Molecular aspects of melatonin (MLT)-mediated therapeutic effects

Life Sciences

Volumn 135, Issue , 2015, Pages 147-157

  Tuli, Hardeep Singh ^a   Kashyap, Dharambir ^b   Sharma, Anil K ^c   Sandhu, Sardul Singh ^d  

^a KURUKSHETRA UNIVERSITY   (India)

^b POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^c MAHARISHI MARKANDESHWAR DEEMED TO BE UNIVERSITY   (India)

^d RANI DURGAVATI UNIVERSITY   (India)

Author keywords

Biosynthesis; Derivatives; Mechanism; Melatonin; Pharmacological effects

Indexed keywords

MELATONIN; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT;

ANTIANGIOGENIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; CELL CYCLE ARREST; DRUG EFFECT; DRUG MECHANISM; HUMAN; MOLECULAR INTERACTION; NONHUMAN; REVIEW; TARGET CELL; THERAPY EFFECT; ANIMAL; METABOLISM;

ANIMALS; ANTIOXIDANTS; HUMANS; MELATONIN;

EID: 84937035914     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2015.06.004     Document Type: Review

References (129)

1. D. Acuña-Castroviejo, G. Escames, J. LeÓn, A. Carazo, and H. Khaldy Mitochondrial regulation by melatonin and its metabolites Adv. Exp. Med. Biol. 527 2003 549 557
2. V. Alvarez-García, A. González, C. Alonso-González, C. Martínez-Campa, and S. Cos Antiangiogenic effects of melatonin in endothelial cell cultures Microvasc. Res. 87 2013 25 33
3. S.A. Andrabi, I. Sayeed, D. Siemen, G. Wolf, and T.W. Horn Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin FASEB J. 18 2004 869 871
4. V.N. Anisimov, I.G. Popovich, M.A. Zabezhinski, S.V. Anisimov, G.M. Vesnushkin, and I.A. Vinogradova Melatonin as antioxidant, geroprotector and anticarcinogen Biochim. Biophys. Acta 1757 5-6 2006 573 589
5. V.N. Anisimova, I.G. Popovicha, M.A. Zabezhinskia, S.V. Anisimovb, G.M. Vesnushkinc, and I.A. Vinogradovad Melatonin as antioxidant, geroprotector and anticarcinogen Biochimica Biophysica Acta (BBA) 2006 1757 573 589
6. F. Balkwill, and L.M. Coussens Cancer: an inflammatory link Nature 431 2004 405 406
7. I. Bejarano, F. Monllor, A.M. Marchena, A. Ortiz, G. Lozano, M.I. Jiménez, P. Gaspar, J.F. García, J.A. Pariente, A.B. Rodríguez, and J. Espino Exogenous melatonin supplementation prevents oxidative stress-evoked DNA damage in human spermatozoa J. Pineal Res. 57 2014 333 339
8. G. Benitez-King Melatonin as a cytoskeleton modulator: implication for physiology and disease J. Pineal Res. 40 2006 1 9
9. D.E. Blask Melatonin, sleep disturbance and cancer risk Sleep Med. Rev. 13 2009 257 264
10. D. Bonnefont-Rousselot, G. Chevé, A. Gozzo, A. Tailleux, V. Guilloz, S. Caisey, E. Teissier, J.C. Fruchart, J. Delattre, D. Jore, D. Lesieur, P. Duriez, and M. Gardès-Albert Melatonin related compounds inhibit lipid peroxidation during copper or free radical-induced LDL oxidation J. Pineal Res. 33 2002 109 117
11. D. Bonnefont-Rousselot, and F. Collin Melatonin: action as antioxidant and potential applications in human disease and aging Toxicology 278 2010 55 67
12. J. Cabrera, G. Negrín, F. Estévez, J. Loro, R.J. Reiter, and J. Quintana Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells J. Pineal Res. 49 2010 45 54
13. S. Carbajo-Pescador, R. Ordoñez, M. Benet, R. Jover, A. García-Palomo, J.L. Mauriz, and J. González-Gallego Inhibition of VEGF expression through blockade of Hif1aand STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells Br. J. Cancer 109 2013 83 91
14. S. Casado-Zapico, V. Martín, G. García-Santos, J. Rodriguez-Blanco, A.M. Sanchez-Sanchez, E. Luño, C. Suarez, J.M. García-Pedrero, S.T. Menendez, and I. Antolín Regulation of the expression of death receptors and their ligands by melatonin in hematological cancer cell lines and in leukemia cells from patients J. Pineal Res. 50 2011 345 355
15. S. Casado-Zapico, J. Rodriguez-Blanco, G. García-Santos, V. Martín, A.M. Sánchez-Sánchez, I. Antolín, and C. Rodriguez Synergistic antitumor effect of melatonin with several chemotherapeutic drugs on human Ewing sarcoma cancer cells: potentiation of the extrinsic apoptotic pathway J. Pineal Res. 48 2010 72 80
16. K. Celinski, S.J. Konturek, P.C. Konturek, T. Brzozowski, C.L. Halina, M. Slomka, P. Malgorzata, and R.R.J. Bielanski Melatonin or L-tryptophan accelerates healing of gastroduodenal ulcers in patients treated with omeprazole J. Pineal Res. 50 2011 389 394
17. M. Chahbouni, G. Escames, C. Venegas, B. Sevilla, J.A. García, L.C. López, A.M. Hoyos, A. Molina-Carballo, and D.A. Castroviejo Melatonin treatment normalizes plasma pro-inflammatory cytokines and nitrosative/oxidative stress in patients suffering from Duchenne muscular dystrophy J. Pineal Res. 48 2010 282 289
18. J. Chen, G. Chen, J. Li, C. Qian, H. Mo, C. Gu, F. Yan, W. Yan, and L. Wang Melatonin attenuates inflammatory response-induced brain edema in early brain injury following a subarachnoid hemorrhage: a possible role for the regulation of pro-inflammatory cytokines J. Pineal Res. 57 3 2014 340 347
19. J. Chen, L. Wang, W. Cheng, H. Qiang, G. Chi, F. Yan, L. Jianru, Y. Wei, and C. Gao Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid haemorrhage J. Pineal Res. 56 2014 12 19
20. Y.A. Cho, K. Noh, S.S. Jue, S.Y. Lee, and E.C. Kim Melatonin promotes hepatic differentiation of human dental pulp stem cells: clinical implications for the prevention of liver fibrosis J. Pineal Res. 58 2015 127 135
21. C. Consilvio, A.M. Vincent, and E.L. Feldman Neuroinflammation, COX-2, and ALS-a dual role? Exp. Neurol. 187 2004 1 10
22. A. Corrales, R. Vidal, S. GarcIa, V. Vidal, P. MartInez, E. García, J. Florez, E. JSB, M.C. Carmen, and N. Rueda Chronic melatonin treatment rescues electrophysiological and neuromorphological deficits in a mouse model of Down syndrome J. Pineal Res. 56 2014 51 61
23. S. Cos, R. Fernandez, A. Guezmes, and E.J. Sanchez-Barcelo Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells Cancer Res. 58 1998 4383 4390
24. S. Cos, M.D. Mediavilla, R. Fernández, D. González-Lamuño, and E.J. Sánchez-Barceló Does melatonin induce apoptosis in MCF-7 human breast cancer cells in vitro? J. Pineal Res. 32 2002 90 96
25. A. Cucina, S. Proietti, F.D. Ansemi, P. Coluccia, S. Dinicola, L. Frati, and M. Bizzarri Evidence for biphasic apoptotic pathway induced by melatonin in MCF-7cells J. Pineal Res. 46 2009 172 180
26. J.C. Cuesta, M. Tajes, A. Jiménez, A.C. Montes, A. Camins, and M. Pallàs Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model J. Pineal Res. 45 2008 497 505
27. G. Di Bella, F. Mascia, L. Gualano, and L. Di Bella Melatonin anticancer effects: review Int. J. Mol. Sci. 14 2013 2410 2430
28. W.G. Dong, Q. Mei, J.P. Yu, J.M. Xu, L. Xiang, and Y. Xu Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis World J. Gastroenterol. 9 2003 1307 1311
29. E. Guneli, K. Tugyan, H. Ozturk, M. Gumustekin, S. Cilaker, and N. Uysal Effect of melatonin on testicular damage in streptozotocin-induced diabetes rats Eur. Surg. Res. 40 2008 354 360
30. H. Ebaid, S.A. Bashandy, I.M. Alhazza, A. Rady, and S. El-Shehry Folic acid and melatonin ameliorate carbon tetrachloride-induced hepatic injury, oxidative stress and inflammation in rats Nutr. Metab. (Lond.) 10 2013 20
31. J. Espino, Á. Ortiz, I. Bejarano, G.M. Lozano, F. Monllor, J.F. García, A.B. Rodríguez, and J.A. Pariente Melatonin protects human spermatozoa from apoptosis via melatonin receptor- and extracellular signal-regulated kinase-mediated pathways Fertil. Steril. 95 2011 2290 2296
32. T.W. Fischer, K. Kleszczyński, L.H. Hardkop, N. Kruse, and D. Zillikens Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2'-deoxyguanosine) in ex vivo human skin J. Pineal Res. 54 3 2013 303 312
33. K. Fukatsu, O. Uchikawa, M. Kawada, T. Yamano, M. Yamashita, K. Kato, K. Hirai, S. Hinuma, M. Miyamoto, and S. Ohkawa Synthesis of a novel series of benzocycloalkene derivatives as melatonin receptor agonists J. Med. Chem. 45 2002 4212 4221
34. G€ogenur I, K€uc€ukakin B, Jensen LP, Reiter RJ, Rosenberg J. Melatonin reduces cardiac morbidity and markers of myocardial ischemia after elective abdominal aortic aneurism repair: a randomized, placebo-controlled, clinical trial. J. Pineal Res. 2014;57:10-15.
35. G. Garcia-Santos, I. Antolin, F. Herrera, V. Martin, J. Podriguez-Blanco, M.D.P. Carrera, and C. Rodriguez Melatonin Induce Apoptosis in Human Neuroblastoma Cancers 41 2006 130 135
36. G. García-Santos, V. Martin, J. Rodriguez-Blanco, F. Herrera, S. Casado-Zapico, A.M. Sanchez-Sanchez, I. Antolin, and C. Rodriguez Fas/Fas ligand regulation mediates cell death in human Ewing's sarcoma cells treated with melatonin Br. J. Cancer 106 2012 1288 1296
37. V. Gayathri, and P.V. Mohanan Protective mechanism of melatonin on kainic acid induced immune modulatory effect on lymphocytes derived from mouse spleen J Clin Cell Immunol 4 2013 172
38. M. Ghielmini, O. Pagani, J. de Jong, S. Pampallona, A. Conti, G. Maestroni, C. Sessa, and F. Cavalli Double-blind randomized study on the myeloprotective effect of melatonin in combination with carboplatin and etoposide in advanced lung cancer Br. J. Cancer 80 1999 1058 1061
39. N. Goncalves Ndo, R.V. Rodrigues, B.V. Jardim-Perassi, M.G. Moschetta, J.R. Lopes, J. Colombo, and D.A. Zuccari Molecular markers of angiogenesis and metastasis in lines of oral carcinoma after treatment with melatonin Anticancer Agents Med Chem. 14 2014 1302 1311
40. R. Hardeland, S.R. Pandi-perumal, and D.P. Cardinali Melatonin Int. J. Biochem. Cell Biol. 380 2006 313 316
41. R. Hardeland, and B. Poeggeler Non-vertebrate melatonin J. Pineal Res. 34 2003 233 241
42. L. He, J.L. Li, J.J. Zhang, P. Su, and S.L. Zheng Microwave assisted synthesis of melatonin Synth. Commun. 33 2003 741 747
43. A.B. Hickman, D.C. Klein, and F. Dyda Melatonin biosynthesis: the structure of serotonin N-acetyltransferase at 2.5 A resolution suggests a catalytic mechanism Mol. Cell 3 1999 23 32
44. H.M. Hugel, and D.J. Kennaway Synthesis and chemistry of melatonin and of related compounds. A review Org. Prep. Proced. Int. 27 1995 1 31
45. M.H. Jang, S.B. Jung, M.H. Lee, C.J. Kim, Y.T. Oh, I. Insug Kang, J. Kim, and E.H. Kim Melatonin attenuates amyloid beta25-35-induced apoptosis in mouse microglial BV2 cells Neurosci. Lett. 380 2005 26 31
46. B.V. Jardim, L.C. Ferreira, T.F. Borin, M.G. Moschetta, G.B. Gelaleti, J.R. Lopes, L.B. Maschio, C. Leonel, N.N. Gonçalves, G.R. Martins, and D.A. Zuccari Evaluation of the anti-angiogenic action of melatonin in breast cancer BMC Proc. 7 2013 1
47. S.H. Javanmard, A. Ziaei, S. Ziaei, E. Ziaei, and M. Mirmohammad-Sadeghi The effect of preoperative melatonin on nuclear erythroid 2-related factor 2 activation in patients undergoing coronary artery bypass grafting surgery Oxid. Med. Cell. Longev. 2013 2013 1 6
48. J.K. Jeong, and S.Y. Park Melatonin regulates the autophagic flux via activation of alpha-7 nicotinic acetylcholine receptors J. Pineal Res. 2015 10.1111/jpi.12235
49. T. Jiang, Q. Chang, Z. Zhao, S. Yan, and L. Wang Melatonin-mediated cytoprotection against hyperglycemic injury in Müller cells PLoS One 7 2012 e50661
50. K.H. Jung, S.W. Hong, H.M. Zheng, D.H. Lee, and S.S. Hong Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model J. Pineal Res. 47 2009 173 183
51. B. Jung-Hynes, T.L. Schmit, S.R. Reagan-Shaw, I.A. Siddiqui, H. Mukhtar, and N. Ahmad Melatonin, a novel Sirt1 inhibitor, imparts anti-proliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model J. Pineal Res. 50 2011 140 149
52. J.W. Kang, E.J. Koh, and S.M. Lee Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway J. Pineal Res. 50 2011 403 411
53. M. Karbownika, A. Lewinski, and R.J. Reiter Anticarcinogenic actions of melatonin which involve antioxidative processes: comparison with other antioxidants Int. J. Biochem. Cell Biol. 33 2001 735 753
54. U. Kilic, E. Kilic, Z. Tuzcu, M. Tuzcu, I.H. Ozercan, O. Yilmaz, F. Sahin, and K. Sahin Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway Nutr. Metab. (Lond.) 10 2013 7
55. H.S. Kim, T.J. Kim, and Y.M. Yoo Melatonin combined with endoplasmic reticulum stress induces cell death via the PI3K/Akt/mTOR pathway in B16F10 melanoma cells PLoS One 9 2014 e92627
56. K. Kleszczynski, S. Zwicker, S. Tukaj, M. Kasperkiewicz, D. Zillikens, R. Wolf, and T.W. Fischer Melatonin compensates silencing of heat shock protein 70 and suppresses ultraviolet radiation induced inflammation in human skin ex vivo and cultured keratinocytes J. Pineal Res. 58 2015 117 126
57. P.O. Koh Melatonin attenuates the focal cerebral ischemic injury by inhibiting the dissociation of pBad from 14 to 3-3 J. Pineal Res. 44 2008 101 106
58. O.R. Kunduzova, G. Escourrou, M.H. Seguelas, P. Delagrange, F.D.L. Farge, C. Cambon, and A. Parini Prevention of apoptotic and necrotic cell death, caspase-3 activation, and renal dysfunction by melatonin after ischemia/reperfusion FASEB J. 17 2003 872 874
59. A. Leja-Szpak, J. Jaworek, P. Pierzchalski, and R.J. Reiter Melatonin induce pro-apoptotic signaling pathway in human pancreatic cell (PANC-1) J. Pineal Res. 49 2010 248 255
60. J. León, J. Casado, S.M. Jiménez Ruiz, M.S. Zurita, C. González-Puga, J.D. Rejón, A. Gila, P. Muñoz de Rueda, E.J. Pavón, R.J. Reiter, A. Ruiz-Extremera, and J. Salmerón Melatonin reduces endothelin-1 expression and secretion in colon cancer cells through the inactivation of FoxO-1 and NFkappabeta J. Pineal Res. 56 2014 415 426
61. A.B. Lerner, J.D. Case, and Y. Takahashi Isolation of melatonin, a pineal factor that lightens melanocytes J. Am. Chem. Soc. 80 1958 2057 2058
62. X.J. Lin, G.P. Mei, L. Jian, Y.L. Li, Z. Dan, S.J. Liu, T.B. Zhao, and M.T. Lin Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats J. Pineal Res. 50 2011 436 444
63. P. Lissoni, S. Barni, M.Á. Mandala, A. Ardizzoia, F. Paolorossi, M. Vaghi, R. Longarini, F. Malugani, and G. Tancini Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status Eur. J. Cancer 12 2009 1688 1692
64. P. Lissoni, M. Chilelli, S. Villa, L. Cerizza, and G. Tancini Five years survival in metastatic non-small cell lung cancer patients treated with chemotherapy alone or chemotherapy and melatonin: a randomized trial J. Pineal Res. 35 2003 12 15
65. P. Lissoni, F. Paolorossil, G. Tancinil, A. Ardizzoial, S. Barnil, F. Briviol, G.J.M. Maestroni, and M. Chilellil A phase II study of tamoxifen plus melatonin in metastatic solid tumour patients Br. J. Cancer 74 1996 1466 1468
66. L. Liu, Y. Xu, and R.J. Reiter Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63 Bone 55 2013 432 438
67. F. Luchetti, M. Betti, B. Canonico, M. Arcangeletti, P. Ferri, F. Galli, and S. Papa ERK MAPK activation mediates the antiapoptotic signaling of melatonin in UVB-stressed U937 cells Free Radic. Biol. Med. 46 2009 339 351
68. F. Luchetti, B. Canonico, M. Betti, M. Arcangeletti, F. Pilolli, M. Piroddi, L. Canesi, S. Papa, and F. Galli Melatonin signaling and cell protection function FASEB J. 24 2010 3603 3624
69. D. Lv, P.L. Cui, S.W. Yao, Y.Q. Xu, and Z.X. Yang Melatonin inhibits the expression of vascular endothelial growth factor in pancreatic cancer cells Chin. J. Cancer Res. 24 2012 310 316
70. L. Mao, L. Yuan, L.M. Slakey, F.E. Jones, M.E. Burow, and S.M. Hill Inhibition of breast cancer cell invasion by melatonin is mediated through regulation of the p38 mitogen-activated protein kinase signaling pathway Breast Cancer Res. 12 2010 R107
71. V. Martin, G. García-Santos, J. Rodriguez-Blanco, S. Casado-Zapico, A. Sanchez-Sanchez, I. Antolin, M. Medina, and C. Rodriguez Melatonin sensitizes human malignant glioma cells against TRAIL-induced cell death Cancer Lett. 287 2010 216 223
72. M.D. Mediavilla, S. Cos, and E.J. Sanchez-Barcelo Melatonin increases p53 and p21WAF1 expression in MCF-7 human breast cancer cells in vitro Life Sci. 65 1999 415 420
73. A. Menendez-Pelaez, and R.J. Reiter Distribution of melatonin in mammalian tissues: the relative importance of cytosolic versus nuclear localization J. Pineal Res. 15 1993 59 69
74. K.J. Min, H.S. Kim, E.J. Park, and T.K. Kwon Melatonin enhances thapsigargin-induced apoptosis through reactive oxygen species-mediated upregulation of CCAAT-enhancer-binding protein homologous protein in human renal cancer cells J. Pineal Res. 53 2012 99 106
75. V. Molpeceres, J.L. Mauriz, M.V.G. Mediavilla, P.G. González, J.P. Barrio, and G. JGL Melatonin is able to reduce the apoptotic liver changes induced by aging via inhibition of the intrinsic pathway of apoptosis J. Gerontol. A Biol. Sci. Med. Sci. 62 2007 687 695
76. M. Mor, G. Spadoni, G. Diamantini, A. Bedini, G. Tarzia, C. Silva, F. Vacondio, M. Rivara, P.V. Plazzi, D. Franceschini, M. Zusso, and P. Giusti Antioxidant and cytoprotective activity of indole derivatives related to melatonin Adv. Exp. Med. Biol. 527 2003 567 575
77. M. Naguib, V. Gottumukkala, and P.A. Goldstein Melatonin and anesthesia: a clinical perspective J. Pineal Res. 42 2007 12 21
78. R. Ordoñez, S. Carbajo-Pescador, N. Prieto-Dominguez, A. García-Palomo, J. González-Gallego, and J.L. Mauriz Inhibition of matrix metalloproteinase-9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in HepG2 liver cancer cells J. Pineal Res. 56 1 2014 20 30
79. F. Ortiz, D.A. Castroviejo, C. Doerrier, J.C. Dayoub, L.C. Lopez, C. Venegas, J.A. García, A. López, H. Volt, M.L. Sanchez, and G. Escames Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis J. Pineal Res. 58 2015 34 49
80. K. Park, Y. Lee, S. Park, S. Lee, Y. Hong, S.K. Lee, and Y. Hong Synergistic effect of melatonin on exercise-induced neuronal reconstruction and functional recovery in a spinal cord injury animal model J. Pineal Res. 48 2010 270 281
81. G. Patki, and Y.S. Lau Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson's disease Pharmacol. Biochem. Behav. 99 2011 704 711
82. M. Perepechaeva, N. Stefanova, and A. Grishanova Expression of genes for AhR and Nrf2 signal pathways in the retina of OXYS rats during the development of retinopathy and melatonin-induced changes in this process Bull. Exp. Biol. Med. 157 2014 424 429
83. J.G. Pizarro, M. Yeste-Velasco, J.L. Esparza, E. Verdaguer, M. Pallàs, A. Camins, and J. Folch The antiproliferative activity of melatonin in B65 rat dopaminergic neuroblastoma cells is related to the downregulation of cell cycle-related genes J. Pineal Res. 45 2008 8 16
84. P. Plaimee, N. Weerapreeyakul, S. Barusrux, and N.P. Johns Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells Cell Prolif. 48 1 2015 67 77
85. W. Qin Melatonin inhibits IL1betainduced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-kappaB activation J. Endocrinol. 214 2012 145 153
86. G. Ramirez-Rodriguez, N.M. Vega-Rivera, J. Oikawa-Sala, A. Gomez Sanchez, L. Ortiz-Lopez, and E. Estrada-Camarena Melatonin synergizes with citalopram to induce antidepressant-like behavior and to promote hippocampal neurogenesis in adult mice J. Pineal Res. 56 2014 450 461
87. C. Rodriguez, M. Jc, and R.M. Sainz Regulation of antioxidant enzyme: a significant role for melatonin J. Pineal Res. 36 2004 1 9
88. R.E. Rosenstein, S.R. Pandi-Perumal, V. Srinivasan, D.W. Spence, and G.M. Brown Cardinali DPMelatonin as a therapeutic tool in ophthalmology: implications for glaucoma and uveitis J. Pineal Res. 49 2010 1 13
89. S.A. Rushworth, and D.J. Macewan The role of Nrf2 and cytoprotection in regulating chemotherapy resistance of human leukemia cells Cancers (Basel) 3 2011 1605 1621
90. S. Samantaray, A. Das, N.P. Thakore, D.D. Matzelle, R.J. Reiter, S.K. Ray, and N.L. Banik Therapeutic potential of melatonin in traumatic central nervous system injury J. Pineal Res. 47 2009 134 142
91. M.L. Sánchez-Hidalgo, C.A. de la Lastra, J.M. Guerrero, and G. Packham Melatonin inhibits cell proliferation and induces caspase activation and apoptosis in human malignant lymphoid cell lines J. Pineal Res. 53 2012 366 373
92. B. San-Miguel, I. Crespo, D. Vallejo, M. Alvarez, J. Prieto, J.G. Gallego, and M.J. Tunon Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus J. Pineal Res. 56 2014 313 321
93. R. Sharma, C.R. McMillan, and L.P. Niles Neural stem cell transplantation and melatonin treatment in a 6-hydroxydopamine model of Parkinson's disease J. Pineal Res. 43 3 2007 245 254
94. I.S. Shin, N.R. Shin, J.W. Park, C.M. Jeon, J.M. Hong, O.K. Kwon, J.S. Kim, I.C. Lee, J.C. Kim, S.R. Oh, and K.S. Ahn Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling J. Pineal Res. 58 2015 50 60
95. E.J. Sohn, G. Won, J. Lee, S. Lee, and S. Kim Upregulation of miRNA3195 and miRNA374b mediates the anti-angiogenic properties of melatonin in hypoxic PC-3 prostate cancer cells J Cancer 6 2015 19 28
96. A. Soliman, A.A. Lacasse, D. Lanoix, S. Lucas, B. Véronique, and V. Cathy Placental melatonin system is present throughout pregnancy and regulates villous trophoblast differentiation J. Pineal Res. 2015 10.1111/jpi.12236
97. J. Song, S.M. Kang, K.M. Lee, and J.E. Lee The protective effect of melatonin on neural stem cell against LPS-induced inflammation Biomed Res Int 854359 2015 10.1155/2015/854359
98. S. Soo Joo, and Y.Y. Min Melatonin induce apoptotic death in LNCaP via p38 JNK pathways: therapeutic implications for prostate cancer J. Pineal Res. 47 2009 8 14
99. V. Srinivasan, G.J.M. Maestroni, D.P. Cardinali, A.I. Esquifino, S.R. Pandi Perumal, and S.C. Miller Melatonin, immune function and aging Immun. Ageing 2 2005 17
100. V. Srinivasan, D.W. Spence, A. Moscovitch, S.R. Pandi-Perumal, I. Trakht, G.M. Brown, and D.P. Cardinali Malaria: therapeutic implications of melatonin J. Pineal Res. 48 2010 1 8
101. V. Srinivasan, D.W. Spence, S.R. Pandi-Perumal, I. Trakht, and D.P. Cardinali Therapeutic actions of melatonin in cancer: possible mechanisms Integr. Cancer Ther. 7 2008 189 203
102. C.K. Sun, F.Y. Lee, Y.H. Kao, H.J. Chiang, P.H. Sung, T.H. Tsai, Y.C. Lin, S. Leu, Y.C. Wu, H.I. Lu, Y.L. Chen, S.Y. Chung, H.L. Su, and H.K. Yip Systemic combined melatonin-mitochondria treatment improves acute respiratory distress syndrome in the rat J. Pineal Res. 58 2015 137 150
103. L.Q. Sun, J. Chen, M. Bruce, J.A. Deskus, J.R. Epperson, K. Takaki, G. Johnson, L. Iben, C.D. Mahle, E. Ryan, and C. Xu Synthesis and structure-activity relationship of novel benzoxazole derivatives as melatonin receptor agonists Bioorg. Med. Chem. Lett. 16 2004 3799 3802
104. G. Swiderska-Kołacz, J. Klusek, and A. Kołataj The effect of melatonin on glutathione and glutathione transferase and glutathione peroxidase activities in the mouse liver and kidney in vivo Neuro Endocrinol. Lett. 27 2006 365 368
105. J. Szmuszkovicz, W. Anthony, and R. Heinzelman Notes-synthesis of N-acetyl-5-methoxytryptamine J. Organomet. Chem. 25 1960 857 859
106. D.X. Tan, L.C. Manchester, R.J. Reiter, W. Qi, M. Zhang, S.T. Weintraub, J. Cabrera, R.M. Sainz, and J.C. Mayo Identification of highly elevated levels at melatonin in bone marrow: its origin and significance Biochim. Biophys. Acta 1472 1999 206 214
107. B.G. Teodoro, F.G. Baraldi, I.H. Sampaio, L.H.M. Bomfim, A.L. Queiroz, M.A. Passos, E.M. Carneiro, L.C. Alberici, R. Gomis, F.G. Amaral, C.N. Jose, M.B. Araujo, T. Lima, S.A. Uyemura, L.R. Silveira, and E. Vieira Melatonin prevents mitochondrial dysfunction and insulin resistance in rat skeletal muscle J. Pineal Res. 57 2014 155 167
108. C. Tomás-Zapico, and A. Coto-Montes A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes J. Pineal Res. 39 2005 99 104
109. F. Torres, G.C. Alejandro, C. Montt, G. Ebensperger, M. Chubretovic, S.F. MarIa, R.V. Reyes, A.J. Llanos, and E.A. Herrera Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep J. Pineal Res. 58 2015 362 373
110. D.N. Tripathi, and G.B. Jena Effect of melatonin on the expression of Nrf2 and NF-kappaB during cyclophosphamide-induced urinary bladder injury in rat J. Pineal Res. 48 2010 324 331
111. O. Trubiani, R. Recchioni, F. Moroni, J. Pizzicannella, S. Caputi, and R.D. Primio Melatonin provokes cell death in human B-lymphoma cells by mitochondrial-dependent apoptotic activation J. Pineal Res. 39 2005 425 431
112. A. Tsotinis, P.A. Afroudakis, P.J. Garratt, A.B. Zbrog, and D. Sugden Benzocyclobutane, benzocycloheptane and heptene derivatives as melatonin agonists and antagonists ChemMedChem 9 2014 2238 2243
113. H.S. Tuli, P. Chaudhari, V. Beniwal, and A.K. Sharma Microbial pigments as natural color sources: current trends and future perspectives J. Food Sci. Technol. 2014 10.1007/s13197-014-1601-6
114. H.S. Tuli, G. Kumar, S.S. Sadhu, A.K. Sharma, and D. Kashyap Apoptotic effect of cordycepin on A549 human lung cancer cells Turk. J. Biol. 39 2015 1408 1414
115. H.S. Tuli, S.S. Sadhu, A.K. Sharma, and P. Gandhi Anti-angiogenic activity of the extracted fermentation broth of an entomopathogenic fungus, Cordyceps militaris 3936 Int J Pharm Pharm Sci 6 2014 581 583
116. H.S. Tuli, A.K. Sharma, S.S. Sandhu, and D. Kashyap Cordycepin: a bioactive metabolite with therapeutic potential Life Sci. 93 2013 863 869
117. H.S. Tuli, A.K. Sharma, and S.S. Sandhu Pharmacological and Therapeutic potential of Cordyceps with special reference to Cordycepin. 3 Biotech 4 2014 1 12
118. M.J. Tunon, B.S. Miguel, I. Crespo, F. Jorquera, E. SantamarIa, M. Alvarez, J. Prieto, and J.G. Gallego Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus J. Pineal Res. 50 2011 38 45
119. J. Vriend, and R.J. Reiter The Keap1-Nrf2-antioxidant response element pathway: a review of its regulation by melatonin and the proteasome Mol. Cell. Endocrinol. 401 2014 213 220
120. F.W. Wang, Z. Wang, Y.M. Zhang, Z.X. Du, X.L. Zhang, Q. Liu, Y.J. Guo, X.G. Li, and A.J. Hao Protective effect of melatonin on bone marrow mesenchymal stem cells against hydrogen peroxide-induced apoptosis in vitro J. Cell. Biochem. 114 10 2013 2346 2355
121. J. Wang, W. Guo, W. Chen, W. Yu, Y. Tian, L. Fu, D. Shi, B. Tong, X. Xiao, W. Huang, and W. Deng Melatonin potentiates the antiproliferative and pro-apoptotic effects of ursolic acid in colon cancer cells by modulating multiple signaling pathways J. Pineal Res. 54 2013 406 416
122. Z. Wang, C. Ma, C.J. Meng, G.Q. Zhu, X.B. Sun, L. Huo, J. Zhang, H.X. Liu, W.C. He, X.M. Shen, Z. Shu, and G. Chen Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model J. Pineal Res. 53 2012 129 137
123. J.Y. Wei, W.M. Li, L.L. Zhou, Q.N. Lu, and W. He Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation J. Pineal Res. 58 2015 429 438
124. S. Xiang, R.T. Dauchy, A. Hauch, L. Mao, L. Yuan, M.A. Wren, V.P. Belancio, D. Mondal, T. Frasch, D.E. Blask, and S.M. Hill Doxorubicin resistance in breast cancer is driven by light at night-induced disruption of the circadian melatonin signal J. Pineal Res. 2015 10.1111/jpi.12239
125. M. Xie, A. Hu, Y. Luo, W. Sun, X. Hu, and S. Tang Interleukin-4 and melatonin ameliorate high glucose and interleukin-1β stimulated inflammatory reaction in human retinal endothelial cells and retinal pigment epithelial cells Mol. Vis. 20 2014 921 928
126. H.M. Yeung, M.W. Hung, C.F. Lau, and M.L. Fung Cardioprotective effects of melatonin against myocardial injuries induced by chronic intermittent hypoxia in rats J. Pineal Res. 58 2015 12 25
127. C. Yi, Y. Zhang, Z. Yu, Y. Xiao, J. Wang, H. Qiu, W. Yu, R. Tang, Y. Yuan, W. Guo, and W. Deng Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2/iNOS and NF-kB/p300 signaling pathways PLoS One 9 2014 e99943
128. A.A. Zamfir Chiru, C.R. Popescu, and D.C. Gheorghe Melatonin and cancer J. Med. Life 7 2014 373 374
129. I.V. Zhdanova, S.Y. Wang, O.U. Leclair, and N.P. Danilova Melatonin promotes sleep-like state in zebrafish Brain Res. 903 2001 263 268