Folic acid and melatonin ameliorate carbon tetrachloride-induced hepatic injury, oxidative stress and inflammation in rats

Nutrition and Metabolism

Volumn 10, Issue 1, 2013, Pages

  Ebaid, Hossam ^a,b   Bashandy, Samir A E ^a,c   Alhazza, Ibrahim M ^a,d   Rady, Ahmed ^a   El Shehry, Sultan ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b MINIA UNIVERSITY   (Egypt)

^c NATIONAL RESEARCH CENTRE   (Egypt)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Akt1; Anti inflammatory effects; Folic acid; Hepatic injury markers; Melatonin; Oxidative stress

Indexed keywords

BILIRUBIN; CARBON TETRACHLORIDE; CATALASE; CHOLESTEROL; FAS ANTIGEN; FOLIC ACID; GAMMA INTERFERON; GLUTATHIONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN; MELATONIN; MESSENGER RNA; PROTEIN; PROTEIN KINASE B; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIRUBIN BLOOD LEVEL; CELL SURVIVAL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; INFLAMMATION; LIPID BLOOD LEVEL; LIPID PEROXIDATION; LIVER FUNCTION; LIVER HISTOLOGY; LIVER INJURY; LIVER PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; UREA BLOOD LEVEL;

RATTUS;

EID: 84873045137     PISSN: None     EISSN: 17437075     Source Type: Journal    
DOI: 10.1186/1743-7075-10-20     Document Type: Article

References (56)

1. Pathological mechanisms in carbon tetrachloride hepatotoxicity. Brattin WJ, GlendeJr EA, Recknagel RO, J Free Radic Biol Med 1985 1 27 38 (Pubitemid 16104819)
2. Carbon tetrachloride hepatotoxicity as a function of age in female Fischer 344 rats. Rikans LE, Hornbrook KR, Cai Y, Mech Ageing Dev 1994 76 89 99 (Pubitemid 24326355)
3. Carbon tetrachloride changes the activity of cytochrome P450 system in the liver of male rats: role of antioxidants. Sheweita SA, El-Gabar MA, Bastawy M, Toxicology 2001 169 83 92 (Pubitemid 33082115)
4. Effect of vitamin E on carbon tetrachlorideinduced lipid peroxidation as demonstrated by in vivo pentane production. Sagai M, Tappel AI, Toxicology Lett. 1978 2 149 155 (Pubitemid 9014908)
5. Melatonin protects the cytochrome P450 system through a novel antioxidant mechanism. Letelier ME, Jara-Sandoval J, Molina-Berríos A, Faúndez M, Aracena-Parks P, Aguilera F, Chem Biol Interact 2010 185 208 214
6. Melatonin synthesis in the human pineal gland: advantages, implications, and difficulties. Ackermann K, Stehle JH, Chronobiol Int 2006 23 369 379 (Pubitemid 43739048)
7. Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Simonneaux V, Ribelayga C, Pharmacol Rev 2003 55 325 395 (Pubitemid 36666050)
8. Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans. Reiter RJ, Tan DX, Mayo JC, Sainz RM, Leon J, Czarnocki Z, Acta Biochim Pol 2003 50 1129 1146 (Pubitemid 38608841)
9. Regulation of antioxidant enzymes: a significant role for melatonin. Rodriguez C, Mayo JC, Sainz RM, Antolin I, Herrera F, Martin V, Reiter RJ, J Pineal Res 2004 36 1 9 (Pubitemid 38130283)
10. Beneficial effect of melatonin treatment on inflammation, apoptosis and oxidative stress on pancreas of a senescence accelerated mice model. Cuesta S, Kireev R, García C, Forman K, Escames G, Vara E, Tresguerres JA, Mech Ageing Dev 2011 132 573 582
11. Melatonin improves inflammation processes in liver of senescence-accelerated prone male mice (SAMP8). Cuesta S, Kireev R, Forman K, García C, Escames G, Ariznavarreta C, Vara E, Tresguerres JA, Exp Gerontol 2010 45 950 956
12. Melatonin reduces oxidative stress in surgical neonates. Gitto E, Romeo C, Reiter RJ, Impellizzeri P, Pesce S, Basile M, Antonuccio P, Trimarchi G, Gentile C, Barberi I, Zuccarello B, J Pediatr Surg 2004 39 184 189 (Pubitemid 38146434)
13. Melatonin prevents hemorrhagic shock-induced liver injury in rats through an Akt-dependent HO-1 pathway. Hsu JT, Kuo CJ, Chen TH, Wang F, Lin CJ, Yeh TS, Hwang TL, Jan YY, J Pineal Res 2012 53 4 410 416
14. Folates and cardiovascular disease. Verhaar MC, Stroes E, Rabelink TJ, Arterioscler Thromb Vasc Biol 2002 22 6 13 (Pubitemid 34076225)
15. Folate-responsive neuropathy: report of 10 cases. Manzoor M, Runcie J, Br Med J 1976 1 1176 1178
16. Folate levels and neural tube defects.Implications for prevention. Daly LE, Kirke PN, Molloy A, Weir DG, Scott JM, JAMA J Am Med Assoc 1995 274 1698 1702
17. Impact of folate deficiency on DNA stability. Duthie SJ, Narayanan S, Brand GM, Pirie L, Grant G, J Nutr 2002 132 2444S 2449S (Pubitemid 34848124)
18. Folate protects against oxidative modification of human LDL. Nakano E, Higgins JA, Powers HJ, Br J Nutr 2001 86 637 639 (Pubitemid 34051424)
19. High-dose folic acid pretreatment blunts cardiac dysfunction during ischemia coupled to maintenance of high-energy phosphates and reduces postreperfusion injury. Moens AL, Champion HC, Claeys MJ, Tavazzi B, Kaminski PM, Wolin MS, Borgonjon DJ, Van Nassauw L, Haile A, Zviman M, Bedja D, Wuyts FL, Elsaesser RS, Cos P, Gabrielson KL, Lazzarino G, Paolocci N, Timmermans JP, Vrints CJ, Kass DA, Circulation 2008 117 1810 1819 (Pubitemid 351507469)
20. Effect of short-term folic acid supplementation on insulin sensitivity and inflammatory markers in overweight subjects. Solini A, Santini E, Ferrannini E, Int J Obes (Lond) 2006 30 1197 1202 (Pubitemid 44141607)
21. Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles, A prospective clinical trial. Rizzo P, Raffone E, Benedetto V, Eur Rev Med Pharmacol Sci 2010 14 555 561
22. Folate deficiency alters melatonin secretion in rats. Fournier I, Ploye F, Cottet-Emard JM, Brun J, Claustrat B, J Nutr 2002 132 2781 2784 (Pubitemid 35013270)
23. Evaluation of the antioxidant, anti-inflammatory and hepatoprotective properties of vanillin in carbon tetrachloride-treated rats. Makni M, Chtourou Y, Fetoui H, Garouiel M, Boudawara T, Zeghal N, Eur J Pharmacol 2011 668 133 139
24. Reduction of procarbazine-induced cleft palates by prenatal folic acid supplementation in rats. Malek FA, Möritz KU, Fanghänel J, Bienengräberc V, Pathol Res Pract 2004 200 33 40 (Pubitemid 38949855)
25. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Okhawa H, Ohishi N, Yagi K, Anal Biochem 1979 95 351 358 (Pubitemid 9194347)
26. Levels of GSH, GR and GST activities in rat lung and liver. Moron MS, Depierre JW, Mannervik B, Biochim Biophys Acta 1979 582 67 78
27. Catalase in vitro. Aebi H, Method Enzymol 1984 105 121 126
28. Melatonin treatment improves the antioxidant status and decreases lipid content in brain and liver of rats. Subramanian P, Mirunalini S, Pandi-Perumal SR, Trakht I, Cardinali DP, Eur J Pharmacol 2007 571 116 119 (Pubitemid 47385902)
29. Folic acid supplementation inhibits NADPH oxidase-mediated superoxide anion production in the kidney. Hwang SY, Siow YL, Au-Yeung KK, House JOK, Am J Physiol Renal Physiol 2010 300 189 F198
30. Whey protein enhances normal inflammatory responses during cutaneous wound healing in diabetic rats. Ebaid H, Salem A, Sayed A, Metwalli A, Lipids Health Dis 2011 10 235
31. Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients. Basu S, Toxicology 2003 189 113 127 (Pubitemid 36725027)
32. Role of osteopontin in regulating hepatic inflammatory responses and toxic liver injury. Ramaiah SK, Rittling S, Expert Opin Drug Metab Toxicol 2007 3 519 526 (Pubitemid 351324961)
33. Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation. Niemela O, Parkkila S, Yla-Herttuala S, Halsted C, Witztum JL, Lanca A, Israel Y, Lab Invest 1994 70 537 546 (Pubitemid 24185024)
34. Melatonin: lowering the high price of free radicals. Reiter RJ, News Physiol Sci 2000 15 246 250
35. Dietary antioxidant compounds and liver health. Vitaglione P, Morisco F, Caporaso N, Fogliano V, Crit Rev Food Sci Nutr 2004 44 575 586 (Pubitemid 40536485)
36. Biomarkers of oxidative stress study: are plasma antioxidants markers of CCl4 poisoning? Kadiska MB, Gladen BC, Baird DD, Dikalov AE, Sohal RS, Hatch GB, Jones DP, Mason RP, Barret JC, J Free Rad Biol Med 2000 28 838 845 (Pubitemid 30235155)
37. Blood pressure modulation and cardiovascular protection by melatonin: potential mechanisms behind. Paulis L, Simko F, Physiol Res 2007 56 671 684
38. Three models of free radical-induced cell injury. Comporti M, Chem Biol Interact 1989 72 1 56 (Pubitemid 19284045)
39. Dietary zinc alters early inflammatory responses during cutaneous wound healing in weanling CD-1 mice. Lim Y, Levy M, Bray TM, J Nutr 2004 134 811 816 (Pubitemid 38456248)
40. Arafat HA: Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. Cheh N, Chipitsyna G, Gong Q, Yeo CJ, HPB (Oxford) 2009 11 373 381
41. Alteration of AP-endonuclease1 expression in curcumin-treated fibrotic rats. Bassiouny AR, Zaky A, Kandeel KM, Ann Hepatol 2011 10 516 530
42. Expression of Fas ligand by hepatic macrophages in patients with fulminant hepatic failure. Mita A, Hashikura Y, Tagawa Y, Nakayama J, Kawakubo M, Miyagawa S, Am J Gastroenterol 2005 100 2551 2559
43. The effects of interleukin-10 on the expression of Fas and FasL in rat hepatic stellate cells. Zhang L, Wang X, Zheng W, Shi M, Med Chem 2006 2 611 616 (Pubitemid 44741616)
44. Apoptosis by death factor. Nagata S, Cell 1997 88 355 365 (Pubitemid 27131377)
45. Mechanisms of carbon tetrachloride toxicity. Recknagel RO, Glende EA, Dolak JA, Waller RL, Pharmacol. Therapeut. 1989 43 139 154 (Pubitemid 19200126)
46. Suppression of c-Myc-induced apoptosis by Rassignalling through PI (3)K and PKB. Kauffmann-Zeh A, Rodriguez-Viciana P, Ulrich E, Gilbert C, Coffer P, Downward J, Evan G, Nature 1997 385 44 548
47. Akt gene therapy for cirrhotic rats with portal hypertension. Huang FZ, Deng G, Liu XY, Luo CQ, Zhong Nan Da XueXueBao Yi Xue Ban 2008 33 31 37
48. The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY. Ezell SA, Polytarchou C, Hatziapostolou M, Guo A, Sanidas I, Bihani T, Comb MJ, Sourvinos G, Tsichlis PN, Proc Natl Acad Sci U S A 2012 109 613 E621
49. Role of the Akt pathway in mRNA translation of interferon-stimulated genes. Kaur S, Sassano A, Dolniak B, Joshi S, Majchrzak-Kita B, Baker DP, Hay N, Fish EN, Platanias LC, Proc Natl Acad Sci U S A 2008 105 4808 4813 (Pubitemid 351753828)
50. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines. Kane LP, Andres PG, Howland KC, Abbas AK, Weiss A, Nat Immunol 2001 2 37 44 (Pubitemid 33704951)
51. Effect of melatonin on the maintenance of cholesterol homeostasis in the rat. Chan TY, Tang PL, Endocrinol. Res. 1995 21 681 696
52. Melatonin inhibits LDL receptor activity and cholesterol synthesis in freshly isolated human mononuclear leucocytes. Muller-Wieland D, Behnke B, Koopmann K, Krone W, Biochem Biophys Res Commun 1994 202 416 421
53. Theoretical considerations of what regulates low-density lipoprotein and high-density lipoprotein cholesterol. Dietschy JM, Am J Clin Nutr 1997 65 1581S 1589S (Pubitemid 27187952)
54. Measurement of catalytic levels of enzymes. Part2. IFCC method for aspartate aminotransferase. Marucci L, Alpini G, Glaser SS, Alvaro D, Benedetti A, Francis H, Phinizy JL, Marzioni M, Mauldin J, Venter J, Baumann B, Ugili L, LeSage G, J Clin Chem Clin Biochem 2002 24 497 510
55. Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse. Gomez TS, Hamann MJ, McCarney S, Savoy DN, Lubking CM, Heldebrant MP, Labno CM, McKean DJ, McNiven MA, Burkhardt JK, Billadeau DD, Nat Immunol 2005 6 261 270 (Pubitemid 41724763)
56. Control of memory CD8+ T cell differentiation by CD80/CD86-CD28 costimulation and restoration by IL-2 during the recall response. Fuse S, Zhang W, Usherwood EJ, J Immunol 2008 180 1148 1157