Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 1, 2006, Pages 83-91

  Hwang, Der Ren ^a   Wu, Yu Shan ^a   Chang, Chun Wei ^a   Lien, Tzu Wen ^a   Chen, Wei Cheng ^a   Tan, Uan Kang ^b   Hsu, John T A ^a,c   Hsieh, Hsing Pang ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b TECHNOLOGY AND SCIENCE INSTITUTE OF NORTHERN TAIWAN   (Taiwan)

^c NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

Anti HCV agents; Hepatitis C virus replicon; Parthenolide; Sesquiterpene lactones

Indexed keywords

1 (4,8 DIMETHYL 13 OXO 3,14 DIOXATRICYCLO[9.3.0.0 2,4 ]TETRADEC 7 EN 12 YL METHYL)PYRROLIDINE 2 CARBOXYLIC ACID; 12 (2 HYDROXYETHYLSULFANYLMETHYL) 4,8 DIMETHYL 12 MORPHOLIN 4 YLMETHYL 3,14 DIOXATRICYCLO[9.3.0.0 2,4 ]TETRADEC 7 EN 13 ONE; 12 (2 HYDROXYETHYLSULFANYLMETHYL) 4,8 DIMETHYL 3,14 DIOXATRICYCLO[9.3.0.0 2,4 ]TETRADEC 7 EN 13 ONE; 12 AZEPAN 1 YLMETHYL 4,8 DIMETHYL 3,14 DIOXATRICYCLO[9.3.0.0 2,4 ]TETRADEC 7 EN 13 ONE; 12 DIETHYLAMINOMETHYL 4,8 DIMETHYL 3,14 DIOXATRICYCLO[9.3.0.0 2,4 ]TETRADEC 7 EN 13 ONE; 12 DIMETHYLAMINOMETHYL 4,8 DIMETHYL 3,14 DIOXATRICYCLO[9.3.0.0 2,4 ]TETRADEC 7 EN 13 ONE; 4(5) ALPHA EPOXY 4,5 DIHYDROSANTONIN; 4,8 DIMETHYL 12 MORPHOLIN 4 YLMETHYL 3,14 DIOXATRICYCLO[9.3.0.0 2,4 ]TETRADEC 7 EN 13 ONE; 4,8 DIMETHYL 12 PIPERIDIN 1 YLMETHYL 3,14 DIOXATRICYCLO[9.3.0.0 2,4 ]TETRADEC 7 EN 13 ONE; 4,8 DIMETHYL 12 PYRROLIDIN 1 YLMETHYL 3,14 DIOXATRICYCLO[9.3.0.0 2,4 ]TETRADEC 7 EN 13 ONE; ALANTOLACTONE; ALPHA INTERFERON; ALPHA METHYLENE GAMMA LACTONE; ARTEMSININ; COSTUNOLIDE; DEHYDROCOSTUS LACTONE; EPOXY (4,5ALPHA) 4,5 DIHYDROSANTONIN; HELENALIN; ITACONIC ANHYDRIDE; LACTONE DERIVATIVE; PARTHENOLIDE; SESQUITERPENE LACTONE DERIVATIVE; TANACETUM PARTHENIUM EXTRACT; TERPENOID; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); DRUG POTENCY; DRUG POTENTIATION; DRUG SYNTHESIS; FEVER; HEPATITIS C VIRUS; MIGRAINE; NONHUMAN; REPLICON; RNA REPLICATION; STRUCTURE ACTIVITY RELATION; TANACETUM PARTHENIUM; VIRUS REPLICATION;

HEPATITIS C VIRUS; TANACETUM PARTHENIUM;

EID: 27744591649     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.07.055     Document Type: Article

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