Synthesis and biological evaluation of l-valine-amidoximeesters as double prodrugs of amidines

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 6, 2011, Pages 1907-1914

  Kotthaus, Joscha ^a   Hungeling, Helen ^a   Reeh, Christiane ^a   Kotthaus, Jürke ^a   Schade, Dennis ^a   Wein, Silvia ^a   Wolffram, Siegfried ^a   Clement, Bernd ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Benzamidine; Biotransformation; Pentamidine; Prodrug; Valine

Indexed keywords

2 (N TERT BUTOXYCARBONYLAMINO) 3 METHYL O BUTYRYLBENZAMIDOXIME; 2 AMINO 3 METHYL O BUTYRYLBENZAMIDOXIME DIHYDROCHLORIDE; 4,4' (PENTAMETHYLENEDIOXY) BIS (2 AMINO 3 METHYL O BUTYRYL)BENZAMIDOXIME TETRAHYDROCHLORIDE; 4,4' (PENTAMETHYLENEDIOXY) BIS [2 (N,N' TERT BUTOXYCARBONYL AMINO) 3 METHYL O BUTYRYL]BENZAMIDOXIME; AMIDE; N VALOXYBENZAMIDE; N,N' BIS(VALOXY)PENTAMIDE; PENTAMIDINE; UNCLASSIFIED DRUG; VALINE AMIDOXIMEESTER DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG PENETRATION; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSFORMATION; ESTERIFICATION; HALF LIFE TIME; LIVER CELL; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; TISSUE DISTRIBUTION;

AMIDINES; ANIMALS; BENZAMIDINES; ESTERS; HUMANS; MICROSOMES, LIVER; OXIDOREDUCTASES; OXIMES; PENTAMIDINE; PRODRUGS; RATS; RECOMBINANT PROTEINS; SWINE; VALINE;

RATTUS; SUS;

EID: 79952445624     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.066     Document Type: Article

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