Melatonin compensates silencing of heat shock protein 70 and suppresses ultraviolet radiation-induced inflammation in human skin ex vivo and cultured keratinocytes

Journal of Pineal Research

Volumn 58, Issue 1, 2015, Pages 117-126

  Kleszczyński, Konrad ^a   Zwicker, Stephanie ^b   Tukaj, Stefan ^a   Kasperkiewicz, Michael ^a   Zillikens, Detlef ^a   Wolf, Ronald ^b   Fischer, Tobias W ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

heat shock protein 70; human full thickness skin organ culture; immunofluorescence; inflammation; melatonin; real time polymerase chain reaction; ultraviolet radiation

Indexed keywords

CASPASE 3; HEAT SHOCK PROTEIN 70; I KAPPA B ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; MELATONIN; RNA; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CASP3 PROTEIN, HUMAN; CASPASE 1; HSP70 HEAT-SHOCK PROTEINS; I-KAPPA B PROTEINS; IL1B PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; INTERLEUKIN-1BETA; INTERLEUKIN-6; NF-KAPPAB INHIBITOR ALPHA; RNA, SMALL INTERFERING;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DERMATITIS; EPIDERMIS; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; PROTEIN EXPRESSION; ULTRAVIOLET RADIATION; UPREGULATION; ADVERSE EFFECTS; ANTAGONISTS AND INHIBITORS; CELLS, CULTURED; DRUG EFFECTS; FEMALE; GENE SILENCING; GENETICS; HUMANS; KERATINOCYTES; MALE; METABOLISM; PATHOLOGY; RADIATION EFFECTS; SUNBURN; ULTRAVIOLET RAYS;

ADULT; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; APOPTOSIS; CASPASE 1; CASPASE 3; CELLS, CULTURED; EPIDERMIS; FEMALE; GENE SILENCING; HSP70 HEAT-SHOCK PROTEINS; HUMANS; I-KAPPA B PROTEINS; INTERLEUKIN-1BETA; INTERLEUKIN-6; KERATINOCYTES; MALE; MELATONIN; RNA, SMALL INTERFERING; SUNBURN; ULTRAVIOLET RAYS;

EID: 84919627240     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12197     Document Type: Article

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