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Volumn 338, Issue 1, 2013, Pages 15-22

Selective elimination of leukemia stem cells: Hitting a moving target

Author keywords

CML; Hematologic malignancies; Leukemia; Microenvironment; Stem cells; Therapeutics

Indexed keywords

BETA CATENIN; CD34 ANTIGEN; CD38 ANTIGEN; CHAPERONE; CYCLOPAMINE; DASATINIB; GDC 0049; IMATINIB; NILOTINIB; PF 04449913; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; VISMODEGIB;

EID: 84882913815     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2012.08.006     Document Type: Review
Times cited : (52)

References (99)
  • 1
    • 0017785769 scopus 로고
    • Primary bioassay of human tumor stem cells
    • Hamburger A.W., Salmon S.E. Primary bioassay of human tumor stem cells. Science 1977, 197:461-463.
    • (1977) Science , vol.197 , pp. 461-463
    • Hamburger, A.W.1    Salmon, S.E.2
  • 3
    • 0022913781 scopus 로고
    • Clonogenic cells in acute myeloblastic leukemia
    • Griffin J.D., Lowenberg B. Clonogenic cells in acute myeloblastic leukemia. Blood 1986, 68:1185-1195.
    • (1986) Blood , vol.68 , pp. 1185-1195
    • Griffin, J.D.1    Lowenberg, B.2
  • 4
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D., Dick J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 1997, 3:730-737.
    • (1997) Nat. Med. , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 6
    • 0030988803 scopus 로고    scopus 로고
    • Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo
    • Blair A., Hogge D.E., Ailles L.E., Lansdorp P.M., Sutherland H.J. Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo. Blood 1997, 89:3104-3112.
    • (1997) Blood , vol.89 , pp. 3104-3112
    • Blair, A.1    Hogge, D.E.2    Ailles, L.E.3    Lansdorp, P.M.4    Sutherland, H.J.5
  • 11
    • 0017653321 scopus 로고
    • Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage
    • Fialkow P.J., Jacobson R.J., Papayannopoulou T. Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am. J. Med. 1977, 63:125-130.
    • (1977) Am. J. Med. , vol.63 , pp. 125-130
    • Fialkow, P.J.1    Jacobson, R.J.2    Papayannopoulou, T.3
  • 12
    • 0025117392 scopus 로고
    • Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
    • Daley G.Q., Van Etten R.A., Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 1990, 247:824-830.
    • (1990) Science , vol.247 , pp. 824-830
    • Daley, G.Q.1    Van Etten, R.A.2    Baltimore, D.3
  • 17
    • 72849159485 scopus 로고
    • Chromosome studies on normal and leukemic human leukocytes
    • Nowell P.C., Hungerford D.A. Chromosome studies on normal and leukemic human leukocytes. J. Nat. Cancer Inst. 1960, 25:85-109.
    • (1960) J. Nat. Cancer Inst. , vol.25 , pp. 85-109
    • Nowell, P.C.1    Hungerford, D.A.2
  • 18
    • 0015694748 scopus 로고
    • Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and giemsa staining
    • Rowley J.D. Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and giemsa staining. Nature 1973, 243:290-293.
    • (1973) Nature , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 19
    • 0021802841 scopus 로고
    • Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
    • Shtivelman E., Lifshitz B., Gale R.P., Canaani E. Fused transcript of abl and bcr genes in chronic myelogenous leukaemia. Nature 1985, 315:550-554.
    • (1985) Nature , vol.315 , pp. 550-554
    • Shtivelman, E.1    Lifshitz, B.2    Gale, R.P.3    Canaani, E.4
  • 20
    • 0022544401 scopus 로고
    • The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene
    • Ben-Neriah Y., Daley G.Q., Mes-Masson A.M., Witte O.N., Baltimore D. The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene. Science 1986, 233:212-214.
    • (1986) Science , vol.233 , pp. 212-214
    • Ben-Neriah, Y.1    Daley, G.Q.2    Mes-Masson, A.M.3    Witte, O.N.4    Baltimore, D.5
  • 21
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre M.E., Mohammed M., Ellwood K., Hsu N., Paquette R., Rao P.N., Sawyers C.L. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001, 293:876-880.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3    Hsu, N.4    Paquette, R.5    Rao, P.N.6    Sawyers, C.L.7
  • 22
    • 0038454621 scopus 로고    scopus 로고
    • Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
    • Bhatia R., Holtz M., Niu N., Gray R., Snyder D.S., Sawyers C.L., Arber D.A., Slovak M.L., Forman S.J. Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood 2003, 101:4701-4707.
    • (2003) Blood , vol.101 , pp. 4701-4707
    • Bhatia, R.1    Holtz, M.2    Niu, N.3    Gray, R.4    Snyder, D.S.5    Sawyers, C.L.6    Arber, D.A.7    Slovak, M.L.8    Forman, S.J.9
  • 23
    • 78049528573 scopus 로고    scopus 로고
    • Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre stop imatinib (STIM) trial
    • Mahon F.X., Rea D., Guilhot J., Guilhot F., Huguet F., Nicolini F., Legros L., Charbonnier A., Guerci A., Varet B., Etienne G., Reiffers J., Rousselot P. Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre stop imatinib (STIM) trial. Lancet Oncol. 2010, 11:1029-1035.
    • (2010) Lancet Oncol. , vol.11 , pp. 1029-1035
    • Mahon, F.X.1    Rea, D.2    Guilhot, J.3    Guilhot, F.4    Huguet, F.5    Nicolini, F.6    Legros, L.7    Charbonnier, A.8    Guerci, A.9    Varet, B.10    Etienne, G.11    Reiffers, J.12    Rousselot, P.13
  • 24
    • 78650949272 scopus 로고    scopus 로고
    • Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity
    • Corbin A.S., Agarwal A., Loriaux M., Cortes J., Deininger M.W., Druker B.J. Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. J. Clin. Invest. 2011, 121:396-409.
    • (2011) J. Clin. Invest. , vol.121 , pp. 396-409
    • Corbin, A.S.1    Agarwal, A.2    Loriaux, M.3    Cortes, J.4    Deininger, M.W.5    Druker, B.J.6
  • 26
    • 77954219134 scopus 로고    scopus 로고
    • The bone marrow microenvironment as a sanctuary for minimal residual disease in CML
    • Nair R.R., Tolentino J., Hazlehurst L.A. The bone marrow microenvironment as a sanctuary for minimal residual disease in CML. Biochem. Pharmacol. 2010, 80:602-612.
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 602-612
    • Nair, R.R.1    Tolentino, J.2    Hazlehurst, L.A.3
  • 27
    • 79952092993 scopus 로고    scopus 로고
    • Leukemia stem cells and microenvironment: biology and therapeutic targeting
    • Konopleva M.Y., Jordan C.T. Leukemia stem cells and microenvironment: biology and therapeutic targeting. J. Clin. Oncol. 2011, 29:591-599.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 591-599
    • Konopleva, M.Y.1    Jordan, C.T.2
  • 29
    • 77956440189 scopus 로고    scopus 로고
    • Critical molecular pathways in cancer stem cells of chronic myeloid leukemia
    • Chen Y., Peng C., Sullivan C., Li D., Li S. Critical molecular pathways in cancer stem cells of chronic myeloid leukemia. Leukemia 2010, 24:1545-1554.
    • (2010) Leukemia , vol.24 , pp. 1545-1554
    • Chen, Y.1    Peng, C.2    Sullivan, C.3    Li, D.4    Li, S.5
  • 31
    • 0027979832 scopus 로고
    • BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death
    • McGahon A., Bissonnette R., Schmitt M., Cotter K.M., Green D.R., Cotter T.G. BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death. Blood 1994, 83:1179-1187.
    • (1994) Blood , vol.83 , pp. 1179-1187
    • McGahon, A.1    Bissonnette, R.2    Schmitt, M.3    Cotter, K.M.4    Green, D.R.5    Cotter, T.G.6
  • 32
    • 0032055535 scopus 로고    scopus 로고
    • BCR-ABL delays apoptosis upstream of procaspase-3 activation
    • Dubrez L., Eymin B., Sordet O., Droin N., Turhan A.G., Solary E. BCR-ABL delays apoptosis upstream of procaspase-3 activation. Blood 1998, 91:2415-2422.
    • (1998) Blood , vol.91 , pp. 2415-2422
    • Dubrez, L.1    Eymin, B.2    Sordet, O.3    Droin, N.4    Turhan, A.G.5    Solary, E.6
  • 33
    • 0032032270 scopus 로고    scopus 로고
    • Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3
    • Amarante-Mendes G.P., Naekyung Kim C., Liu L., Huang Y., Perkins C.L., Green D.R., Bhalla K. Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3. Blood 1998, 91:1700-1705.
    • (1998) Blood , vol.91 , pp. 1700-1705
    • Amarante-Mendes, G.P.1    Naekyung Kim, C.2    Liu, L.3    Huang, Y.4    Perkins, C.L.5    Green, D.R.6    Bhalla, K.7
  • 34
    • 0032556921 scopus 로고    scopus 로고
    • BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner
    • Cambier N., Chopra R., Strasser A., Metcalf D., Elefanty A.G. BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner. Oncogene 1998, 16:335-348.
    • (1998) Oncogene , vol.16 , pp. 335-348
    • Cambier, N.1    Chopra, R.2    Strasser, A.3    Metcalf, D.4    Elefanty, A.G.5
  • 35
    • 20844463226 scopus 로고    scopus 로고
    • + progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli
    • + progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli. Leukemia 2005, 19:1034-1041.
    • (2005) Leukemia , vol.19 , pp. 1034-1041
    • Holtz, M.S.1    Forman, S.J.2    Bhatia, R.3
  • 36
    • 33744486584 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
    • Copland M., Hamilton A., Elrick L.J., Baird J.W., Allan E.K., Jordanides N., Barow M., Mountford J.C., Holyoake T.L. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood 2006, 107:4532-4539.
    • (2006) Blood , vol.107 , pp. 4532-4539
    • Copland, M.1    Hamilton, A.2    Elrick, L.J.3    Baird, J.W.4    Allan, E.K.5    Jordanides, N.6    Barow, M.7    Mountford, J.C.8    Holyoake, T.L.9
  • 38
    • 63149129655 scopus 로고    scopus 로고
    • Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy
    • Kang M.H., Reynolds C.P. Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin. Cancer Res. 2009, 15:1126-1132.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 1126-1132
    • Kang, M.H.1    Reynolds, C.P.2
  • 39
    • 20344385260 scopus 로고    scopus 로고
    • Targeting apoptosis pathways in cancer therapy
    • Ghobrial I.M., Witzig T.E., Adjei A.A. Targeting apoptosis pathways in cancer therapy. Cancer J. Clin. 2005, 55:178-194.
    • (2005) Cancer J. Clin. , vol.55 , pp. 178-194
    • Ghobrial, I.M.1    Witzig, T.E.2    Adjei, A.A.3
  • 40
    • 84859650054 scopus 로고    scopus 로고
    • Activation of apoptosis signaling eliminates CD34(+) progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors
    • Mak D.H., Wang R.Y., Schober W.D., Konopleva M., Cortes J., Kantarjian H., Andreeff M., Carter B.Z. Activation of apoptosis signaling eliminates CD34(+) progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors. Leukemia 2012, 26:788-794.
    • (2012) Leukemia , vol.26 , pp. 788-794
    • Mak, D.H.1    Wang, R.Y.2    Schober, W.D.3    Konopleva, M.4    Cortes, J.5    Kantarjian, H.6    Andreeff, M.7    Carter, B.Z.8
  • 41
    • 84859726070 scopus 로고    scopus 로고
    • ABT-737 increases tyrosine kinase inhibitor-induced apoptosis in chronic myeloid leukemia cells through XIAP downregulation and sensitizes CD34(+) CD38(-) population to imatinib
    • Airiau K., Mahon F.X., Josselin M., Jeanneteau M., Turcq B., Belloc F. ABT-737 increases tyrosine kinase inhibitor-induced apoptosis in chronic myeloid leukemia cells through XIAP downregulation and sensitizes CD34(+) CD38(-) population to imatinib. Exp. Hematol. 2012.
    • (2012) Exp. Hematol.
    • Airiau, K.1    Mahon, F.X.2    Josselin, M.3    Jeanneteau, M.4    Turcq, B.5    Belloc, F.6
  • 43
    • 67449150167 scopus 로고    scopus 로고
    • A Wnt survival guide: from flies to human disease
    • Chien A.J., Conrad W.H., Moon R.T. A Wnt survival guide: from flies to human disease. J. Invest. Dermatol. 2009, 129:1614-1627.
    • (2009) J. Invest. Dermatol. , vol.129 , pp. 1614-1627
    • Chien, A.J.1    Conrad, W.H.2    Moon, R.T.3
  • 44
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T., Clevers H. Wnt signalling in stem cells and cancer. Nature 2005, 434:843-850.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 51
    • 77954977940 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: mechanisms of blastic transformation
    • Perrotti D., Jamieson C., Goldman J., Skorski T. Chronic myeloid leukemia: mechanisms of blastic transformation. J. Clin. Invest. 2010, 120:2254-2264.
    • (2010) J. Clin. Invest. , vol.120 , pp. 2254-2264
    • Perrotti, D.1    Jamieson, C.2    Goldman, J.3    Skorski, T.4
  • 52
    • 33645220566 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and Akt are essential for Sonic hedgehog signaling
    • Riobo N.A., Lu K., Ai X., Haines G.M., Emerson C.P. Phosphoinositide 3-kinase and Akt are essential for Sonic hedgehog signaling. Proc. Nat. Acad. Sci. USA 2006, 103:4505-4510.
    • (2006) Proc. Nat. Acad. Sci. USA , vol.103 , pp. 4505-4510
    • Riobo, N.A.1    Lu, K.2    Ai, X.3    Haines, G.M.4    Emerson, C.P.5
  • 54
    • 14644394305 scopus 로고    scopus 로고
    • Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos
    • Gering M., Patient R. Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos. Dev. Cell 2005, 8:389-400.
    • (2005) Dev. Cell , vol.8 , pp. 389-400
    • Gering, M.1    Patient, R.2
  • 55
    • 33749000855 scopus 로고    scopus 로고
    • Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration
    • Trowbridge J.J., Scott M.P., Bhatia M. Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc. Nat. Acad. Sci. USA 2006, 103:14134-14139.
    • (2006) Proc. Nat. Acad. Sci. USA , vol.103 , pp. 14134-14139
    • Trowbridge, J.J.1    Scott, M.P.2    Bhatia, M.3
  • 60
    • 0032486433 scopus 로고    scopus 로고
    • Teratogen-mediated inhibition of target tissue response to Shh signaling
    • Cooper M.K., Porter J.A., Young K.E., Beachy P.A. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 1998, 280:1603-1607.
    • (1998) Science , vol.280 , pp. 1603-1607
    • Cooper, M.K.1    Porter, J.A.2    Young, K.E.3    Beachy, P.A.4
  • 61
    • 0031723219 scopus 로고    scopus 로고
    • The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction
    • Incardona J.P., Gaffield W., Kapur R.P., Roelink H. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 1998, 125:3553-3562.
    • (1998) Development , vol.125 , pp. 3553-3562
    • Incardona, J.P.1    Gaffield, W.2    Kapur, R.P.3    Roelink, H.4
  • 65
    • 67650289584 scopus 로고    scopus 로고
    • Mechanisms of hedgehog pathway activation in cancer and implications for therapy
    • Scales S.J., De Sauvage F.J. Mechanisms of hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol. Sci. 2009, 30:303-312.
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 303-312
    • Scales, S.J.1    De Sauvage, F.J.2
  • 68
    • 79960935826 scopus 로고    scopus 로고
    • Hedgehog fights back: mechanisms of acquired resistance against smoothened antagonists
    • Metcalfe C., De Sauvage F.J. Hedgehog fights back: mechanisms of acquired resistance against smoothened antagonists. Cancer Res. 2011, 71:5057-5061.
    • (2011) Cancer Res. , vol.71 , pp. 5057-5061
    • Metcalfe, C.1    De Sauvage, F.J.2
  • 73
    • 33750303818 scopus 로고    scopus 로고
    • Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells
    • Fiskus W., Pranpat M., Balasis M., Bali P., Estrella V., Kumaraswamy S., Rao R., Rocha K., Herger B., Lee F., Richon V., Bhalla K. Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells. Clin. Cancer Res. 2006, 12:5869-5878.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 5869-5878
    • Fiskus, W.1    Pranpat, M.2    Balasis, M.3    Bali, P.4    Estrella, V.5    Kumaraswamy, S.6    Rao, R.7    Rocha, K.8    Herger, B.9    Lee, F.10    Richon, V.11    Bhalla, K.12
  • 74
    • 0043016178 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells
    • Nimmanapalli R., Fuino L., Bali P., Gasparetto M., Glozak M., Tao J., Moscinski L., Smith C., Wu J., Jove R., Atadja P., Bhalla K. Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells. Cancer Res. 2003, 63:5126-5135.
    • (2003) Cancer Res. , vol.63 , pp. 5126-5135
    • Nimmanapalli, R.1    Fuino, L.2    Bali, P.3    Gasparetto, M.4    Glozak, M.5    Tao, J.6    Moscinski, L.7    Smith, C.8    Wu, J.9    Jove, R.10    Atadja, P.11    Bhalla, K.12
  • 75
    • 0038620379 scopus 로고    scopus 로고
    • Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl-positive human acute leukemia cells
    • Nimmanapalli R., Fuino L., Stobaugh C., Richon V., Bhalla K. Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl-positive human acute leukemia cells. Blood 2003, 101:3236-3239.
    • (2003) Blood , vol.101 , pp. 3236-3239
    • Nimmanapalli, R.1    Fuino, L.2    Stobaugh, C.3    Richon, V.4    Bhalla, K.5
  • 76
    • 77952105211 scopus 로고    scopus 로고
    • Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate
    • Zhang B., Strauss A.C., Chu S., Li M., Ho Y., Shiang K.D., Snyder D.S., Huettner C.S., Shultz L., Holyoake T., Bhatia R. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell 2010, 17:427-442.
    • (2010) Cancer Cell , vol.17 , pp. 427-442
    • Zhang, B.1    Strauss, A.C.2    Chu, S.3    Li, M.4    Ho, Y.5    Shiang, K.D.6    Snyder, D.S.7    Huettner, C.S.8    Shultz, L.9    Holyoake, T.10    Bhatia, R.11
  • 77
    • 84863011183 scopus 로고    scopus 로고
    • Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib
    • Li L., Wang L., Li L., Wang Z., Ho Y., McDonald T., Holyoake T.L., Chen W., Bhatia R. Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib. Cancer Cell 2012, 21:266-281.
    • (2012) Cancer Cell , vol.21 , pp. 266-281
    • Li, L.1    Wang, L.2    Li, L.3    Wang, Z.4    Ho, Y.5    McDonald, T.6    Holyoake, T.L.7    Chen, W.8    Bhatia, R.9
  • 78
    • 67649861052 scopus 로고    scopus 로고
    • Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia
    • Chen Y., Hu Y., Zhang H., Peng C., Li S. Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nat. Genet. 2009, 41:783-792.
    • (2009) Nat. Genet. , vol.41 , pp. 783-792
    • Chen, Y.1    Hu, Y.2    Zhang, H.3    Peng, C.4    Li, S.5
  • 79
    • 79958829892 scopus 로고    scopus 로고
    • Combined effects of novel heat shock protein 90 inhibitor NVP-AUY922 and nilotinib in a random mutagenesis screen
    • Tauchi T., Okabe S., Ashihara E., Kimura S., Maekawa T., Ohyashiki K. Combined effects of novel heat shock protein 90 inhibitor NVP-AUY922 and nilotinib in a random mutagenesis screen. Oncogene 2011, 30:2789-2797.
    • (2011) Oncogene , vol.30 , pp. 2789-2797
    • Tauchi, T.1    Okabe, S.2    Ashihara, E.3    Kimura, S.4    Maekawa, T.5    Ohyashiki, K.6
  • 80
    • 35448967331 scopus 로고    scopus 로고
    • Part I: Mechanisms of resistance to imatinib in chronic myeloid leukaemia
    • Apperley J.F. Part I: Mechanisms of resistance to imatinib in chronic myeloid leukaemia. Lancet Oncol. 2007, 8:1018-1029.
    • (2007) Lancet Oncol. , vol.8 , pp. 1018-1029
    • Apperley, J.F.1
  • 81
    • 0033568250 scopus 로고    scopus 로고
    • Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia
    • Holyoake T., Jiang X., Eaves C., Eaves A. Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. Blood 1999, 94:2056-2064.
    • (1999) Blood , vol.94 , pp. 2056-2064
    • Holyoake, T.1    Jiang, X.2    Eaves, C.3    Eaves, A.4
  • 83
    • 81555214617 scopus 로고    scopus 로고
    • Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment
    • Chu S., McDonald T., Lin A., Chakraborty S., Huang Q., Snyder D.S., Bhatia R. Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment. Blood 2011, 118:5565-5572.
    • (2011) Blood , vol.118 , pp. 5565-5572
    • Chu, S.1    McDonald, T.2    Lin, A.3    Chakraborty, S.4    Huang, Q.5    Snyder, D.S.6    Bhatia, R.7
  • 84
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
    • Graham S.M., Jorgensen H.G., Allan E., Pearson C., Alcorn M.J., Richmond L., Holyoake T.L. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood 2002, 99:319-325.
    • (2002) Blood , vol.99 , pp. 319-325
    • Graham, S.M.1    Jorgensen, H.G.2    Allan, E.3    Pearson, C.4    Alcorn, M.J.5    Richmond, L.6    Holyoake, T.L.7
  • 85
    • 0036738149 scopus 로고    scopus 로고
    • Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins
    • Konopleva M., Konoplev S., Hu W., Zaritskey A.Y., Afanasiev B.V., Andreeff M. Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins. Leukemia 2002, 16:1713-1724.
    • (2002) Leukemia , vol.16 , pp. 1713-1724
    • Konopleva, M.1    Konoplev, S.2    Hu, W.3    Zaritskey, A.Y.4    Afanasiev, B.V.5    Andreeff, M.6
  • 87
    • 56349149675 scopus 로고    scopus 로고
    • Miscreant myeloproliferative disorder stem cells
    • Jamieson C.H., Barroga C.F., Vainchenker W.P. Miscreant myeloproliferative disorder stem cells. Leukemia 2008, 22:2011-2019.
    • (2008) Leukemia , vol.22 , pp. 2011-2019
    • Jamieson, C.H.1    Barroga, C.F.2    Vainchenker, W.P.3
  • 92
    • 77958501473 scopus 로고    scopus 로고
    • DNA damage-mediated induction of a chemoresistant niche
    • Gilbert L.A., Hemann M.T. DNA damage-mediated induction of a chemoresistant niche. Cell 2010, 143:355-366.
    • (2010) Cell , vol.143 , pp. 355-366
    • Gilbert, L.A.1    Hemann, M.T.2
  • 94
    • 33749515476 scopus 로고    scopus 로고
    • Targeting of CD44 eradicates human acute myeloid leukemic stem cells
    • Jin L., Hope K.J., Zhai Q., Smadja-Joffe F., Dick J.E. Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat. Med. 2006, 12:1167-1174.
    • (2006) Nat. Med. , vol.12 , pp. 1167-1174
    • Jin, L.1    Hope, K.J.2    Zhai, Q.3    Smadja-Joffe, F.4    Dick, J.E.5
  • 95
    • 33749521890 scopus 로고    scopus 로고
    • Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells
    • Krause D.S., Lazarides K., von Andrian U.H., Van Etten R.A. Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells. Nat. Med. 2006, 12:1175-1180.
    • (2006) Nat. Med. , vol.12 , pp. 1175-1180
    • Krause, D.S.1    Lazarides, K.2    von Andrian, U.H.3    Van Etten, R.A.4
  • 96
    • 42249103574 scopus 로고    scopus 로고
    • CXCR4 is required for the quiescence of primitive hematopoietic cells
    • Nie Y., Han Y.C., Zou Y.R. CXCR4 is required for the quiescence of primitive hematopoietic cells. J. Exp. Med. 2008, 205:777-783.
    • (2008) J. Exp. Med. , vol.205 , pp. 777-783
    • Nie, Y.1    Han, Y.C.2    Zou, Y.R.3
  • 97
    • 33845445939 scopus 로고    scopus 로고
    • Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches
    • Sugiyama T., Kohara H., Noda M., Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006, 25:977-988.
    • (2006) Immunity , vol.25 , pp. 977-988
    • Sugiyama, T.1    Kohara, H.2    Noda, M.3    Nagasawa, T.4


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