Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells

British Journal of Cancer

Volumn 109, Issue 1, 2013, Pages 83-91

  Carbajo Pescador, S ^a   Ordonez R ^a   Benet, M ^b,c   Jover, R ^b,c,d   Garcia Palomo A ^e   Mauriz, J L ^a,b   Gonzalez Gallego J ^a,b  

^a UNIVERSITY OF LEÓN   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c HOSPITAL UNIVERSITARIO LA FE   (Spain)

^d UNIVERSITY OF VALENCIA   (Spain)

^e Complejo Asistencial Universitario de León   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MELATONIN; STAT3 PROTEIN; VASCULOTROPIN;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL HYPOXIA; CELL STRAIN HEPG2; CELLULAR DISTRIBUTION; CHROMATIN IMMUNOPRECIPITATION; DRUG MEGADOSE; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANGIOGENESIS INHIBITORS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL HYPOXIA; COBALT; CYCLIC S-OXIDES; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER NEOPLASMS; MELATONIN; NEOVASCULARIZATION, PATHOLOGIC; P300-CBP TRANSCRIPTION FACTORS; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84880263145     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2013.285     Document Type: Article

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