Synthesis of 13-amino costunolide derivatives as anticancer agents

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 16, 2006, Pages 4195-4199

  Srivastava, Sanjay K ^a   Abraham, Aji ^a   Bhat, Beena ^a   Jaggi, Manu ^a   Singh, Anu T ^a   Sanna, Vinod K ^a   Singh, Gurvinder ^a   Agarwal, Shiv K ^a   Mukherjee, Rama ^a   Burman, Anand C ^a  

^a DABUR RESEARCH FOUNDATION   (India)

Author keywords

Anticancer; Costunolide derivatives

Indexed keywords

ANTINEOPLASTIC AGENT; BENZENE DERIVATIVE; COSTUNOLIDE; MORPHOLINE DERIVATIVE; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; THIOMORPHOLINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL SPECIFICITY; CELL STRAIN 3T3; CELL STRAIN K 562; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG SAFETY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE; LUNG CANCER; MOUTH CANCER; OVARY CANCER; PANCREAS CANCER; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; K562 CELLS; MICE; MODELS, CHEMICAL; SESQUITERPENES;

EID: 33745817829     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.05.083     Document Type: Article

References (11)

1. Sun C.-H., Syu W.-J., Don M.-J., Lu J.-J., and Lee G.-H. J. Nat. Prod. 66 (2003) 1175
2. Hibasami H., Yamada Y., Moteki H., Katsuzaki H., Imai K., Yoshioka K., and Komiya T. Int. J. Mol. Med. 12 (2003) 147
3. Okugawa H., Ueda R., Matsumoto K., Kawanishi K., and Kato A. Phytomedicine (1996) 147
4. Bocca C., Gabriel L., Bozzo F., and Miglietta A. Chem. Biol. Interact. 147 (2004) 79
5. Lee M.-G., Lee K.-T., Chi S.-G., and Park J.-H. Biol. Pharm. Bull. 24 (2001) 303
6. Zhang S., Won Y.-K., Ong C.-N., and Shen H.-M. Curr. Med. Chem. Anti-Canc. Agents 5 (2005) 239
7. 3, 300 MHz) δ 4.83-4.80 (m, 1H), 4.67-4.51 (m, 2H), 2.80-2.77 (m, 2H), 2.64-2.58 (m, 1H), 2.40-1.95 (m, 11H), 1.68 (s, 3H), 1.66-1.52 (3H), 1.41 (s, 3H), 1.25-1.61 (m, 4H), 0.91 (d, 3H, J = 6.3 Hz); MS (ES+) m/z (relative intensity) 332 (M+H) (100), 354 (M+H+Na) (30). Similarly, other 13-amino costunolide derivatives were synthesized and characterized by spectroscopic tools.
8. Matsuda H., Kageura T., Inoue Y., Morikawa T., and Yoshikawa M. Tetrahedron 56 (2000) 7763
9. 1 = absorbance of control sample at 540 nm.
10. Park H.J., Jung W.T., Basnet P., Kadota S., and Namba T. J. Nat. Prod. 59 (1996) 1128
11. Mosmann T. J. Immunol. Methods 65 (1983) 55