Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation

Journal of Pineal Research

Volumn 58, Issue 4, 2015, Pages 429-438

  Wei, Jia Yi ^a   Li, Wan Ming ^a   Zhou, Lin Lin ^a   Lu, Qiu Nan ^a   He, Wei ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

apoptosis; CaMKII ; colorectal cancer; HDAC4; histone acetylation; melatonin

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II ALPHA; HISTONE DEACETYLASE 4; MELATONIN; PROTEIN BCL 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; HDAC4 PROTEIN, HUMAN; HISTONE DEACETYLASE; REPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; AUTOPHOSPHORYLATION; CANCER GROWTH; CELL PROLIFERATION; CELL VIABILITY; CLINICAL EFFECTIVENESS; COLORECTAL CANCER CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; DRUG MECHANISM; ENZYME INACTIVATION; GENETIC TRANSFECTION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; LOVO CELL; NUCLEAR IMPORT; NUCLEAR LOCALIZATION SIGNAL; PHARMACOLOGICAL PARAMETERS; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; TRANSIENT TRANSFECTION; ACETYLATION; CHROMATIN IMMUNOPRECIPITATION; COLORECTAL TUMOR; DRUG EFFECTS; METABOLISM; TUMOR CELL LINE;

ACETYLATION; APOPTOSIS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; COLORECTAL NEOPLASMS; HISTONE DEACETYLASES; HUMANS; MELATONIN; REPRESSOR PROTEINS;

EID: 84926509470     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12226     Document Type: Article

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