Anti-cancer activity of carbamate derivatives of melampomagnolide B

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 15, 2014, Pages 3499-3502

  Janganati, Venumadhav ^a   Penthala, Narsimha Reddy ^a   Madadi, Nikhil Reddy ^a   Chen, Zheng ^a   Crooks, Peter A ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Anti cancer activity; Carbamates; Heterocyclic amines; Melampomagnolide B; Parthenolide

Indexed keywords

ANTILEUKEMIC AGENT; ANTINEOPLASTIC AGENT; CARBAMIC ACID DERIVATIVE; MELAMPOMAGNOLIDE B; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; [1ALPHA METHYL 8 METHYLENE 9 OXO 1ALPHA,2,3,6,7, 7ALPHA,8,9,10ALPHA,10BETA DECAHYDROOXIRENOL(2',3':9,10)CYCLODECAL[1,2 B]FURAN 5 YL]METHYL (3 MORPHOLINOPROPYL)CARBAMATE; [1ALPHA METHYL 8 METHYLENE 9 OXO 1ALPHA,2,3,6,7, 7ALPHA,8,9,10ALPHA,10BETA DECAHYDROOXIRENOL(2',3':9,10)CYCLODECAL[1,2 B]FURAN 5 YL]METHYL [3 (1H IMIDAZOL 1 YL)PROPYL]CARBAMATE; [1ALPHA METHYL 8 METHYLENE 9 OXO 1ALPHA,2,3,6,7, 7ALPHA,8,9,10ALPHA,10BETA DECAHYDROOXIRENOL(2',3':9,10)CYCLODECAL[1,2 B]FURAN 5 YL]METHYL [5 (METHYLTHIO) 1H 1,2,4 TRIAZOL 3 YL]CARBAMATE; [1ALPHA METHYL 8 METHYLENE 9 OXO 1ALPHA,2,3,6,7, 7ALPHA,8,9,10ALPHA,10BETA DECAHYDROOXIRENOL[2',3':9,10]CYCLODECAL[1,2 B]FURAN 5 YL]METHYL 4,4 DIFLUOROPIPERIDINE 1 CARBOXYLATE; [1ALPHA METHYL 8 METHYLENE 9 OXO 1ALPHA,2,3,6,7, 7ALPHA,8,9,10ALPHA,10BETA DECAHYDROOXIRENOL[2',3':9,10]CYCLODECAL[1,2 B]FURAN 5 YL]METHYL [2 (PYRIDIN 2 YL)ETHYL]CARBAMATE; [1ALPHA METHYL 8 METHYLENE 9 OXO 1ALPHA,2,3,6,7, 7ALPHA,8,9,10ALPHA,10BETA DECAHYDROOXIRENOL[2',3':9,10]CYCLODECAL[1,2 B]FURAN 5 YL]METHYL [2 (PYRROLIDIN 1 YL)ETHYL]CARBAMATE; [1ALPHA METHYL 8 METHYLENE 9 OXO 1ALPHA,2,3,6,7, 7ALPHA,8,9,10ALPHA,10BETA DECAHYDROOXIRENOL[2',3':9,10]CYCLODECAL[1,2 B]FURAN 5 YL]METHYL [2 MORPHOLINO ETHYL]CARBAMATE; HYDROXYL GROUP; PARTHENOLIDE; SESQUITERPENE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CANCER CELL; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; CENTRAL NERVOUS SYSTEM TUMOR; COLON CANCER; CONTROLLED STUDY; DRUG HALF LIFE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; KIDNEY CANCER; LEUKEMIA; LEUKEMIA CELL LINE; LUNG CANCER; LUNG CANCER CELL LINE; LUNG NON SMALL CELL CANCER; MELANOMA; MICHAEL ADDITION; NUCLEAR MAGNETIC RESONANCE; OVARY CANCER; OXIDATIVE STRESS; PROSTATE CANCER; RENAL CANCER CELL LINE; STRUCTURE ACTIVITY RELATION; BIOLOGICAL ACTIVITY; CANCER CELL LINE; NON SMALL CELL LUNG CANCER; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; SYNTHESIS; TANACETUM PARTHENIUM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARBAMATES; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP; TANACETUM PARTHENIUM;

EID: 84904063662     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.05.059     Document Type: Article

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