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Volumn 3, Issue 2, 2013, Pages 121-142

Cell surface markers of cancer stem cells: Diagnostic macromolecules and targets for drug delivery

Author keywords

Anticancer agents; Cancer stem cell markers; Cancer stem cells; Cell surface proteins; Disease relapse; Flow cytometry

Indexed keywords

ADECATUMUMAB; BESTATIN; CATUMAXOMAB; CD123 ANTIGEN; CD133 ANTIGEN; CD33 ANTIGEN; CD44V ANTIGEN; CELL SURFACE MARKER; DOCETAXEL; EDRECOLOMAB; EPITHELIAL CELL ADHESION MOLECULE; FLUOROURACIL; MICROSOMAL AMINOPEPTIDASE; MONOCLONAL ANTIBODY; MT 110; UNCLASSIFIED DRUG;

EID: 84874793651     PISSN: 2190393X     EISSN: 21903948     Source Type: Journal    
DOI: 10.1007/s13346-012-0075-1     Document Type: Review
Times cited : (18)

References (232)
  • 1
    • 33845364233 scopus 로고    scopus 로고
    • Cancer stem cells and oncology therapeutics
    • Al-Hajj M. Cancer stem cells and oncology therapeutics. Curr Opin Oncol. 2007; 19: 61-4.
    • (2007) Curr Opin Oncol , vol.19 , pp. 61-64
    • Al-Hajj, M.1
  • 2
    • 17844390670 scopus 로고    scopus 로고
    • Will cancer stem cells provide new therapeutic targets?
    • Behbod F, Rosen JM. Will cancer stem cells provide new therapeutic targets? Carcinogenesis. 2005; 26: 703-11.
    • (2005) Carcinogenesis , vol.26 , pp. 703-711
    • Behbod, F.1    Rosen, J.M.2
  • 3
    • 58149380742 scopus 로고    scopus 로고
    • Stem cell concepts renew cancer research
    • Dick JE. Stem cell concepts renew cancer research. Blood. 2008; 112: 4793-807.
    • (2008) Blood , vol.112 , pp. 4793-4807
    • Dick, J.E.1
  • 5
    • 71849094172 scopus 로고    scopus 로고
    • Potential for therapeutic targeting of tumor stem cells
    • Saini V, Shoemaker RH. Potential for therapeutic targeting of tumor stem cells. Cancer Sci. 2010; 101: 16-21.
    • (2010) Cancer Sci , vol.101 , pp. 16-21
    • Saini, V.1    Shoemaker, R.H.2
  • 6
    • 35848968478 scopus 로고    scopus 로고
    • Evaluating therapeutic efficacy against cancer stem cells: new challenges posed by a new paradigm
    • Wang JCY. Evaluating therapeutic efficacy against cancer stem cells: new challenges posed by a new paradigm. Cell Stem Cell. 2007; 1: 497-501.
    • (2007) Cell Stem Cell , vol.1 , pp. 497-501
    • Wang, J.C.Y.1
  • 7
    • 33947433676 scopus 로고    scopus 로고
    • Cancer stem cells: at the headwaters of tumor development
    • Ward RJ, Dirks PB. Cancer stem cells: at the headwaters of tumor development. Annu Rev Pathol-Mech. 2007; 2: 175-89.
    • (2007) Annu Rev Pathol-Mech , vol.2 , pp. 175-189
    • Ward, R.J.1    Dirks, P.B.2
  • 9
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997; 3: 730-7.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 10
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukemia after transplantation into SCID mice
    • Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-cortes J, et al. A cell initiating human acute myeloid leukemia after transplantation into SCID mice. Nature. 1994; 367: 645-8.
    • (1994) Nature , vol.367 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3    Murdoch, B.4    Hoang, T.5    Caceres-Cortes, J.6
  • 12
    • 0022913781 scopus 로고
    • Clonogenic cells in acute myeloblastic leukemia
    • Griffin JD, Lowenberg B. Clonogenic cells in acute myeloblastic leukemia. Blood. 1986; 68: 1185-95.
    • (1986) Blood , vol.68 , pp. 1185-1195
    • Griffin, J.D.1    Lowenberg, B.2
  • 13
    • 0020609330 scopus 로고
    • Stem cells in normal and leukemic hematopoiesis (Henry Stratton Lecture)
    • McCulloch EA. Stem cells in normal and leukemic hematopoiesis (Henry Stratton Lecture). Blood. 1983; 62: 1-13.
    • (1983) Blood , vol.62 , pp. 1-13
    • McCulloch, E.A.1
  • 14
    • 79960989834 scopus 로고    scopus 로고
    • Stem cell quiescence
    • Li L, Bhatia R. Stem cell quiescence. Clin Cancer Res. 2011; 17: 4936-41.
    • (2011) Clin Cancer Res , vol.17 , pp. 4936-4941
    • Li, L.1    Bhatia, R.2
  • 17
    • 84858002750 scopus 로고    scopus 로고
    • Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance
    • Natarajan K, Xie Y, Baer MR, Ross DD. Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance. Biochem Pharmacol. 2012; 83: 1084-103.
    • (2012) Biochem Pharmacol , vol.83 , pp. 1084-1103
    • Natarajan, K.1    Xie, Y.2    Baer, M.R.3    Ross, D.D.4
  • 18
    • 84874800783 scopus 로고    scopus 로고
    • American Cancer Society. Cancer facts & figures 2011. ACS
    • American Cancer Society. Cancer facts & figures 2011. ACS. 2011.
    • (2011)
  • 19
    • 16844363378 scopus 로고    scopus 로고
    • The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
    • Guzman ML, Rossi RM, Karnischky L, Li XJ, Peterson DR, Howard DS, et al. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood. 2005; 105: 4163-9.
    • (2005) Blood , vol.105 , pp. 4163-4169
    • Guzman, M.L.1    Rossi, R.M.2    Karnischky, L.3    Li, X.J.4    Peterson, D.R.5    Howard, D.S.6
  • 20
    • 33749515476 scopus 로고    scopus 로고
    • Targeting of CD44 eradicates human acute myeloid leukemic stem cells
    • Jin L, Hope KJ, Zhai Q, Smadja-Joffe F, Dick JE. Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med. 2006; 12: 1167-74.
    • (2006) Nat Med , vol.12 , pp. 1167-1174
    • Jin, L.1    Hope, K.J.2    Zhai, Q.3    Smadja-Joffe, F.4    Dick, J.E.5
  • 21
    • 77749317560 scopus 로고    scopus 로고
    • Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML
    • Saito Y, Uchida N, Tanaka S, Suzuki N, Tomizawa-Murasawa M, Sone A, et al. Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML. Nat Biotechnol. 2010; 28: 275-80.
    • (2010) Nat Biotechnol , vol.28 , pp. 275-280
    • Saito, Y.1    Uchida, N.2    Tanaka, S.3    Suzuki, N.4    Tomizawa-Murasawa, M.5    Sone, A.6
  • 22
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. New Engl J Med. 2001; 344: 1031-7.
    • (2001) New Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3    Peng, B.4    Buchdunger, E.5    Ford, J.M.6
  • 23
    • 11144354274 scopus 로고    scopus 로고
    • High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemia
    • Kantarjian H, Talpaz M, O'Brien SS, Garcia-Manero G, Verstovsek S, Giles F, et al. High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemia. Blood. 2004; 103: 2873-8.
    • (2004) Blood , vol.103 , pp. 2873-2878
    • Kantarjian, H.1    Talpaz, M.2    O'Brien, S.S.3    Garcia-Manero, G.4    Verstovsek, S.5    Giles, F.6
  • 25
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
    • Graham SM, Jorgensen HG, Allan E, Pearson C, Alcorn MJ, Richmond L, et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood. 2002; 99: 319-25.
    • (2002) Blood , vol.99 , pp. 319-325
    • Graham, S.M.1    Jorgensen, H.G.2    Allan, E.3    Pearson, C.4    Alcorn, M.J.5    Richmond, L.6
  • 26
    • 79953042645 scopus 로고    scopus 로고
    • CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?
    • Zoeller M. CD44: can a cancer-initiating cell profit from an abundantly expressed molecule? Nat Rev Cancer. 2011; 11: 254-67.
    • (2011) Nat Rev Cancer , vol.11 , pp. 254-267
    • Zoeller, M.1
  • 27
    • 79951681568 scopus 로고    scopus 로고
    • Cancer stem cells: a new framework for the design of tumor therapies
    • Garvalov BK, Acker T. Cancer stem cells: a new framework for the design of tumor therapies. J Mol Med-Jmm. 2011; 89: 95-107.
    • (2011) J Mol Med-Jmm , vol.89 , pp. 95-107
    • Garvalov, B.K.1    Acker, T.2
  • 28
    • 28244472369 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic prostate cancer stem cells
    • Collins AT, Berry PA, Hyde C, Stower MJ, Maitland NJ. Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res. 2005; 65: 10946-51.
    • (2005) Cancer Res , vol.65 , pp. 10946-10951
    • Collins, A.T.1    Berry, P.A.2    Hyde, C.3    Stower, M.J.4    Maitland, N.J.5
  • 29
    • 79953113373 scopus 로고    scopus 로고
    • Therapeutics formulated to target cancer stem cells: Is it in our future?
    • Clayton S, Mousa SA. Therapeutics formulated to target cancer stem cells: is it in our future? Cancer Cell Int. 2011; 11: 7.
    • (2011) Cancer Cell Int. , vol.11 , pp. 7
    • Clayton, S.1    Mousa, S.A.2
  • 32
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
    • Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer. 2008; 8: 755-68.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 33
    • 72449210651 scopus 로고    scopus 로고
    • Cancer stem cells: cell culture, markers, and targets for new therapies
    • Gilbert CA, Ross AH. Cancer stem cells: cell culture, markers, and targets for new therapies. J Cell Biochem. 2009; 108: 1031-8.
    • (2009) J Cell Biochem , vol.108 , pp. 1031-1038
    • Gilbert, C.A.1    Ross, A.H.2
  • 34
    • 78650035864 scopus 로고    scopus 로고
    • Cancer stem cells: problems for therapy?
    • Alison MR, Lim SML, Nicholson LJ. Cancer stem cells: problems for therapy? J Pathol. 2011; 223: 147-61.
    • (2011) J Pathol , vol.223 , pp. 147-161
    • Alison, M.R.1    Lim, S.M.L.2    Nicholson, L.J.3
  • 35
    • 7744236303 scopus 로고    scopus 로고
    • Cancer sten cell biology: from leukemia to solid tumors
    • Jordan CT. Cancer sten cell biology: from leukemia to solid tumors. Curr Opin Cell Biol. 2004; 16: 708-12.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 708-712
    • Jordan, C.T.1
  • 37
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 2011; 61: 212-36.
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 38
    • 79951670098 scopus 로고    scopus 로고
    • Leukemia stem cells
    • Testa U. Leukemia stem cells. Ann Hematol. 2011; 90: 245-71.
    • (2011) Ann Hematol , vol.90 , pp. 245-271
    • Testa, U.1
  • 39
    • 0030988803 scopus 로고    scopus 로고
    • Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo
    • Blair A, Hogge DE, Ailles LE, Lansdorp PM, Sutherland HJ. Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo. Blood. 1997; 89: 3104-12.
    • (1997) Blood , vol.89 , pp. 3104-3112
    • Blair, A.1    Hogge, D.E.2    Ailles, L.E.3    Lansdorp, P.M.4    Sutherland, H.J.5
  • 40
    • 0032402173 scopus 로고    scopus 로고
    • Most acute myeloid leukemia progenitor cells with long-term proliferative ability in vitro and in vivo have the phenotype CD34(+)/CD71(-)/HLA-DR
    • Blair A, Hogge DE, Sutherland HJ. Most acute myeloid leukemia progenitor cells with long-term proliferative ability in vitro and in vivo have the phenotype CD34(+)/CD71(-)/HLA-DR. Blood. 1998; 92: 4325-35.
    • (1998) Blood , vol.92 , pp. 4325-4335
    • Blair, A.1    Hogge, D.E.2    Sutherland, H.J.3
  • 41
    • 0034097928 scopus 로고    scopus 로고
    • Primitive acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo lack surface expression of c-kit (CD 117)
    • Blair A, Sutherland HJ. Primitive acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo lack surface expression of c-kit (CD 117). Exp Hematol. 2000; 28: 660-71.
    • (2000) Exp Hematol , vol.28 , pp. 660-671
    • Blair, A.1    Sutherland, H.J.2
  • 42
    • 0033815950 scopus 로고    scopus 로고
    • The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells
    • Jordan CT, Upchurch D, Szilvassy SJ, Guzman ML, Howard DS, Pettigrew AL, et al. The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells. Leukemia. 2000; 14: 1777-84.
    • (2000) Leukemia , vol.14 , pp. 1777-1784
    • Jordan, C.T.1    Upchurch, D.2    Szilvassy, S.J.3    Guzman, M.L.4    Howard, D.S.5    Pettigrew, A.L.6
  • 46
    • 43249119125 scopus 로고    scopus 로고
    • Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia
    • de Figueiredo-Pontes LL, Pintao M-CT, Oliveira LCO, Dalmazzo LFF, Jacomo RH, Garcia AB, et al. Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia. Cytom Part B-Clin Cy. 2008; 74B: 163-8.
    • (2008) Cytom Part B-Clin Cy , vol.74 B , pp. 163-168
    • de Figueiredo-Pontes, L.L.1    Pintao, M.-C.T.2    Oliveira, L.C.O.3    Dalmazzo, L.F.F.4    Jacomo, R.H.5    Garcia, A.B.6
  • 47
    • 34948839959 scopus 로고    scopus 로고
    • The novel AML stem cell-associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells
    • van Rhenen A, van Dongen GAMS, Kelder A, Rombouts EJ, Feller N, Moshaver B, et al. The novel AML stem cell-associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells. Blood. 2007; 110: 2659-66.
    • (2007) Blood , vol.110 , pp. 2659-2666
    • van Rhenen, A.1    van Dongen, G.A.M.S.2    Kelder, A.3    Rombouts, E.J.4    Feller, N.5    Moshaver, B.6
  • 49
    • 0033919668 scopus 로고    scopus 로고
    • Expression of CD44 variant exons in acute myeloid leukemia is more common and more complex than that observed in normal blood, bone marrow or CD34(+) cells
    • Bendall LJ, Bradstock KF, Gottlieb DJ. Expression of CD44 variant exons in acute myeloid leukemia is more common and more complex than that observed in normal blood, bone marrow or CD34(+) cells. Leukemia. 2000; 14: 1239-46.
    • (2000) Leukemia , vol.14 , pp. 1239-1246
    • Bendall, L.J.1    Bradstock, K.F.2    Gottlieb, D.J.3
  • 50
    • 77749294821 scopus 로고    scopus 로고
    • Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells
    • 17ra9
    • Saito Y, Kitamura H, Hijikata A, Tomizawa-Murasawa M, Tanaka S, Takagi S, et al. Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells. Sci Transl Med. 2010; 2: 17ra9.
    • (2010) Sci Transl Med. , vol.2
    • Saito, Y.1    Kitamura, H.2    Hijikata, A.3    Tomizawa-Murasawa, M.4    Tanaka, S.5    Takagi, S.6
  • 51
    • 67650632683 scopus 로고    scopus 로고
    • CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
    • Majeti R, Chao MP, Alizadeh AA, Pang WW, Jaiswal S, Gibbs Jr KD, et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell. 2009; 138: 286-99.
    • (2009) Cell , vol.138 , pp. 286-299
    • Majeti, R.1    Chao, M.P.2    Alizadeh, A.A.3    Pang, W.W.4    Jaiswal, S.5    Gibbs Jr., K.D.6
  • 53
    • 0034141934 scopus 로고    scopus 로고
    • A primitive hematopoietic cell is the target for the leukemic transformation in human Philadelphia-positive acute lymphoblastic leukemia
    • Cobaleda C, Gutierrez-Cianca N, Perez-Losada J, Flores T, Garcia-Sanz R, Gonzalez M, et al. A primitive hematopoietic cell is the target for the leukemic transformation in human Philadelphia-positive acute lymphoblastic leukemia. Blood. 2000; 95: 1007-13.
    • (2000) Blood , vol.95 , pp. 1007-1013
    • Cobaleda, C.1    Gutierrez-Cianca, N.2    Perez-Losada, J.3    Flores, T.4    Garcia-Sanz, R.5    Gonzalez, M.6
  • 54
    • 0036280235 scopus 로고    scopus 로고
    • Bcr-Abl variants: biological and clinical aspects
    • Advani AS, Pendergast AM. Bcr-Abl variants: biological and clinical aspects. Leukemia Res. 2002; 26: 713-20.
    • (2002) Leukemia Res , vol.26 , pp. 713-720
    • Advani, A.S.1    Pendergast, A.M.2
  • 55
    • 0036341359 scopus 로고    scopus 로고
    • Philadelphia chromosome-positive acute lymphoblastic leukemia- current concepts and future perspectives
    • Faderl S, Garcia-Manero G, Thomas DA, Kantarjian HM. Philadelphia chromosome-positive acute lymphoblastic leukemia- current concepts and future perspectives. Rev Clin Exp Hematol. 2002; 6: 142-60.
    • (2002) Rev Clin Exp Hematol , vol.6 , pp. 142-160
    • Faderl, S.1    Garcia-Manero, G.2    Thomas, D.A.3    Kantarjian, H.M.4
  • 57
    • 19044399684 scopus 로고    scopus 로고
    • Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling
    • Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R, et al. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell. 2002; 1: 133-43.
    • (2002) Cancer Cell , vol.1 , pp. 133-143
    • Yeoh, E.J.1    Ross, M.E.2    Shurtleff, S.A.3    Williams, W.K.4    Patel, D.5    Mahfouz, R.6
  • 59
    • 33846242910 scopus 로고    scopus 로고
    • Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia
    • Cox CV, Martin HM, Kearns PR, Virgo P, Evely RS, Blair A. Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia. Blood. 2007; 109: 674-82.
    • (2007) Blood , vol.109 , pp. 674-682
    • Cox, C.V.1    Martin, H.M.2    Kearns, P.R.3    Virgo, P.4    Evely, R.S.5    Blair, A.6
  • 60
    • 65149100417 scopus 로고    scopus 로고
    • Expression of CD133 on leukemia-initiating cells in childhood ALL
    • Cox CV, Diamanti P, Evely RS, Kearns PR, Blair A. Expression of CD133 on leukemia-initiating cells in childhood ALL. Blood. 2009; 113: 3287-96.
    • (2009) Blood , vol.113 , pp. 3287-3296
    • Cox, C.V.1    Diamanti, P.2    Evely, R.S.3    Kearns, P.R.4    Blair, A.5
  • 61
    • 63149111992 scopus 로고    scopus 로고
    • CD9 correlates with cancer stem cell potentials in human B-acute lymphoblastic leukemia cells
    • Nishida H, Yamazaki H, Yamada T, Iwata S, Dang NH, Inukai T, et al. CD9 correlates with cancer stem cell potentials in human B-acute lymphoblastic leukemia cells. Biochem Bioph Res Co. 2009; 382: 57-62.
    • (2009) Biochem Bioph Res Co , vol.382 , pp. 57-62
    • Nishida, H.1    Yamazaki, H.2    Yamada, T.3    Iwata, S.4    Dang, N.H.5    Inukai, T.6
  • 62
    • 65049090853 scopus 로고    scopus 로고
    • CD90 and CD110 correlate with cancer stem cell potentials in human T-acute lymphoblastic leukemia cells
    • Yamazaki H, Nishida H, Iwata S, Dang NH, Morimoto C. CD90 and CD110 correlate with cancer stem cell potentials in human T-acute lymphoblastic leukemia cells. Biochem Bioph Res Co. 2009; 383: 172-7.
    • (2009) Biochem Bioph Res Co , vol.383 , pp. 172-177
    • Yamazaki, H.1    Nishida, H.2    Iwata, S.3    Dang, N.H.4    Morimoto, C.5
  • 63
    • 0033568250 scopus 로고    scopus 로고
    • Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia
    • Holyoake T, Jiang XY, Eaves C, Eaves A. Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. Blood. 1999; 94: 2056-64.
    • (1999) Blood , vol.94 , pp. 2056-2064
    • Holyoake, T.1    Jiang, X.Y.2    Eaves, C.3    Eaves, A.4
  • 68
    • 70149115254 scopus 로고    scopus 로고
    • Tumor-endothelial interaction links the CD44(+)/CD24(-) phenotype with poor prognosis in early-stage breast cancer
    • Buess M, Rajski M, Vogel-Durrer BML, Herrmann R, Rochlitz C. Tumor-endothelial interaction links the CD44(+)/CD24(-) phenotype with poor prognosis in early-stage breast cancer. Neoplasia. 2009; 11: 987-1002.
    • (2009) Neoplasia , vol.11 , pp. 987-1002
    • Buess, M.1    Rajski, M.2    Vogel-Durrer, B.M.L.3    Herrmann, R.4    Rochlitz, C.5
  • 70
    • 0032897547 scopus 로고    scopus 로고
    • Functional activity of murine CD34(+) and CD34(-) hematopoietic stem cell populations
    • Donnelly DS, Zelterman D, Sharkis S, Krause DS. Functional activity of murine CD34(+) and CD34(-) hematopoietic stem cell populations. Exp Hematol. 1999; 27: 788-96.
    • (1999) Exp Hematol , vol.27 , pp. 788-796
    • Donnelly, D.S.1    Zelterman, D.2    Sharkis, S.3    Krause, D.S.4
  • 71
    • 77952045656 scopus 로고    scopus 로고
    • In situ identification of putative cancer stem cells by multiplexing ALDH1, CD44, and cytokeratin identifies breast cancer patients with poor prognosis
    • Neumeister V, Agarwal S, Bordeaux J, Camp RL, Rimm DL. In situ identification of putative cancer stem cells by multiplexing ALDH1, CD44, and cytokeratin identifies breast cancer patients with poor prognosis. Am J Pathol. 2010; 176: 2131-8.
    • (2010) Am J Pathol , vol.176 , pp. 2131-2138
    • Neumeister, V.1    Agarwal, S.2    Bordeaux, J.3    Camp, R.L.4    Rimm, D.L.5
  • 72
    • 40949116308 scopus 로고    scopus 로고
    • Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors
    • Cho RW, Wang X, Diehn M, Shedden K, Chen GY, Sherlock G, et al. Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells. 2008; 26: 364-71.
    • (2008) Stem Cells , vol.26 , pp. 364-371
    • Cho, R.W.1    Wang, X.2    Diehn, M.3    Shedden, K.4    Chen, G.Y.5    Sherlock, G.6
  • 74
    • 79954937171 scopus 로고    scopus 로고
    • Clinicopathological significance and prognostic value of CD133 expression in triple-negative breast carcinoma
    • Zhao P, Lu Y, Jiang X, Li X. Clinicopathological significance and prognostic value of CD133 expression in triple-negative breast carcinoma. Cancer Sci. 2011; 102: 1107-11.
    • (2011) Cancer Sci , vol.102 , pp. 1107-1111
    • Zhao, P.1    Lu, Y.2    Jiang, X.3    Li, X.4
  • 75
    • 73449142873 scopus 로고    scopus 로고
    • Expression of CD133, PAX2, ESA, and GPR30 in invasive ductal breast carcinomas
    • Liu Q, Li J-g, Zheng X-y, Jin F, Dong H-t. Expression of CD133, PAX2, ESA, and GPR30 in invasive ductal breast carcinomas. Chinese Med J-Peking. 2009; 122: 2763-9.
    • (2009) Chinese Med J-Peking , vol.122 , pp. 2763-2769
    • Liu, Q.1    Li, J.-G.2    Zheng, X.-Y.3    Jin, F.4    Dong, H.-T.5
  • 76
    • 77951242343 scopus 로고    scopus 로고
    • Co-expression of CD173 (H2) and CD174 (Lewis Y) with CD44 suggests that fucosylated histo-blood group antigens are markers of breast cancer-initiating cells
    • Lin W-M, Karsten U, Goletz S, Cheng R-C, Cao Y. Co-expression of CD173 (H2) and CD174 (Lewis Y) with CD44 suggests that fucosylated histo-blood group antigens are markers of breast cancer-initiating cells. Vichows Arch. 2010; 456: 403-9.
    • (2010) Vichows Arch , vol.456 , pp. 403-409
    • Lin, W.-M.1    Karsten, U.2    Goletz, S.3    Cheng, R.-C.4    Cao, Y.5
  • 77
    • 79952807457 scopus 로고    scopus 로고
    • Expression of CD176 (Thomsen-Friedenreich antigen) on lung, breast and liver cancer-initiating cells
    • Lin W-M, Karsten U, Goletz S, Cheng R-C, Cao Y. Expression of CD176 (Thomsen-Friedenreich antigen) on lung, breast and liver cancer-initiating cells. Int J Exp Pathol. 2011; 92: 97-105.
    • (2011) Int J Exp Pathol , vol.92 , pp. 97-105
    • Lin, W.-M.1    Karsten, U.2    Goletz, S.3    Cheng, R.-C.4    Cao, Y.5
  • 78
    • 44449115111 scopus 로고    scopus 로고
    • Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells
    • Vassilopoulos A, Wang R-H, Petrovas C, Ambrozak D, Koup R, Deng C-X. Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells. Int J Biol Sci. 2008; 4: 133-42.
    • (2008) Int J Biol Sci , vol.4 , pp. 133-142
    • Vassilopoulos, A.1    Wang, R.-H.2    Petrovas, C.3    Ambrozak, D.4    Koup, R.5    Deng, C.-X.6
  • 81
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 2007; 445: 106-10.
    • (2007) Nature , vol.445 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 83
    • 45749102020 scopus 로고    scopus 로고
    • CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors
    • Shmelkov SV, Butler JM, Hooper AT, Hormigo A, Kushner J, Milde T, et al. CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. J Clin Invest. 2008; 118: 2111-20.
    • (2008) J Clin Invest , vol.118 , pp. 2111-2120
    • Shmelkov, S.V.1    Butler, J.M.2    Hooper, A.T.3    Hormigo, A.4    Kushner, J.5    Milde, T.6
  • 84
    • 58149269566 scopus 로고    scopus 로고
    • CD44 is of functional importance for colorectal cancer stem cells
    • Du L, Wang H, He L, Zhang J, Ni B, Wang X, et al. CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res. 2008; 14: 6751-60.
    • (2008) Clin Cancer Res , vol.14 , pp. 6751-6760
    • Du, L.1    Wang, H.2    He, L.3    Zhang, J.4    Ni, B.5    Wang, X.6
  • 85
    • 70249130832 scopus 로고    scopus 로고
    • Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer
    • Horst D, Kriegl L, Engel J, Kirchner T, Jung A. Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer. Cancer Invest. 2009; 27: 844-50.
    • (2009) Cancer Invest , vol.27 , pp. 844-850
    • Horst, D.1    Kriegl, L.2    Engel, J.3    Kirchner, T.4    Jung, A.5
  • 86
    • 77955051047 scopus 로고    scopus 로고
    • Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer
    • Lugli A, Iezzi G, Hostettler I, Muraro MG, Mele V, Tornillo L, et al. Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer. Brit J Cancer. 2010; 103: 382-90.
    • (2010) Brit J Cancer , vol.103 , pp. 382-390
    • Lugli, A.1    Iezzi, G.2    Hostettler, I.3    Muraro, M.G.4    Mele, V.5    Tornillo, L.6
  • 87
    • 51649111430 scopus 로고    scopus 로고
    • Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity
    • Vermeulen L, Todaro M, Mello FdS, Sprick MR, Kemper K, Alea MP, et al. Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. Proc Natl Acad Sci USA. 2008; 105: 13427-32.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 13427-13432
    • Vermeulen, L.1    Todaro, M.2    Mello, F.S.3    Sprick, M.R.4    Kemper, K.5    Alea, M.P.6
  • 88
    • 79952006805 scopus 로고    scopus 로고
    • Recurrence-free survival more than 10 years after liver resection for hepatocellular carcinoma
    • Eguchi S, Kanematsu T, Arii S, Omata M, Kudo M, Sakamoto M, et al. Recurrence-free survival more than 10 years after liver resection for hepatocellular carcinoma. Brit J Surg. 2011; 98: 552-7.
    • (2011) Brit J Surg , vol.98 , pp. 552-557
    • Eguchi, S.1    Kanematsu, T.2    Arii, S.3    Omata, M.4    Kudo, M.5    Sakamoto, M.6
  • 89
    • 34249980343 scopus 로고    scopus 로고
    • Identification and characterization of tumorigenic liver cancer stem/progenitor cells
    • Ma S, Chan K-W, Hu L, Lee TK-W, Wo JY-H, Ng I-L, et al. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology. 2007; 132: 2542-56.
    • (2007) Gastroenterology , vol.132 , pp. 2542-2556
    • Ma, S.1    Chan, K.-W.2    Hu, L.3    Lee, T.K.-W.4    Wo, J.Y.-H.5    Ng, I.-L.6
  • 90
    • 77949891635 scopus 로고    scopus 로고
    • Cancer stem/progenitor cells are highly enriched in CD133+CD44+ population in hepatocellular carcinoma
    • Zhu Z, Hao X, Yan M, Yao M, Ge C, Gu J, et al. Cancer stem/progenitor cells are highly enriched in CD133+CD44+ population in hepatocellular carcinoma. Int J Cancer. 2010; 126: 2067-78.
    • (2010) Int J Cancer , vol.126 , pp. 2067-2078
    • Zhu, Z.1    Hao, X.2    Yan, M.3    Yao, M.4    Ge, C.5    Gu, J.6
  • 91
    • 77957051282 scopus 로고    scopus 로고
    • Characterization of the epithelial cell adhesion molecule (EpCAM) plus cell population in hepatocellular carcinoma cell lines
    • Kimura O, Takahashi T, Ishii N, Inoue Y, Ueno Y, Kogure T, et al. Characterization of the epithelial cell adhesion molecule (EpCAM) plus cell population in hepatocellular carcinoma cell lines. Cancer Sci. 2010; 101: 2145-55.
    • (2010) Cancer Sci , vol.101 , pp. 2145-2155
    • Kimura, O.1    Takahashi, T.2    Ishii, N.3    Inoue, Y.4    Ueno, Y.5    Kogure, T.6
  • 92
    • 60449087921 scopus 로고    scopus 로고
    • EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    • Yamashita T, Ji JF, Budhu A, Forgues M, Yang W, Wang H-Y, et al. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology. 2009; 136: 1012-24.
    • (2009) Gastroenterology , vol.136 , pp. 1012-1024
    • Yamashita, T.1    Ji, J.F.2    Budhu, A.3    Forgues, M.4    Yang, W.5    Wang, H.-Y.6
  • 94
    • 38549139140 scopus 로고    scopus 로고
    • Significance of CD90(+) cancer stem cells in human liver cancer
    • Yang ZF, Ho DW, Ng MN, Lau CK, Yu WC, Ngai P, et al. Significance of CD90(+) cancer stem cells in human liver cancer. Cancer Cell. 2008; 13: 153-66.
    • (2008) Cancer Cell , vol.13 , pp. 153-166
    • Yang, Z.F.1    Ho, D.W.2    Ng, M.N.3    Lau, C.K.4    Yu, W.C.5    Ngai, P.6
  • 95
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis P. Wnt signaling and cancer. Gene Dev. 2000; 14: 1837-51.
    • (2000) Gene Dev , vol.14 , pp. 1837-1851
    • Polakis, P.1
  • 96
    • 49249122615 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells
    • Yang W, Yan H-X, Chen L, Liu Q, He Y-Q, Yu L-X, et al. Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells. Cancer Res. 2008; 68: 4287-95.
    • (2008) Cancer Res , vol.68 , pp. 4287-4295
    • Yang, W.1    Yan, H.-X.2    Chen, L.3    Liu, Q.4    He, Y.-Q.5    Yu, L.-X.6
  • 99
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann PC, Huber SL, Herrler T, Aicher A, Ellwart JW, Guba M, et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell. 2007; 1: 313-23.
    • (2007) Cell Stem Cell , vol.1 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3    Aicher, A.4    Ellwart, J.W.5    Guba, M.6
  • 101
    • 27144557960 scopus 로고    scopus 로고
    • A tumorigenic subpopulation with stem cell properties in melanomas
    • Fang D, Nguyen TK, Leishear K, Finko R, Kulp AN, Hotz S, et al. A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res. 2005; 65: 9328-37.
    • (2005) Cancer Res , vol.65 , pp. 9328-9337
    • Fang, D.1    Nguyen, T.K.2    Leishear, K.3    Finko, R.4    Kulp, A.N.5    Hotz, S.6
  • 102
    • 33847639310 scopus 로고    scopus 로고
    • Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential
    • Monzani E, Facchetti F, Galmozzi E, Corsini E, Benetti A, Cavazzin C, et al. Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential. Eur J Cancer. 2007; 43: 935-46.
    • (2007) Eur J Cancer , vol.43 , pp. 935-946
    • Monzani, E.1    Facchetti, F.2    Galmozzi, E.3    Corsini, E.4    Benetti, A.5    Cavazzin, C.6
  • 104
  • 105
    • 70349547152 scopus 로고    scopus 로고
    • Identification and targeting of cancer stem cells
    • Schatton T, Frank NY, Frank MH. Identification and targeting of cancer stem cells. Bioessays. 2009; 31: 1038-49.
    • (2009) Bioessays , vol.31 , pp. 1038-1049
    • Schatton, T.1    Frank, N.Y.2    Frank, M.H.3
  • 107
    • 0035404677 scopus 로고    scopus 로고
    • Prevalence estimates for primary brain tumors in the United States by behavior and major histology groups
    • Davis FG, Kupelian V, Freels S, McCarthy B, Surawicz T. Prevalence estimates for primary brain tumors in the United States by behavior and major histology groups. Neuro-Oncology. 2001; 3: 152-8.
    • (2001) Neuro-Oncology , vol.3 , pp. 152-158
    • Davis, F.G.1    Kupelian, V.2    Freels, S.3    McCarthy, B.4    Surawicz, T.5
  • 108
    • 79960902716 scopus 로고    scopus 로고
    • Glioblastoma multiforme with very rapid growth and long-term survival in children: Report of two cases and review of the literature
    • Khalatbari MR, Hamidi M, Moharamzad Y. Glioblastoma multiforme with very rapid growth and long-term survival in children: report of two cases and review of the literature. Child Nerv Syst. 2011; 27: 1347-52.
    • (2011) Child Nerv Syst. , vol.27 , pp. 1347-1352
    • Khalatbari, M.R.1    Hamidi, M.2    Moharamzad, Y.3
  • 109
    • 45549093647 scopus 로고    scopus 로고
    • Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis
    • Eyler CE, Rich JN. Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol. 2008; 26: 2839-45.
    • (2008) J Clin Oncol , vol.26 , pp. 2839-2845
    • Eyler, C.E.1    Rich, J.N.2
  • 110
    • 80054975669 scopus 로고    scopus 로고
    • Targeting glioma stem cells: a novel framework for brain tumors
    • Binello E, Germano IM. Targeting glioma stem cells: a novel framework for brain tumors. Cancer Sci. 2011; 102: 1958-66.
    • (2011) Cancer Sci , vol.102 , pp. 1958-1966
    • Binello, E.1    Germano, I.M.2
  • 116
    • 51049101689 scopus 로고    scopus 로고
    • Targeting cancer stem cells through L1CAM suppresses glioma growth
    • Bao S, Wu Q, Li Z, Sathornsumetee S, Wang H, McLendon RE, et al. Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res. 2008; 68: 6043-8.
    • (2008) Cancer Res , vol.68 , pp. 6043-6048
    • Bao, S.1    Wu, Q.2    Li, Z.3    Sathornsumetee, S.4    Wang, H.5    McLendon, R.E.6
  • 117
    • 33748051406 scopus 로고    scopus 로고
    • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
    • Bao S, Wu Q, Sathornsumetee S, Hao Y, Li Z, Hjelmeland AB, et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res. 2006; 66: 7843-8.
    • (2006) Cancer Res , vol.66 , pp. 7843-7848
    • Bao, S.1    Wu, Q.2    Sathornsumetee, S.3    Hao, Y.4    Li, Z.5    Hjelmeland, A.B.6
  • 118
    • 65349115320 scopus 로고    scopus 로고
    • SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma
    • Son MJ, Woolard K, Nam D-H, Lee J, Fine HA. SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma. Cell Stem Cell. 2009; 4: 440-52.
    • (2009) Cell Stem Cell , vol.4 , pp. 440-452
    • Son, M.J.1    Woolard, K.2    Nam, D.-H.3    Lee, J.4    Fine, H.A.5
  • 119
    • 58649111264 scopus 로고    scopus 로고
    • Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma
    • Read T-A, Fogarty MP, Markant SL, McLendon RE, Wei Z, Ellison DW, et al. Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell. 2009; 15: 135-47.
    • (2009) Cancer Cell , vol.15 , pp. 135-147
    • Read, T.-A.1    Fogarty, M.P.2    Markant, S.L.3    McLendon, R.E.4    Wei, Z.5    Ellison, D.W.6
  • 120
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer. 2005; 5: 275-84.
    • (2005) Nat Rev Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 123
    • 76149125786 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer
    • Su Y, Qiu Q, Zhang X, Jiang Z, Leng Q, Liu Z, et al. Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer. Cancer Epidem Biomar. 2010; 19: 327-37.
    • (2010) Cancer Epidem Biomar , vol.19 , pp. 327-337
    • Su, Y.1    Qiu, Q.2    Zhang, X.3    Jiang, Z.4    Leng, Q.5    Liu, Z.6
  • 124
    • 69549114870 scopus 로고    scopus 로고
    • Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells
    • Chan KS, Espinosa I, Chao M, Wong D, Ailles L, Diehn M, et al. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Nat Acad Sci. 2009; 106: 14016-21.
    • (2009) Proc Nat Acad Sci , vol.106 , pp. 14016-14021
    • Chan, K.S.1    Espinosa, I.2    Chao, M.3    Wong, D.4    Ailles, L.5    Diehn, M.6
  • 125
    • 48249150771 scopus 로고    scopus 로고
    • + subset: novel methods for isolating undetermined cancer stem (initiating) cells
    • + subset: novel methods for isolating undetermined cancer stem (initiating) cells. Cancer Invest. 2008; 26: 725-33.
    • (2008) Cancer Invest , vol.26 , pp. 725-733
    • Yang, Y.M.1    Chang, J.W.2
  • 126
    • 70349246548 scopus 로고    scopus 로고
    • Subpopulations of stem-like cells in side population cells from the human bladder transitional cell cancer cell line T24
    • Ning ZF, Huang YJ, Lin TX, Zhou YX, Jiang C, Xu KW, et al. Subpopulations of stem-like cells in side population cells from the human bladder transitional cell cancer cell line T24. J Int Med Res. 2009; 37: 621-30.
    • (2009) J Int Med Res , vol.37 , pp. 621-630
    • Ning, Z.F.1    Huang, Y.J.2    Lin, T.X.3    Zhou, Y.X.4    Jiang, C.5    Xu, K.W.6
  • 127
    • 70349224237 scopus 로고    scopus 로고
    • Hoechst 33342 side population identification is a conserved and unified mechanism in urological cancers
    • Oates JE, Grey BR, Addla SK, Samuel JD, Hart CA, Ramani VAC, et al. Hoechst 33342 side population identification is a conserved and unified mechanism in urological cancers. Stem Cells Dev. 2009; 18: 1515-21.
    • (2009) Stem Cells Dev , vol.18 , pp. 1515-1521
    • Oates, J.E.1    Grey, B.R.2    Addla, S.K.3    Samuel, J.D.4    Hart, C.A.5    Ramani, V.A.C.6
  • 130
    • 79959535385 scopus 로고    scopus 로고
    • New therapies for castration-resistant prostate cancer: efficacy and safety
    • Beltran H, Beer TM, Carducci MA, de Bono J, Gleave M, Hussain M, et al. New therapies for castration-resistant prostate cancer: efficacy and safety. Eur Urol. 2011; 60: 279-90.
    • (2011) Eur Urol , vol.60 , pp. 279-290
    • Beltran, H.1    Beer, T.M.2    Carducci, M.A.3    de Bono, J.4    Gleave, M.5    Hussain, M.6
  • 134
    • 39049101676 scopus 로고    scopus 로고
    • Portrait of PTEN: messages from mutant mice
    • Suzuki A, Nakano T, Mak TW, Sasaki T. Portrait of PTEN: messages from mutant mice. Cancer Sci. 2008; 99: 209-13.
    • (2008) Cancer Sci , vol.99 , pp. 209-213
    • Suzuki, A.1    Nakano, T.2    Mak, T.W.3    Sasaki, T.4
  • 135
    • 49249091523 scopus 로고    scopus 로고
    • Identification and characterization of ovarian cancer-initiating cells from primary human tumors
    • Zhang S, Balch C, Chan MW, Lai H-C, Matei D, Schilder JM, et al. Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res. 2008; 68: 4311-20.
    • (2008) Cancer Res , vol.68 , pp. 4311-4320
    • Zhang, S.1    Balch, C.2    Chan, M.W.3    Lai, H.-C.4    Matei, D.5    Schilder, J.M.6
  • 136
    • 79957480642 scopus 로고    scopus 로고
    • Molecular portraits of intratumoral heterogeneity in human ovarian cancer
    • Choi YP, Shim HS, Gao M-Q, Kang S, Cho NH. Molecular portraits of intratumoral heterogeneity in human ovarian cancer. Cancer Lett. 2011; 307: 62-71.
    • (2011) Cancer Lett , vol.307 , pp. 62-71
    • Choi, Y.P.1    Shim, H.S.2    Gao, M.-Q.3    Kang, S.4    Cho, N.H.5
  • 139
    • 77952240931 scopus 로고    scopus 로고
    • + cells from hierarchically organized ovarian cancer are enriched in cancer stem cells
    • + cells from hierarchically organized ovarian cancer are enriched in cancer stem cells. Oncogene. 2010; 29: 2672-80.
    • (2010) Oncogene , vol.29 , pp. 2672-2680
    • Gao, M.Q.1    Choi, Y.P.2    Kang, S.3    Youn, J.H.4    Cho, N.H.5
  • 140
    • 78649908639 scopus 로고    scopus 로고
    • Mullerian inhibiting substance preferentially inhibits stem/progenitors in human ovarian cancer cell lines compared with chemotherapeutics
    • Wei X, Dombkowski D, Meirelles K, Pieretti-Vanmarcke R, Szotek PP, Chang HL, et al. Mullerian inhibiting substance preferentially inhibits stem/progenitors in human ovarian cancer cell lines compared with chemotherapeutics. Proc Natl Acad Sci USA. 2010; 107: 18874-9.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 18874-18879
    • Wei, X.1    Dombkowski, D.2    Meirelles, K.3    Pieretti-Vanmarcke, R.4    Szotek, P.P.5    Chang, H.L.6
  • 141
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta PB, Onder TT, Jiang GZ, Tao K, Kuperwasser C, Weinberg RA, et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009; 138: 645-59.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.Z.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6
  • 144
    • 0030817282 scopus 로고    scopus 로고
    • Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells
    • Weigmann A, Corbeil D, Hellwig A, Huttner WB. Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. Proc Natl Acad Sci USA. 1997; 94: 12425-30.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12425-12430
    • Weigmann, A.1    Corbeil, D.2    Hellwig, A.3    Huttner, W.B.4
  • 145
    • 58049201990 scopus 로고    scopus 로고
    • The stem cell-associated antigen CD133 (prominin-1) is a molecular therapeutic target for metastatic melanoma
    • Rappa G, Fodstad O, Lorico A. The stem cell-associated antigen CD133 (prominin-1) is a molecular therapeutic target for metastatic melanoma. Stem Cells. 2008; 26: 3008-17.
    • (2008) Stem Cells. , vol.26 , pp. 3008-3017
    • Rappa, G.1    Fodstad, O.2    Lorico, A.3
  • 146
    • 70349100257 scopus 로고    scopus 로고
    • CD133 as a marker for cancer stem cells: progresses and concerns
    • Wu YJ, Wu PY. CD133 as a marker for cancer stem cells: progresses and concerns. Stem Cells Dev. 2009; 18: 1127-34.
    • (2009) Stem Cells Dev , vol.18 , pp. 1127-1134
    • Wu, Y.J.1    Wu, P.Y.2
  • 147
    • 49749144107 scopus 로고    scopus 로고
    • The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells
    • Bidlingmaier S, Zhu X, Liu B. The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells. J Mol Med-Jmm. 2008; 86: 1025-32.
    • (2008) J Mol Med-Jmm , vol.86 , pp. 1025-1032
    • Bidlingmaier, S.1    Zhu, X.2    Liu, B.3
  • 149
    • 78751702579 scopus 로고    scopus 로고
    • Photothermolysis of glioblastoma stem-like cells targeted by carbon nanotubes conjugated with CD133 monoclonal antibody
    • Wang C-H, Chiou S-H, Chou C-P, Chen Y-C, Huang Y-J, Peng C-A. Photothermolysis of glioblastoma stem-like cells targeted by carbon nanotubes conjugated with CD133 monoclonal antibody. Nanomed-Nanotechnol. 2011; 7: 69-79.
    • (2011) Nanomed-Nanotechnol , vol.7 , pp. 69-79
    • Wang, C.-H.1    Chiou, S.-H.2    Chou, C.-P.3    Chen, Y.-C.4    Huang, Y.-J.5    Peng, C.-A.6
  • 150
    • 84855778719 scopus 로고    scopus 로고
    • Development and characterization of immuno-nanocarriers targeting the cancer stem cell marker AC133
    • Bourseau-Guilmain E, Bejaud J, Griveau A, Lautram N, Hindre F, Weyland M, et al. Development and characterization of immuno-nanocarriers targeting the cancer stem cell marker AC133. Int J Pharm. 2012; 423: 93-101.
    • (2012) Int J Pharm , vol.423 , pp. 93-101
    • Bourseau-Guilmain, E.1    Bejaud, J.2    Griveau, A.3    Lautram, N.4    Hindre, F.5    Weyland, M.6
  • 154
    • 34547579096 scopus 로고    scopus 로고
    • Characterisation of the new EpCAM-specific antibody HO-3: implications for trifunctional antibody immunotherapy of cancer
    • Ruf P, Gires O, Jager M, Fellinger K, Atz J, Lindhofer H. Characterisation of the new EpCAM-specific antibody HO-3: implications for trifunctional antibody immunotherapy of cancer. Brit J Cancer. 2007; 97: 315-21.
    • (2007) Brit J Cancer , vol.97 , pp. 315-321
    • Ruf, P.1    Gires, O.2    Jager, M.3    Fellinger, K.4    Atz, J.5    Lindhofer, H.6
  • 155
    • 77953665930 scopus 로고    scopus 로고
    • Structural and functional characterization of the trifunctional antibody catumaxomab
    • Chelius D, Ruf P, Gruber P, Ploscher M, Liedtke R, Gansberger E, et al. Structural and functional characterization of the trifunctional antibody catumaxomab. MABS. 2010; 2: 309-19.
    • (2010) Mabs , vol.2 , pp. 309-319
    • Chelius, D.1    Ruf, P.2    Gruber, P.3    Ploscher, M.4    Liedtke, R.5    Gansberger, E.6
  • 156
    • 76149114375 scopus 로고    scopus 로고
    • Elimination of cancer stem cells (CD133+/EpCAM+) from malignant ascites by the trifunctional antibody catumaxomab: results from a pivotal phase II/III study
    • Lindhofer H, Schoberth A, Pelster D, Hess J, Herold J, Jager M. Elimination of cancer stem cells (CD133+/EpCAM+) from malignant ascites by the trifunctional antibody catumaxomab: results from a pivotal phase II/III study. J Clin Oncol. 2009; 27.
    • (2009) J Clin Oncol. , pp. 27
    • Lindhofer, H.1    Schoberth, A.2    Pelster, D.3    Hess, J.4    Herold, J.5    Jager, M.6
  • 157
    • 84855401998 scopus 로고    scopus 로고
    • Immunomonitoring results of a phase II/III study of malignant ascites patients treated with the trifunctional antibody catumaxomab (anti-EpCAM × anti-CD3)
    • Jager M, Schoberth A, Ruf P, Hess J, Hennig M, Schmalfeldt B, et al. Immunomonitoring results of a phase II/III study of malignant ascites patients treated with the trifunctional antibody catumaxomab (anti-EpCAM × anti-CD3). Cancer Res. 2012; 72: 24-32.
    • (2012) Cancer Res , vol.72 , pp. 24-32
    • Jager, M.1    Schoberth, A.2    Ruf, P.3    Hess, J.4    Hennig, M.5    Schmalfeldt, B.6
  • 158
    • 77956344338 scopus 로고    scopus 로고
    • Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM × anti-CD3) as a targeted cancer immunotherapy
    • Seimetz D, Lindhofer H, Bokemeyer C. Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM × anti-CD3) as a targeted cancer immunotherapy. Cancer Treat Rev. 2010; 36: 458-67.
    • (2010) Cancer Treat Rev , vol.36 , pp. 458-467
    • Seimetz, D.1    Lindhofer, H.2    Bokemeyer, C.3
  • 159
    • 28744445538 scopus 로고    scopus 로고
    • MT110: a novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors
    • Brischwein K, Schlereth B, Guller B, Steiger C, Wolf A, Lutterbuese R, et al. MT110: a novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors. Mol Immunol. 2006; 43: 1129-43.
    • (2006) Mol Immunol , vol.43 , pp. 1129-1143
    • Brischwein, K.1    Schlereth, B.2    Guller, B.3    Steiger, C.4    Wolf, A.5    Lutterbuese, R.6
  • 160
    • 58849085569 scopus 로고    scopus 로고
    • BiTE: teaching antibodies to engage T-cells for cancer therapy
    • Baeuerle PA, Kufer P, Bargou R. BiTE: teaching antibodies to engage T-cells for cancer therapy. Curr Opin Mol Ther. 2009; 11: 22-30.
    • (2009) Curr Opin Mol Ther , vol.11 , pp. 22-30
    • Baeuerle, P.A.1    Kufer, P.2    Bargou, R.3
  • 161
    • 39149130004 scopus 로고    scopus 로고
    • Therapeutic window of MuS110, a single-chain antibody construct bispecific for murine EpCAM and murine CD3
    • Amann M, Brischwein K, Lutterbuese P, Parr L, Petersen L, Lorenczewski G, et al. Therapeutic window of MuS110, a single-chain antibody construct bispecific for murine EpCAM and murine CD3. Cancer Res. 2008; 68: 143-51.
    • (2008) Cancer Res , vol.68 , pp. 143-151
    • Amann, M.1    Brischwein, K.2    Lutterbuese, P.3    Parr, L.4    Petersen, L.5    Lorenczewski, G.6
  • 162
    • 78149460436 scopus 로고    scopus 로고
    • Highly efficient elimination of colorectal tumor-initiating cells by an EpCAM/CD3-bispecific antibody engaging human T cells
    • Herrmann I, Baeuerle PA, Friedrich M, Murr A, Filusch S, Ruttinger D, et al. Highly efficient elimination of colorectal tumor-initiating cells by an EpCAM/CD3-bispecific antibody engaging human T cells. PLoS One. 2010; 5.
    • (2010) PLoS One. , pp. 5
    • Herrmann, I.1    Baeuerle, P.A.2    Friedrich, M.3    Murr, A.4    Filusch, S.5    Ruttinger, D.6
  • 165
    • 0028224082 scopus 로고
    • Randomized trial of monoclonal-antibody for adjuvant therapy of resected Dukes-C colorectal-carcinoma
    • Riethmuller G, Schneidergadicke E, Schlimok G, Schmiegel W, Raab R, Hoffken K, et al. Randomized trial of monoclonal-antibody for adjuvant therapy of resected Dukes-C colorectal-carcinoma. Lancet. 1994; 343: 1177-83.
    • (1994) Lancet , vol.343 , pp. 1177-1183
    • Riethmuller, G.1    Schneidergadicke, E.2    Schlimok, G.3    Schmiegel, W.4    Raab, R.5    Hoffken, K.6
  • 166
    • 0033398990 scopus 로고    scopus 로고
    • Monoclonal antibody therapy with Edrecolomab in breast cancer patients: monitoring of elimination of disseminated cytokeratin-positive tumor cells in bone marrow
    • Braun S, Hepp F, Kentenich CRM, Janni W, Pantel K, Riethmuller G, et al. Monoclonal antibody therapy with Edrecolomab in breast cancer patients: monitoring of elimination of disseminated cytokeratin-positive tumor cells in bone marrow. Clin Cancer Res. 1999; 5: 3999-4004.
    • (1999) Clin Cancer Res , vol.5 , pp. 3999-4004
    • Braun, S.1    Hepp, F.2    Kentenich, C.R.M.3    Janni, W.4    Pantel, K.5    Riethmuller, G.6
  • 167
    • 0036643516 scopus 로고    scopus 로고
    • In vitro and in vivo activity of MT201, a fully human monoclonal antibody for pancarcinoma treatment
    • Naundorf S, Preithner S, Mayer P, Lippold S, Wolf A, Hanakam F, et al. In vitro and in vivo activity of MT201, a fully human monoclonal antibody for pancarcinoma treatment. Int J Cancer. 2002; 100: 101-10.
    • (2002) Int J Cancer , vol.100 , pp. 101-110
    • Naundorf, S.1    Preithner, S.2    Mayer, P.3    Lippold, S.4    Wolf, A.5    Hanakam, F.6
  • 168
    • 20444452496 scopus 로고    scopus 로고
    • Adjuvant therapy with edrecolomab versus observation in stage II colon cancer: a multicenter randomized phase III study
    • Hartung G, Hofheinz RD, Dencausse Y, Sturm J, Kopp-Schneider A, Dietrich G, et al. Adjuvant therapy with edrecolomab versus observation in stage II colon cancer: a multicenter randomized phase III study. Onkologie. 2005; 28: 347-50.
    • (2005) Onkologie , vol.28 , pp. 347-350
    • Hartung, G.1    Hofheinz, R.D.2    Dencausse, Y.3    Sturm, J.4    Kopp-Schneider, A.5    Dietrich, G.6
  • 169
    • 84865535404 scopus 로고    scopus 로고
    • Phase IB study of the EpCAM antibody adecatumumab combined with docetaxel in patients with EpCAM-positive relapsed or refractory advanced-stage breast cancer
    • Schmidt M, Ruttinger D, Sebastian M, Hanusch CA, Marschner N, Baeuerle PA et al. Phase IB study of the EpCAM antibody adecatumumab combined with docetaxel in patients with EpCAM-positive relapsed or refractory advanced-stage breast cancer. Ann Oncol. 2012.
    • (2012) Ann Oncol.
    • Schmidt, M.1    Ruttinger, D.2    Sebastian, M.3    Hanusch, C.A.4    Marschner, N.5    Baeuerle, P.A.6
  • 170
    • 0020577072 scopus 로고
    • A cell-surface molecule involved in organ-specific homing of lymphocytes
    • Gallatin WM, Weissman IL, Butcher EC. A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature. 1983; 304: 30-4.
    • (1983) Nature , vol.304 , pp. 30-34
    • Gallatin, W.M.1    Weissman, I.L.2    Butcher, E.C.3
  • 171
  • 172
    • 0024560984 scopus 로고
    • A lymphocyte molecule implicated in lymph-node homing is a member of the cartilage link protein family
    • Stamenkovic I, Amiot M, Pesando JM, Seed B. A lymphocyte molecule implicated in lymph-node homing is a member of the cartilage link protein family. Cell. 1989; 56: 1057-62.
    • (1989) Cell , vol.56 , pp. 1057-1062
    • Stamenkovic, I.1    Amiot, M.2    Pesando, J.M.3    Seed, B.4
  • 173
    • 10744221425 scopus 로고    scopus 로고
    • Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44
    • Teriete P, Banerji S, Noble M, Blundell CD, Wright AJ, Pickford AR, et al. Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44. Mol Cell. 2004; 13: 483-96.
    • (2004) Mol Cell , vol.13 , pp. 483-496
    • Teriete, P.1    Banerji, S.2    Noble, M.3    Blundell, C.D.4    Wright, A.J.5    Pickford, A.R.6
  • 174
    • 11844256383 scopus 로고    scopus 로고
    • Mechanism and biological significance of CD44 cleavage
    • Nagano O, Saya H. Mechanism and biological significance of CD44 cleavage. Cancer Sci. 2004; 95: 930-5.
    • (2004) Cancer Sci , vol.95 , pp. 930-935
    • Nagano, O.1    Saya, H.2
  • 175
    • 42949092833 scopus 로고    scopus 로고
    • Hyaluronan-CD44-ERK1/2 regulate human aortic smooth muscle cell motility during aging
    • Vigetti D, Viola M, Karousou E, Rizzi M, Moretto P, Genasetti A, et al. Hyaluronan-CD44-ERK1/2 regulate human aortic smooth muscle cell motility during aging. J Biol Chem. 2008; 283: 4448-58.
    • (2008) J Biol Chem , vol.283 , pp. 4448-4458
    • Vigetti, D.1    Viola, M.2    Karousou, E.3    Rizzi, M.4    Moretto, P.5    Genasetti, A.6
  • 176
    • 33645220093 scopus 로고    scopus 로고
    • Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion
    • Cheng CH, Sharp PA. Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion. Mol Cell Biol. 2006; 26: 362-70.
    • (2006) Mol Cell Biol , vol.26 , pp. 362-370
    • Cheng, C.H.1    Sharp, P.A.2
  • 177
    • 0027269982 scopus 로고
    • Identification of hyaluronic-acid binding-sites in the extracellular domain of Cd44
    • Peach RJ, Hollenbaugh D, Stamenkovic I, Aruffo A. Identification of hyaluronic-acid binding-sites in the extracellular domain of Cd44. J Cell Biol. 1993; 122: 257-64.
    • (1993) J Cell Biol , vol.122 , pp. 257-264
    • Peach, R.J.1    Hollenbaugh, D.2    Stamenkovic, I.3    Aruffo, A.4
  • 178
    • 0027425915 scopus 로고
    • Cd44 participates in the adhesion of human colorectal-carcinoma cells to laminin and type-IV collagen
    • Ishii S, Ford R, Thomas P, Nachman A, Steele G, Jessup JM. Cd44 participates in the adhesion of human colorectal-carcinoma cells to laminin and type-IV collagen. Surg Oncol. 1993; 2: 255-64.
    • (1993) Surg Oncol , vol.2 , pp. 255-264
    • Ishii, S.1    Ford, R.2    Thomas, P.3    Nachman, A.4    Steele, G.5    Jessup, J.M.6
  • 179
    • 0026557413 scopus 로고
    • Lymphocyte Cd44 binds the Cooh-terminal heparin-binding domain of fibronectin
    • Jalkanen S, Jalkanen M. Lymphocyte Cd44 binds the Cooh-terminal heparin-binding domain of fibronectin. J Cell Biol. 1992; 116: 817-25.
    • (1992) J Cell Biol , vol.116 , pp. 817-825
    • Jalkanen, S.1    Jalkanen, M.2
  • 180
    • 67651159117 scopus 로고    scopus 로고
    • Cancer cells in transit: the vascular interactions of tumor cells
    • Konstantopoulos K, Thomas SN. Cancer cells in transit: the vascular interactions of tumor cells. Ann Rev Biomed Eng. 2009; 11: 177-202.
    • (2009) Ann Rev Biomed Eng , vol.11 , pp. 177-202
    • Konstantopoulos, K.1    Thomas, S.N.2
  • 181
    • 0028273202 scopus 로고
    • A novel ligand for Cd44 is sulfated proteoglycan
    • Toyamasorimachi N, Miyasaka M. A novel ligand for Cd44 is sulfated proteoglycan. Int Immunol. 1994; 6: 655-60.
    • (1994) Int Immunol , vol.6 , pp. 655-660
    • Toyamasorimachi, N.1    Miyasaka, M.2
  • 182
    • 0031571729 scopus 로고    scopus 로고
    • Phorbol myristate acetate stimulates the dimerization of CD44 involving a cysteine in the transmembrane domain
    • Liu DC, Sy MS. Phorbol myristate acetate stimulates the dimerization of CD44 involving a cysteine in the transmembrane domain. J Immunol. 1997; 159: 2702-11.
    • (1997) J Immunol , vol.159 , pp. 2702-2711
    • Liu, D.C.1    Sy, M.S.2
  • 183
    • 0033598190 scopus 로고    scopus 로고
    • Analysis of CD44-containing lipid rafts: recruitment of annexin II and stabilization by the actin cytoskeleton
    • Oliferenko S, Paiha K, Harder T, Gerke V, Schwarzler C, Schwarz H, et al. Analysis of CD44-containing lipid rafts: recruitment of annexin II and stabilization by the actin cytoskeleton. J Cell Biol. 1999; 146: 843-54.
    • (1999) J Cell Biol , vol.146 , pp. 843-854
    • Oliferenko, S.1    Paiha, K.2    Harder, T.3    Gerke, V.4    Schwarzler, C.5    Schwarz, H.6
  • 185
    • 0034116088 scopus 로고    scopus 로고
    • The CD44-initiated pathway of T-cell extravasation uses VLA-4 but not LFA-1 for firm adhesion
    • Siegelman MH, Stanescu D, Estess P. The CD44-initiated pathway of T-cell extravasation uses VLA-4 but not LFA-1 for firm adhesion. J Clin Invest. 2000; 105: 683-91.
    • (2000) J Clin Invest , vol.105 , pp. 683-691
    • Siegelman, M.H.1    Stanescu, D.2    Estess, P.3
  • 186
    • 33845907908 scopus 로고    scopus 로고
    • Leukaemia-niche retreats for stem cells
    • Williams DA, Cancelas JA. Leukaemia-niche retreats for stem cells. Nature. 2006; 444: 827-8.
    • (2006) Nature , vol.444 , pp. 827-828
    • Williams, D.A.1    Cancelas, J.A.2
  • 187
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis
    • Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell. 2008; 14: 818-29.
    • (2008) Dev Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 188
    • 3042697038 scopus 로고    scopus 로고
    • Hyaluronan: from extracellular glue to pericellular cue
    • Toole BP. Hyaluronan: from extracellular glue to pericellular cue. Nat Rev Cancer. 2004; 4: 528-39.
    • (2004) Nat Rev Cancer , vol.4 , pp. 528-539
    • Toole, B.P.1
  • 190
    • 33748320471 scopus 로고    scopus 로고
    • New strategies for the treatment of acute myeloid leukemia including antibodies and other novel agents
    • Tallman MS. New strategies for the treatment of acute myeloid leukemia including antibodies and other novel agents. Hematology Am Soc Hematol Educ Program. 2005: 143-50.
    • (2005) Hematology Am Soc Hematol Educ Program , pp. 143-150
    • Tallman, M.S.1
  • 191
    • 33644827383 scopus 로고    scopus 로고
    • Bone-marrow haematopoietic-stem-cell niches
    • Wilson A, Trumpp A. Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol. 2006; 6: 93-106.
    • (2006) Nat Rev Immunol , vol.6 , pp. 93-106
    • Wilson, A.1    Trumpp, A.2
  • 192
    • 23244435467 scopus 로고    scopus 로고
    • How do stem cells find their way home?
    • Lapidot T, Dar A, Kollet O. How do stem cells find their way home? Blood. 2005; 106: 1901-10.
    • (2005) Blood , vol.106 , pp. 1901-1910
    • Lapidot, T.1    Dar, A.2    Kollet, O.3
  • 193
    • 62549090127 scopus 로고    scopus 로고
    • CD44 targeting reduces tumour growth and prevents post-chemotherapy relapse of human breast cancers xenografts
    • Marangoni E, Lecomte N, Durand L, de Pinieux G, Decaudin D, Chomienne C, et al. CD44 targeting reduces tumour growth and prevents post-chemotherapy relapse of human breast cancers xenografts. Brit J Cancer. 2009; 100: 918-22.
    • (2009) Brit J Cancer , vol.100 , pp. 918-922
    • Marangoni, E.1    Lecomte, N.2    Durand, L.3    de Pinieux, G.4    Decaudin, D.5    Chomienne, C.6
  • 195
    • 0033597108 scopus 로고    scopus 로고
    • The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2
    • Taylor VC, Buckley CD, Douglas M, Cody AJ, Simmons DL, Freeman SD. The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2. J Biol Chem. 1999; 274: 11505-12.
    • (1999) J Biol Chem , vol.274 , pp. 11505-11512
    • Taylor, V.C.1    Buckley, C.D.2    Douglas, M.3    Cody, A.J.4    Simmons, D.L.5    Freeman, S.D.6
  • 196
    • 14344285159 scopus 로고    scopus 로고
    • Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells
    • Vitale C, Romagnani C, Puccetti A, Olive D, Costello R, Chiossone L, et al. Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells. Proc Natl Acad Sci U S A. 2001; 98: 5764-9.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 5764-5769
    • Vitale, C.1    Romagnani, C.2    Puccetti, A.3    Olive, D.4    Costello, R.5    Chiossone, L.6
  • 197
    • 33645063449 scopus 로고    scopus 로고
    • A CD33-specific single-chain immunotoxin mediates potent apoptosis of cultured human myeloid leukaemia cells
    • Schwemmlein M, Peipp M, Barbin K, Saul D, Stockmeyer B, Repp R, et al. A CD33-specific single-chain immunotoxin mediates potent apoptosis of cultured human myeloid leukaemia cells. Br J Haematol. 2006; 133: 141-51.
    • (2006) Br J Haematol , vol.133 , pp. 141-151
    • Schwemmlein, M.1    Peipp, M.2    Barbin, K.3    Saul, D.4    Stockmeyer, B.5    Repp, R.6
  • 198
    • 0042303836 scopus 로고    scopus 로고
    • Antibody-targeted chemotherapy with immunoconjugates of calicheamicin
    • Damle NK, Frost P. Antibody-targeted chemotherapy with immunoconjugates of calicheamicin. Curr Opin Pharmacol. 2003; 3: 386-90.
    • (2003) Curr Opin Pharmacol , vol.3 , pp. 386-390
    • Damle, N.K.1    Frost, P.2
  • 199
    • 0036007596 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia
    • Hamann PR, Hinman LM, Hollander I, Beyer CF, Lindh D, Holcomb R, et al. Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia. Bioconjug Chem. 2002; 13: 47-58.
    • (2002) Bioconjug Chem , vol.13 , pp. 47-58
    • Hamann, P.R.1    Hinman, L.M.2    Hollander, I.3    Beyer, C.F.4    Lindh, D.5    Holcomb, R.6
  • 200
    • 0036007598 scopus 로고    scopus 로고
    • An anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia. Choice of linker
    • Hamann PR, Hinman LM, Beyer CF, Lindh D, Upeslacis J, Flowers DA, et al. An anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia. Choice of linker. Bioconjug Chem. 2002; 13: 40-6.
    • (2002) Bioconjug Chem , vol.13 , pp. 40-46
    • Hamann, P.R.1    Hinman, L.M.2    Beyer, C.F.3    Lindh, D.4    Upeslacis, J.5    Flowers, D.A.6
  • 201
    • 13544266555 scopus 로고    scopus 로고
    • CD33-directed therapy with gemtuzumab ozogamicin in acute myeloid leukemia: progress in understanding cytotoxicity and potential mechanisms of drug resistance
    • Linenberger ML. CD33-directed therapy with gemtuzumab ozogamicin in acute myeloid leukemia: progress in understanding cytotoxicity and potential mechanisms of drug resistance. Leukemia. 2005; 19: 176-82.
    • (2005) Leukemia , vol.19 , pp. 176-182
    • Linenberger, M.L.1
  • 202
    • 84874803248 scopus 로고    scopus 로고
    • http://www. fda. gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm216458. htm.
  • 204
    • 33646860759 scopus 로고    scopus 로고
    • Beyond mere markers-functions for CD34 family of sialomucins in hematopoiesis
    • Furness SGB, McNagny K. Beyond mere markers-functions for CD34 family of sialomucins in hematopoiesis. Immunol Res. 2006; 34: 13-32.
    • (2006) Immunol Res , vol.34 , pp. 13-32
    • Furness, S.G.B.1    McNagny, K.2
  • 205
    • 0021250078 scopus 로고
    • Antigenic analysis of hematopoiesis.3. A hematopoietic progenitor-cell surface-antigen defined by a monoclonal-antibody raised against Kg-1a cells
    • Civin CI, Strauss LC, Brovall C, Fackler MJ, Schwartz JF, Shaper JH. Antigenic analysis of hematopoiesis. 3. A hematopoietic progenitor-cell surface-antigen defined by a monoclonal-antibody raised against Kg-1a cells. J Immunol. 1984; 133: 157-65.
    • (1984) J Immunol , vol.133 , pp. 157-165
    • Civin, C.I.1    Strauss, L.C.2    Brovall, C.3    Fackler, M.J.4    Schwartz, J.F.5    Shaper, J.H.6
  • 207
    • 59549100452 scopus 로고    scopus 로고
    • Novel functions of the CD34 family
    • Nielsen JS, McNagny KM. Novel functions of the CD34 family. J Cell Sci. 2008; 121: 3683-92.
    • (2008) J Cell Sci , vol.121 , pp. 3683-3692
    • Nielsen, J.S.1    McNagny, K.M.2
  • 208
  • 209
  • 211
    • 0028200101 scopus 로고
    • Characterization of murine CD34, a marker for hematopoietic progenitor and stem-cells
    • Krause DS, Ito T, Fackler MJ, Smith OM, Collector MI, Sharkis SJ, et al. Characterization of murine CD34, a marker for hematopoietic progenitor and stem-cells. Blood. 1994; 84: 691-701.
    • (1994) Blood , vol.84 , pp. 691-701
    • Krause, D.S.1    Ito, T.2    Fackler, M.J.3    Smith, O.M.4    Collector, M.I.5    Sharkis, S.J.6
  • 212
    • 33749054263 scopus 로고    scopus 로고
    • Na+/H + exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins
    • Tan PC, Furness SGB, Merkens H, Lin SJ, McCoy ML, Roskelley CD, et al. Na+/H + exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins. Stem Cells. 2006; 24: 1150-61.
    • (2006) Stem Cells , vol.24 , pp. 1150-1161
    • Tan, P.C.1    Furness, S.G.B.2    Merkens, H.3    Lin, S.J.4    McCoy, M.L.5    Roskelley, C.D.6
  • 213
    • 0029016926 scopus 로고
    • Full-length but not truncated Cd34 inhibits hematopoietic-cell differentiation of M1 cells
    • Fackler MJ, Krause DS, Smith OM, Civin CI, May WS. Full-length but not truncated Cd34 inhibits hematopoietic-cell differentiation of M1 cells. Blood. 1995; 85: 3040-7.
    • (1995) Blood , vol.85 , pp. 3040-3047
    • Fackler, M.J.1    Krause, D.S.2    Smith, O.M.3    Civin, C.I.4    May, W.S.5
  • 216
  • 218
    • 79951698213 scopus 로고    scopus 로고
    • Aminopeptidase N (CD13) as a target for cancer chemotherapy
    • Wickstrom M, Larsson R, Nygren P, Gullbo J. Aminopeptidase N (CD13) as a target for cancer chemotherapy. Cancer Sci. 2011; 102: 501-8.
    • (2011) Cancer Sci , vol.102 , pp. 501-508
    • Wickstrom, M.1    Larsson, R.2    Nygren, P.3    Gullbo, J.4
  • 219
    • 33947585099 scopus 로고    scopus 로고
    • The structure and main functions of aminopeptidase N
    • Luan YP, Xu WF. The structure and main functions of aminopeptidase N. Curr Med Chem. 2007; 14: 639-47.
    • (2007) Curr Med Chem , vol.14 , pp. 639-647
    • Luan, Y.P.1    Xu, W.F.2
  • 220
    • 0017236348 scopus 로고
    • Bestatin, an inhibitor of aminopeptidase-B, produced by actinomycetes
    • Umezawa H, Aoyagi T, Suda H, Hamada M, Takeuchi T. Bestatin, an inhibitor of aminopeptidase-B, produced by actinomycetes. J Antibiot. 1976; 29: 97-9.
    • (1976) J Antibiot , vol.29 , pp. 97-99
    • Umezawa, H.1    Aoyagi, T.2    Suda, H.3    Hamada, M.4    Takeuchi, T.5
  • 222
    • 0025831834 scopus 로고
    • Bestatin, an aminopeptidase inhibitor with a multi-pharmacological function
    • Mathe G. Bestatin, an aminopeptidase inhibitor with a multi-pharmacological function. Biomed Pharmacother. 1991; 45: 49-54.
    • (1991) Biomed Pharmacother , vol.45 , pp. 49-54
    • Mathe, G.1
  • 223
    • 0033046028 scopus 로고    scopus 로고
    • Induction of apoptosis by bestatin (ubenimex) in human leukemic cell lines
    • Sekine K, Fujii H, Abe F. Induction of apoptosis by bestatin (ubenimex) in human leukemic cell lines. Leukemia. 1999; 13: 729-34.
    • (1999) Leukemia , vol.13 , pp. 729-734
    • Sekine, K.1    Fujii, H.2    Abe, F.3
  • 224
    • 0029781804 scopus 로고    scopus 로고
    • Induction of apoptosis by ubenimex (Bestatin(R)) in human non-small-cell lung cancer cell lines
    • Ezawa K, Minato K, Dobashi K. Induction of apoptosis by ubenimex (Bestatin(R)) in human non-small-cell lung cancer cell lines. Biomed Pharmacother. 1996; 50: 283-9.
    • (1996) Biomed Pharmacother , vol.50 , pp. 283-289
    • Ezawa, K.1    Minato, K.2    Dobashi, K.3
  • 225
    • 0035146853 scopus 로고    scopus 로고
    • Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation
    • Thunnissen MMGM, Nordlund P, Haeggstrom JZ. Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation. Nat Struct Biol. 2001; 8: 131-5.
    • (2001) Nat Struct Biol , vol.8 , pp. 131-135
    • Thunnissen, M.M.G.M.1    Nordlund, P.2    Haeggstrom, J.Z.3
  • 226
    • 84874816685 scopus 로고    scopus 로고
    • Leukotriene A4 hydrolase, the gatekeeper of chemotactic leukotriene B4 biosynthesis
    • Tholander F, Rudberg P, Thunnissen M, Haeggstrom JZ. Leukotriene A4 hydrolase, the gatekeeper of chemotactic leukotriene B4 biosynthesis. Prostag Oth Lipid M. 2006; 79: 157.
    • (2006) Prostag Oth Lipid M , vol.79 , pp. 157
    • Tholander, F.1    Rudberg, P.2    Thunnissen, M.3    Haeggstrom, J.Z.4
  • 227
    • 79951907904 scopus 로고    scopus 로고
    • Flow cytometric analysis of CD123 is useful for immunophenotyping classical Hodgkin lymphoma
    • Fromm JR. Flow cytometric analysis of CD123 is useful for immunophenotyping classical Hodgkin lymphoma. Cytom Part B-Clin Cy. 2011; 80B: 91-9.
    • (2011) Cytom Part B-Clin Cy , vol.80 B , pp. 91-99
    • Fromm, J.R.1
  • 228
    • 67649200331 scopus 로고    scopus 로고
    • Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells
    • Jin LQ, Lee EM, Ramshaw HS, Busfield SJ, Peoppl AG, Wilkinson L, et al. Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells. Cell Stem Cell. 2009; 5: 31-42.
    • (2009) Cell Stem Cell , vol.5 , pp. 31-42
    • Jin, L.Q.1    Lee, E.M.2    Ramshaw, H.S.3    Busfield, S.J.4    Peoppl, A.G.5    Wilkinson, L.6
  • 229
    • 0027443140 scopus 로고
    • Molecular-cloning of integrin-associated protein-an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha-nu-beta-3-dependent ligand-binding
    • Lindberg FP, Gresham HD, Schwarz E, Brown EJ. Molecular-cloning of integrin-associated protein-an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha-nu-beta-3-dependent ligand-binding. J Cell Biol. 1993; 123: 485-96.
    • (1993) J Cell Biol , vol.123 , pp. 485-496
    • Lindberg, F.P.1    Gresham, H.D.2    Schwarz, E.3    Brown, E.J.4
  • 230
    • 0035280238 scopus 로고    scopus 로고
    • Integrin-associated protein (CD47) and its ligands
    • Brown EJ, Frazier WA. Integrin-associated protein (CD47) and its ligands. Trends Cell Biol. 2001; 11: 130-5.
    • (2001) Trends Cell Biol , vol.11 , pp. 130-135
    • Brown, E.J.1    Frazier, W.A.2
  • 231
    • 47349105855 scopus 로고    scopus 로고
    • Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47
    • Hatherley D, Graham SC, Turner J, Harlos K, Stuart DI, Barclay AN. Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. Mol Cell. 2008; 31: 266-77.
    • (2008) Mol Cell , vol.31 , pp. 266-277
    • Hatherley, D.1    Graham, S.C.2    Turner, J.3    Harlos, K.4    Stuart, D.I.5    Barclay, A.N.6
  • 232
    • 79952282655 scopus 로고    scopus 로고
    • Monoclonal antibody therapy directed against human acute myeloid leukemia stem cells
    • Majeti R. Monoclonal antibody therapy directed against human acute myeloid leukemia stem cells. Oncogene. 2011; 30: 1009-19.
    • (2011) Oncogene , vol.30 , pp. 1009-1019
    • Majeti, R.1


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