Design, synthesis, and biological evaluation of halogenated N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: Discovery of an isoform-selective small molecule phospholipase D2 inhibitor

Journal of Medicinal Chemistry

Volumn 53, Issue 18, 2010, Pages 6706-6719

  Lavieri, Robert R ^a   Scott, Sarah A ^a   Selvy, Paige E ^a   Kim, Kwangho ^b   Jadhav, Satyawan ^a   Morrison, Ryan D ^b   Daniels, J Scott ^a,b   Brown, H Alex ^a,b   Lindsley, Craig W ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOENZYME; N [2 (4 OXO 1 PHENYL 1,3,8 TRIAZASPIRO[4.5]DECAN 8 YL)ETHYL]BENZAMIDE DERIVATIVE; N [2 [1 (3 FLUOROPHENYL) 4 OXO 1,3,8 TRIAZASPIRO[4.5]DECAN 8 YL]ETHYL] 2 NAPHTHAMIDE; PHOSPHOLIPASE D2; PHOSPHOLIPASE INHIBITOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; N-(2-(1-(3-FLUOROPHENYL)-4-OXO-1,3,8-TRIAZASPIRO(4.5)DECAN-8-YL)ETHYL)-2-NAPHTHAMIDE; NAPHTHALENE DERIVATIVE; PHOSPHOLIPASE D; PLASMA PROTEIN; PROTEIN BINDING; SPIRO COMPOUND;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CELL INVASION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; HUMAN TISSUE; IC 50; NONHUMAN; PROTEIN ANALYSIS; RAT; ALLOSTERISM; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL PROLIFERATION; DRUG EFFECTS; DRUG SCREENING; LIVER MICROSOME; MALE; METABOLISM; SPRAGUE DAWLEY RAT; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ALLOSTERIC REGULATION; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOOD PROTEINS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; ISOENZYMES; MALE; MICROSOMES, LIVER; NAPHTHALENES; PHOSPHOLIPASE D; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SPIRO COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956730942     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100814g     Document Type: Article

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