Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration

Science

Volumn 345, Issue 6195, 2014, Pages 455-459

  Ishimura, Ryuta ^a   Nagy, Gabor ^a   Dotu, Ivan ^b   Zhou, Huihao ^c   Yang, Xiang Lei ^c   Schimmel, Paul ^c   Senju, Satoru ^d   Nishimura, Yasuharu ^d   Chuang, Jeffrey H ^b   Ackerman, Susan L ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b JACKSON LABORATORY   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDES AND PROTEINS; PROTEIN GTPBP2; RIBOSOME RECYCLING FACTOR; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; ARGININE TRANSFER RNA; CELL CYCLE PROTEIN; GTPBP2 PROTEIN, MOUSE; GUANINE NUCLEOTIDE BINDING PROTEIN; PELOTA PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM; GENE; GENE EXPRESSION; GENE MUTATION; HETEROZYGOSITY; INTRON; MOUSE; NERVE DEGENERATION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN INTERACTION; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSFER RNA GENE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL NUCLEUS; CEREBELLUM; DEGENERATIVE DISEASE; GENETICS; METABOLISM; PATHOLOGY; PROTEIN SYNTHESIS; RIBOSOME; RNA SPLICING;

ANIMALS; CELL CYCLE PROTEINS; CELL NUCLEUS; CEREBELLUM; GTP-BINDING PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICROFILAMENT PROTEINS; NEURODEGENERATIVE DISEASES; POINT MUTATION; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA SPLICE SITES; RNA, TRANSFER, ARG;

EID: 84904806049     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1249749     Document Type: Article

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