메뉴 건너뛰기




Volumn 56, Issue 1, 2014, Pages 20-30

Inhibition of matrix metalloproteinase-9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in HepG2 liver cancer cells

Author keywords

hepatocellular carcinoma; interleukin 1 ; matrix metalloproteinases; melatonin; nuclear factor kappa B

Indexed keywords

GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MELATONIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TUMOR NECROSIS FACTOR ALPHA;

EID: 84890117464     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12092     Document Type: Article
Times cited : (103)

References (81)
  • 2
    • 80053088189 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • El-Serag HB,. Hepatocellular carcinoma. N Engl J Med 2011; 365: 1118-1127.
    • (2011) N Engl J Med , vol.365 , pp. 1118-1127
    • El-Serag, H.B.1
  • 3
    • 0030751882 scopus 로고    scopus 로고
    • The prediction of risk of recurrence and time to recurrence of hepatocellular carcinoma after orthotopic liver transplantation: A pilot study
    • Marsh JW, Dvorchik I, Subotin M, et al. The prediction of risk of recurrence and time to recurrence of hepatocellular carcinoma after orthotopic liver transplantation: a pilot study. Hepatology 1997; 26: 444-450.
    • (1997) Hepatology , vol.26 , pp. 444-450
    • Marsh, J.W.1    Dvorchik, I.2    Subotin, M.3
  • 4
    • 0345701478 scopus 로고    scopus 로고
    • Metastatic hepatocellular carcinoma of the maxillary sinus: A rare autopsy case without lung metastasis and a review
    • Okada H, Kamino Y, Shimo M, et al. Metastatic hepatocellular carcinoma of the maxillary sinus: a rare autopsy case without lung metastasis and a review. Int J Oral Maxillofac Surg 2003; 32: 97-100.
    • (2003) Int J Oral Maxillofac Surg , vol.32 , pp. 97-100
    • Okada, H.1    Kamino, Y.2    Shimo, M.3
  • 5
    • 64749091536 scopus 로고    scopus 로고
    • Vascular invasion is the most important predictor of survival in HCC, but how do we find it?
    • Thuluvath PJ,. Vascular invasion is the most important predictor of survival in HCC, but how do we find it? J Clin Gastroenterol 2009; 43: 101-102.
    • (2009) J Clin Gastroenterol , vol.43 , pp. 101-102
    • Thuluvath, P.J.1
  • 6
    • 84860251082 scopus 로고    scopus 로고
    • PPARgamma inhibits hepatocellular carcinoma metastases in vitro and in mice
    • Shen B, Chu ES, Zhao G, et al. PPARgamma inhibits hepatocellular carcinoma metastases in vitro and in mice. Br J Cancer 2012; 106: 1486-1494.
    • (2012) Br J Cancer , vol.106 , pp. 1486-1494
    • Shen, B.1    Chu, E.S.2    Zhao, G.3
  • 7
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited
    • Fidler IJ,. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003; 3: 453-458.
    • (2003) Nat Rev Cancer , vol.3 , pp. 453-458
    • Fidler, I.J.1
  • 8
    • 0345643514 scopus 로고    scopus 로고
    • Regulation of matrix metalloproteinase expression in tumor invasion
    • Westermarck J, Kahari VM,. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J 1999; 13: 781-792.
    • (1999) FASEB J , vol.13 , pp. 781-792
    • Westermarck, J.1    Kahari, V.M.2
  • 9
    • 34249034397 scopus 로고    scopus 로고
    • Matrix metalloproteinase polymorphisms are associated with bladder cancer invasiveness
    • Kader AK, Liu J, Shao L, et al. Matrix metalloproteinase polymorphisms are associated with bladder cancer invasiveness. Clin Cancer Res 2007; 13: 2614-2620.
    • (2007) Clin Cancer Res , vol.13 , pp. 2614-2620
    • Kader, A.K.1    Liu, J.2    Shao, L.3
  • 10
    • 0029741786 scopus 로고    scopus 로고
    • Overexpression of matrix metalloproteinase 9 gene in hepatocellular carcinoma with invasive potential
    • Arii S, Mise M, Harada T, et al. Overexpression of matrix metalloproteinase 9 gene in hepatocellular carcinoma with invasive potential. Hepatology 1996; 24: 316-322.
    • (1996) Hepatology , vol.24 , pp. 316-322
    • Arii, S.1    Mise, M.2    Harada, T.3
  • 11
    • 46049093970 scopus 로고    scopus 로고
    • Resveratrol inhibits tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells
    • Yu H, Pan C, Zhao S, et al. Resveratrol inhibits tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells. Biomed Pharmacother 2008; 62: 366-372.
    • (2008) Biomed Pharmacother , vol.62 , pp. 366-372
    • Yu, H.1    Pan, C.2    Zhao, S.3
  • 12
    • 0034472617 scopus 로고    scopus 로고
    • Matrix metalloproteinases in tumor invasion and metastasis
    • Stamenkovic I,. Matrix metalloproteinases in tumor invasion and metastasis. Semin Cancer Biol 2000; 10: 415-433.
    • (2000) Semin Cancer Biol , vol.10 , pp. 415-433
    • Stamenkovic, I.1
  • 13
    • 1542495411 scopus 로고    scopus 로고
    • Structural basis of matrix metalloproteinase function
    • Bode W,. Structural basis of matrix metalloproteinase function. Biochem Soc Symp 2003; 70: 1-14.
    • (2003) Biochem Soc Symp , vol.70 , pp. 1-14
    • Bode, W.1
  • 14
    • 77956301181 scopus 로고    scopus 로고
    • Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion
    • Bourboulia D, Stetler-Stevenson WG,. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): positive and negative regulators in tumor cell adhesion. Semin Cancer Biol 2010; 20: 161-168.
    • (2010) Semin Cancer Biol , vol.20 , pp. 161-168
    • Bourboulia, D.1    Stetler-Stevenson, W.G.2
  • 15
    • 0038487864 scopus 로고    scopus 로고
    • The role of Matrix Metaloproteinases in the progression of periodontitis, and the use of specific inhibitors to these enzymes in the treatment of the periodontal disease
    • Nasatzky E, Rubinstein Y, Goultschin J, et al. The role of Matrix Metaloproteinases in the progression of periodontitis, and the use of specific inhibitors to these enzymes in the treatment of the periodontal disease. Refuat Hapeh Vehashinayim 2003; 20: 81.
    • (2003) Refuat Hapeh Vehashinayim , vol.20 , pp. 81
    • Nasatzky, E.1    Rubinstein, Y.2    Goultschin, J.3
  • 16
    • 84869026665 scopus 로고    scopus 로고
    • Matrix metalloproteinase 9 (MMP-9)-dependent processing of betaig-h3 protein regulates cell migration, invasion, and adhesion
    • Kim YH, Kwon HJ, Kim DS,. Matrix metalloproteinase 9 (MMP-9)-dependent processing of betaig-h3 protein regulates cell migration, invasion, and adhesion. J Biol Chem 2012; 287: 38957-38969.
    • (2012) J Biol Chem , vol.287 , pp. 38957-38969
    • Kim, Y.H.1    Kwon, H.J.2    Kim, D.S.3
  • 17
    • 84862246990 scopus 로고    scopus 로고
    • TNF-alpha stimulates MMP-2 and MMP-9 activities in human corneal epithelial cells via the activation of FAK/ERK signaling
    • Yang YN, Wang F, Zhou W, et al. TNF-alpha stimulates MMP-2 and MMP-9 activities in human corneal epithelial cells via the activation of FAK/ERK signaling. Ophthalmic Res 2012; 48: 165-170.
    • (2012) Ophthalmic Res , vol.48 , pp. 165-170
    • Yang, Y.N.1    Wang, F.2    Zhou, W.3
  • 18
    • 26444584958 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and liver carcinogenesis
    • Arsura M, Cavin LG,. Nuclear factor-kappaB and liver carcinogenesis. Cancer Lett 2005; 229: 157-169.
    • (2005) Cancer Lett , vol.229 , pp. 157-169
    • Arsura, M.1    Cavin, L.G.2
  • 19
    • 43649109029 scopus 로고    scopus 로고
    • Inflammation and cancer: Role of nuclear factor-kappaB activation
    • Maeda S, Omata M,. Inflammation and cancer: role of nuclear factor-kappaB activation. Cancer Sci 2008; 99: 836-842.
    • (2008) Cancer Sci , vol.99 , pp. 836-842
    • Maeda, S.1    Omata, M.2
  • 20
    • 18144381589 scopus 로고    scopus 로고
    • Changes in oxidative stress markers and NF-kappa B activation induced by sprint exercise
    • Cuevas MJ, Almar M, García-González JC, et al. Changes in oxidative stress markers and NF-kappa B activation induced by sprint exercise. Free Radical Res 2005; 39: 431-439.
    • (2005) Free Radical Res , vol.39 , pp. 431-439
    • Cuevas, M.J.1    Almar, M.2    García-González, J.C.3
  • 21
    • 68249102426 scopus 로고    scopus 로고
    • Melatonin reduces cardiac inflammatory injury induced by acute exercise
    • Veneroso C, Tuñon MJ, González-Gallego J, et al. Melatonin reduces cardiac inflammatory injury induced by acute exercise. J Pineal Res 2009; 47: 184-191.
    • (2009) J Pineal Res , vol.47 , pp. 184-191
    • Veneroso, C.1    Tuñon, M.J.2    González-Gallego, J.3
  • 22
    • 77955906264 scopus 로고    scopus 로고
    • The nuclear factor NF-kappaB pathway in inflammation
    • Lawrence T,. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol 2009; 1: a001651.
    • (2009) Cold Spring Harb Perspect Biol , vol.1
    • Lawrence, T.1
  • 23
    • 33745581994 scopus 로고    scopus 로고
    • Melatonin ameliorates nonalcoholic fatty liver induced by high-fat diet in rats
    • Pan M, Song YL, Xu JM, et al. Melatonin ameliorates nonalcoholic fatty liver induced by high-fat diet in rats. J Pineal Res 2006; 41: 79-84.
    • (2006) J Pineal Res , vol.41 , pp. 79-84
    • Pan, M.1    Song, Y.L.2    Xu, J.M.3
  • 24
    • 34548600128 scopus 로고    scopus 로고
    • Melatonin treatment improves the antioxidant status and decreases lipid content in brain and liver of rats
    • Subramanian P, Mirunalini S, Pandi-Perumal SR, et al. Melatonin treatment improves the antioxidant status and decreases lipid content in brain and liver of rats. Eur J Pharmacol 2007; 571: 116-119.
    • (2007) Eur J Pharmacol , vol.571 , pp. 116-119
    • Subramanian, P.1    Mirunalini, S.2    Pandi-Perumal, S.R.3
  • 25
    • 64649093159 scopus 로고    scopus 로고
    • Melatonin ameliorates methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in rats
    • Tahan V, Atug O, Akin H, et al. Melatonin ameliorates methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in rats. J Pineal Res 2009; 46: 401-407.
    • (2009) J Pineal Res , vol.46 , pp. 401-407
    • Tahan, V.1    Atug, O.2    Akin, H.3
  • 26
    • 34948823454 scopus 로고    scopus 로고
    • N-acetylcysteine attenuates oxidative stress and liver pathology in rats with non-alcoholic steatohepatitis
    • Thong-Ngam D, Samuhasaneeto S, Kulaputana O, et al. N-acetylcysteine attenuates oxidative stress and liver pathology in rats with non-alcoholic steatohepatitis. World J Gastroenterol 2007; 13: 5127-5132.
    • (2007) World J Gastroenterol , vol.13 , pp. 5127-5132
    • Thong-Ngam, D.1    Samuhasaneeto, S.2    Kulaputana, O.3
  • 27
    • 77954323682 scopus 로고    scopus 로고
    • Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells
    • Cabrera J, Negrin G, Estevez F, et al. Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells. J Pineal Res 2010; 49: 45-54.
    • (2010) J Pineal Res , vol.49 , pp. 45-54
    • Cabrera, J.1    Negrin, G.2    Estevez, F.3
  • 28
    • 77953611988 scopus 로고    scopus 로고
    • P38 MAPK and NF-kappaB pathways are involved in naphtho[1,2-b] furan-4,5-dione induced anti-proliferation and apoptosis of human hepatoma cells
    • Chiu CC, Chen JY, Lin KL, et al. p38 MAPK and NF-kappaB pathways are involved in naphtho[1,2-b] furan-4,5-dione induced anti-proliferation and apoptosis of human hepatoma cells. Cancer Lett 2010; 295: 92-99.
    • (2010) Cancer Lett , vol.295 , pp. 92-99
    • Chiu, C.C.1    Chen, J.Y.2    Lin, K.L.3
  • 29
    • 22044439575 scopus 로고    scopus 로고
    • Antiproliferative activity of melatonin by transcriptional inhibition of cyclin D1 expression: A molecular basis for melatonin-induced oncostatic effects
    • Cini G, Neri B, Pacini A, et al. Antiproliferative activity of melatonin by transcriptional inhibition of cyclin D1 expression: a molecular basis for melatonin-induced oncostatic effects. J Pineal Res 2005; 39: 12-20.
    • (2005) J Pineal Res , vol.39 , pp. 12-20
    • Cini, G.1    Neri, B.2    Pacini, A.3
  • 30
    • 0033951733 scopus 로고    scopus 로고
    • In vitro effects of melatonin on cell proliferation in a colon adenocarcinoma line
    • Farriol M, Venereo Y, Orta X, et al. In vitro effects of melatonin on cell proliferation in a colon adenocarcinoma line. J Appl Toxicol 2000; 20: 21-24.
    • (2000) J Appl Toxicol , vol.20 , pp. 21-24
    • Farriol, M.1    Venereo, Y.2    Orta, X.3
  • 31
    • 0034830607 scopus 로고    scopus 로고
    • Effects of melatonin on the proliferation and cis- diamminedichloroplatinum (CDDP) sensitivity of cultured human ovarian cancer cells
    • Futagami M, Sato S, Sakamoto T, et al. Effects of melatonin on the proliferation and cis-diamminedichloroplatinum (CDDP) sensitivity of cultured human ovarian cancer cells. Gynecol Oncol 2001; 82: 544-549.
    • (2001) Gynecol Oncol , vol.82 , pp. 544-549
    • Futagami, M.1    Sato, S.2    Sakamoto, T.3
  • 32
    • 34447500401 scopus 로고    scopus 로고
    • Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture
    • Garcia-Navarro A, Gonzalez-Puga C, Escames G, et al. Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture. J Pineal Res 2007; 43: 195-205.
    • (2007) J Pineal Res , vol.43 , pp. 195-205
    • Garcia-Navarro, A.1    Gonzalez-Puga, C.2    Escames, G.3
  • 33
    • 33746516109 scopus 로고    scopus 로고
    • Melatonin induces apoptosis in human neuroblastoma cancer cells
    • Garcia-Santos G, Antolin I, Herrera F, et al. Melatonin induces apoptosis in human neuroblastoma cancer cells. J Pineal Res 2006; 41: 130-135.
    • (2006) J Pineal Res , vol.41 , pp. 130-135
    • Garcia-Santos, G.1    Antolin, I.2    Herrera, F.3
  • 34
    • 79952547344 scopus 로고    scopus 로고
    • Melatonin reduces pancreatic tumor cell viability by altering mitochondrial physiology
    • Gonzalez A, Del Castillo-Vaquero A, Miro-Moran A, et al. Melatonin reduces pancreatic tumor cell viability by altering mitochondrial physiology. J Pineal Res 2010; 50: 250-260.
    • (2010) J Pineal Res , vol.50 , pp. 250-260
    • Gonzalez, A.1    Del Castillo-Vaquero, A.2    Miro-Moran, A.3
  • 35
    • 0023698530 scopus 로고
    • Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture
    • Hill SM, Blask DE,. Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. Cancer Res 1988; 48: 6121-6126.
    • (1988) Cancer Res , vol.48 , pp. 6121-6126
    • Hill, S.M.1    Blask, D.E.2
  • 36
    • 0035117708 scopus 로고    scopus 로고
    • Anti-angiogenic activity of melatonin in advanced cancer patients
    • Lissoni P, Rovelli F, Malugani F, et al. Anti-angiogenic activity of melatonin in advanced cancer patients. Neuro Endocrinol Lett 2001; 22: 45-47.
    • (2001) Neuro Endocrinol Lett , vol.22 , pp. 45-47
    • Lissoni, P.1    Rovelli, F.2    Malugani, F.3
  • 37
    • 84856706859 scopus 로고    scopus 로고
    • Melatonin prevents human pancreatic carcinoma cell PANC-1-induced human umbilical vein endothelial cell proliferation and migration by inhibiting vascular endothelial growth factor expression
    • Cui P, Yu M, Peng X, et al. Melatonin prevents human pancreatic carcinoma cell PANC-1-induced human umbilical vein endothelial cell proliferation and migration by inhibiting vascular endothelial growth factor expression. J Pineal Res 2012; 52: 236-243.
    • (2012) J Pineal Res , vol.52 , pp. 236-243
    • Cui, P.1    Yu, M.2    Peng, X.3
  • 38
    • 84874948547 scopus 로고    scopus 로고
    • Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF-1 in a mouse tumor model
    • Kim KJ, Choi JS, Kang I, et al. Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF-1 in a mouse tumor model. J Pineal Res 2012; 54: 264-270.
    • (2012) J Pineal Res , vol.54 , pp. 264-270
    • Kim, K.J.1    Choi, J.S.2    Kang, I.3
  • 39
    • 78650087766 scopus 로고    scopus 로고
    • Matrix metalloproteinases in health and disease: Regulation by melatonin
    • Swarnakar S, Paul S, Singh LP, et al. Matrix metalloproteinases in health and disease: regulation by melatonin. J Pineal Res 2011; 50: 8-20.
    • (2011) J Pineal Res , vol.50 , pp. 8-20
    • Swarnakar, S.1    Paul, S.2    Singh, L.P.3
  • 40
    • 84865038800 scopus 로고    scopus 로고
    • Melatonin suppresses migration and invasion via inhibition of oxidative stress pathway in glioma cells
    • Wang J, Hao H, Yao L, et al. Melatonin suppresses migration and invasion via inhibition of oxidative stress pathway in glioma cells. J Pineal Res 2012; 53: 180-187.
    • (2012) J Pineal Res , vol.53 , pp. 180-187
    • Wang, J.1    Hao, H.2    Yao, L.3
  • 41
    • 84879581073 scopus 로고    scopus 로고
    • Annexin A2 silencing inhibits invasion, migration, and tumorigenic potential of hepatoma cells
    • Zhang HJ, Yao DF, Yao M, et al. Annexin A2 silencing inhibits invasion, migration, and tumorigenic potential of hepatoma cells. World J Gastroenterol 2013; 19: 3792-3801.
    • (2013) World J Gastroenterol , vol.19 , pp. 3792-3801
    • Zhang, H.J.1    Yao, D.F.2    Yao, M.3
  • 42
    • 57149147490 scopus 로고    scopus 로고
    • ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration
    • Ortiz-Lopez L, Morales-Mulia S, Ramirez-Rodriguez G, et al. ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration. J Pineal Res 2009; 46: 15-21.
    • (2009) J Pineal Res , vol.46 , pp. 15-21
    • Ortiz-Lopez, L.1    Morales-Mulia, S.2    Ramirez-Rodriguez, G.3
  • 43
    • 0032188888 scopus 로고    scopus 로고
    • Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells
    • Cos S, Fernandez R, Guezmes A, et al. Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. Cancer Res 1998; 58: 4383-4390.
    • (1998) Cancer Res , vol.58 , pp. 4383-4390
    • Cos, S.1    Fernandez, R.2    Guezmes, A.3
  • 44
    • 84880263145 scopus 로고    scopus 로고
    • Inhibition of VEGF expression through blockade of Hif1alpha and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells
    • Carbajo-Pescador S, Ordonez R, Benet M, et al. Inhibition of VEGF expression through blockade of Hif1alpha and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells. Br J Cancer 2013; 109: 83-91.
    • (2013) Br J Cancer , vol.109 , pp. 83-91
    • Carbajo-Pescador, S.1    Ordonez, R.2    Benet, M.3
  • 45
    • 84873743356 scopus 로고    scopus 로고
    • Melatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells
    • Carbajo-Pescador S, Steinmetz C, Kashyap A, et al. Melatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells. Br J Cancer 2013; 108: 442-449.
    • (2013) Br J Cancer , vol.108 , pp. 442-449
    • Carbajo-Pescador, S.1    Steinmetz, C.2    Kashyap, A.3
  • 46
    • 80054818699 scopus 로고    scopus 로고
    • Melatonin modulation of intracellular signaling pathways in hepatocarcinoma HepG2 cell line: Role of the MT1 receptor
    • Carbajo-Pescador S, Garcia-Palomo A, Martin-Renedo J, et al. Melatonin modulation of intracellular signaling pathways in hepatocarcinoma HepG2 cell line: role of the MT1 receptor. J Pineal Res 2011; 51: 463-471.
    • (2011) J Pineal Res , vol.51 , pp. 463-471
    • Carbajo-Pescador, S.1    Garcia-Palomo, A.2    Martin-Renedo, J.3
  • 47
    • 70350068403 scopus 로고    scopus 로고
    • Changes in the expression of melatonin receptors induced by melatonin treatment in hepatocarcinoma HepG2 cells
    • Carbajo-Pescador S, Martin-Renedo J, Garcia-Palomo A, et al. Changes in the expression of melatonin receptors induced by melatonin treatment in hepatocarcinoma HepG2 cells. J Pineal Res 2009; 47: 330-338.
    • (2009) J Pineal Res , vol.47 , pp. 330-338
    • Carbajo-Pescador, S.1    Martin-Renedo, J.2    Garcia-Palomo, A.3
  • 48
    • 53749085741 scopus 로고    scopus 로고
    • Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line
    • Martin-Renedo J, Mauriz JL, Jorquera F, et al. Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line. J Pineal Res 2008; 45: 532-540.
    • (2008) J Pineal Res , vol.45 , pp. 532-540
    • Martin-Renedo, J.1    Mauriz, J.L.2    Jorquera, F.3
  • 49
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD,. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 50
    • 33845546703 scopus 로고    scopus 로고
    • The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions
    • Apte RN, Dotan S, Elkabets M, et al. The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions. Cancer Metastasis Rev 2006; 25: 387-408.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 387-408
    • Apte, R.N.1    Dotan, S.2    Elkabets, M.3
  • 51
    • 0033845583 scopus 로고    scopus 로고
    • Extrahepatic metastases of hepatocellular carcinoma
    • Katyal S, Oliver JH 3rd, Peterson MS, et al. Extrahepatic metastases of hepatocellular carcinoma. Radiology 2000; 216: 698-703.
    • (2000) Radiology , vol.216 , pp. 698-703
    • Katyal, S.1    Oliver III, J.H.2    Peterson, M.S.3
  • 52
    • 84866143444 scopus 로고    scopus 로고
    • New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment
    • Noel A, Gutierrez-Fernandez A, Sounni NE, et al. New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment. Front Pharmacol 2012; 3: 140.
    • (2012) Front Pharmacol , vol.3 , pp. 140
    • Noel, A.1    Gutierrez-Fernandez, A.2    Sounni, N.E.3
  • 53
    • 84872137580 scopus 로고    scopus 로고
    • Role of metalloproteinases and their inhibitors in tumors
    • Coronato S, Laguens G, di Girolamo V,. Role of metalloproteinases and their inhibitors in tumors. Medicina (B Aires) 2012; 72: 495-502.
    • (2012) Medicina (B Aires) , vol.72 , pp. 495-502
    • Coronato, S.1    Laguens, G.2    Di Girolamo, V.3
  • 54
    • 84881481410 scopus 로고    scopus 로고
    • Matrix metalloproteinases in cancer: Their value as diagnostic and prognostic markers and therapeutic targets
    • Hadler-Olsen E, Winberg JO, Uhlin-Hansen L,. Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets. Tumour Biol 2013; 34: 2041-2051.
    • (2013) Tumour Biol , vol.34 , pp. 2041-2051
    • Hadler-Olsen, E.1    Winberg, J.O.2    Uhlin-Hansen, L.3
  • 55
    • 67651172980 scopus 로고    scopus 로고
    • Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis elegans
    • Hahm JH, Kim S, Paik YK,. Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis elegans. Aging Cell 2009; 8: 473-483.
    • (2009) Aging Cell , vol.8 , pp. 473-483
    • Hahm, J.H.1    Kim, S.2    Paik, Y.K.3
  • 56
    • 84869473662 scopus 로고    scopus 로고
    • Melatonin as adjuvant cancer care with and without chemotherapy: A systematic review and meta-analysis of randomized trials
    • Seely D, Wu P, Fritz H, et al. Melatonin as adjuvant cancer care with and without chemotherapy: a systematic review and meta-analysis of randomized trials. Integr Cancer Ther 2012; 11: 293-303.
    • (2012) Integr Cancer Ther , vol.11 , pp. 293-303
    • Seely, D.1    Wu, P.2    Fritz, H.3
  • 57
    • 84862299740 scopus 로고    scopus 로고
    • The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: A meta-analysis of randomized controlled trials
    • Wang YM, Jin BZ, Ai F, et al. The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials. Cancer Chemother Pharmacol 2012; 69: 1213-1220.
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 1213-1220
    • Wang, Y.M.1    Jin, B.Z.2    Ai, F.3
  • 58
    • 0032442440 scopus 로고    scopus 로고
    • Effects of melatonin on proliferation of cancer cell lines
    • Papazisis KT, Kouretas D, Geromichalos GD, et al. Effects of melatonin on proliferation of cancer cell lines. J Pineal Res 1998; 25: 211-218.
    • (1998) J Pineal Res , vol.25 , pp. 211-218
    • Papazisis, K.T.1    Kouretas, D.2    Geromichalos, G.D.3
  • 59
    • 0032964066 scopus 로고    scopus 로고
    • The oncostatic action of melatonin in an ovarian carcinoma cell line
    • Petranka J, Baldwin W, Biermann J, et al. The oncostatic action of melatonin in an ovarian carcinoma cell line. J Pineal Res 1999; 26: 129-136.
    • (1999) J Pineal Res , vol.26 , pp. 129-136
    • Petranka, J.1    Baldwin, W.2    Biermann, J.3
  • 60
    • 0032848858 scopus 로고    scopus 로고
    • Melatonin-induced inhibition of proliferation and G1/S cell cycle transition delay of human choriocarcinoma JAr cells: Possible involvement of MT2 (MEL1B) receptor
    • Shiu SY, Li L, Xu JN, et al. Melatonin-induced inhibition of proliferation and G1/S cell cycle transition delay of human choriocarcinoma JAr cells: possible involvement of MT2 (MEL1B) receptor. J Pineal Res 1999; 27: 183-192.
    • (1999) J Pineal Res , vol.27 , pp. 183-192
    • Shiu, S.Y.1    Li, L.2    Xu, J.N.3
  • 61
    • 79953862700 scopus 로고    scopus 로고
    • Melatonin and cancer: Current knowledge and its application to oral cavity tumours
    • Cutando A, Aneiros-Fernandez J, Aneiros-Cachaza J, et al. Melatonin and cancer: current knowledge and its application to oral cavity tumours. J Oral Pathol Med 2011; 40: 593-597.
    • (2011) J Oral Pathol Med , vol.40 , pp. 593-597
    • Cutando, A.1    Aneiros-Fernandez, J.2    Aneiros-Cachaza, J.3
  • 62
    • 4644310412 scopus 로고    scopus 로고
    • TNF-alpha and IL-1beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells
    • Nee LE, McMorrow T, Campbell E, et al. TNF-alpha and IL-1beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells. Kidney Int 2004; 66: 1376-1386.
    • (2004) Kidney Int , vol.66 , pp. 1376-1386
    • Nee, L.E.1    McMorrow, T.2    Campbell, E.3
  • 63
    • 42149105217 scopus 로고    scopus 로고
    • Role of melatonin in regulating matrix metalloproteinase-9 via tissue inhibitors of metalloproteinase-1 during protection against endometriosis
    • Paul S, Sharma AV, Mahapatra PD, et al. Role of melatonin in regulating matrix metalloproteinase-9 via tissue inhibitors of metalloproteinase-1 during protection against endometriosis. J Pineal Res 2008; 44: 439-449.
    • (2008) J Pineal Res , vol.44 , pp. 439-449
    • Paul, S.1    Sharma, A.V.2    Mahapatra, P.D.3
  • 64
    • 78349240002 scopus 로고    scopus 로고
    • Melatonin inhibits postischemic matrix metalloproteinase-9 (MMP-9) activation via dual modulation of plasminogen/plasmin system and endogenous MMP inhibitor in mice subjected to transient focal cerebral ischemia
    • Tai SH, Chen HY, Lee EJ, et al. Melatonin inhibits postischemic matrix metalloproteinase-9 (MMP-9) activation via dual modulation of plasminogen/plasmin system and endogenous MMP inhibitor in mice subjected to transient focal cerebral ischemia. J Pineal Res 2010; 49: 332-341.
    • (2010) J Pineal Res , vol.49 , pp. 332-341
    • Tai, S.H.1    Chen, H.Y.2    Lee, E.J.3
  • 65
    • 79960425073 scopus 로고    scopus 로고
    • Inhibition of breast cancer cell invasion by melatonin is mediated through regulation of the p38 mitogen-activated protein kinase signaling pathway
    • Mao L, Yuan L, Slakey LM, et al. Inhibition of breast cancer cell invasion by melatonin is mediated through regulation of the p38 mitogen-activated protein kinase signaling pathway. Breast Cancer Res 2010; 12: R107.
    • (2010) Breast Cancer Res , vol.12
    • Mao, L.1    Yuan, L.2    Slakey, L.M.3
  • 66
    • 84866303931 scopus 로고    scopus 로고
    • Melatonin inhibits IL1beta-induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-kappaB activation
    • Qin W, Lu W, Li H, et al. Melatonin inhibits IL1beta-induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-kappaB activation. J Endocrinol 2012; 214: 145-153.
    • (2012) J Endocrinol , vol.214 , pp. 145-153
    • Qin, W.1    Lu, W.2    Li, H.3
  • 67
    • 84879459578 scopus 로고    scopus 로고
    • Melatonin inhibits matrix metalloproteinase-9 activity by binding to its active site
    • Rudra DS, Pal U, Maiti NC, et al. Melatonin inhibits matrix metalloproteinase-9 activity by binding to its active site. J Pineal Res 2013; 54: 398-405.
    • (2013) J Pineal Res , vol.54 , pp. 398-405
    • Rudra, D.S.1    Pal, U.2    Maiti, N.C.3
  • 68
    • 3242758083 scopus 로고    scopus 로고
    • Suppression of matrix metalloproteinase-9 transcription by transforming growth factor-beta is mediated by a nuclear factor-kappaB site
    • Ogawa K, Chen F, Kuang C, et al. Suppression of matrix metalloproteinase-9 transcription by transforming growth factor-beta is mediated by a nuclear factor-kappaB site. Biochem J 2004; 381: 413-422.
    • (2004) Biochem J , vol.381 , pp. 413-422
    • Ogawa, K.1    Chen, F.2    Kuang, C.3
  • 69
    • 77954428063 scopus 로고    scopus 로고
    • ROS-NFkappaB mediates TGF-beta1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion
    • Tobar N, Villar V, Santibanez JF,. ROS-NFkappaB mediates TGF-beta1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion. Mol Cell Biochem 2010; 340: 195-202.
    • (2010) Mol Cell Biochem , vol.340 , pp. 195-202
    • Tobar, N.1    Villar, V.2    Santibanez, J.F.3
  • 70
    • 0035988849 scopus 로고    scopus 로고
    • Activation of NF-kappa B, AP-1 and STAT transcription factors is a frequent and early event in human hepatocellular carcinomas
    • Liu P, Kimmoun E, Legrand A, et al. Activation of NF-kappa B, AP-1 and STAT transcription factors is a frequent and early event in human hepatocellular carcinomas. J Hepatol 2002; 37: 63-71.
    • (2002) J Hepatol , vol.37 , pp. 63-71
    • Liu, P.1    Kimmoun, E.2    Legrand, A.3
  • 71
    • 84864975206 scopus 로고    scopus 로고
    • Melatonin inhibits matrix metalloproteinase-9 (MMP-9) activation in the lipopolysaccharide (LPS)-stimulated RAW 264.7 and BV2 cells and a mouse model of meningitis
    • Chang CC, Tien CH, Lee EJ, et al. Melatonin inhibits matrix metalloproteinase-9 (MMP-9) activation in the lipopolysaccharide (LPS)-stimulated RAW 264.7 and BV2 cells and a mouse model of meningitis. J Pineal Res 2012; 53: 188-197.
    • (2012) J Pineal Res , vol.53 , pp. 188-197
    • Chang, C.C.1    Tien, C.H.2    Lee, E.J.3
  • 72
    • 84870372396 scopus 로고    scopus 로고
    • Tectorigenin sensitizes paclitaxel-resistant human ovarian cancer cells through downregulation of the Akt and NFkappaB pathway
    • Yang YI, Lee KT, Park HJ, et al. Tectorigenin sensitizes paclitaxel-resistant human ovarian cancer cells through downregulation of the Akt and NFkappaB pathway. Carcinogenesis 2012; 33: 2488-2498.
    • (2012) Carcinogenesis , vol.33 , pp. 2488-2498
    • Yang, Y.I.1    Lee, K.T.2    Park, H.J.3
  • 73
    • 84862501584 scopus 로고    scopus 로고
    • Carnosic acid modulates Akt/IKK/NF-kappaB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells
    • Kar S, Palit S, Ball WB, et al. Carnosic acid modulates Akt/IKK/NF-kappaB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells. Apoptosis 2012; 17: 735-747.
    • (2012) Apoptosis , vol.17 , pp. 735-747
    • Kar, S.1    Palit, S.2    Ball, W.B.3
  • 74
    • 80155160468 scopus 로고    scopus 로고
    • Antimetastatic effect and mechanism of ovatodiolide in MDA-MB-231 human breast cancer cells
    • Lin KL, Tsai PC, Hsieh CY, et al. Antimetastatic effect and mechanism of ovatodiolide in MDA-MB-231 human breast cancer cells. Chem Biol Interact 2011; 194: 148-158.
    • (2011) Chem Biol Interact , vol.194 , pp. 148-158
    • Lin, K.L.1    Tsai, P.C.2    Hsieh, C.Y.3
  • 75
    • 84865101209 scopus 로고    scopus 로고
    • Sorafenib inhibits TPA-induced MMP-9 and VEGF expression via suppression of ERK/NF-kappaB pathway in hepatocellular carcinoma cells
    • Chiang IT, Liu YC, Wang WH, et al. Sorafenib inhibits TPA-induced MMP-9 and VEGF expression via suppression of ERK/NF-kappaB pathway in hepatocellular carcinoma cells. In Vivo 2012; 26: 671-681.
    • (2012) Vivo , vol.26 , pp. 671-681
    • Chiang, I.T.1    Liu, Y.C.2    Wang, W.H.3
  • 76
    • 0042090509 scopus 로고    scopus 로고
    • Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: Correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1
    • Shishodia S, Majumdar S, Banerjee S, et al. Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res 2003; 63: 4375-4383.
    • (2003) Cancer Res , vol.63 , pp. 4375-4383
    • Shishodia, S.1    Majumdar, S.2    Banerjee, S.3
  • 77
    • 33947598693 scopus 로고    scopus 로고
    • Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation
    • Sethi G, Ahn KS, Pandey MK, et al. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation. Blood 2007; 109: 2727-2735.
    • (2007) Blood , vol.109 , pp. 2727-2735
    • Sethi, G.1    Ahn, K.S.2    Pandey, M.K.3
  • 78
    • 80051484401 scopus 로고    scopus 로고
    • Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: Role of the phosphatidylinositol 3-kinase/Akt pathway
    • Buhrmann C, Mobasheri A, Busch F, et al. Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem 2011; 286: 28556-28566.
    • (2011) J Biol Chem , vol.286 , pp. 28556-28566
    • Buhrmann, C.1    Mobasheri, A.2    Busch, F.3
  • 79
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • Aggarwal BB, Shishodia S,. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 2006; 71: 1397-1421.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 80
    • 58849158423 scopus 로고    scopus 로고
    • Vanillin inhibits matrix metalloproteinase-9 expression through down-regulation of nuclear factor-kappaB signaling pathway in human hepatocellular carcinoma cells
    • Liang JA, Wu SL, Lo HY, et al. Vanillin inhibits matrix metalloproteinase-9 expression through down-regulation of nuclear factor-kappaB signaling pathway in human hepatocellular carcinoma cells. Mol Pharmacol 2009; 75: 151-157.
    • (2009) Mol Pharmacol , vol.75 , pp. 151-157
    • Liang, J.A.1    Wu, S.L.2    Lo, H.Y.3
  • 81
    • 34249913180 scopus 로고    scopus 로고
    • Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1
    • Huang CS, Fan YE, Lin CY, et al. Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1. J Nutr Biochem 2007; 18: 449-456.
    • (2007) J Nutr Biochem , vol.18 , pp. 449-456
    • Huang, C.S.1    Fan, Y.E.2    Lin, C.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.