Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases

Nature Communications

Volumn 6, Issue , 2015, Pages

  Niehues, Sven ^a,b   Bussmann, Julia ^a,b   Steffes, Georg ^a,b   Erdmann, Ines ^c,d   Köhrer, Caroline ^e   Sun, Litao ^f   Wagner, Marina ^a,b   Schäfer, Kerstin ^a,b   Wang, Guangxia ^a,b   Koerdt, Sophia N ^a,b   Stum, Morgane ^g   RajBhandary, Uttam L ^e   Thomas, Ulrich ^c   Aberle, Hermann ^h   Burgess, Robert W ^g   Yang, Xiang Lei ^f   Dieterich, Daniela ^c,d   Storkebaum, Erik ^a,b  

^a MAX PLANCK INSTITUTE FOR MOLECULAR BIOMEDICINE   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c LEIBNIZ INSTITUTE FOR NEUROBIOLOGY   (Germany)

^d OTTO VON GUERICKE UNIVERSITY   (Germany)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f SCRIPPS RESEARCH INSTITUTE   (United States)

^g JACKSON LABORATORY   (United States)

^h HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSFER RNA LIGASE; GLYCINE TRANSFER RNA LIGASE; MUTANT PROTEIN; TYROSINE TRANSFER RNA LIGASE;

AMINO ACID; ENZYME ACTIVITY; FLY; GENE EXPRESSION; GENETIC ANALYSIS; MUTATION; NEUROLOGY; PATHOGENICITY; PHENOTYPE; PROTEIN; RNA; SENSORY SYSTEM;

AMINOACYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR DISTRIBUTION; FRUIT FLY MODEL; GENE MUTATION; GENE OVEREXPRESSION; HEREDITARY MOTOR SENSORY NEUROPATHY; LIFESPAN; MOTOR DYSFUNCTION; NONHUMAN; PROTEIN PROCESSING; PROTEIN SYNTHESIS; SENSORY NERVE CELL; ANIMAL; DISEASE MODEL; DROSOPHILA; GENETICS; HUMAN; LIFE EXPECTANCY; METABOLISM; MOTONEURON; MOVEMENT (PHYSIOLOGY); MUTATION; NEUROMUSCULAR JUNCTION; PATHOLOGY; PHENOTYPE; SITE DIRECTED MUTAGENESIS; TRANSGENIC ANIMAL;

LEPISOSTEIDAE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CHARCOT-MARIE-TOOTH DISEASE; DISEASE MODELS, ANIMAL; DROSOPHILA; GLYCINE-TRNA LIGASE; HUMANS; LIFE EXPECTANCY; MOTOR NEURONS; MOVEMENT; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEUROMUSCULAR JUNCTION; PHENOTYPE; PROTEIN BIOSYNTHESIS; SENSORY RECEPTOR CELLS; TYROSINE-TRNA LIGASE;

EID: 84936818254     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8520     Document Type: Article

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