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Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 13, 2002, Pages 1779-1783

The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: A new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection

(7) Hewawasam, Piyasena a Fan, Wenhong a Knipe, Jay a Moon, Sandra L a Boissard, Christopher G a Gribkoff, Valentin K a Starrett Jr , John E a

a BRISTOL MYERS SQUIBB (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOQUINOLINE DERIVATIVE; POTASSIUM CHANNEL STIMULATING AGENT; CALCIUM ACTIVATED POTASSIUM CHANNEL; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; NEUROPROTECTIVE AGENT; QUINOLONE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DRUG ACETYLATION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG PENETRATION; DRUG SYNTHESIS; DRUG TARGETING; ELECTROPHYSIOLOGY; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; OOCYTE; RAT; STEREOSPECIFICITY; STROKE; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS; ANIMAL; BLOOD; BRAIN; CELL CLONE; CELL MEMBRANE POTENTIAL; CEREBROVASCULAR ACCIDENT; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; MALE; METABOLISM; PATCH CLAMP; SYNTHESIS;

ANIMAL; BRAIN; CEREBROVASCULAR ACCIDENT; CLONE CELLS; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGY; MALE; MEMBRANE POTENTIALS; NEUROPROTECTIVE AGENTS; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; QUINOLONES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS; ANIMALS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS;

XENOPUS LAEVIS;

EID: 0037042779 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/S0960-894X(02)00240-8 Document Type: Article

Times cited : (109)

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