CMT-associated mutations in glycyl- and tyrosyl-tRNA synthetases exhibit similar pattern of toxicity and share common genetic modifiers in Drosophila

Neurobiology of Disease

Volumn 68, Issue , 2014, Pages 180-189

  Ermanoska, Biljana ^a,b   Motley, William W ^c,d   Leitão Gonçalves, Ricardo ^a,b   Asselbergh, Bob ^a,b   Lee, LaTasha H ^e   De Rijk, Peter ^a   Sleegers, Kristel ^a,b   Ooms, Tinne ^a,b   Godenschwege, Tanja A ^e   Timmerman, Vincent ^a,b   Fischbeck, Kenneth H ^c   Jordanova, Albena ^a,b  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e FLORIDA ATLANTIC UNIVERSITY   (United States)

Author keywords

Aminoacyl tRNA synthetase; Charcot Marie Tooth disease; Drosophila

Indexed keywords

GLYCINE TRANSFER RNA LIGASE; TYROSINE TRANSFER RNA LIGASE; DEXTRAN; DROSOPHILA PROTEIN; FLUORO-RUBY; RHODAMINE;

ADULT; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA; ELECTROPHYSIOLOGY; FEMALE; GARS GENE; GENE EXPRESSION; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC LINKAGE; GENETIC MODIFIER; GENETIC PARAMETERS; HEREDITARY MOTOR SENSORY NEUROPATHY; LOSS OF FUNCTION MUTATION; MALE; MOTOR DYSFUNCTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RETINA DEGENERATION; TOXICITY; YARS GENE; ANIMAL; COMPLICATION; DISEASE MODEL; FORELIMB; GENETICS; HUMAN; MEMBRANE POTENTIAL; METABOLISM; MUTATION; NERVE CELL; NERVE FIBER; PATHOLOGY; PERIPHERAL NERVOUS SYSTEM DISEASES; PHYSIOLOGY; RETINA; RETINAL DEGENERATION; TRANSGENIC ANIMAL; ULTRASTRUCTURE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CHARCOT-MARIE-TOOTH DISEASE; DEXTRANS; DISEASE MODELS, ANIMAL; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; GLYCINE-TRNA LIGASE; HUMANS; MALE; MEMBRANE POTENTIALS; MUTATION; NERVE FIBERS; NEURONS; PERIPHERAL NERVOUS SYSTEM DISEASES; RETINA; RETINAL DEGENERATION; RHODAMINES; TYROSINE-TRNA LIGASE; WINGS, ANIMAL;

EID: 84901338850     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.04.020     Document Type: Article

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