ERK MAPK activation mediates the antiapoptotic signaling of melatonin in UVB-stressed U937 cells

Free Radical Biology and Medicine

Volumn 46, Issue 3, 2009, Pages 339-351

  Luchetti, F ^a   Betti, M ^a,b   Canonico, B ^a   Arcangeletti, M ^a   Ferri, P ^a   Galli, F ^b   Papa, S ^a  

^a UNIVERSITY OF URBINO   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Apoptosis; bcl 2; caspases; ERK; JNK; Melatonin; p38 MAPK; Reactive oxygen species; U937 cells; UVB

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE; MELATONIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN U937; CYTOPLASM; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PHOSPHORYLATION; PRIORITY JOURNAL; STRESS; ULTRAVIOLET B RADIATION;

APOPTOSIS; CYTOCHROMES C; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; HUMANS; IMIDAZOLES; MELATONIN; MITOCHONDRIA; MONOCYTES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRIDINES; RADIATION TOLERANCE; SIGNAL TRANSDUCTION; U937 CELLS; ULTRAVIOLET RAYS;

EID: 58149095471     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2008.09.017     Document Type: Article

References (53)

1. Pandi-Perumal S.R., Trakht I., Srinivasan V., Spence D.W., Maestroni G.J., Zisapel N., and Cardinali D.P. Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways. Prog. Neurobiol. 85 (2008) 335-353
2. Szczepanik M. Melatonin and its influence on immune system. J. Physiol. Pharmacol. 58 Suppl 6 (2007) 115-124
3. Luchetti F., Canonico B., Curci R., Battistelli M., Mannello F., Papa S., Tarzia G., and Falcieri E. Melatonin prevents apoptosis induced by UV-B treatment in U937 cell line. J. Pineal Res. 40 (2006) 158-167
4. Radogna F., Cristofanon S., Paternoster L., D'Alessio M., De Nicola M., Cerella C., Dicato M., Diederich M., and Ghibelli L. Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl-2. J. Pineal Res. 44 (2008) 316-325
5. Newmeyer D.D., and Ferguson-Miller S. Mitochondria: releasing power for life and unleashing the machineries of death. Cell 112 (2003) 481-490
6. Herrlich P., Sachsenmaier C., Radler-Pohl A., Gebel S., Blattner C., and Rahmsdorf H.G. The mammalian UV response: mechanism of DNA damage induced gene expression. Adv. Enzyme Regul. 34 (1994) 381-395
7. Latonen L., and Laiho M. Cellular UV damage responses-functions of tumour suppressor p53. Biochim. Biophys. Acta 1775 (2005) 71-89
8. Rezvani H.R., Mazurier F., Cario-Andrè M., Pain C., Ged C., Taieb A., and de Verneuil H. Protective effects of catalase overexpression on UV-B induced apoptosis in normal human keratinocytes. J. Biol. Chem. 281 (2006) 17999-18007
9. Feng Z., and Zhang J.T. Protective effect of melatonin on beta-amyloid-induced apoptosis in rat astroglioma C6 cells and its mechanism. Free Radic. Biol. Med. 37 (2004) 1790-1801
10. Acuna-Castroviejo D., Escames G., Rodriguez M.I., and Lopez L.C. Melatonin role in the mitochondrial function. Front. Biosci. 12 (2007) 947-963
11. Chiang C.W., Yan L., and Yang E. Phosphatases and regulation of cell death. Methods Enzymol. 446 (2008) 237-257
12. Junttila M.R., Li S.P., and Westermarck J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22 (2008) 954-965
13. Kurland J.F., Voehringer D.W., and Meyn R.E. The MEK/ERK pathway acts upstream of NF kappa B1 (p50) homodimer activity and Bcl-2 expression in a murine B-cell lymphoma cell line. MEK inhibition restores radiation-induced apoptosis. J. Biol. Chem. 278 (2003) 32465-32470
14. Torres M., and Forman H.J. Redox signalling and the MAP kinase pathways. Biofactors 17 (2003) 287-296
15. McCubrey J.A., Lahair M.M., and Franklin R.A. Reactive oxygen species-induced activation of the MAP kinase signaling pathways. Antioxid. Redox Signal. 8 (2006) 1775-1789
16. Giorgio M., Trinei M., Migliaccio E., and Pelicci P.G. Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?. Nat. Rev. Mol. Cell. Biol. 8 (2007) 722-728
17. Johnson G.L., and Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298 (2002) 1911-1912
18. Monick M.M., Powers L.S., Barret C.W., Hinde S., Ashare A., Groskreutz D.J., Nyunoya T., Coleman M., Spitz D.R., and Hunninghake G.W. Constitutive ERK MAPK activity regulates macrophage ATP production and mitochondrial integrity. J. Immunol. 80 (2008) 7485-7496
19. Xia Z., Dickens M., Raingeaud J., Davis R.J., and Greenberger M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270 (1995) 1326-1331
20. Farley N., Pedraza-Alva G., Serrano-Gomez D., Nagaleekar V., Aronshtam A., Krahl T., Thornoton T., and Rincon M. p38 mitogen-activated protein kinase mediates the Fas-induced mitochondrial death pathway in CD 8+ T cells. Mol. Cell. Biol. 26 (2006) 2118-2129
21. Anoopkumar-Dukie S., Conere T., Carey J.B., and Allshire A. Radical mediators and mitogen-activated protein kinase signaling in oxygen-dependent radiosensitivity of human tumor cell lines. Free Radic. Biol. Med 39 (2005) 188-194
22. Granata F., Frattini A., Loffredo S., Del Prete A., Sozzani S., Marone G., and Triggiani M. Signaling events involved in cytokine and chemokine production induced by secretory phospholipase A2 in human lung macrophages. Eur. J. Immunol. 36 (2006) 1938-1950
23. Mansat-de Mas V., Bezombes C., Quillet-Mary A., Bettaieb A., De Thonel D'Orgeix A., Laurent G., and Jaffrezou J.P. Implication of radical oxygen species in ceramide generation, c-Jun terminal kinase activation and apoptosis induced by daunorubicin. Mol. Pharmacol. 56 (1999) 867-874
24. Yung J.Y., Yoo C.I., Kim H.T., Kwon C.H., Park J.Y., and Kim Y.K. Role of mitogen-activated protein kinase (MAPK) in troglitazone-induced osteoblastic cell death. Toxicology 234 (2007) 73-82
25. 2-induced cell death. Eur. J. Pharmacol. 483 (2004) 163-173
26. Yan L., Vatner D.E., O'Connor J.P., Ivessa A., Ge H., Chen W., Hirotani S., Ishikawa Y., Sadoshima J., and Vatner S.F. Type 5 Adenylyl cyclase disruption increases longevity and protects against stress. Cell 130 (2007) 247-258
27. Turjanski A.G., Vaque J.P., and Gutkind J.S. MAP kinases and the control of nuclear events. Oncogene 26 (2007) 3240-3253
28. Hayashi Y., Sanada K., Hirota T., Shimizu F., and Fukuda Y. p38 mitogen-activated protein kinase regulates oscillation of chick pineal circadian clock. J. Biol. Chem. 278 (2003) 25166-25171
29. Chan A.S.L., Lai F.P.L., Lo R.K.H., Voyno-Yasenetskaya T.A., Stanbridge E.J., and Womg Y.H. Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussin toxin-sensitive and -insensitive G proteins. Cell Signal. 14 (2002) 249-257
30. Bondi C.D., McKeon R.M., Bennett J.M., Ignatius P.F., Brydon L., Jockers R., Melan M.A., and Witt-Enderby P.A. MT1 melatonin receptor internalization underlies melatonin-induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulation. J. Pineal Res. 44 (2008) 288-298
31. Rodio N.M., Doctor J.S., and Witt-Enderby P.A. Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade. J. Pineal Res. 40 (2006) 332-342
32. Roy D., and Belsham D.D. Melatonin receptor activation regulates GmRH gene expression and secretion in GT1-7 GmRH neurons. Signal transduction mechanisms. J. Biol. Chem. 277 (2002) 251-258
33. Rincon Castro L.M., Gallant M., and Niles L.P. Novel targets for valproic acid: up-regulation of melatonin receptors and neurotrophic factors in C6 glioma cells. J. Neurochem. 95 (2005) 1227-1236
34. Cul P., Yu M., Luo Z., Dai M., Han J., Xiu R., and Yang Z. Intracellular signaling pathways involved in cell growth inhibition of human umbilical vein endothelial cells by melatonin. J. Pineal Res. 44 (2008) 107-114
35. Zhu H.Q., Cheng X.W., Xiao L.L., Jiang Z.K., Zhou Q., Gui S.Y., Wei W., and Wang Y. Melatonin prevents oxidized low-density lipoprotein-induced increase of myosin light chain kinase activation and expression in HUVEC through ERK/MAPK signaling transduction. J. Pineal Res. 45 (2008) 328-334
36. Rothe G., and Valet G. Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2′,7′-dichlorofluorescin. J. Leukoc. Biol. 47 (1990) 440-448
37. Cantoni O., Fiorani M., Cattabeni F., and Bellomo G. DNA breakage caused by hydrogen peroxide produced during the metabolism of 2-methyl-1,4-naphthoquinone (menadione) does not contribute to the cytotoxic action of the quinone. Biochem. Pharmacol. 42 (1991) 220-222
38. Canonico B., Zamai L., Burattini S., Granger V., Mannello F., Gobbi P., Felici C., Falcieri E., Reilly J.T., Barnett D., and Papa S. Evaluation of leukocyte stabilisation in TransFix-trated blood samples by flow cytometry and trasmission electron microscopy. J. Immunol. Methods 295 (2004) 67-78
39. Ehrenberg B., Montana V., Wei M.D., Wuskell J.P., and Loew L.M. Membrane potential can be determined in individual cells from the Nernstian distribution of cationic dyes. Biophys. J. 53 (1988) 785-794
40. Betti M., Minelli A., Canonico B., Castaldo P., Magi S., Aisa M.C., Piroddi M., Di Tomaso V., and Galli F. Antiproliferative effect of tocopherols (vitamin E) on murine glioma C6 cells: homologue-specific control of PKC/ERK and cyclin signalling. Free Radic. Biol. Med. 41 (2006) 464-472
41. Fischer T.W., Scholz G., Knoll B., Hipler U.C., and Elsner P. Melatonin reduces UV-induced reactive oxygen species in a dose-dependent manner in IL-3-stimulated leukocytes. J. Pineal Res. 31 (2001) 39-45
42. Fischer T.W., Scholz G., Knoll B., Hipler U.C., and Elsner P. Melatonin suppresses reactive oxygen species induced by UV irradiation in leukocytes. J. Pineal Res. 37 (2004) 107-112
43. Fischer T.W., Sweatman T.W., Semak I., Sayre R.M., Wortsman J., and Slominski A. Constitutive and UV-induced metabolism of melatonin in keratinocytes and cell-free systems. FASEB J. 20 (2006) 1564-1576
44. Avogaro A., de Kreutzenberg S.V., and Fadini G.P. Oxidative stress and vascular disease in diabetes: is the dichotomization of insulin signaling still valid?. Free Radic. Biol. Med. 44 (2008) 1209-1215
45. Katiyar S.K., and Meeran S.M. Obesity increases the risk of UV radiation-induced oxidative stress and activation of MAPK and NF-kappaB signaling. Free Radic. Biol. Med. 42 (2007) 299-310
46. Zhou L.L., Zhou L.Y., Luo K.Q., and Chang D.C. Smac/DIABLO and cytochrome c are released from mitochondria through a similar mechanism during UV-induced apoptosis. Apoptosis 10 (2005) 289-299
47. Gaitanaki C., Papatriantafyllou M., Stathopoulou K., and Beis I. Effects of various oxidants and antioxidants on the p38-MAPK signalling pathway in the perfused amphibian heart. Mol. Cell. Biochem. 291 (2006) 107-117
48. Vijayalaxmi V., Reiter R.J., Tan D.X., Herman T.S., and Thomas C.R. Melatonin as a radioprotective agent: a review. Int. J. Radiat. Oncol. Biol. Phys. 59 (2004) 639-653
49. Malemud C.J. Inhibitors of stress-activated protein/mitogen-activated protein kinase pathways. Curr. Opin. Pharmacol. 7 (2007) 339-343
50. Salinthone S., Yadav V., Bourdette D.N., and Carr D.W. Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS. Endocr. Metab. Immune Disord. Drug Targets 8 (2008) 132-142
51. Chetsawang B., Putthaprasart C., Phansuwan-Pujito P., and Govitrapong P. Melatonin protects against hydrogen peroxide-induced cell death signaling in SH-SY5Y cultured cells: involvement of nuclear factor kappa B, Bax and Bcl-2. J. Pineal Res. 41 (2006) 116-123
52. Reiter R.J., Acuña-Castroviejo D., Tan D.X., and Burkhardt S. Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system. Ann. N. Y. Acad. Sci. 939 (2001) 200-215
53. Jang J.H., and Surh Y.J. Bcl-2 attenuation of oxidative cell death is associated with up-regulation of gamma-glutamylcysteine ligase via constitutive NF-kappaB activation. J. Biol. Chem. 279 (2004) 38779-38786