Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death

ACS Chemical Biology

Volumn 8, Issue 5, 2013, Pages 923-929

  Adams, Drew J ^a,b   Boskovic, Zarko V ^a,b,c   Theriault, Jimmy R ^a   Wang, Alex J ^a   Stern, Andrew M ^a   Wagner, Bridget K ^a   Shamji, Alykhan F ^a   Schreiber, Stuart L ^a,b,c  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BRD 5459; BRD 56491; BRD 9092; BUTHIONINE SULFOXIMINE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; 1,3 DIOXOLANE DERIVATIVE; MOLECULAR LIBRARY; MOLECULAR PROBE; PIPERLONGUMININE;

ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL DEATH; CELL TRANSFORMATION; CELL VIABILITY; CONTROLLED STUDY; ELECTROPHILICITY; ENHANCER REGION; GENOTYPE; GLUTATHIONE METABOLISM; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULE; OSTEOSARCOMA CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; BONE NEOPLASMS; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; METABOLISM; MOLECULAR LIBRARY; MOLECULAR PROBE; OSTEOSARCOMA; PATHOLOGY; PHARMACOLOGY; PROCEDURES; TRANSFORMED CELL LINE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BONE NEOPLASMS; BUTHIONINE SULFOXIMINE; CELL DEATH; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL SURVIVAL; DIOXOLANES; DRUG SCREENING ASSAYS, ANTITUMOR; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR PROBES; OSTEOSARCOMA; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SMALL MOLECULE LIBRARIES;

EID: 84878026528     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb300653v     Document Type: Article

References (31)

1. Trachootham, D., Alexandre, J., and Huang, P. (2009) Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat. Rev. Drug Discovery 8, 579-591
2. Winterbourn, C. C. and Hampton, M. B. (2008) Thiol chemistry and specificity in redox signaling Free Radical Biol. Med. 45, 549-561
3. Murphy, M. P., Holmgren, A., Larsson, N. G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., Nystrom, T., Belousov, V., Schumacker, P. T., and Winterbourn, C. C. (2011) Unraveling the biological roles of reactive oxygen species Cell Metab. 13, 361-366
4. Baird, L. and Dinkova-Kostova, A. T. (2011) The cytoprotective role of the Keap1-Nrf2 pathway Arch. Toxicol. 85, 241-272
5. Ma, Z. A. (2012) The role of peroxidation of mitochondrial membrane phospholipids in pancreatic beta-cell failure Curr. Diabetes Rev. 8, 69-75
6. Victor, V. M., Rocha, M., Herance, R., and Hernandez-Mijares, A. (2011) Oxidative stress and mitochondrial dysfunction in type 2 diabetes Curr. Pharm. Des. 17, 3947-3958
7. Chen, A. F., Chen, D. D., Daiber, A., Faraci, F. M., Li, H., Rembold, C. M., and Laher, I. (2012) Free radical biology of the cardiovascular system Clin. Sci. (London) 123, 73-91
8. Andersen, J. K. (2004) Oxidative stress in neurodegeneration: cause or consequence? Nat. Med. 10 (Suppl) S18-25
9. Li, Q., Spencer, N. Y., Pantazis, N. J., and Engelhardt, J. F. (2011) Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicity J. Biol. Chem. 286, 40151-40162
10. Haigis, M. C. and Yankner, B. A. (2010) The aging stress response Mol. Cell 40, 333-344
11. Harman, D. (1956) Aging: a theory based on free radical and radiation chemistry J. Gerontol. 11, 298-300
12. Schumacker, P. T. (2006) Reactive oxygen species in cancer cells: live by the sword, die by the sword Cancer Cell 10, 175-176 (Pubitemid 44311072)
13. Luo, J., Solimini, N. L., and Elledge, S. J. (2009) Principles of cancer therapy: oncogene and non-oncogene addiction Cell 136, 823-837
14. Watson, J. (2013) Oxidants, antioxidants and the current incurability of metastatic cancers Open Biol. 3, 120144
15. Szatrowski, T. P. and Nathan, C. F. (1991) Production of large amounts of hydrogen peroxide by human tumor cells Cancer Res. 51, 794-798
16. Lee, A. C., Fenster, B. E., Ito, H., Takeda, K., Bae, N. S., Hirai, T., Yu, Z. X., Ferrans, V. J., Howard, B. H., and Finkel, T. (1999) Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species J. Biol. Chem. 274, 7936-7940
17. Wondrak, G. T. (2009) Redox-directed cancer therapeutics: molecular mechanisms and opportunities Antioxid. Redox Signaling 11, 3013-3069
18. Trachootham, D., Zhou, Y., Zhang, H., Demizu, Y., Chen, Z., Pelicano, H., Chiao, P. J., Achanta, G., Arlinghaus, R. B., Liu, J., and Huang, P. (2006) Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate Cancer Cell 10, 241-252 (Pubitemid 44311067)
19. Guzman, M. L., Rossi, R. M., Neelakantan, S., Li, X., Corbett, C. A., Hassane, D. C., Becker, M. W., Bennett, J. M., Sullivan, E., Lachowicz, J. L., Vaughan, A., Sweeney, C. J., Matthews, W., Carroll, M., Liesveld, J. L., Crooks, P. A., and Jordan, C. T. (2007) An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells Blood 110, 4427-4435 (Pubitemid 351377809)
20. Raj, L., Ide, T., Gurkar, A. U., Foley, M., Schenone, M., Li, X., Tolliday, N. J., Golub, T. R., Carr, S. A., Shamji, A. F., Stern, A. M., Mandinova, A., Schreiber, S. L., and Lee, S. W. (2011) Selective killing of cancer cells by a small molecule targeting the stress response to ROS Nature 475, 231-234
21. Dolma, S., Lessnick, S. L., Hahn, W. C., and Stockwell, B. R. (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells Cancer Cell 3, 285-296 (Pubitemid 37443883)
22. Shaw, A. T., Winslow, M. M., Magendantz, M., Ouyang, C., Dowdle, J., Subramanian, A., Lewis, T. A., Maglathin, R. L., Tolliday, N., and Jacks, T. (2011) Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress Proc. Natl. Acad. Sci. U.S.A. 108, 8773-8778
23. Wagner, B. K., Kitami, T., Gilbert, T. J., Peck, D., Ramanathan, A., Schreiber, S. L., Golub, T. R., and Mootha, V. K. (2008) Large-scale chemical dissection of mitochondrial function Nat. Biotechnol. 26, 343-351 (Pubitemid 351355127)
24. Hur, W., Sun, Z., Jiang, T., Mason, D. E., Peters, E. C., Zhang, D. D., Luesch, H., Schultz, P. G., and Gray, N. S. (2010) A small-molecule inducer of the antioxidant response element Chem. Biol. 17, 537-547
25. Adams, D. J., Dai, M., Pellegrino, G., Wagner, B. K., Stern, A. M., Shamji, A. F., and Schreiber, S. L. (2012) Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs Proc. Natl. Acad. Sci. U.S.A. 109, 15115-15120
26. Fang, J., Nakamura, H., and Iyer, A. K. (2007) Tumor-targeted induction of oxystress for cancer therapy J. Drug Targeting 15, 475-486 (Pubitemid 47213870)
27. Hagenbuchner, J., Kuznetsov, A., Hermann, M., Hausott, B., Obexer, P., and Ausserlechner, M. J. (2012) FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3 J. Cell Sci. 125, 1191-1203
28. Levy, E. J., Anderson, M. E., and Meister, A. (1993) Transport of glutathione diethyl ester into human cells Proc. Natl. Acad. Sci. U.S.A. 90, 9171-9175 (Pubitemid 23306474)
29. Hahn, W. C., Counter, C. M., Lundberg, A. S., Beijersbergen, R. L., Brooks, M. W., and Weinberg, R. A. (1999) Creation of human tumour cells with defined genetic elements Nature 400, 464-468 (Pubitemid 29361801)
30. Lundberg, A. S., Randell, S. H., Stewart, S. A., Elenbaas, B., Hartwell, K. A., Brooks, M. W., Fleming, M. D., Olsen, J. C., Miller, S. W., Weinberg, R. A., and Hahn, W. C. (2002) Immortalization and transformation of primary human airway epithelial cells by gene transfer Oncogene 21, 4577-4586 (Pubitemid 34785734)
31. Elenbaas, B., Spirio, L., Koerner, F., Fleming, M. D., Zimonjic, D. B., Donaher, J. L., Popescu, N. C., Hahn, W. C., and Weinberg, R. A. (2001) Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells Genes Dev. 15, 50-65 (Pubitemid 32060682)