Memantine transport across the mouse blood-brain barrier is mediated by a cationic influx H+ antiporter

Molecular Pharmaceutics

Volumn 10, Issue 12, 2013, Pages 4491-4498

  Mehta, Dharmini C ^a   Short, Jennifer L ^a   Nicolazzo, Joseph A ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

blood brain barrier; memantine; organic cation transporter; transcardiac perfusion

Indexed keywords

AMANTADINE; ANTIPORTER; CARNITINE; CHOLINE; HYDROGEN; MEMANTINE; QUININE; SODIUM ION; TETRYLAMMONIUM;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CELL PH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DISPOSITION; DRUG TRANSPORT; HEART PERFUSION; MALE; MEMBRANE DEPOLARIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIPORTERS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CARRIER PROTEINS; CATIONS; HYDROGEN; HYDROGEN-ION CONCENTRATION; MALE; MEMANTINE; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; ORGANIC CATION TRANSPORT PROTEINS;

EID: 84889259063     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400316e     Document Type: Article

References (43)

1. Alzheimer's Disease Fact Sheet, National Institute on Ageing: Silver Spring, 2012.
2. Molinuevo, J. L.; Llado, A.; Rami, L. Memantine: targeting glutamate excitotoxicity in Alzheimer's disease and other dementias Am. J. Alzheimer's Dis. Other Dementias 2005, 20, 77-85 (Pubitemid 40547347)
3. O'Neil, M. J. The Merck Index-An Encyclopedia of Chemicals, Drugs, and Biologicals, 13 th ed.; Merck and Co.: Whitehouse Station, NJ, 2001; p 1041.
4. Product monograph: Exiba® memantine hydrochloride tablets 10mg; Lundbeck Inc: Canada, 2011.
5. Beconi, M. G.; Howland, D.; Park, L.; Lyons, K.; Giuliano, J.; Dominguez, C.; Munoz-Sanjuan, I.; Pacifici, R. Pharmacokinetics of memantine in rats and mice PLoS Curr. 2011, 3, 1-27
6. Busch, A. E.; Karbach, U.; Miska, D.; Gorboulev, V.; Akhoundova, A.; Volk, C.; Arndt, P.; Ulzheimer, J. C.; Sonders, M. S.; Baumann, C.; Waldegger, S.; Lang, F.; Koepsell, H. Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine Mol. Pharmacol. 1998, 54, 342-352 (Pubitemid 28368824)
7. Amphoux, A.; Vialou, V.; Drescher, E.; Brüss, M.; La Cour, C. M.; Rochat, C.; Millan, M. J.; Giros, B.; Bönisch, H.; Gautron, S. Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain Neuropharmacology 2006, 50, 941-952 (Pubitemid 43810126)
8. Fourie, J.; Escobar, M. R.; Sitar, D. S. NMDA receptor antagonists to characterize rat renal organic cation transporter function Eur. J. Pharmacol. 2002, 452, 1-10 (Pubitemid 35248119)
9. Andre, P.; Debray, M.; Scherrmann, J. M.; Cisternino, S. Clonidine transport at the mouse blood-brain barrier by a new H+ antiporter that interacts with addictive drugs J. Cereb. Blood Flow Metab. 2009, 29, 1293-304
10. --dependent transporter in the brain uptake of amantadine and rimantadine Mol. Pharmaceutics 2012, 9, 883-893
11. Kim, M. H.; Maeng, H. J.; Yu, K. H.; Lee, K. R.; Tsuruo, T.; Kim, D. D.; Shim, C. K.; Chung, S. J. Evidence of carrier-mediated transport in the penetration of donepezil into the rat brain J. Pharm. Sci. 2010, 99, 1548-1566
12. Murakami, H.; Sawada, N.; Koyabu, N.; Ohtani, H.; Sawada, Y. Characteristics of choline transport across the blood-brain barrier in mice: correlation with in vitro data Pharm. Res. 2000, 17, 1526-30 (Pubitemid 32217562)
13. Koepsell, H.; Endou, H. The SLC22 drug transporter family Pfluegers Arch. 2004, 447, 666-76 (Pubitemid 38241452)
14. Ciarimboli, G. Organic cation transporters Xenobiotica 2008, 38, 936-71
15. Koepsell, H.; Lips, K.; Volk, C. Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications Pharm. Res. 2007, 24, 1227-51 (Pubitemid 46876495)
16. Dahlin, A.; Royall, J.; Hohmann, J. G.; Wang, J. Expression profiling of the solute carrier gene family in the mouse brain J. Pharmacol. Exp. Ther. 2009, 329, 558-570
17. Lin, C. J.; Tai, Y.; Huang, M. T.; Tsai, Y.-F.; Hsu, H.-J.; Tzen, K.-Y.; Liou, H.-H. Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood-brain barrier and MPTP-induced dopaminergic toxicity in rodents J. Neurochem. 2010, 114, 717-727
18. Andre, P.; Saubamea, B.; Cochois-Guegan, V.; Marie-Claire, C.; Cattelotte, J.; Smirnova, M.; Schinkel, A. H.; Scherrmann, J.-M.; Cisternino, S. Transport of biogenic amine neurotransmitters at the mouse blood-retina and blood-brain barriers by uptake1 and uptake2 J. Cereb. Blood Flow Metab. 2012, 32, 1989-2001
19. Dohgu, S.; Yamauchi, A.; Takata, F.; Sawada, Y.; Higuchi, S.; Naito, M.; Tsuruo, T.; Shirabe, S.; Niwa, M.; Katamine, S.; Kataoka, Y. Uptake and efflux of quinacrine, a candidate for the treatment of prion diseases, at the blood-brain barrier Cell. Mol. Neurobiol. 2004, 24, 205-217 (Pubitemid 38481018)
20. Inano, A.; Sai, Y.; Nikaido, H.; Hasimoto, N.; Asano, M.; Tsuji, A.; Tamai, I. Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2 Biopharm. Drug Dispos. 2003, 24, 357-365 (Pubitemid 37427998)
21. Spector, R. Transport of amantadine and rimantadine through the blood-brain barrier J. Pharmacol. Exp. Ther. 1988, 244, 516-9 (Pubitemid 18076589)
22. Moellentin, D.; Picone, C.; Leadbetter, E. Memantine-induced myoclonus and delirium exacerbated by trimethoprim Ann. Pharmacother. 2008, 42, 443-7 (Pubitemid 351429614)
23. Banks, W. A.; Morley, J. E.; Lynch, J. L.; Lynch, K. M.; Mooradian, A. D. Insulin detemir is not transported across the blood-brain barrier Peptides 2010, 31, 2284-2288
24. Jin, L.; Li, J.; Nation, R. L.; Nicolazzo, J. A. Impact of P-glycoprotein inhibition and lipopolysaccharide administration on blood-brain barrier transport of colistin in mice Antimicrob. Agents Chemother. 2011, 55, 502-507
25. Smith, Q. R. Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system Pharm. Biotechnol. 1996, 8, 285-307
26. Grossberg, G. T.; Edwards, K. R.; Zhao, Q. Rationale for combination therapy with galantamine and memantine in Alzheimer's disease J. Clin. Pharmacol. 2006, 46, 17S-26S (Pubitemid 43882808)
27. Mehta, D. C.; Short, J. L.; Nicolazzo, J. A. Reduced CNS exposure of memantine in a triple transgenic mouse model of Alzheimer's disease assessed using a novel LC-MS technique J. Pharm. Biomed. Anal. 2013, 85, 198-206
28. Camenisch, G.; Folkers, G.; van de Waterbeemd, H. Review of theoretical passive drug absorption models: historical background, recent developments and limitations Pharm. Acta Helv. 1996, 71, 309-327 (Pubitemid 26402757)
29. Keep, R.; Xiang, J.; Lorris Betz, A. Potassium transport at the blood-brain and blood-CSF barriers. In Frontiers in Cerebral Vascular Biology; Drewes, L.; Betz, A. L., Springer US: New York, 1993; Vol. 331, pp 43-54. (Pubitemid 23180888)
30. Kakehi, M.; Koyabu, N.; Nakamura, T.; Uchiumi, T.; Kuwano, M.; Ohtani, H.; Sawada, Y. Functional characterization of mouse cation transporter mOCT2 compared with mOCT1 Biochem. Biophys. Res. Commun. 2002, 296, 644-650
31. Hsu, P.; Haffner, J.; Albuquerque, M. L. C.; Leffler, C. W. pHi in piglet cerebral microvascular endothelial cells: recovery from an acid load Proc. Soc. Exp. Biol. Med. 1996, 212, 256-262
32. +/organic cation antiport system in rat renal brush-border membranes J. Biol. Chem. 1988, 263, 11150-11154
33. Ennis, S. R.; Ren, X.-d.; Betz, A. L. Mechanisms of sodium transport at the blood-brain barrier studied with in situ perfusion of rat brain J. Neurochem. 1996, 66, 756-763 (Pubitemid 26036707)
34. Tamai, I.; Yabuuchi, H.; Nezu, J.-i.; Sai, Y.; Oku, A.; Shimane, M.; Tsuji, A. Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1 FEBS Lett. 1997, 419, 107-111 (Pubitemid 28011227)
35. Wu, X.; George, R. L.; Huang, W.; Wang, H.; Conway, S. J.; Leibach, F. H.; Ganapathy, V. Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta Biochim. Biophys. Acta 2000, 1466, 315-327 (Pubitemid 30312986)
36. Yabuuchi, H.; Tamai, I.; Nezu, J.; Sakamoto, K.; Oku, A.; Shimane, M.; Sai, Y.; Tsuji, A. Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations J. Pharmacol. Exp. Ther. 1999, 289, 768-73 (Pubitemid 29191230)
37. Tamai, I.; Ohashi, R.; Nezu, J. I.; Sai, Y.; Kobayashi, D.; Oku, A.; Shimane, M.; Tsuji, A. Molecular and functional characterization of organic cation/carnitine transporter family in mice J. Biol. Chem. 2000, 275, 40064-72 (Pubitemid 32064631)
38. Gründemann, D.; Harlfinger, S.; Golz, S.; Geerts, A.; Lazar, A.; Berkels, R.; Jung, N.; Rubbert, A.; Schömig, E. Discovery of the ergothioneine transporter Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 5256-5261
39. Nakamichi, N.; Shima, H.; Asano, S.; Ishimoto, T.; Sugiura, T.; Matsubara, K.; Kusuhara, H.; Sugiyama, Y.; Sai, Y.; Miyamoto, K.-I.; Tsuji, A.; Kato, Y. Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin J. Pharm. Sci. 2013, 102, 3407-3417
40. Peltekova, V. D.; Wintle, R. F.; Rubin, L. A.; Amos, C. I.; Huang, Q.; Gu, X.; Newman, B.; Oene, M. V.; Cescon, D.; Greenberg, G.; Griffiths, A. M.; St George-Hyslop, P. H.; Siminovitch, K. A. Functional variants of OCTN cation transporter genes are associated with Crohn disease Nat. Genet. 2004, 36, 471-475 (Pubitemid 38620030)
41. Tamai, I.; Nakanishi, T.; Kobayashi, D.; China, K.; Kosugi, Y.; Nezu, J.-i.; Sai, Y.; Tsuji, A. Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations Mol. Pharmaceutics 2003, 1, 57-66
42. Hayden, F. G.; Minocha, A.; Spyker, D. A.; Hoffman, H. E. Comparative single-dose pharmacokinetics of amantadine hydrochloride and rimantadine hydrochloride in young and elderly adults Antimicrob. Agents Chemother. 1985, 28, 216-221 (Pubitemid 15019952)
43. Vieira, J. L. F.; Borges, L. M. G.; Nascimento, M. T. S.; Gomes, A. L. S. Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil Braz. J. Infect. Dis. 2008, 12, 353-354