    • Single-dose pharmacokinetics, safety, and tolerance of linopirdine (DuP 996) in healthy young adults and elderly volunteers
    • Pieniaszek, H. J., Jr.; Fiske, W. D.; Saxton, T. D.; Kim, Y. S.; Garner, D. M.; Xilinas, M.; Martz, R. Single-dose pharmacokinetics, safety, and tolerance of linopirdine (DuP 996) in healthy young adults and elderly volunteers J. Clin. Pharmacol. 1995, 35 (1) 22-30
    • (1995) J. Clin. Pharmacol. , vol.35 , Issue.1 , pp. 22-30
    • Pieniaszek Jr., H.J.1    Fiske, W.D.2    Saxton, T.D.3    Kim, Y.S.4    Garner, D.M.5    Xilinas, M.6    Martz, R.7
  • 7
    • 78649910308 scopus 로고    scopus 로고
    • The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels
    • Soh, H.; Tzingounis, A. V. The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels Mol. Pharmacol. 2010, 78 (6) 1088-1095
    • (2010) Mol. Pharmacol. , vol.78 , Issue.6 , pp. 1088-1095
    • Soh, H.1    Tzingounis, A.V.2
  • 8
    • 84864952390 scopus 로고    scopus 로고
    • For information on the Molecular Libraries Probe Production Centers Network (MLPCN)
    • For information on the Molecular Libraries Probe Production Centers Network (MLPCN), see http://mli.nih.gov/mli/.
  • 9
    • 84864938633 scopus 로고    scopus 로고
    • For information on the Vanderbilt Specialized Chemistry Center
    • For information on the Vanderbilt Specialized Chemistry Center, see: http://www.mc.vanderbilt.edu/centers/mlpcn/index.html.
  • 10
    • 84864938635 scopus 로고    scopus 로고
    • ML252 has been declared a probe via the Molecular Libraries Probe Production Centers Network (MLPCN) and is available through the network, see.
    • ML252 has been declared a probe via the Molecular Libraries Probe Production Centers Network (MLPCN) and is available through the network, see: http://mli.nih.gov/mli/.
  • 11
    • 77249122159 scopus 로고    scopus 로고
    • Physicochemical space for optimum oral bioavailability: Contribution of human intestinal absorption and first-pass elimination
    • Varma, M. V. S.; Obach, R. S.; Rotter, C.; Miller, H. R.; Chang, G.; Steyn, S. J.; El-Kattan, A.; Troutman, M. D. Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination J. Med. Chem. 2010, 53 (3) 1098-1108
    • (2010) J. Med. Chem. , vol.53 , Issue.3 , pp. 1098-1108
    • Varma, M.V.S.1    Obach, R.S.2    Rotter, C.3    Miller, H.R.4    Chang, G.5    Steyn, S.J.6    El-Kattan, A.7    Troutman, M.D.8
  • 12
    • 77956627250 scopus 로고    scopus 로고
    • Strategic Use of Plasma and Microsome Binding to Exploit in Vitro Clearance in Early Drug Discovery
    • Chang, G.; Steyn, S. J.; Umland, J. P.; Scott, D. O. Strategic Use of Plasma and Microsome Binding To Exploit in Vitro Clearance in Early Drug Discovery ACS Med. Chem. Lett. 2010, 1 (1) 50-63
    • (2010) ACS Med. Chem. Lett. , vol.1 , Issue.1 , pp. 50-63
    • Chang, G.1    Steyn, S.J.2    Umland, J.P.3    Scott, D.O.4
  • 13
    • 80054878125 scopus 로고    scopus 로고
    • Discovery, synthesis, and structure-activity relationship of a series of N -aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener
    • Yu, H.; Wu, M.; Townsend, S. D.; Zou, B.; Long, S.; Daniels, J. S.; McManus, O. B.; Li, M.; Lindsley, C. W.; Hopkins, C. R. Discovery, synthesis, and structure-activity relationship of a series of N -aryl-bicyclo[2.2.1] heptane-2-carboxamides: characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener ACS Chem. Neurosci. 2011, 2, 572-577
    • (2011) ACS Chem. Neurosci. , vol.2 , pp. 572-577
    • Yu, H.1    Wu, M.2    Townsend, S.D.3    Zou, B.4    Long, S.5    Daniels, J.S.6    McManus, O.B.7    Li, M.8    Lindsley, C.W.9    Hopkins, C.R.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.