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Volumn 12, Issue 6, 2010, Pages

Inhibition of breast cancer cell invasion by melatonin is mediated through regulation of the p38 mitogen-activated protein kinase signaling pathway

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; GELATINASE A; GELATINASE B; LUZINDOLE; MATRIGEL; MELATONIN; MELATONIN 1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; STROMAL CELL DERIVED FACTOR 1; MATRIX METALLOPROTEINASE; TRYPTAMINE DERIVATIVE;

EID: 79960425073     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2794     Document Type: Article
Times cited : (145)

References (46)
  • 1
    • 0023994153 scopus 로고
    • Neuroimmunomodulation in cancer patients: correlations between melatonin and beta-endorphin blood levels and T helper/suppressor ratio
    • Barni S, Lissoni P, Crispino S, Cattaneo G, Rovelli F, Fumagalli G, Tancini G. Neuroimmunomodulation in cancer patients: correlations between melatonin and beta-endorphin blood levels and T helper/suppressor ratio. Int J Biol Markers 1988, 3:82-86.
    • (1988) Int J Biol Markers , vol.3 , pp. 82-86
    • Barni, S.1    Lissoni, P.2    Crispino, S.3    Cattaneo, G.4    Rovelli, F.5    Fumagalli, G.6    Tancini, G.7
  • 3
    • 0032188888 scopus 로고    scopus 로고
    • Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells
    • Cos S, Fernandez R, Guezmes A, Sanchez-Barcelo EJ. Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. Cancer Res 1998, 58:4383-4390.
    • (1998) Cancer Res , vol.58 , pp. 4383-4390
    • Cos, S.1    Fernandez, R.2    Guezmes, A.3    Sanchez-Barcelo, E.J.4
  • 5
    • 0035667704 scopus 로고    scopus 로고
    • The effect of light regimen and melatonin on the development of spontaneous mammary tumors in HER-2/neu transgenic mice is related to a downregulation of HER-2/neu gene expression
    • Baturin DA, Alimova IN, Anisimov VN, Popovich IG, Zabezhinski MA, Provinciali M, Mancini R, Franceschi C. The effect of light regimen and melatonin on the development of spontaneous mammary tumors in HER-2/neu transgenic mice is related to a downregulation of HER-2/neu gene expression. Neuro Endocrinol Lett 2001, 22:441-447.
    • (2001) Neuro Endocrinol Lett , vol.22 , pp. 441-447
    • Baturin, D.A.1    Alimova, I.N.2    Anisimov, V.N.3    Popovich, I.G.4    Zabezhinski, M.A.5    Provinciali, M.6    Mancini, R.7    Franceschi, C.8
  • 6
    • 0042913095 scopus 로고    scopus 로고
    • Melatonin inhibits telomerase activity in the MCF-7 tumor cell line both in vivo an in vitro
    • 10.1034/j.1600-079X.2003.00077.x, 12932205
    • Leon-Blanco MM, Guerrero JM, Reiter RJ, Calvo JR, Pozo D. Melatonin inhibits telomerase activity in the MCF-7 tumor cell line both in vivo an in vitro. J Pineal Res 2003, 35:204-211. 10.1034/j.1600-079X.2003.00077.x, 12932205.
    • (2003) J Pineal Res , vol.35 , pp. 204-211
    • Leon-Blanco, M.M.1    Guerrero, J.M.2    Reiter, R.J.3    Calvo, J.R.4    Pozo, D.5
  • 7
    • 0025848088 scopus 로고
    • Retinoic acid modulates both invasion and plasma membrane ruffling of MCF-7 human mammary carcinoma cells in vitro
    • 1972531, 1648947
    • Bracke ME, Van Larebeke NA, Vyncke BM, Mareel MM. Retinoic acid modulates both invasion and plasma membrane ruffling of MCF-7 human mammary carcinoma cells in vitro. Br J Cancer 1991, 63:867-872. 1972531, 1648947.
    • (1991) Br J Cancer , vol.63 , pp. 867-872
    • Bracke, M.E.1    Van Larebeke, N.A.2    Vyncke, B.M.3    Mareel, M.M.4
  • 8
    • 0025163024 scopus 로고
    • The presence of plasmin receptors on three mammary carcinoma MCF-7 sublines
    • 10.1002/ijc.2910460432, 2170280
    • Correc P, Fondaneche M-C, Bracke M, Burtin P. The presence of plasmin receptors on three mammary carcinoma MCF-7 sublines. Int J Cancer 1990, 46:745-750. 10.1002/ijc.2910460432, 2170280.
    • (1990) Int J Cancer , vol.46 , pp. 745-750
    • Correc, P.1    Fondaneche, M.-C.2    Bracke, M.3    Burtin, P.4
  • 9
    • 0037429725 scopus 로고    scopus 로고
    • The ErbB receptors and their role in cancer progression
    • 10.1016/S0014-4827(02)00099-X, 12648469
    • Holbro T, Civenni G, Hynes NE. The ErbB receptors and their role in cancer progression. Exp Cell Res 2003, 284:99-110. 10.1016/S0014-4827(02)00099-X, 12648469.
    • (2003) Exp Cell Res , vol.284 , pp. 99-110
    • Holbro, T.1    Civenni, G.2    Hynes, N.E.3
  • 10
    • 0023857935 scopus 로고
    • Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading
    • Berger MS, Locher GW, Saurer S, Gullick WJ, Waterfield MD, Groner B, Hynes NE. Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading. Cancer Res 1988, 48:1238-1243.
    • (1988) Cancer Res , vol.48 , pp. 1238-1243
    • Berger, M.S.1    Locher, G.W.2    Saurer, S.3    Gullick, W.J.4    Waterfield, M.D.5    Groner, B.6    Hynes, N.E.7
  • 11
    • 0034899503 scopus 로고    scopus 로고
    • Hyperactivation of MAPK induces loss of ERα expression in breast cancer cells
    • 10.1210/me.15.8.1344, 11463858
    • Oh AS, Lorant LA, Holloway JN, Miller DL, Kern FG, El-Ashry D. Hyperactivation of MAPK induces loss of ERα expression in breast cancer cells. Mol Endocrinol 2001, 15:1344-1359. 10.1210/me.15.8.1344, 11463858.
    • (2001) Mol Endocrinol , vol.15 , pp. 1344-1359
    • Oh, A.S.1    Lorant, L.A.2    Holloway, J.N.3    Miller, D.L.4    Kern, F.G.5    El-Ashry, D.6
  • 12
    • 0000446084 scopus 로고    scopus 로고
    • ERBB-2 overexpression confers PI 3' kinase-dependent invasion capacity on human mammary epithelial cells
    • 10.1054/bjoc.1999.0979, 2363331, 10682681
    • Ignatoski KM, Maehama T, Markwart SM, Dixon JE, Livant DL, Ethier SP. ERBB-2 overexpression confers PI 3' kinase-dependent invasion capacity on human mammary epithelial cells. Br J Cancer 2000, 82:666-674. 10.1054/bjoc.1999.0979, 2363331, 10682681.
    • (2000) Br J Cancer , vol.82 , pp. 666-674
    • Ignatoski, K.M.1    Maehama, T.2    Markwart, S.M.3    Dixon, J.E.4    Livant, D.L.5    Ethier, S.P.6
  • 13
    • 0030968290 scopus 로고    scopus 로고
    • Overexpression of the c-erbB-2 gene enhanced intrinsic metastasis potential in human breast cancer cells without increasing their transformation abilities
    • Tan M, Yao J, Yu D. Overexpression of the c-erbB-2 gene enhanced intrinsic metastasis potential in human breast cancer cells without increasing their transformation abilities. Cancer Res 1997, 57:1199-1205.
    • (1997) Cancer Res , vol.57 , pp. 1199-1205
    • Tan, M.1    Yao, J.2    Yu, D.3
  • 15
    • 33646516014 scopus 로고    scopus 로고
    • MMP-2 mediates ethanol-induced invasion of mammary epithelial cells over-expressing ErbB2
    • 10.1002/ijc.21769, 16450376
    • Ke Z, Lin H, Fan Z, Cai TQ, Kaplan RA, Ma C, Bower KA, Shi X, Luo J. MMP-2 mediates ethanol-induced invasion of mammary epithelial cells over-expressing ErbB2. Int J Cancer 2006, 119:8-16. 10.1002/ijc.21769, 16450376.
    • (2006) Int J Cancer , vol.119 , pp. 8-16
    • Ke, Z.1    Lin, H.2    Fan, Z.3    Cai, T.Q.4    Kaplan, R.A.5    Ma, C.6    Bower, K.A.7    Shi, X.8    Luo, J.9
  • 18
    • 0042941765 scopus 로고    scopus 로고
    • Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro
    • Chen Y, Stamatoyannopoulos G, Song CZ. Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro. Cancer Res 2003, 63:4801-4804.
    • (2003) Cancer Res , vol.63 , pp. 4801-4804
    • Chen, Y.1    Stamatoyannopoulos, G.2    Song, C.Z.3
  • 19
    • 17144384436 scopus 로고    scopus 로고
    • Defective p38 mitogen-activated protein kinase signaling impairs chemotaxic but not proliferative responses to stromal-derived factor-1alpha in acute lymphoblastic leukemia
    • Bendall LJ, Baraz R, Juarez J, She W, Bradstock KF. Defective p38 mitogen-activated protein kinase signaling impairs chemotaxic but not proliferative responses to stromal-derived factor-1alpha in acute lymphoblastic leukemia. Cancer Res 2005, 65:3290-3298.
    • (2005) Cancer Res , vol.65 , pp. 3290-3298
    • Bendall, L.J.1    Baraz, R.2    Juarez, J.3    She, W.4    Bradstock, K.F.5
  • 22
    • 2242463086 scopus 로고    scopus 로고
    • Rac1-MKK3-p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cell
    • 10.1074/jbc.M209542200, 12377770
    • Han Q, Leng J, Bian D, Mahanivong C, Carpenter KA, Pan ZK, Han J, Huang S. Rac1-MKK3-p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cell. J Biol Chem 2002, 277:48379-48385. 10.1074/jbc.M209542200, 12377770.
    • (2002) J Biol Chem , vol.277 , pp. 48379-48385
    • Han, Q.1    Leng, J.2    Bian, D.3    Mahanivong, C.4    Carpenter, K.A.5    Pan, Z.K.6    Han, J.7    Huang, S.8
  • 23
    • 0141482096 scopus 로고    scopus 로고
    • P38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells
    • Kim MS, Lee EJ, Kim HR, Moon A. p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells. Cancer Res 2003, 63:5454-5461.
    • (2003) Cancer Res , vol.63 , pp. 5454-5461
    • Kim, M.S.1    Lee, E.J.2    Kim, H.R.3    Moon, A.4
  • 24
    • 21844438240 scopus 로고    scopus 로고
    • Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines
    • 10.1091/mbc.E04-10-0945, 1165397, 15843433
    • Cardone RA, Bagorda A, Bellizzi A, Busco G, Guerra L, Paradiso A, Casavola V, Zaccolo M, Reshkin SJ. Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines. Mol Biol Cell 2005, 16:3117-3127. 10.1091/mbc.E04-10-0945, 1165397, 15843433.
    • (2005) Mol Biol Cell , vol.16 , pp. 3117-3127
    • Cardone, R.A.1    Bagorda, A.2    Bellizzi, A.3    Busco, G.4    Guerra, L.5    Paradiso, A.6    Casavola, V.7    Zaccolo, M.8    Reshkin, S.J.9
  • 25
    • 17644367566 scopus 로고    scopus 로고
    • H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells
    • 10.1074/jbc.M411625200, 15677464
    • Shin I, Kim S, Song H, Kim HR, Moon A. H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells. J Biol Chem 2005, 280:14675-14683. 10.1074/jbc.M411625200, 15677464.
    • (2005) J Biol Chem , vol.280 , pp. 14675-14683
    • Shin, I.1    Kim, S.2    Song, H.3    Kim, H.R.4    Moon, A.5
  • 26
    • 23944499856 scopus 로고    scopus 로고
    • The cAMP signaling pathway activates CREB through PKA, p38 and MSK1 in NIH 3T3 cells
    • 10.1016/j.cellsig.2005.02.003, 16125054
    • Delghandi MP, Johannessen M, Moens U. The cAMP signaling pathway activates CREB through PKA, p38 and MSK1 in NIH 3T3 cells. Cell Signal 2005, 17:1343-1351. 10.1016/j.cellsig.2005.02.003, 16125054.
    • (2005) Cell Signal , vol.17 , pp. 1343-1351
    • Delghandi, M.P.1    Johannessen, M.2    Moens, U.3
  • 27
    • 0033304803 scopus 로고    scopus 로고
    • Regulation of alkaline phoaphatase activity of p38 MAP kinase in response to activation of Gi protein-coupled receptors by epinephrine in osteoblast-like cells
    • 10.1210/en.140.7.3177, 10385412
    • Suzuki A, Palmer G, Bonjour JP, Caverzasio J. Regulation of alkaline phoaphatase activity of p38 MAP kinase in response to activation of Gi protein-coupled receptors by epinephrine in osteoblast-like cells. Endocrinology 1999, 140:3177-3182. 10.1210/en.140.7.3177, 10385412.
    • (1999) Endocrinology , vol.140 , pp. 3177-3182
    • Suzuki, A.1    Palmer, G.2    Bonjour, J.P.3    Caverzasio, J.4
  • 28
    • 0033567184 scopus 로고    scopus 로고
    • Endothelin-1 activates p38 mitogen-activated protein kinase and cytosolic phospholiase A2 in cat iris sphincter smooth muscle cells
    • 10.1042/0264-6021:3420087, 1220440, 10432304
    • Husain S, Abdel-Latif AA. Endothelin-1 activates p38 mitogen-activated protein kinase and cytosolic phospholiase A2 in cat iris sphincter smooth muscle cells. Biochem J 1999, 342:87-96. 10.1042/0264-6021:3420087, 1220440, 10432304.
    • (1999) Biochem J , vol.342 , pp. 87-96
    • Husain, S.1    Abdel-Latif, A.A.2
  • 29
    • 33744970255 scopus 로고    scopus 로고
    • The signaling pathways linking to lysophosphatidic aid-promoted meiotic maturation in mice
    • 10.1016/j.lfs.2006.01.028, 16492384
    • Komatsu J, Yamano S, Kuwahara A, Tokumura A, Irahara M. The signaling pathways linking to lysophosphatidic aid-promoted meiotic maturation in mice. Life Sci 2006, 79:506-511. 10.1016/j.lfs.2006.01.028, 16492384.
    • (2006) Life Sci , vol.79 , pp. 506-511
    • Komatsu, J.1    Yamano, S.2    Kuwahara, A.3    Tokumura, A.4    Irahara, M.5
  • 30
    • 0034704157 scopus 로고    scopus 로고
    • Beta 2-adrenergic receptor-induced p38 MAPK activation is mediated by protein kinase A rather than by Gi or Gbeta gamma in a adult mouse cardiomyocytes
    • 10.1074/jbc.M006325200, 11018034
    • Zheng M, Zhang SJ, Zhu WZ, Ziman B, Kobilka BK, Xiao RP. Beta 2-adrenergic receptor-induced p38 MAPK activation is mediated by protein kinase A rather than by Gi or Gbeta gamma in a adult mouse cardiomyocytes. J Biol Chem 2000, 275:40635-40640. 10.1074/jbc.M006325200, 11018034.
    • (2000) J Biol Chem , vol.275 , pp. 40635-40640
    • Zheng, M.1    Zhang, S.J.2    Zhu, W.Z.3    Ziman, B.4    Kobilka, B.K.5    Xiao, R.P.6
  • 31
    • 0036161980 scopus 로고    scopus 로고
    • Melatonin inhibits estrogen receptor transactivation and cAMP levels in MCF-7 human breast cancer cells
    • 10.1023/A:1013301408464, 11859872
    • Kiefer TL, Yuan L, Ram PT, Hill SM. Melatonin inhibits estrogen receptor transactivation and cAMP levels in MCF-7 human breast cancer cells. Breast Cancer Res Treat 2002, 71:37-45. 10.1023/A:1013301408464, 11859872.
    • (2002) Breast Cancer Res Treat , vol.71 , pp. 37-45
    • Kiefer, T.L.1    Yuan, L.2    Ram, P.T.3    Hill, S.M.4
  • 32
    • 0037188428 scopus 로고    scopus 로고
    • Involvement of the mt1 melatonin receptor in human breast cancer
    • 10.1016/S0304-3835(01)00873-4, 11888668
    • Ram PT, Dai J, Yuan L, Dong C, Kiefer TL, Lai L, Hill SM. Involvement of the mt1 melatonin receptor in human breast cancer. Cancer Lett 2002, 179:141-150. 10.1016/S0304-3835(01)00873-4, 11888668.
    • (2002) Cancer Lett , vol.179 , pp. 141-150
    • Ram, P.T.1    Dai, J.2    Yuan, L.3    Dong, C.4    Kiefer, T.L.5    Lai, L.6    Hill, S.M.7
  • 33
    • 0942301172 scopus 로고    scopus 로고
    • Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells
    • 10.1038/sj.onc.1206910, 14712221
    • Fernandis AZ, Prasad A, Band H, Klosel R, Ganju RK. Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells. Oncogene 2004, 23:157-167. 10.1038/sj.onc.1206910, 14712221.
    • (2004) Oncogene , vol.23 , pp. 157-167
    • Fernandis, A.Z.1    Prasad, A.2    Band, H.3    Klosel, R.4    Ganju, R.K.5
  • 34
    • 0037188823 scopus 로고    scopus 로고
    • MT1 melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells
    • 10.1016/S0303-7207(02)00029-1, 12088876
    • Yuan L, Collins AR, Dai J, Dubocovich ML, Hill SM. MT1 melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells. Mol Cell Endocrinol 2002, 192:147-156. 10.1016/S0303-7207(02)00029-1, 12088876.
    • (2002) Mol Cell Endocrinol , vol.192 , pp. 147-156
    • Yuan, L.1    Collins, A.R.2    Dai, J.3    Dubocovich, M.L.4    Hill, S.M.5
  • 35
    • 0037427569 scopus 로고    scopus 로고
    • Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice
    • 10.1016/S0304-3835(02)00502-5, 12445677
    • Collins A, Yuan L, Kiefer TL, Cheng Q, Lai L, Hill SM. Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice. Cancer Lett 2003, 189:49-57. 10.1016/S0304-3835(02)00502-5, 12445677.
    • (2003) Cancer Lett , vol.189 , pp. 49-57
    • Collins, A.1    Yuan, L.2    Kiefer, T.L.3    Cheng, Q.4    Lai, L.5    Hill, S.M.6
  • 36
    • 34547154349 scopus 로고    scopus 로고
    • P38 MAP-kinases pathway regulation, function and role in human diseases
    • Cuenda A, Rousseau S. p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta 2007, 1773:1358-1375.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 1358-1375
    • Cuenda, A.1    Rousseau, S.2
  • 37
    • 2942529276 scopus 로고    scopus 로고
    • The biology of the Ets1 proto-oncogene
    • 10.1186/1476-4598-2-29, 194255, 12971829
    • Dittmer J. The biology of the Ets1 proto-oncogene. Mol Cancer 2003, 2:29. 10.1186/1476-4598-2-29, 194255, 12971829.
    • (2003) Mol Cancer , vol.2 , pp. 29
    • Dittmer, J.1
  • 38
    • 0037018260 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway
    • 10.1038/sj.onc.1205297, 11948414
    • Paumelle R, Tulasne D, Kherrouche Z, Plaza S, Leroy C, Reveneau S, Vandenbunder B, Fafeur V. Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway. Oncogene 2002, 21:2309-2319. 10.1038/sj.onc.1205297, 11948414.
    • (2002) Oncogene , vol.21 , pp. 2309-2319
    • Paumelle, R.1    Tulasne, D.2    Kherrouche, Z.3    Plaza, S.4    Leroy, C.5    Reveneau, S.6    Vandenbunder, B.7    Fafeur, V.8
  • 39
    • 34447130377 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 activity and expression is reduced by melatonin during prevention of ethanol-induced gastric ulcer in mice
    • 10.1111/j.1600-079X.2007.00443.x, 17614836
    • Swarnakar S, Mishra A, Ganguly K, Sharma AV. Matrix metalloproteinase-9 activity and expression is reduced by melatonin during prevention of ethanol-induced gastric ulcer in mice. J Pineal Res 2007, 43:56-64. 10.1111/j.1600-079X.2007.00443.x, 17614836.
    • (2007) J Pineal Res , vol.43 , pp. 56-64
    • Swarnakar, S.1    Mishra, A.2    Ganguly, K.3    Sharma, A.V.4
  • 40
    • 42149105217 scopus 로고    scopus 로고
    • Role of melatonin in regulating matrix metalloproteinase-9 via tissue inhibitors of metalloproteinase-1 during protection against endometriosis
    • 10.1111/j.1600-079X.2007.00547.x, 18298469
    • Paul S, Sharma AV, Mahapatra PD, Bhattacharya P, Reiter RJ, Swarnakar S. Role of melatonin in regulating matrix metalloproteinase-9 via tissue inhibitors of metalloproteinase-1 during protection against endometriosis. J Pineal Res 2008, 44:439-449. 10.1111/j.1600-079X.2007.00547.x, 18298469.
    • (2008) J Pineal Res , vol.44 , pp. 439-449
    • Paul, S.1    Sharma, A.V.2    Mahapatra, P.D.3    Bhattacharya, P.4    Reiter, R.J.5    Swarnakar, S.6
  • 42
    • 0036153763 scopus 로고    scopus 로고
    • Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins
    • 10.1016/S0898-6568(01)00240-6, 11812653
    • Chan AS, Lai FP, Lo RK, Voyno-Yasenetskaya TA, Stanbridge EJ, Wong YH. Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins. Cell Signal 2002, 14:249-257. 10.1016/S0898-6568(01)00240-6, 11812653.
    • (2002) Cell Signal , vol.14 , pp. 249-257
    • Chan, A.S.1    Lai, F.P.2    Lo, R.K.3    Voyno-Yasenetskaya, T.A.4    Stanbridge, E.J.5    Wong, Y.H.6
  • 43
    • 12344307153 scopus 로고    scopus 로고
    • Signal transduction pathways involved in melatonin-induced neuroprotection after focal cerebral ischemic in mice
    • 10.1111/j.1600-079X.2004.00178.x, 15617539
    • Kilic U, Kilic E, Reiter RJ, Bassetti CL, Hermann DM. Signal transduction pathways involved in melatonin-induced neuroprotection after focal cerebral ischemic in mice. J Pineal Res 2005, 38:67-71. 10.1111/j.1600-079X.2004.00178.x, 15617539.
    • (2005) J Pineal Res , vol.38 , pp. 67-71
    • Kilic, U.1    Kilic, E.2    Reiter, R.J.3    Bassetti, C.L.4    Hermann, D.M.5
  • 44
    • 33645473088 scopus 로고    scopus 로고
    • Melatonin enhances alkaline phoshoatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade
    • 10.1111/j.1600-079X.2006.00318.x, 16635021
    • Radio NM, Doctor JS, Witt-Enderby PA. Melatonin enhances alkaline phoshoatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade. J Pineal Res 2006, 40:332-342. 10.1111/j.1600-079X.2006.00318.x, 16635021.
    • (2006) J Pineal Res , vol.40 , pp. 332-342
    • Radio, N.M.1    Doctor, J.S.2    Witt-Enderby, P.A.3
  • 45
    • 77952058710 scopus 로고    scopus 로고
    • P38gamma MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9
    • 10.1074/jbc.M110.105429, 20231272
    • Loesch M, Zhi HY, Hou SW, Qi XM, Li RS, Basir Z, Iftner T, Cuenda A, Chen G. p38gamma MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9. J Biol Chem 2010, 285:15149-15158. 10.1074/jbc.M110.105429, 20231272.
    • (2010) J Biol Chem , vol.285 , pp. 15149-15158
    • Loesch, M.1    Zhi, H.Y.2    Hou, S.W.3    Qi, X.M.4    Li, R.S.5    Basir, Z.6    Iftner, T.7    Cuenda, A.8    Chen, G.9


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