Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 15, 2015, Pages 4737-4745

  Kempema, Aaron M ^a   Widen, John C ^a   Hexum, Joseph K ^a   Andrews, Timothy E ^a   Wang, Dan ^a   Rathe, Susan K ^b   Meece, Frederick A ^a   Noble, Klara E ^c   Sachs, Zohar ^c   Largaespada, David A ^b,c   Harki, Daniel A ^a,b,c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Acute myeloid leukemia; Bone marrow toxicity; Cyclopropanation; Parthenolide; Sesquiterpene lactone

Indexed keywords

ANTILEUKEMIC AGENT; COSTUNOLIDE; CYCLOPROPANE; CYTARABINE; DIMETHYLAMINO PARTHENOLIDE; DOXORUBICIN; MELAMPOMAGNOLIDE B; MICHELIOLIDE; PARTHENOLIDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ALKENE; ANTINEOPLASTIC AGENT; SESQUITERPENE;

ACUTE MYELOBLASTIC LEUKEMIA; ANIMAL CELL; ANTILEUKEMIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BONE MARROW CELL; CANCER INHIBITION; CELL LEVEL; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC50; LEUKEMIA CELL; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; ACUTE MYELOID LEUKEMIA; ANIMAL; CANCER STEM CELL; CELL SURVIVAL; CHEMISTRY; CONFORMATION; CYTOLOGY; DRUG EFFECTS; DRUG SCREENING; METABOLISM; MORTALITY; SYNTHESIS; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ALKENES; ANIMALS; ANTINEOPLASTIC AGENTS; BONE MARROW CELLS; CELL LINE, TUMOR; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICE; MOLECULAR CONFORMATION; NEOPLASTIC STEM CELLS; REACTIVE OXYGEN SPECIES; SESQUITERPENES;

EID: 84937513987     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.05.037     Document Type: Article

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